DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ wang-2007-18 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261793X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation wang-2007-19 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261790X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation wang-2007-20 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261794X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation wang-2007-21 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261791X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation wang-2007-22 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261795X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation wang-2007-23 ecolx Escherichia coli molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Wang J., Lohman GJ., Stubbe J. DIP original experiment: DIP-261792X Proceedings of the National Academy of Sciences of the United States of America 2007 IMEx Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Wang J., Lohman GJ., Stubbe J. Only protein-protein interactions imex curation rir2_ecoli Ribonucleoside-diphosphate reductase 1 subunit beta Ribonucleotide reductase 1 Protein B2 Protein R2 nrdB ftsB b2235 JW2229 protein protein ecoli Escherichia coli (strain K12) MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL rir1_ecoli Ribonucleoside-diphosphate reductase 1 subunit alpha nrdA dnaF Protein B1 b2234 Ribonucleoside-diphosphate reductase 1 R1 subunit Ribonucleotide reductase 1 JW2228 protein protein ecoli Escherichia coli (strain K12) MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI rir1_human Ribonucleoside-diphosphate reductase large subunit Ribonucleoside-diphosphate reductase subunit M1 Ribonucleotide reductase large subunit RRM1 RR1 protein protein human Homo sapiens Human MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS rir2_human Ribonucleoside-diphosphate reductase subunit M2 RRM2 RR2 Ribonucleotide reductase small subunit Ribonucleotide reductase small chain protein protein human Homo sapiens Human MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF nrdb-1 3160401 N/A 3160407 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false nrda-nrdb-1 3160402 N/A 3160407 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3160408 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false rrm1-1 3160403 N/A 3160409 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false rrm1-rrm2-1 3160404 N/A 3160410 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli N/A 3160409 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false rrm2-1 3160405 N/A 3160410 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false nrda-1 3160406 N/A 3160408 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false