DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ shangary-2008-1 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Shangary S., Qin D., McEachern D., Liu M., Miller RS., Qiu S., Nikolovska-Coleska Z., Ding K., Ding K., Wang G., Chen J., Bernard D., Zhang J., Lu Y., Gu Q., Shah RB., Pienta KJ., Ling X., Kang S., Guo M., Sun Y., Yang D., Wang S. DIP original experiment: DIP-68510X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Shangary S., Qin D., McEachern D., Liu M., Miller RS., Qiu S., Nikolovska-Coleska Z., Ding K., Ding K., Wang G., Chen J., Bernard D., Zhang J., Lu Y., Gu Q., Shah RB., Pienta KJ., Ling X., Kang S., Guo M., Sun Y., Yang D., Wang S. Only protein-protein interactions imex curation shangary-2008-2 human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Shangary S., Qin D., McEachern D., Liu M., Miller RS., Qiu S., Nikolovska-Coleska Z., Ding K., Ding K., Wang G., Chen J., Bernard D., Zhang J., Lu Y., Gu Q., Shah RB., Pienta KJ., Ling X., Kang S., Guo M., Sun Y., Yang D., Wang S. DIP original experiment: DIP-217255X Proceedings of the National Academy of Sciences of the United States of America 2008 IMEx Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Shangary S., Qin D., McEachern D., Liu M., Miller RS., Qiu S., Nikolovska-Coleska Z., Ding K., Ding K., Wang G., Chen J., Bernard D., Zhang J., Lu Y., Gu Q., Shah RB., Pienta KJ., Ling X., Kang S., Guo M., Sun Y., Yang D., Wang S. Only protein-protein interactions imex curation mdm2_human E3 ubiquitin-protein ligase Mdm2 MDM2 p53-binding protein Mdm2 Oncoprotein Mdm2 Double minute 2 protein RING-type E3 ubiquitin transferase Mdm2 protein protein human Homo sapiens Human MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD tp53-mdm2-27 3168713 N/A 3168715 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3168716 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false tp53-mdm2-28 3168714 N/A 3168715 unspecified role unspecified role prey prey human Homo sapiens Human N/A 3168716 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association false false false 1 nodeMerge04 2011-10-21