MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint landreh-2012-1 Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide. in vitro In vitro fluorescence fluorescence technology fluorescence experimental particp experimental participant identification experimental particp Landreh M., Alvelius G., Willander H., Stukenborg JB., Söder O., Johansson J., Jörnvall H. FEBS J. (1742-464X) 2012 landreh-2012-2 Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide. in vitro In vitro dls dynamic light scattering dls experimental particp experimental participant identification experimental particp Landreh M., Alvelius G., Willander H., Stukenborg JB., Söder O., Johansson J., Jörnvall H. FEBS J. (1742-464X) 2012 landreh-2012-3 Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide. in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column experimental particp experimental participant identification experimental particp Landreh M., Alvelius G., Willander H., Stukenborg JB., Söder O., Johansson J., Jörnvall H. FEBS J. (1742-464X) 2012 ins_human Insulin INS protein protein human Homo sapiens Human MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver mint homomint Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730] ins-ins-4 1322796 ins_human Insulin 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified ins_human C-peptide 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified P01308:p.Glu67Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false c-peptide C-peptide polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false homomint mint f1 sf1 sf2 f4 f5 sf5 ins-ins-5 1322796 ins_human Insulin 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified ins_human C-peptide 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified c-peptide C-peptide polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain false P01308:p.Glu83Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false homomint mint f1 sf1 sf2 f4 f5 sf5 ins-ins-6 1322796 ins_human C-peptide 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified P01308:p.Glu83Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false P01308:p.Glu59Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false c-peptide C-peptide polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain false P01308:p.Glu67Ala mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false ins_human Insulin 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction false false false homomint mint f1 sf1 sf2 f4 f5 sf5 ins-ins-7 1322796 ins_human Insulin 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified ins_human Insulin 1322799 ms participant Identification by mass spectrometry ms participant unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction false false false homomint mint f1 sf1 sf2 f4 f5 sf5 ins-ins-8 1322797 ins_human C-peptide 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified c-peptide C-peptide polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain false ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction false false false f2a homomint mint ins-ins-9 1322797 ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction false false false f2a homomint mint ins-ins-10 1322798 ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified ins_human C-peptide 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified c-peptide C-peptide polyprotein frag polyprotein fragment polyprotein frag certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false f2b homomint mint ins-ins-11 1322798 ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified ins_human Insulin 1322799 predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified direct interaction direct interaction false false false f2b homomint mint