IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ mick-2012-2 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Cell (0092-8674) 2012 Only protein-protein interactions imex curation mick-2012-4 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. bn-page blue native page bn-page western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Cell (0092-8674) 2012 Only protein-protein interactions imex curation mick-2012-5 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. bn-page blue native page bn-page sequence tag sequence tag identification sequence tag Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. The SILAC normalized light-over-heavy (L/H; replicates 1 and 3) or heavy-over-light (H/L; replicates 2 and 4) ratios were calculated. Ratios were log-transformed, and the mean log10 ratio across all experiments was calculated for each protein. A one-sided t test was performed to determine p values for all proteins quantified in at least two experiments. Proteins considered to specifically enrich with the bait protein MITRAC12 were required to be identified with at least two peptides as well as quantified with a mean ratio of ≥15 and a p value of < 0.01. SILAC data obtained from affinity-purified MITRAC12 complexes data were subjected to hierarchical clustering performed in the R environment using Euclidian distances and complete linkage. Only proteins reliably identified in both repeats with at least two peptides were considered and common contaminants like keratins were excluded. In addition, proteins were required to be enriched in both repeats with a minimum SILAC ratio of three in at least one replicate. MITRAC12-containing complexes from isolated by anti-tag coip from differentially SILAC labeled mitochondria for subsequent separation by BN-PAGE. BN-PAGE gel was sliced into 20 strips, the proteins identified were then clustered as described in 'author-confidence'. Cluster 5 identified proteins that peaked in fractions 1 or 2, indicating that these did not run into the gel and therefore could represent aggregates and have not been reported. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Cell (0092-8674) 2012 Only protein-protein interactions imex curation mick-2012-1 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Peptides and proteins were identified with a false discovery rate of <1% employing the following search criteria: MS tolerance for “first search” 20 ppm, initial MS and MS/MS mass tolerances of 6 ppm and 0.4 Da, respectively; at least one unique peptide (≥6 amino acids); trypsin as enzyme with a maximum of two missed cleavages; methionine oxidation and dimethylation at lysine or arginine as variable modification; 13C615N2-lysine and 13C615N4-arginine as heavy labeled amino acids. If peptides were assigned to different proteins or multiple isoforms, the respective proteins were reported as a single protein group. For SILAC (stable isotope labeling of amino acids in cell culture)-based quantification of proteins or protein groups, “razor” peptides and a minimum ratio count of two were considered. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Cell (0092-8674) 2012 Only protein-protein interactions imex curation mick-2012-3 MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mick D.U., Dennerlein S., Wiese H., Reinhold R., Pacheu-Grau D., Lorenzi I., Sasarman F., Weraarpachai W., Shoubridge E.A., Warscheid B., Rehling P. Source of SURF1 taken from IMAGE clone designation IRATp970C0445D given in PMID: 21470975 by the same group. peter.rehling@medizin.uni-goettingen.de Cell (0092-8674) 2012 Only protein-protein interactions imex curation coa3_human Cytochrome c oxidase assembly factor 3 homolog, mitochondrial COA3 CCDC56 MITRAC12 Coiled-coil domain-containing protein 56 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa HSPC009 protein protein human Homo sapiens Human MASSGAGDPLDSKRGEAPFAQRIDPTREKLTPEQLHSMRQAELAQWQKVLPRRRTRNIVTGLGIGALVLAIYGYTFYSISQERFLDELEDEAKAARARALARASGS surf1_human Surfeit locus protein 1 SURF1 SURF-1 protein protein human Homo sapiens Human MAAVAALQLGLRAAGLGRAPASAAWRSVLRVSPRPGVAWRPSRCGSSAAEASATKAEDDSFLQWVLLLIPVTAFGLGTWQVQRRKWKLNLIAELESRVLAEPVPLPADPMELKNLEYRPVKVRGCFDHSKELYMMPRTMVDPVREAREGGLISSSTQSGAYVVTPFHCTDLGVTILVNRGFVPRKKVNPETRQKGQIEGEVDLIGMVRLTETRQPFVPENNPERNHWHYRDLEAMARITGAEPIFIDANFQSTVPGGPIGGQTRVTLRNEHLQYIVTWYGLSAATSYLWFKKFLRGTPGV cox1_human Cytochrome c oxidase subunit 1 MT-CO1 COI COXI MTCO1 Cytochrome c oxidase polypeptide I protein protein human Homo sapiens Human MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS taco1_human Translational activator of cytochrome c oxidase 1 PRO0477 TACO1 CCDC44 Translational activator of mitochondrially-encoded cytochrome c oxidase I Coiled-coil domain-containing protein 44 protein protein human Homo sapiens Human MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGHNKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKSTIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGARHSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLHQVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE cx6a2_human Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 COX6A COX6AH Cytochrome c oxidase polypeptide VIa-heart Cytochrome c oxidase subunit VIA-muscle protein protein human Homo sapiens Human MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFRPYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP cox14_human Cytochrome c oxidase assembly protein COX14 COX14 C12orf62 protein protein human Homo sapiens Human MPTGKQLADIGYKTFSTSMMLLTVYGGYLCSVRVYHYFQWRRAQRQAAEEQKTSGIM cox41_human Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 COX4 Cytochrome c oxidase subunit IV isoform 1 Cytochrome c oxidase polypeptide IV protein protein human Homo sapiens Human MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK cox5a_human Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase polypeptide Va COX5A protein protein human Homo sapiens Human MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV coa1_human Cytochrome c oxidase assembly factor 1 homolog COA1 C7orf44 MITRAC15 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa protein protein human Homo sapiens Human MMWQKYAGSRRSMPLGARILFHGVFYAGGFAIVYYLIQKFHSRALYYKLAVEQLQSHPEAQEALGPPLNIHYLKLIDRENFVDIVDAKLKIPVSGSKSEGLLYVHSSRGGPFQRWHLDEVFLELKDGQQIPVFKLSGENGDEVKKE tim21_human Mitochondrial import inner membrane translocase subunit Tim21 TIMM21 TIM21-like protein, mitochondrial HSPC154 C18orf55 TIM21 protein protein human Homo sapiens Human MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCGLQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFGESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGSGEYDFRYIFVEIESYPRRTIIIEDNRSQDD coxm1_human COX assembly mitochondrial protein homolog CMC1 C3orf68 protein protein human Homo sapiens Human MALDPADQHLRHVEKDVLIPKIMREKAKERCSEQVQDFTKCCKNSGVLMVVKCRKENSALKECLTAYYNDPAFYEECKMEYLKEREEFRKTGIPTKKRLQKLPTSM ndub8_human NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NADH-ubiquinone oxidoreductase ASHI subunit Complex I-ASHI NDUFB8 protein protein human Homo sapiens Human MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI tim23_human Mitochondrial import inner membrane translocase subunit Tim23 TIMM23 TIM23 protein protein human Homo sapiens Human MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLTGLTLTSLYALYNNWEHMKGSLLQQSL tim50_human Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 TIM50 PRO1512 protein protein human Homo sapiens Human MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSKQP ucri_human Cytochrome b-c1 complex subunit Rieske, mitochondrial Ubiquinol-cytochrome c reductase iron-sulfur subunit Rieske iron-sulfur protein Complex III subunit 5 Rieske protein UQCRFS1 UQCRFS1 Cytochrome b-c1 complex subunit 5 protein protein human Homo sapiens Human MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG cox6c_human Cytochrome c oxidase subunit 6C COX6C Cytochrome c oxidase polypeptide VIc protein protein human Homo sapiens Human MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSVK ndua9_human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NADH-ubiquinone oxidoreductase 39 kDa subunit Complex I-39kD NDUFA9 NDUFS2L protein protein human Homo sapiens Human MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPCRQLHHALMPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDKYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETKNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIVKPSDIFGREDRFLNSFASMHRFGPIPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPSRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI atp6_human ATP synthase subunit a MT-ATP6 ATP6 ATPASE6 MTATP6 F-ATPase protein 6 protein protein human Homo sapiens Human MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT ecsit_human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Protein SITPEC ECSIT protein protein human Homo sapiens Human MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS atpo_human ATP synthase subunit O, mitochondrial ATP5PO ATP synthase peripheral stalk subunit OSCP ATP5O ATPO Oligomycin sensitivity conferral protein protein protein human Homo sapiens Human MAAPAVSGLSRQVRCFSTSVVRPFAKLVRPPVQVYGIEGRYATALYSAASKQNKLEQVEKELLRVAQILKEPKVAASVLNPYVKRSIKVKSLNDITAKERFSPLTTNLINLLAENGRLSNTQGVVSAFSTMMSVHRGEVPCTVTSASPLEEATLSELKTVLKSFLSQGQVLKLEAKTDPSILGGMIVRIGEKYVDMSVKTKIQKLGRAMREIV at5f1_human ATP synthase F(0) complex subunit B1, mitochondrial ATP5PB ATP synthase peripheral stalk-membrane subunit b ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b ATP5F1 protein protein human Homo sapiens Human MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPVPPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM vdac1_human Voltage-dependent anion-selective channel protein 1 VDAC1 VDAC Outer mitochondrial membrane protein porin 1 Plasmalemmal porin Porin 31HL Porin 31HM protein protein human Homo sapiens Human MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA vdac2_human Voltage-dependent anion-selective channel protein 2 VDAC2 Outer mitochondrial membrane protein porin 2 protein protein human Homo sapiens Human MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA atpg_human ATP synthase subunit gamma, mitochondrial ATP5F1C ATP synthase F1 subunit gamma ATP5C ATP5C1 ATP5CL1 F-ATPase gamma subunit protein protein human Homo sapiens Human MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD fxrd1_human FAD-dependent oxidoreductase domain-containing protein 1 FP634 FOXRED1 protein protein human Homo sapiens Human MIRRVLPHGMGRGLLTRRPGTRRGGFSLDWDGKVSEIKKKIKSILPGRSCDLLQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQEGAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFRREGLGSNYLGGRSPTEQEEPDPANLEVDHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKIQENNII atp5h_human ATP synthase subunit d, mitochondrial ATP5PD ATP synthase peripheral stalk subunit d ATP5H My032 protein protein human Homo sapiens Human MAGRKLALKTIDWVAFAEIIPQNQKAIASSLKSWNETLTSRLAALPENPPAIDWAYYKANVAKAGLVDDFEKKFNALKVPVPEDKYTAQVDAEEKEDVKSCAEWVSLSKARIVEYEKEMEKMKNLIPFDQMTIEDLNEAFPETKLDKKKYPYWPHQPIENL atpb_human ATP synthase subunit beta, mitochondrial ATP5F1B ATP synthase F1 subunit beta ATP5B ATPMB ATPSB protein protein human Homo sapiens Human MLGFVGRVAAAPASGALRRLTPSASLPPAQLLLRAAPTAVHPVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHSS atp5l_human ATP synthase subunit g, mitochondrial ATP5MG ATP synthase membrane subunit g ATP5L protein protein human Homo sapiens Human MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV acad9_human Complex I assembly factor ACAD9, mitochondrial ACAD9 Acyl-CoA dehydrogenase family member 9 protein protein human Homo sapiens Human MSGCGLFLRTTAAARACRGLVVSTANRRLLRTSPPVRAFAKELFLGKIKKKEVFPFPEVSQDELNEINQFLGPVEKFFTEEVDSRKIDQEGKIPDETLEKLKSLGLFGLQVPEEYGGLGFSNTMYSRLGEIISMDGSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVWITNGGLANIFTVFAKTEVVDSDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQAKVSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRFGKTIMEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANTFCVEAYLQNLFSLSQLDKYAPENLDEQIKKVSQQILEKRAYICAHPLDRTC atpd_human ATP synthase subunit delta, mitochondrial ATP5F1D ATP synthase F1 subunit delta ATP5D F-ATPase delta subunit protein protein human Homo sapiens Human MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE atpa_human ATP synthase subunit alpha, mitochondrial ATP5F1A ATP synthase F1 subunit alpha ATP5A ATP5A1 ATP5AL2 ATPM protein protein human Homo sapiens Human MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKLKEIVTNFLAGFEA vdac3_human Voltage-dependent anion-selective channel protein 3 VDAC3 Outer mitochondrial membrane protein porin 3 protein protein human Homo sapiens Human MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA adt3_human ADP/ATP translocase 3 SLC25A6 ANT3 CDABP0051 Adenine nucleotide translocator 3 ADP,ATP carrier protein 3 Solute carrier family 25 member 6 ADP,ATP carrier protein, isoform T2 AAC3 protein protein human Homo sapiens Human MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI tm223_human Transmembrane protein 223 TMEM223 protein protein human Homo sapiens Human MAAPWRRWPTGLLAVLRPLLTCRPLQGTTLQRDVLLFEHDRGRFFTILGLFCAGQGVFWASMAVAAVSRPPVPVQPLDAEVPNRGPFDLRSALWRYGLAVGCGAIGALVLGAGLLFSLRSVRSVVLRAGGQQVTLTTHAPFGLGAHFTVPLKQVSCMAHRGEVPAMLPLKVKGRRFYFLLDKTGHFPNTKLFDNTVGAYRSL adt2_human ADP/ATP translocase 2 SLC25A5 ANT2 Adenine nucleotide translocator 2 ADP,ATP carrier protein 2 Solute carrier family 25 member 5 ADP,ATP carrier protein, fibroblast isoform AAC2 protein protein human Homo sapiens Human MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT sim20_human Small integral membrane protein 20 SMIM20 C4orf52 MITRAC7 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa protein protein human Homo sapiens Human MSRNLRTALIFGGFISLIGAAFYPIYFRPLMRLEEYKKEQAINRAGIVQEDVQPPGLKVWSDPFGRK rm40_human 39S ribosomal protein L40, mitochondrial Nuclear localization signal-containing protein deleted in velocardiofacial syndrome Up-regulated in metastasis MRPL40 NLVCF URIM Mitochondrial large ribosomal subunit protein mL40 protein protein human Homo sapiens Human MTASVLRSISLALRPTSGLLGTWQTQLRETHQRASLLSFWELIPMRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR rdh13_human Retinol dehydrogenase 13 RDH13 SDR7C3 Short chain dehydrogenase/reductase family 7C member 3 PSEC0082 UNQ736/PRO1430 protein protein human Homo sapiens Human MSRYLLPLSALGTVAGAAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGLEAPSVREQPLPR rm46_human 39S ribosomal protein L46, mitochondrial Mitochondrial large ribosomal subunit protein mL46 MRPL46 C15orf4 LIECG2 P2ECSL protein protein human Homo sapiens Human MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL rm48_human 39S ribosomal protein L48, mitochondrial Mitochondrial large ribosomal subunit protein mL48 CGI-118 HSPC290 MRPL48 protein protein human Homo sapiens Human MSGTLEKVLCLRNNTIFKQAFSLLRFRTSGEKPIYSVGGILLSISRPYKTKPTHGIGKYKHLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIKVEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPEGVRLSVKEHTEEDFKGRFKARPELEELLAKLK cox2_human Cytochrome c oxidase subunit 2 MT-CO2 COII COXII MTCO2 Cytochrome c oxidase polypeptide II COX2 protein protein human Homo sapiens Human MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL cmc2_human Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 ARALAR2 Mitochondrial aspartate glutamate carrier 2 Solute carrier family 25 member 13 Citrin protein protein human Homo sapiens Human MAAAKVALTKRADPAELRTIFLKYASIEKNGEFFMSPNDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQVFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNARTGRVTAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTTSHQVSFSYFNGFNSLLNNMELIRKIYSTLAGTRKDVEVTKEEFVLAAQKFGQVTPMEVDILFQLADLYEPRGRMTLADIERIAPLEEGTLPFNLAEAQRQKASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYIDFGGVKPMGSEPVPKSRINLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSVSTSKAIGGGP ndua4_human Cytochrome c oxidase subunit NDUFA4 NADH-ubiquinone oxidoreductase MLRQ subunit Complex I-MLRQ NDUFA4 protein protein human Homo sapiens Human MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPNDQYKFYSVNVDYSKLKKERPDF cx6b1_human Cytochrome c oxidase subunit 6B1 COX6B1 COX6B Cytochrome c oxidase subunit VIb isoform 1 protein protein human Homo sapiens Human MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWVTDWDEQRAEGTFPGKI cox3_human Cytochrome c oxidase subunit 3 MT-CO3 COIII COXIII MTCO3 Cytochrome c oxidase polypeptide III protein protein human Homo sapiens Human MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS cox7b_human Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase polypeptide VIIb COX7B protein protein human Homo sapiens Human MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQVGIEWNLSPVGRVTPKEWRNQ sco1_human Protein SCO1 homolog, mitochondrial SCO1 SCOD1 protein protein human Homo sapiens Human MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGYCLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS cx7a2_human Cytochrome c oxidase subunit 7A2, mitochondrial COX7AL Cytochrome c oxidase subunit VIIa-liver/heart COX7A2 protein protein human Homo sapiens Human MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE pnkd_human Probable hydrolase PNKD Paroxysmal nonkinesiogenic dyskinesia protein Myofibrillogenesis regulator 1 Trans-activated by hepatitis C virus core protein 2 PNKD KIAA1184 MR1 TAHCCP2 FKSG19 UNQ2491/PRO5778 protein protein human Homo sapiens Human MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK m2om_human Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 SLC20A4 Solute carrier family 25 member 11 protein protein human Homo sapiens Human MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG sfxn1_human Sideroflexin-1 SFXN1 protein protein human Homo sapiens Human MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL tpc_human Mitochondrial thiamine pyrophosphate carrier SLC25A19 DNC MUP1 Mitochondrial uncoupling protein 1 Solute carrier family 25 member 19 protein protein human Homo sapiens Human MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR mpcp_human Phosphate carrier protein, mitochondrial SLC25A3 PHC OK/SW-cl.48 Phosphate transport protein Solute carrier family 25 member 3 protein protein human Homo sapiens Human MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTQ 78714C85931B22D5 rm14_human 39S ribosomal protein L14, mitochondrial MRPL14 RPML32 MRPL32 39S ribosomal protein L32, mitochondrial Mitochondrial large ribosomal subunit protein uL14m protein protein human Homo sapiens Human MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPTSLRKREGEYSKVLAIAQNFV tmm65_human Transmembrane protein 65 TMEM65 protein protein human Homo sapiens Human MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS scmc1_human Calcium-binding mitochondrial carrier protein SCaMC-1 SLC25A24 APC1 MCSC1 SCAMC1 Mitochondrial ATP-Mg/Pi carrier protein 1 Mitochondrial Ca(2+)-dependent solute carrier protein 1 Small calcium-binding mitochondrial carrier protein 1 Solute carrier family 25 member 24 protein protein human Homo sapiens Human MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK sfxn4_human Sideroflexin-4 Breast cancer resistance marker 1 SFXN4 BCRM1 protein protein human Homo sapiens Human MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQSFIRRFLQWTELLDPTNVFISVESIENSRQLLCTNEDVSSPASADQRIQEAWKRSLATVHPDSSNLIPKLFRPAAFLPFMAPTVFLSMTPLKGIKSVILPQVFLCAYMAAFNSINGNRSYTCKPLERSLLMAGAVASSTFLGVIPQFVQMKYGLTGPWIKRLLPVIFLVQASGMNVYMSRSLESIKGIAVMDKEGNVLGHSRIAGTKAVRETLASRIVLFGTSALIPEVFTYFFKRTQYFRKNPGSLWILKLSCTVLAMGLMVPFSFSIFPQIGQIQYCSLEEKIQSPTEETEIFYHRGV cox15_human Cytochrome c oxidase assembly protein COX15 homolog COX15 protein protein human Homo sapiens Human MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAEFQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGMKGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTLLALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK mavs_human Mitochondrial antiviral-signaling protein Interferon beta promoter stimulator protein 1 Virus-induced-signaling adapter CARD adapter inducing interferon beta Putative NF-kappa-B-activating protein 031N MAVS IPS1 KIAA1271 VISA protein protein human Homo sapiens Human MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH cox16_human Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial COX16 C14orf112 HSPC203 PTD019 protein protein human Homo sapiens Human MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENKISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT cia30_human Complex I intermediate-associated protein 30, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1 NDUFAF1 CIA30 CGI-65 protein protein human Homo sapiens Human MALVHKLLRGTYFLRKFSKPTSALYPFLGIRFAEYSSSLQKPVASPGKASSQRKTEGDLQGDHQKEVALDITSSEEKPDVSFDKAIRDEAIYHFRLLKDEIVDHWRGPEGHPLHEVLLEQAKVVWQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQSALLYGTLSSEAPQDGESTRSGYCAMISRIPRGAFERKMSYDWSQFNTLYLRVRGDGRPWMVNIKEDTDFFQRTNQMYSYFMFTRGGPYWQEVKIPFSKFFFSNRGRIRDVQHELPLDKISSIGFTLADKVDGPFFLEIDFIGVFTDPAHTEEFAYENSPELNPRLFK b4drs6_human Sidoreflexin protein protein human Homo sapiens Human MESKMGELPLDINIQEPRWDQSTFLGRARHFFTVTDPRNLLLSGAQLEASRNIVQNYRAGVVTPGITEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQGSKDEGHCRRGRSECLCSLRKTPTVVFWQWVNQSFNAIVNYSNRSGDTPITVRQLGTAYVSATTGAVATALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVADEAGQRLGYSVTAAKQGIFQVVISRICMAIPAMAIPPLIMDTLEKKDFLKRRPWLGAPLQVGLVGFCLVFATPLCCALFPQKSSIHISNLEPELRAQIHEQNPSVEVVYYNKGL nduc2_human NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 HLC1 NADH-ubiquinone oxidoreductase subunit B14.5b Complex I-B14.5b Human lung cancer oncogene 1 protein protein protein human Homo sapiens Human MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR oma1_human Metalloendopeptidase OMA1, mitochondrial OMA1 MPRP1 Metalloprotease-related protein 1 Overlapping with the m-AAA protease 1 homolog protein protein human Homo sapiens Human MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS tm177_human Transmembrane protein 177 TMEM177 protein protein human Homo sapiens Human MAGPLWRTAAFVQRHRTGLLVGSCAGLFGVPISYHLFPDPVVQWLYQYWPQGQPAPLPPQLQSLFQEVLQDIGVPSGHCYKPFTTFTFQPVSAGFPRLPAGAVVGIPASFLGDLVINTNHPVVIHGHTVDWRSPAGARLRASLTLSREAQKFALAREVVYLESSTTAVHALLAPACLAGTWALGVGAKYTLGLHAGPMNLRAAFSLVAAVAGFVAYAFSQDSLTHAVESWLDRRTASLSAAYACGGVEFYEKLLSGNLALRSLLGKDGEKLYTPSGNIVPRHLFRIKHLPYTTRRDSVLQMWRGMLNPGRS tidc1_human Complex I assembly factor TIMMDC1, mitochondrial Translocase of inner mitochondrial membrane domain-containing protein 1 UNQ247/PRO284 TIMMDC1 C3orf1 Protein M5-14 protein protein human Homo sapiens Human MEVPPPAPRSFLCRALCLFPRVFAAEAVTADSEVLEERQKRLPYVPEPYYPESGWDRLRELFGKDEQQRISKDLANICKTAATAGIIGWVYGGIPAFIHAKQQYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWGWRTAVFVTIFNTVNTSLNVYRNKDALSHFVIAGAVTGSLFRINVGLRGLVAGGIIGALLGTPVGGLLMAFQKYSGETVQERKQKDRKALHELKLEEWKGRLQVTEHLPEKIESSLQEDEPENDAKKIEALLNLPRNPSVIDKQDKD q305v2_human NADH-ubiquinone oxidoreductase chain 2 ND2 protein protein human Homo sapiens Human MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTFSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPSPIPPHTHRPYHATPTYLPFYTNNLMEI cox11_human Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 protein protein human Homo sapiens Human MGGLWRPGWRCVPFCGWRWIHPGSPTRAAERVEPFLRPEWSGTGGAERGLRWLGTWKRCSLRARHPALQPPRRPKSSNPFTRAQEEERRRQNKTTLTYVAAVAVGMLGASYAAVPLYRLYCQTTGLGGSAVAGHASDKIENMVPVKDRIIKISFNADVHASLQWNFRPQQTEIYVVPGETALAFYRAKNPTDKPVIGISTYNIVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYIDPEFAEDPRMIKVDLITLSYTFFEAKEGHKLPVPGYN cmc1_human Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 ARALAR1 Mitochondrial aspartate glutamate carrier 1 Solute carrier family 25 member 12 protein protein human Homo sapiens Human MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ dnjb1_human DnaJ homolog subfamily B member 1 DNAJB1 DNAJ1 HDJ1 HSPF1 Heat shock 40 kDa protein 1 Human DnaJ protein 1 DnaJ protein homolog 1 protein protein human Homo sapiens Human MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI ocad2_human OCIA domain-containing protein 2 Ovarian carcinoma immunoreactive antigen-like protein OCIAD2 protein protein human Homo sapiens Human MASASARGNQDKDAHFPPPSKQSLLFCPKSKLHIHRAEISKIMRECQEESFWKRALPFSLVSMLVTQGLVYQGYLAANSRFGSLPKVALAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIKHGLSEKGDSQPSAS tmm70_human Transmembrane protein 70, mitochondrial TMEM70 protein protein human Homo sapiens Human MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK surf1-coa3-1 1374977 n/a 1374982 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role bait bait c-terminal zz tag zz tag ZZ tag ZZ tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false Fig. 1E Minute amounts of COX1 were also coisolated coa3-mt_co1 1374977 n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role prey prey physical association physical association false false false Fig. 1G, 1I participants seperated both by SDS-PAGE and BN-PAGE coa3-mt_co1-7 1374977 n/a 1374985 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey association association false false false Fig. 3A, 3D, Supp. Fig. 1A coa3-coa1-1 1374977 n/a 1374986 unspecified role unspecified role prey prey n/a 1374987 unspecified role unspecified role prey prey n/a 1374988 unspecified role unspecified role prey prey n/a 1374989 unspecified role unspecified role prey prey n/a 1374990 unspecified role unspecified role prey prey n/a 1374991 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role prey prey association association false false false Fig. 3C cox14-mt_co1 1374977 n/a 1374987 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1374984 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey association association false false false Fig. 3D cmc1-coa3-2 1374977 n/a 1374982 unspecified role unspecified role prey prey n/a 1374992 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role prey prey association association false false false Fig. 4F coa3-mt_co1-4 1374977 n/a 1374984 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374991 unspecified role unspecified role prey prey association association false false false Fig. 5D participants seperated both by SDS-PAGE and BN-PAGE coa3-mt_co1-5 1374977 n/a 1374984 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false Fig. 7B coa1-coa3 1374977 n/a 1374984 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role prey prey n/a 1374990 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374991 unspecified role unspecified role prey prey n/a 1374993 unspecified role unspecified role prey prey association association false false false Fig. 4B timm23-timm21 1374977 n/a 1374994 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374991 unspecified role unspecified role prey prey physical association physical association false false false Fig. 5E timm21-coa1 1374977 n/a 1374990 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role prey prey n/a 1374991 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false association association false false false Fig. 5F timm23-timm50 1374977 n/a 1374995 unspecified role unspecified role prey prey n/a 1374994 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false Supp Fig. 2A timm21-coa3-2 1374977 n/a 1374991 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374995 unspecified role unspecified role prey prey n/a 1374984 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role prey prey n/a 1374993 unspecified role unspecified role prey prey n/a 1374988 unspecified role unspecified role prey prey n/a 1374994 unspecified role unspecified role prey prey association association false false false Fig. 6D timm21-coa3-1 1374977 n/a 1374991 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role prey prey association association false false false Fig. 7B timm21-coa1-1 1374977 n/a 1374984 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role prey prey n/a 1374990 unspecified role unspecified role prey prey n/a 1374994 unspecified role unspecified role prey prey n/a 1374991 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false association association false false false Fig. 7E, 7B. When the synthesis of mitochondria-encoded proteins was inhibited by thiamphenicol, the interaction of TIM21 with COX1 and MITRAC12 was strongly reduced without influencing the interaction with TIM23. Blocking cytosolic translation with emetine and concomitantly import of nuclear-encoded subunits reduced the interaction between TIM21 and TIM23, whereas the interaction with COX1 and MITRAC12 remained unaffected. co6a-cox5a 1374977 n/a 1374986 unspecified role unspecified role prey prey n/a 1374996 unspecified role unspecified role prey prey n/a 1374991 unspecified role unspecified role prey prey n/a 1374984 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey n/a 1374997 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374982 unspecified role unspecified role prey prey n/a 1374993 unspecified role unspecified role prey prey n/a 1374989 unspecified role unspecified role prey prey association association false false false Fig. 6E cox6a2-coa3 1374977 n/a 1374998 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role prey prey n/a 1374988 unspecified role unspecified role prey prey n/a 1374989 unspecified role unspecified role prey prey n/a 1374984 unspecified role unspecified role prey prey n/a 1374986 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false association association false false false Fig. 6F coa3-mt_co1-2 1374978 n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1374982 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false Fig. 1H coa3-mt_co1-3 1374978 n/a 1374982 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1374984 unspecified role unspecified role neutral component neutral component region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Supp Fig. 1B coa3-cox14 1374978 n/a 1374982 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1374987 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 3E Proteins first isolated by anti-Flag coimmunoprecipitation cmc1-coa3-1 1374978 n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1374992 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1374982 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 4E Proteins first isolated by anti-Flag coimmunoprecipitation cox4i1-mt_co1 1374978 n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1374988 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 1H cox4i1-mt_co1-1 1374978 n/a 1374998 unspecified role unspecified role neutral component neutral component n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1374988 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 1H acad9-atp5a1 1374979 n/a 1374999 unspecified role unspecified role neutral component neutral component n/a 1375000 unspecified role unspecified role neutral component neutral component n/a 1375001 unspecified role unspecified role neutral component neutral component n/a 1375002 unspecified role unspecified role neutral component neutral component n/a 1375003 unspecified role unspecified role neutral component neutral component n/a 1375004 unspecified role unspecified role neutral component neutral component n/a 1375005 unspecified role unspecified role neutral component neutral component n/a 1375006 unspecified role unspecified role neutral component neutral component n/a 1375007 unspecified role unspecified role neutral component neutral component n/a 1375008 unspecified role unspecified role neutral component neutral component n/a 1375009 unspecified role unspecified role neutral component neutral component n/a 1375010 unspecified role unspecified role neutral component neutral component n/a 1375011 unspecified role unspecified role neutral component neutral component n/a 1375012 unspecified role unspecified role neutral component neutral component n/a 1375013 unspecified role unspecified role neutral component neutral component association association false false false Fig. 5B, Supp Table 2 Cluster 1 c4orf52-cmc1 1374979 n/a 1374992 unspecified role unspecified role neutral component neutral component n/a 1375014 unspecified role unspecified role neutral component neutral component n/a 1374984 unspecified role unspecified role neutral component neutral component n/a 1375015 unspecified role unspecified role neutral component neutral component n/a 1374991 unspecified role unspecified role neutral component neutral component n/a 1374987 unspecified role unspecified role neutral component neutral component n/a 1374983 unspecified role unspecified role neutral component neutral component n/a 1375016 unspecified role unspecified role neutral component neutral component n/a 1375017 unspecified role unspecified role neutral component neutral component n/a 1375018 unspecified role unspecified role neutral component neutral component n/a 1375019 unspecified role unspecified role neutral component neutral component n/a 1375020 unspecified role unspecified role neutral component neutral component n/a 1375021 unspecified role unspecified role neutral component neutral component association association false false false Fig 5B, Supp. Table 2 Cluster 2 cox4i1-cox5a-1 1374979 n/a 1375022 unspecified role unspecified role neutral component neutral component n/a 1375023 unspecified role unspecified role neutral component neutral component n/a 1374988 unspecified role unspecified role neutral component neutral component n/a 1375024 unspecified role unspecified role neutral component neutral component n/a 1375025 unspecified role unspecified role neutral component neutral component n/a 1375026 unspecified role unspecified role neutral component neutral component n/a 1375027 unspecified role unspecified role neutral component neutral component n/a 1375028 unspecified role unspecified role neutral component neutral component n/a 1375029 unspecified role unspecified role neutral component neutral component n/a 1374989 unspecified role unspecified role neutral component neutral component n/a 1375030 unspecified role unspecified role neutral component neutral component n/a 1374997 unspecified role unspecified role neutral component neutral component association association false false false Fig. 5B, Supp Table 2 Cluster 3 cox15-mrpl14 1374979 n/a 1375031 unspecified role unspecified role neutral component neutral component n/a 1375032 unspecified role unspecified role neutral component neutral component n/a 1375033 unspecified role unspecified role neutral component neutral component n/a 1375034 unspecified role unspecified role neutral component neutral component n/a 1375035 unspecified role unspecified role neutral component neutral component n/a 1375036 unspecified role unspecified role neutral component neutral component n/a 1375037 unspecified role unspecified role neutral component neutral component n/a 1375038 unspecified role unspecified role neutral component neutral component n/a 1374995 unspecified role unspecified role neutral component neutral component n/a 1375039 unspecified role unspecified role neutral component neutral component association association false false false Fig. 5B, Supp. Table 2 Cluster 4 surf1-coa3 1374980 n/a 1374982 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role bait bait c-terminal zz tag zz tag ZZ tag ZZ tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false physical association physical association false false false Fig. 1A coa3-b4drs6 1374980 n/a 1375022 unspecified role unspecified role prey prey n/a 1375040 unspecified role unspecified role prey prey n/a 1375026 unspecified role unspecified role prey prey n/a 1374990 unspecified role unspecified role prey prey n/a 1374989 unspecified role unspecified role prey prey n/a 1374997 unspecified role unspecified role prey prey n/a 1375039 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey n/a 1375026 unspecified role unspecified role prey prey n/a 1374991 unspecified role unspecified role prey prey n/a 1374984 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1375041 unspecified role unspecified role prey prey n/a 1374992 unspecified role unspecified role prey prey n/a 1374987 unspecified role unspecified role prey prey n/a 1375042 unspecified role unspecified role prey prey n/a 1375034 unspecified role unspecified role prey prey n/a 1375043 unspecified role unspecified role prey prey n/a 1375044 unspecified role unspecified role prey prey n/a 1375015 unspecified role unspecified role prey prey n/a 1375038 unspecified role unspecified role prey prey n/a 1375032 unspecified role unspecified role prey prey n/a 1375045 unspecified role unspecified role prey prey n/a 1375000 unspecified role unspecified role prey prey n/a 1375017 unspecified role unspecified role prey prey n/a 1375019 unspecified role unspecified role prey prey n/a 1375046 unspecified role unspecified role prey prey n/a 1375047 unspecified role unspecified role prey prey n/a 1375048 unspecified role unspecified role prey prey n/a 1375049 unspecified role unspecified role prey prey n/a 1375031 unspecified role unspecified role prey prey n/a 1375050 unspecified role unspecified role prey prey n/a 1375051 unspecified role unspecified role prey prey n/a 1375030 unspecified role unspecified role prey prey n/a 1375052 unspecified role unspecified role prey prey n/a 1375053 unspecified role unspecified role prey prey n/a 1374988 unspecified role unspecified role prey prey association association false false false Figure 3B and Table S1 MITRAC12-containing complexes were purified via MITRAC12FLAG after differential stable isotope labeling with amino acids in cell culture. Significance thresholds were set at p values < 0.01 and mean enrichment ratios > 15 coa3-mt_co1-6 1374981 n/a 1374984 unspecified role unspecified role prey prey n/a 1374983 unspecified role unspecified role prey prey n/a 1374982 unspecified role unspecified role bait bait association association false false false Fig. 1F