mpidb The Microbial Protein Interaction Database karimova-2012-2 The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery. ecolx Escherichia coli adenylate cyclase adenylate cyclase complementation bacterial two-hybrid bacterial two-hybrid adenylate cyclase predetermined predetermined participant predetermined Karimova G., Davi M., Ladant D. Genomic E. coli chromosomal DNA J. Bacteriol. (0021-9193) 2012 Only protein-protein interactions imex curation karimova-2012-1 The β-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery. ecolx Escherichia coli adenylate cyclase adenylate cyclase complementation bacterial two-hybrid bacterial two-hybrid adenylate cyclase nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Karimova G., Davi M., Ladant D. Genomic E. coli chromosomal DNA J. Bacteriol. (0021-9193) 2012 Only protein-protein interactions imex curation yfgm_ecoli Ancillary SecYEG translocon subunit yfgM Periplasmic chaperone YfgM JW2497 b2513 protein protein ecoli Escherichia coli (strain K12) MEIYENENDQVEAVKRFFAENGKALAVGVILGVGALIGWRYWNSHQVDSARSASLAYQNAVTAVSEGKPDSIPAAEKFAAENKNTYGALASLELAQQFVDKNELEKAAAQLQQGLADTSDENLKAVINLRLARVQVQLKQADAALKTLDTIKGEGWAAIVADLRGEALLSKGDKQGARSAWEAGVKSDVTPALSEMMQMKINNLSI blr_ecoli Divisome-associated membrane protein Blr blr Beta-lactam resistance protein JW5963 b4409 protein protein ecoli Escherichia coli (strain K12) MNRLIELTGWIVLVVSVILLGVASHIDNYQPPEQSASVQHK ftsq_ecoli Cell division protein FtsQ ftsQ b0093 JW0091 protein protein ecoli Escherichia coli (strain K12) MSQAALNTRNSEEEVSSRRNNGTRLAGILFLLTVLTTVLVSGWVVLGWMEDAQRLPLSKLVLTGERHYTRNDDIRQSILALGEPGTFMTQDVNIIQTQIEQRLPWIKQVSVRKQWPDELKIHLVEYVPIARWNDQHMVDAEGNTFSVPPERTSKQVLPMLYGPEGSANEVLQGYREMGQMLAKDRFTLKEAAMTARRSWQLTLNNDIKLNLGRGDTMKRLARFVELYPVLQQQAQTDGKRISYVDLRYDSGAAVGWAPLPPEESTQQQNQAQAEQQ ftsw_ecoli Probable peptidoglycan glycosyltransferase FtsW ftsW Cell division protein FtsW Cell wall polymerase Lipid II flippase FtsW Peptidoglycan polymerase JW0087 b0089 protein protein ecoli Escherichia coli (strain K12) MRLSLPRLKMPRLPGFSILVWISTALKGWVMGSREKDTDSLIMYDRTLLWLTFGLAAIGFIMVTSASMPIGQRLTNDPFFFAKRDGVYLILAFILAIITLRLPMEFWQRYSATMLLGSIILLMIVLVVGSSVKGASRWIDLGLLRIQPAELTKLSLFCYIANYLVRKGDEVRNNLRGFLKPMGVILVLAVLLLAQPDLGTVVVLFVTTLAMLFLAGAKLWQFIAIIGMGISAVVLLILAEPYRIRRVTAFWNPWEDPFGSGYQLTQSLMAFGRGELWGQGLGNSVQKLEYLPEAHTDFIFAIIGEELGYVGVVLALLMVFFVAFRAMSIGRKALEIDHRFSGFLACSIGIWFSFQALVNVGAAAGMLPTKGLTLPLISYGGSSLLIMSTAIMMLLRIDYETRLEKAQAFVRGSR ftsn_ecoli Cell division protein FtsN ftsN msgA b3933 JW3904 protein protein ecoli Escherichia coli (strain K12) MAQRDYVRRSQPAPSRRKKSTSRKKQRNLPAVSPAMVAIAAAVLVTFIGGLYFITHHKKEESETLQSQKVTGNGLPPKPEERWRYIKELESRQPGVRAPTEPSAGGEVKTPEQLTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASSQQPYQDLLQTPAHTTAQSKPQQAAPVARAADAPKPTAEKKDERRWMVQCGSFRGAEQAETVRAQLAFEGFDSKITTNNGWNRVVIGPVKGKENADSTLNRLKMAGHTNCIRLAAGG ftsk_ecoli DNA translocase FtsK ftsK b0890 JW0873 protein protein ecoli Escherichia coli (strain K12) MSQEYIEDKEVTLTKLSSGRRLLEALLILIVLFAVWLMAALLSFNPSDPSWSQTAWHEPIHNLGGMPGAWLADTLFFIFGVMAYTIPVIIVGGCWFAWRHQSSDEYIDYFAVSLRIIGVLALILTSCGLAAINADDIWYFASGGVIGSLLSTTLQPLLHSSGGTIALLCVWAAGLTLFTGWSWVTIAEKLGGWILNILTFASNRTRRDDTWVDEDEYEDDEEYEDENHGKQHESRRARILRGALARRKRLAEKFINPMGRQTDAALFSGKRMDDDEEITYTARGVAADPDDVLFSGNRATQPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANSGGPRPQVKEGIGPQLPRPKRIRVPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQYNDDEIDAMQQDELARQFAQTQQQRYGEQYQHDVPVNAEDADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVPPQPQYQQPQQPVAPQPQYQQPQQPVAPQQQYQQPQQPVAPQQQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSEVEPVDTFALEQMARLVEARLADFRIKADVVNYSPGPVITRFELNLAPGVKAARISNLSRDLARSLSTVAVRVVEVIPGKPYVGLELPNKKRQTVYLREVLDNAKFRDNPSPLTVVLGKDIAGEPVVADLAKMPHLLVAGTTGSGKSVGVNAMILSMLYKAQPEDVRFIMIDPKMLELSVYEGIPHLLTEVVTDMKDAANALRWCVNEMERRYKLMSALGVRNLAGYNEKIAEADRMMRPIPDPYWKPGDSMDAQHPVLKKEPYIVVLVDEFADLMMTVGKKVEELIARLAQKARAAGIHLVLATQRPSVDVITGLIKANIPTRIAFTVSSKIDSRTILDQAGAESLLGMGDMLYSGPNSTLPVRVHGAFVRDQEVHAVVQDWKARGRPQYVDGITSDSESEGGAGGFDGAEELDPLFDQAVQFVTEKRKASISGVQRQFRIGYNRAARIIEQMEAQGIVSEQGHNGNREVLAPPPFD ftsi_ecoli Peptidoglycan D,D-transpeptidase FtsI ftsI pbpB b0084 Penicillin-binding protein 3 JW0082 Essential cell division protein FtsI Murein transpeptidase Peptidoglycan synthase FtsI protein protein ecoli Escherichia coli (strain K12) MKAAAKTQKPKRQEEHANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVKEGDMRSLRVQQVSTSRGMITDRSGRPLAVSVPVKAIWADPKEVHDAGGISVGDRWKALANALNIPLDQLSARINANPKGRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKEAMRNRTITDVFEPGSTVKPMVVMTALQRGVVRENSVLNTIPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESIVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALTTGDKNEFVINQGEGTGGRS This sequence has been withdrawn from Uniprot. ftsl_ecoli Cell division protein FtsL ftsL mraR b0083 JW0081 yabD protein protein ecoli Escherichia coli (strain K12) MISRVTEALSKVKGSMGSHERHALPGVIGDDLLRFGKLPLCLFICIILTAVTVVTTAHHTRLLTAQREQLVLERDALDIEWRNLILEENALGDHSRVERIATEKLQMQHVDPSQENIVVQK flk_ecoli Flagellar regulator flk flk b2321 JW2318 div Fluke protein protein ecoli Escherichia coli (strain K12) MIQPISGPPPGQPPGQGDNLPSGTGNQPLSSQQRTSLESLMTKVTSLTQQQRAELWAGIRHDIGLSGDSPLLSRHFPAAEHNLAQRLLAAQKSHSARQLLAQLGEYLRLGNNRQAVTDYIRHNFGQTPLNQLSPEQLKTILTLLQEGKMVIPQPQQREATDRPLLPAEHNALKQLVTKLAAATGEPSKQIWQSMLELSGVKDGELIPAKLFNHLVTWLQARQTLSQQNTPTLESLQMTLKQPLDASELAALSAYIQQKYGLSAQSSLSSAQAEDILNQLYQRRVKGIDPRVMQPLLNPFPPMMDTLQNMATRPALWILLVAIILMLVWLVR rsea_ecoli Anti-sigma-E factor RseA yfiJ rseA mclA b2572 JW2556 Regulator of SigE Sigma-E anti-sigma factor RseA Sigma-E factor negative regulatory protein protein protein ecoli Escherichia coli (strain K12) MQKEQLSALMDGETLDSELLNELAHNPEMQKTWESYHLIRDSMRGDTPEVLHFDISSRVMAAIEEEPVRQPATLIPEAQPAPHQWQKMPFWQKVRPWAAQLTQMGVAACVSLAVIVGVQHYNGQSETSQQPETPVFNTLPMMGKASPVSLGVPSEATANNGQQQQVQEQRRRINAMLQDYELQRRLHSEQLQFEQAQTQQAAVQVPGIQTLGTQSQ blr-yfgm-1 1340081 not-defined-1345717559 1340083 unspecified role unspecified role prey prey not-defined-1677000566 1340084 unspecified role unspecified role bait bait P56976:p.Val12[2] P56976-12-13 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1, 6 blr-ftsq-1 1340081 not-defined-1775007463 1340085 unspecified role unspecified role prey prey not-defined-2141186080 1340084 unspecified role unspecified role bait bait val12val_val P56976-12-13 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1 blr-ftsw-1 1340081 not-defined-1621856722 1340086 unspecified role unspecified role prey prey not-defined-2013646026 1340084 unspecified role unspecified role bait bait P56976:p.Val12[2] P56976-12-13 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1, 6 yfgm-blr 1340081 not-defined-1345717559 1340083 unspecified role unspecified role bait bait not-defined-1677000566 1340084 unspecified role unspecified role prey prey physical association physical association false false false Figure 1 blr-ftsn-1 1340081 not-defined-1159439673 1340087 unspecified role unspecified role prey prey not-defined-1240967676 1340084 unspecified role unspecified role bait bait P56976:p.Val12[2] P56976-12-13 mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1, 6 blr-ftsk-1 1340081 not-defined-1214994417 1340088 unspecified role unspecified role prey prey p46889-1-271 P46889-1-271 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-1071431271 1340084 unspecified role unspecified role bait bait val12val_val P56976-12-13 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1, 6 blr-ftsi-1 1340081 not-defined-296511466 1340089 unspecified role unspecified role prey prey not-defined-969275305 1340084 unspecified role unspecified role bait bait val12val_val P56976-12-13 mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1 blr-ftsl-1 1340081 not-defined-1648260110 1340090 unspecified role unspecified role prey prey not-defined-1471432280 1340084 unspecified role unspecified role bait bait P56976:p.Val12[2] P56976-12-13 mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing insertion analysis insertion analysis certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1 ftsn-blr 1340081 not-defined-1159439673 1340087 unspecified role unspecified role bait bait not-defined-1240967676 1340084 unspecified role unspecified role prey prey physical association physical association false false false Figure 1 ftsk-blr 1340081 not-defined-1214994417 1340088 unspecified role unspecified role bait bait p46889-1-271 P46889-1-271 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-1071431271 1340084 unspecified role unspecified role prey prey physical association physical association false false false Figure 1 ftsi-blr 1340081 not-defined-296511466 1340089 unspecified role unspecified role bait bait not-defined-969275305 1340084 unspecified role unspecified role prey prey physical association physical association false false false Figure 1 ftsl-blr-1 1340081 not-defined-1648260110 1340090 unspecified role unspecified role bait bait not-defined-1471432280 1340084 unspecified role unspecified role prey prey physical association physical association false false false Figure 1 blr-ftsn-2 1340081 not-defined-1159439673 1340087 unspecified role unspecified role prey prey not-defined-1240967676 1340084 unspecified role unspecified role bait bait P56976:p.Val12[2] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Figure 1 ftsl-flk 1340082 not-defined-2095620043 1340091 unspecified role unspecified role prey prey region P15286-114-331 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-1220909422 1340090 unspecified role unspecified role bait bait physical association physical association false false false Table 4 ftsl-rsea 1340082 not-defined-1516931789 1340092 unspecified role unspecified role prey prey region P0AFX7-68-216 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-1508230349 1340090 unspecified role unspecified role bait bait physical association physical association false false false Table 4 ftsl-yfgm 1340082 not-defined-857477673 1340090 unspecified role unspecified role bait bait not-defined-923275389 1340083 unspecified role unspecified role prey prey region P76576-17-206 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Table 4 ftsl-blr 1340082 not-defined-1245475559 1340090 unspecified role unspecified role bait bait not-defined-1683579197 1340084 unspecified role unspecified role prey prey region P56976-3-41 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Table 4 ftsl-ftsi 1340082 not-defined-2070739691 1340089 unspecified role unspecified role prey prey region P0AD68-9-193 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-1971153788 1340090 unspecified role unspecified role bait bait physical association physical association false false false Table 4 ftsl-ftsw-1 1340082 not-defined-883649558 1340086 unspecified role unspecified role prey prey region P0ABG4-23-213 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false not-defined-903348739 1340090 unspecified role unspecified role bait bait physical association physical association false false false Table 4