HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html http://www.agbase.msstate.edu/hpi/main.html thome-2001-1 human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J. Virus - Publications including interactions involving viral proteins margot.thomemiazza@ib.unil.ch The Journal of cell biology 2001 imex curation Only protein-protein interactions imex curation thome-2001-2 human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J. Virus - Publications including interactions involving viral proteins margot.thomemiazza@ib.unil.ch The Journal of cell biology 2001 imex curation Only protein-protein interactions imex curation thome-2001-3 human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 confocal microscopy confocal microscopy tag visualisation tag visualisation Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J. Virus - Publications including interactions involving viral proteins margot.thomemiazza@ib.unil.ch The Journal of cell biology 2001 imex curation Only protein-protein interactions imex curation bcl10_mouse B-cell lymphoma/leukemia 10 Bcl10 Ciper Clap B-cell CLL/lymphoma 10 CED-3/ICH-1 prodomain homologous E10-like regulator CARD-containing molecule enhancing NF-kappa-B Cellular homolog of vCARMEN Mammalian CARD-containing adapter molecule E10 Cellular-E10 CARD-like apoptotic protein protein protein mouse Mus musculus Mouse MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ mint homomint Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex vclap_ehv2 CARD domain-containing protein E10 E10 protein protein EHV-2 Equine herpesvirus 2 (strain 86/87) MAEKYPLQAGDPCVTLTEEDIWDVERLCLEELRVLLVSHLKSHKHLDHLRAKKILSREDAEEVSSRATSRSRAGLLVDMCQDHPRGFQCLKESCKNEVGQEHLVDLLERAFEKHCGDKLTQKWWESGADGRNPRRPPGSEDNSGYTALLPTNPSGGGPSIGSGHSRPRGRDDSGGIGGGVYPFSHGGARVVGGGWGGWGESGGAGRGGSLLSGGHGGHPPHGGPGGGGRDYYGGGGSGYYESIPEPANFPNSGGGGRGGGVRYDAGGDGRLGGLPPDPQEVDDPSLSVQGRGGPAPDPPSPPLRTRRFFCC traf6_human TNF receptor-associated factor 6 TRAF6 RNF85 Interleukin-1 signal transducer RING finger protein 85 E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6 protein protein human Homo sapiens Human MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV e10-bcl10-1 1938261 N/A 1938264 unspecified role unspecified role prey prey n terminus vsv tag vsv tag vesicular stomatitis virus tag vesicular stomatitis virus tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1938265 unspecified role unspecified role bait bait n terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q66677:p.Leu49Arg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false 3A traf6-e10-1 1938262 N/A 1938265 unspecified role unspecified role prey prey n terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q66677:p.[Pro278Gly;Glu280Ala] mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false N/A 1938266 unspecified role unspecified role bait bait physical association physical association false false false 3B e10-bcl10-3 1938263 N/A 1938264 unspecified role unspecified role neutral component neutral component n terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 1938265 unspecified role unspecified role neutral component neutral component n terminus vsv tag vsv tag vesicular stomatitis virus tag vesicular stomatitis virus tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false colocalization colocalization false false false 4B