DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ hallows-2006-1 in vitro In vitro acetylase assay acetylase assay predetermined predetermined participant predetermined Hallows WC., Lee S., Denu JM. DIP original experiment: DIP-263313X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC., Lee S., Denu JM. Only protein-protein interactions imex curation hallows-2006-2 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Hallows WC., Lee S., Denu JM. DIP original experiment: DIP-263316X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC., Lee S., Denu JM. Only protein-protein interactions imex curation hallows-2006-3 in vitro In vitro acetylase assay acetylase assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hallows WC., Lee S., Denu JM. DIP original experiment: DIP-263314X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC., Lee S., Denu JM. Only protein-protein interactions imex curation hallows-2006-4 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Hallows WC., Lee S., Denu JM. DIP original experiment: DIP-263317X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC., Lee S., Denu JM. Only protein-protein interactions imex curation hallows-2006-5 in vitro In vitro deacetylase assay deacetylase assay predetermined predetermined participant predetermined Hallows WC., Lee S., Denu JM. DIP original experiment: DIP-263315X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Hallows WC., Lee S., Denu JM. Only protein-protein interactions imex curation lysac_salty Peptidyl-lysine N-acetyltransferase Pat pat yfiQ STM2651 Protein lysine acetyltransferase protein protein salty Salmonella typhimurium MSQQGLEALLRPKSIAVIGASMKPHRAGYLMMRNLLAGGFNGPVLPVTPAWKAVLGVMAWPDIASLPFTPDLAILCTNASRNLALLDALGAKGCKTCIILSAPTSQHEELLACARHYKMRLLGPNSLGLLAPWQGLNASFSPVPIKQGKLAFISQSAAVSNTILDWAQQREMGFSYFIALGDSLDIDVDELLDYLARDSKTSAILLYLEQLSDARRFVSAARSASRNKPILVIKSGRSPAAQRLLNTSAGMDPAWDAAIQRAGLLRVQDTHELFSAVETLSHMRPLRGDRLMIISNGAAPAALALDELWSRNGKLATLSEETCLQLRQALPAHIDIANPLDLCDDASSEHYVKTLDILLASQDFDALMVIHSPSAAAPGTESAHALIETIKRHPRGKFVTLLTNWCGEFSSQEARRLFSEAGLPTYRTPEGTITAFMHMVEYRRNQKQLRETPALPSNLTSNTAEAHNLLQRAIAEGAASLDTHEVQPILHAYGLHTLPTWIASDSAEAVHIAEQIGYPVALKLRSPDIPHKSEVQGVMLYLRTASEVQQAANAIFDRVKMAWPQARIHGLLVQSMANRAGAQELRVVVEHDPVFGPLIMLGEGGVEWRPEEQAVVALPPLNMNLARYLVIQGIKQRKIRARSALRPLDIVGLSQLLVQVSNLIVDCPEIQRLDIHPLLASASEFTALDVTLDIAPFDGDNESRLAVRPYPHQLEEWVEMKNGDRCLFRPILPEDEPQLRQFIAQVTKEDLYYRYFSEINEFTHEDLANMTQIDYDREMAFVAVRRMDNAEEILGVTRAISDPDNVDAEFAVLVRSDLKGLGLGRRLMEKLIAYTRDHGLKRLNGITMPNNRGMVALARKLGFQVDIQLEEGIVGLTLNLAKCDES acsa_mouse Acetyl-coenzyme A synthetase, cytoplasmic Acetyl-CoA synthetase 1 Propionate--CoA ligase Acss2 Acas2 Acecs1 Acetate--CoA ligase Acetyl-CoA synthetase Acyl-CoA synthetase short-chain family member 2 Acyl-activating enzyme protein protein mouse Mus musculus Mouse MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGNIAKEFYWKTACPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGIQKGDRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPDVQICWNEGVDLWWHELMQQAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTIGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEGRLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINHLFSHRCLTTQ sir3_human NAD-dependent protein deacetylase sirtuin-3, mitochondrial SIRT3 SIR2L3 SIR2-like protein 3 Regulatory protein SIR2 homolog 3 protein protein human Homo sapiens Human MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK acs2l_mouse Acetyl-coenzyme A synthetase 2-like, mitochondrial Acss1 Acas2 Acas2l Acetate--CoA ligase 2 Acetyl-CoA synthetase 2 Acyl-CoA synthetase short-chain family member 1 Propionate--CoA ligase protein protein mouse Mus musculus Mouse MAARSLGSGVGRLLRGLQGRSGQSGWSLSVSRSTATRLPGCVPAAAQPGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLNVSVNCLDQHVQKSPETIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKAVITFNQGLRGGRVVELKKIVDEAVKSCPTVQHVLVAHRTDTKVPMGSLDIPLEQEMAKEAPVCTPESMSSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPVLMDEKGNVLEGGDVSGALCISQAWPGMARTIYGDHQRFVDAYFRAYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKDNISDENMVVNELKLSVATKIAKYAVPDQILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEILSAFQKYEEQRAATN Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2) mint sir1_human NAD-dependent protein deacetylase sirtuin-1 NAD-dependent protein deacylase sirtuin-1 SIRT1 SIR2L1 SIR2-like protein 1 Regulatory protein SIR2 homolog 1 protein protein human Homo sapiens Human MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS acss2-pat-1 3145137 N/A 3145142 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli N/A 3145143 enzyme target enzyme target substrate substrate unspecified role unspecified role acK661 acK661 naclys N-acetylated L-lysine NAcLys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli acetylation acetylation reaction acetylation false false false acss2-sirt3-1 3145138 N/A 3145143 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli N/A 3145144 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deacetylation deacetylation reaction deacetylation false false false acss1-pat-1 3145139 N/A 3145145 enzyme target enzyme target substrate substrate unspecified role unspecified role AcK635 AcK635 naclys N-acetylated L-lysine NAcLys modified residue ms mass detection of residue modification modified residue ms certain certain sequence position certain certain certain sequence position certain false ecolx Escherichia coli N/A 3145142 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli acetylation acetylation reaction acetylation false false false acss2-sirt1-1 3145140 N/A 3145143 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli N/A 3145146 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deacetylation deacetylation reaction deacetylation false false false acss1-sirt3-3 3145141 N/A 3145145 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli N/A 3145144 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deacetylation deacetylation reaction deacetylation false false false