HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html http://www.agbase.msstate.edu/hpi/main.html brown-1999-3 Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart. chick-embryonic_fibroblast Chick embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. affinity techniques affinity technology affinity techniques weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Brown C.B., Boyer A.S., Runyan R.B., Barnett J.V. joey.barnett@mcmail.vanderbilt.edu Science (0036-8075) 1999 imex curation Only protein-protein interactions imex curation q90998_chick TGFBR3 protein protein chick Gallus gallus (Chicken) Chicken MSSSCVTPVFALMILCFADAGPVPRSECVLSPVNSSHPVHALLESFTVLSGCASRGTTGLPQEVHVLNLRNPDEGLDHHEREVTLHLTPISSVHIHQKPLVFLLNSPLPLVWKLKTERLAPGIRRVFFVSSGSIVWFEKGNFSLSAETEEKNFPERNEHLLQWAQKEYGAVTSFTELKISRNIYIKVGEDQVFPPTCNIEKNFLSLNYLAGYLQPKRAEGCLMSNLVQEREVHIIELITPNSNPYSAFQVDIIVDIKPSQPGAKLERNVVLILKCKKSVNWVIKSHDVQGKLEVITSNSIGFGKETERSMTMSKSVIPDIPSSHESLIKWAYEHKYSPVTSYTKAPVANRFHLQLEHTEEMNDEEDHSLPPELTELLHGAKNPALSDGLTFPFHINRGGHETGGEGIFPSRDSVDTLINHDFEHSLSKHKEPEEVQGSADVALSIKCDDKVMTVAVEKDSLQASGYTRTELSLLDHSCKARMNGTHFILESLPNKCGTRTSYILDKIVYFNSIVIQLSSPAEGSSFDDDDMESGDNGFPGDADEGDVTFSNWPEIAFNCTLHQPEKDFFNPAMFWPPEPHITNVTFNMELYKTDLFLAPSQGLFSVAENGPIYVEVSVTKADISLGFAIQTCFVSPFSNPDRMSDYTIIENICPKDESVKFYSTEKLNFPIAHAQKDKKRFSFVFKPIFNISLLFLHCELTLCTNIDKDTQRLPKCVPPDEACTSLNVDMILAMMHNKKTFTKPLVITHEGKPEDSSLPKSNVRQPSVFYGLDTLTVVGIAFAAFVIGALLTGALWFIYSHTGEAAGRRQVPTSPPASENSSAAHSIGSTQSTPCSSSSAT tgfb1_human Transforming growth factor beta-1 proprotein TGFB1 TGFB protein protein human Homo sapiens Human MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS tgfb1-tgfbr3 1384946 n/a TBRIII 1384947 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level n/a I125-TGF-B1 1384948 unspecified role unspecified role neutral component neutral component engineered engineered i125-tgfb1 125i radiolabel 125i radiolabel I125 125I 125I I125 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false true replication-based confidence replication-based confidence replication score Methods based on counting the number of replicates in which an interaction has been observed. 3 1C The interaction does not occur under these conditions Binding of TBRIII and TGFB1 reduces as concentration of antiserum against extracellular domain of TBRIII increases