DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ balastik-2008-1 human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113270X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation balastik-2008-2 in vitro In vitro comigration in sds comigration in sds page comigration in sds predetermined predetermined participant predetermined Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113268X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation balastik-2008-3 in vitro In vitro comigration in sds comigration in sds page comigration in sds weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113272X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation balastik-2008-4 mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113273X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation balastik-2008-5 human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113269X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation balastik-2008-6 human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. DIP original experiment: DIP-113271X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Balastik M., Ferraguti F., Pires-da Silva A., Lee TH., Alvarez-Bolado G., Lu KP., Gruss P. Only protein-protein interactions imex curation trim2_mouse Tripartite motif-containing protein 2 Trim2 Narf E3 ubiquitin-protein ligase TRIM2 Kiaa0517 Neural activity-related RING finger protein RING-type E3 ubiquitin transferase TRIM2 protein protein mouse Mus musculus Mouse MASEGASIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDSSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ mint May contribute to the alteration of neural cellular mechanisms nfl_mouse Neurofilament light polypeptide Neurofilament triplet L protein 68 kDa neurofilament protein Nefl Nfl Nf68 protein protein mouse Mus musculus Mouse MSSFGYDPYFSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRSTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYSGLQSSSYLMSARSFPAYYTSHVQEEQTEVEETIEATKAEEAKDEPPSEGEAEEEEKEKEEGEEEEGAEEEEAAKDESEDTKEEEEGGEGEEEDTKESEEEEKKEESAGEEQVAKKKD ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG trim2-nefl-1 3175675 N/A 3175681 unspecified role unspecified role bait bait Region 1-440 Region 1-440 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3175682 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false trim2-ub-1 3175676 N/A 3175681 unspecified role unspecified role unspecified role unspecified role Region 1-440 Region 1-440 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3175683 unspecified role unspecified role unspecified role unspecified role direct interaction direct interaction false false false nefl-ub-1 3175677 N/A 3175682 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3175683 unspecified role unspecified role unspecified role unspecified role direct interaction direct interaction false false false trim2-nefl-2 3175678 N/A 3175681 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false mouse Mus musculus Mouse N/A 3175682 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association false false false ub-trim2-1 3175679 N/A 3175681 unspecified role unspecified role prey prey Region 1-440 Region 1-440 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false human Homo sapiens Human N/A 3175683 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false human Homo sapiens Human physical association physical association false false false ub-nefl-1 3175680 N/A 3175683 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal false human Homo sapiens Human N/A 3175682 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association false false false