<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3158934">
                <names>
                    <shortLabel>yang-2007-8</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="17637340" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="wwpdb" dbAc="MI:0805" id="1R6U" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2007.05.009" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15648031" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-8798" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-67810X" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="562">
                        <names>
                            <shortLabel>ecolx</shortLabel>
                            <fullName>Escherichia coli</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Yang XL., Guo M., Kapoor M., Ewalt KL., Otero FJ., Skene RJ., McRee DE., Schimmel P.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-67810X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2007</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Yang XL.,  Guo M.,  Kapoor M.,  Ewalt KL.,  Otero FJ.,  Skene RJ.,  McRee DE.,  Schimmel P.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3158935">
                <names>
                    <shortLabel>sywc_human</shortLabel>
                    <fullName>Tryptophan--tRNA ligase, cytoplasmic</fullName>
                    <alias typeAc="MI:0301" type="gene name">WARS1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">IFI53</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Interferon-induced protein 53</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Tryptophanyl-tRNA synthetase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">WARS</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">WRS</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P23381" version="SP_80" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_211"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009068" version="SP_211"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000392882" version="SP_211" refType="transcript"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000451460" version="SP_211" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AZX" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QUH" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_776049.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005268101.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016877117.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019210" secondary="kinase inhibitor activity" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004830" secondary="tryptophan-tRNA ligase activity" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001933" secondary="negative regulation of protein phosphorylation" version="SP_211"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29493N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000355338" version="SP_211" refType="transcript"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P78535" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000376620" version="SP_211" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045765" secondary="regulation of angiogenesis" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1R6T" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QUJ" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_998810.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002305" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1R6U" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QUI" version="SP_211"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-379716" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006720312.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011535437.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006436" secondary="tryptophanyl-tRNA aminoacylation" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016877118.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UDL3" version="SP_80" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q502Y0" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_211"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001412" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UJI" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004175.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010835" secondary="regulation of protein ADP-ribosylation" version="SP_211"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002306" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011535435.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AKE" version="SP_211"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A6NGN1" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006412" secondary="translation" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2DR2" version="SP_211"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A6NID3" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UJJ" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011535438.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_998811.1"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-721244" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q53XB6" version="SP_104" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006469" secondary="negative regulation of protein kinase activity" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2QUK" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1ULH" version="SP_211"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1O5T" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_211"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UDI5" version="SP_109" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000738" version="SP_211"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000347495" version="SP_211" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014729" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_211"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000557135" version="SP_211" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_211"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016877116.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031334" secondary="positive regulation of protein-containing complex assembly" version="SP_211"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_211"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000140105" version="SP_211" refType="gene"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-8798-1" id="3158936">
                <names>
                    <shortLabel>wars-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-58926E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-8798-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15648043" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3158934</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3158937">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15648047" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3158935</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3158938">
                                <names>
                                    <shortLabel>Region 48-471</shortLabel>
                                    <fullName>Region 48-471</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15648048" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="48"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="471"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
