DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ essalmani-2008-1 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. DIP original experiment: DIP-68647X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. Only protein-protein interactions imex curation essalmani-2008-2 in vitro In vitro protease assay protease assay ms participant Identification by mass spectrometry ms participant Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. DIP original experiment: DIP-68645X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. Only protein-protein interactions imex curation essalmani-2008-3 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. DIP original experiment: DIP-68648X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. Only protein-protein interactions imex curation essalmani-2008-4 in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. DIP original experiment: DIP-68646X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Essalmani R., Zaid A., Marcinkiewicz J., Chamberland A., Pasquato A., Seidah NG., Prat A. Only protein-protein interactions imex curation gdf11_mouse Growth/differentiation factor 11 Gdf11 Bmp11 Bone morphogenetic protein 11 protein protein mouse Mus musculus Mouse MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAGVGGERSSRPAPSAPPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS mint Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern pcsk7_rat Proprotein convertase subtilisin/kexin type 7 Pcsk7 Pc7 Prohormone convertase 7 Proprotein convertase 7 Subtilisin/kexin-like protease PC7 protein protein rat Rattus norvegicus (Rat) Rat MPKGRQKVPRLDARLGLPICLCLELAIFFLVPQVMGLTEAGGLDTLGAGGLSWAVHLDSLEGERKEESLIQQANAVAQAAGLVNAGRIGELQGHYLFVQPAGHGQAMEAEAMRQQAEAVLAKHEAVRWHSEQRLLKRAKRSIHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATQYEDHRADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVLWNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGVYRLVIRDVGDEPLQVGILQQWQLTLYGSTWSPVDIKDRQSLLESAMSGKYLHDDFTLPCPPGLKIPEEDGYSITPNTLKTLVLVGCFSVFWTIYYMLEVCLSQRSKASTHGCRRGCCPWPPQSQNSKEVGTALESMPLCSSKDLDGVDSEHGDCTTASSLLAPELLGEADWSLSQNSKSDLDCPPHQPPDLKDGQIC p29122-1 Proprotein convertase subtilisin/kexin type 6 PCSK6 PACE4 Paired basic amino acid cleaving enzyme 4 Subtilisin-like proprotein convertase 4 Subtilisin/kexin-like protease PACE4 PACE4 protein protein human Homo sapiens Human MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG furin_human Furin FURIN FUR PACE PCSK3 Paired basic amino acid residue-cleaving enzyme Dibasic-processing enzyme protein protein human Homo sapiens Human MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL p41413-2 Proprotein convertase subtilisin/kexin type 5 Proprotein convertase 5 Proprotein convertase 6 Subtilisin/kexin-like protease PC5 Short Pcsk5 protein protein rat Rattus norvegicus (Rat) Rat MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG gdf11-pcsk7-1 3170071 N/A 3170075 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 290-301 Region 290-301 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9Z1W4:p.Asn297Asp N297D mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3170076 enzyme enzyme unspecified role unspecified role rat Rattus norvegicus (Rat) Rat direct interaction direct interaction false false false gdf11-pcsk6-1 3170072 N/A 3170075 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 290-301 Region 290-301 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9Z1W4:p.Asn297Asp N297D mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3170077 enzyme enzyme unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction false false false furin-gdf11-1 3170073 N/A 3170075 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 290-301 Region 290-301 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9Z1W4:p.Asn297Asp N297D mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3170078 enzyme enzyme unspecified role unspecified role human Homo sapiens Human direct interaction direct interaction false false false gdf11-pcsk5-1 3170074 N/A 3170075 enzyme target enzyme target substrate substrate unspecified role unspecified role Region 290-301 Region 290-301 binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Q9Z1W4:p.Asn297Asp N297D mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3170079 enzyme enzyme unspecified role unspecified role rat Rattus norvegicus (Rat) Rat direct interaction direct interaction false false false