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    <entry>
        <source releaseDate="2017-08-31+01:00">
            <names>
                <shortLabel>DIP</shortLabel>
                <fullName>Database of Interacting Proteins</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
                <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
                <attribute name="postalAddress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
                <attribute name="url">http://dip.doe-mbi.ucla.edu/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="3142276">
                <names>
                    <shortLabel>yamaguchi-2006-5</shortLabel>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="16531242" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-66150X" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2005.11.024" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15573607" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-8340" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="7108">
                        <names>
                            <shortLabel>spofr</shortLabel>
                            <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>x-ray diffraction</shortLabel>
                        <fullName>x-ray crystallography</fullName>
                        <alias typeAc="MI:0303" type="go synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">X-ray</alias>
                        <alias typeAc="MI:1041" type="synonym">x-ray diffraction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0114" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1272" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Yamaguchi H., Kasa M., Amano M., Kaibuchi K., Hakoshima T.</attribute>
                    <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-66150X</attribute>
                    <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
                    <attribute name="title" nameAc="MI:1091">Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil.</attribute>
                    <attribute name="author-list" nameAc="MI:0636">Yamaguchi H.,  Kasa M.,  Amano M.,  Kaibuchi K.,  Hakoshima T.</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="3142277">
                <names>
                    <shortLabel>rock2_bovin</shortLabel>
                    <fullName>Rho-associated protein kinase 2</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Rho-associated, coiled-coil-containing protein kinase II</alias>
                    <alias typeAc="MI:0301" type="gene name">ROCK2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Rho-associated, coiled-coil-containing protein kinase 2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">p164 ROCK-2</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q28021" version="SP_103" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002219" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018107" secondary="peptidyl-threonine phosphorylation" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000961" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072518" secondary="Rho-dependent protein serine/threonine kinase activity" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030036" secondary="actin cytoskeleton organization" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_183"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2H9V" version="SP_183"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F2U" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005813" secondary="centrosome" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901888" secondary="regulation of cell junction assembly" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_183"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UIX" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030866" secondary="cortical actin cytoskeleton organization" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042752" secondary="regulation of circadian rhythm" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_183"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-3862767" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015008" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011993" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000281" secondary="mitotic cytokinesis" version="SP_183"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_776877.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006939" secondary="smooth muscle contraction" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007266" secondary="Rho protein signal transduction" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001849" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020684" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010825" secondary="positive regulation of centrosome duplication" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048598" secondary="embryonic morphogenesis" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031032" secondary="actomyosin structure organization" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011072" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005856" secondary="cytoskeleton" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048511" secondary="rhythmic process" version="SP_183"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037311" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031267" secondary="small GTPase binding" version="SP_183"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_183"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29038N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032956" secondary="regulation of actin cytoskeleton organization" version="SP_183"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9913">
                    <names>
                        <shortLabel>bovin</shortLabel>
                        <fullName>Bos taurus (Bovine)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Bovine</alias>
                    </names>
                </organism>
                <sequence>MSRPPPTGKMPGAPEAVSGDGAGASRQRKLEALIRDPRSPINVESLLDGLNPLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCKENDSIQSRKNEESQEIQKKLYTLEEHLSTEIQAKEELEQKCKSVNTRLEKVAKELEEEITLRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDVKNGKILLAKVELEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEETEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLSEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKEAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDTEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-8340-1" id="3142278">
                <names>
                    <shortLabel>rock2-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="dip" dbAc="MI:0465" id="DIP-57039E" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-8340-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-15573618" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>3142276</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="3142279">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-15573622" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>3142277</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="3142280">
                                <names>
                                    <shortLabel>Region 18-417</shortLabel>
                                    <fullName>Region 18-417</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-15573623" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="18"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="417"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7108">
                                <names>
                                    <shortLabel>spofr</shortLabel>
                                    <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
