DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ arita-2006-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262774X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation arita-2006-2 in vitro In vitro deamination deamination assay aminase assay deamination predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262777X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation arita-2006-3 in vitro In vitro deamination deamination assay aminase assay deamination predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262779X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation arita-2006-4 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262775X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation arita-2006-5 in vitro In vitro deamination deamination assay aminase assay deamination predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262778X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation arita-2006-6 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. DIP original experiment: DIP-262776X Proceedings of the National Academy of Sciences of the United States of America 2006 IMEx Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4. Arita K., Shimizu T., Hashimoto H., Hidaka Y., Yamada M., Sato M. Only protein-protein interactions imex curation h3(413) Histone 3 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) KQTARKSTGG padi4_human Protein-arginine deiminase type-4 PADI4 PADI5 PDI5 Protein-arginine deiminase type IV Peptidylarginine deiminase IV HL-60 PAD PAD4 protein protein human Homo sapiens Human MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP h4(110) Histone 4 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) SGRGKGGKGL h3(1423) Histone 3 peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) KAPRKQLATK h3(413)-padi4-1 3143032 N/A 3143038 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3143039 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false h3(413)-padi4-2 3143033 N/A 3143038 enzyme target enzyme target substrate substrate unspecified role unspecified role Arg5 Arg5 cit L-citrulline (S)-2-amino-5-(carbamoylamino)pentanoic acid 2-amino-5-(aminocarbonyl)aminopentanoic acid L-citrulline MOD_RES Citrulline N5-(aminocarbonyl)ornithine N5-carbamoylornithine N5-carbamylornithine alpha-amino-delta-ureidovaleric acid delta-ureidonorvaline Cit Citrulline Deamidated Deamidation citrullinationr certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3143039 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deamination deamination reaction deamination false false false h4(110)-padi4-1 3143034 N/A 3143040 enzyme target enzyme target substrate substrate unspecified role unspecified role Arg3 Arg3 cit L-citrulline (S)-2-amino-5-(carbamoylamino)pentanoic acid 2-amino-5-(aminocarbonyl)aminopentanoic acid L-citrulline MOD_RES Citrulline N5-(aminocarbonyl)ornithine N5-carbamoylornithine N5-carbamylornithine alpha-amino-delta-ureidovaleric acid delta-ureidonorvaline Cit Citrulline Deamidated Deamidation citrullinationr certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3143039 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deamination deamination reaction deamination false false false h3(1423)-padi4-1 3143035 N/A 3143041 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3143039 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false h3(1423)-padi4-2 3143036 N/A 3143041 enzyme target enzyme target substrate substrate unspecified role unspecified role Arg4 Arg4 cit L-citrulline (S)-2-amino-5-(carbamoylamino)pentanoic acid 2-amino-5-(aminocarbonyl)aminopentanoic acid L-citrulline MOD_RES Citrulline N5-(aminocarbonyl)ornithine N5-carbamoylornithine N5-carbamylornithine alpha-amino-delta-ureidovaleric acid delta-ureidonorvaline Cit Citrulline Deamidated Deamidation citrullinationr certain certain sequence position certain certain certain sequence position certain false in vitro In vitro N/A 3143039 enzyme enzyme unspecified role unspecified role ecolx Escherichia coli deamination deamination reaction deamination false false false h4(110)-padi4-2 3143037 N/A 3143040 unspecified role unspecified role unspecified role unspecified role in vitro In vitro N/A 3143039 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction false false false