IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ reddy-2010-7 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. drome-schneider_2 Drosophila melanogaster late embryo cells Fruit fly schneider_2 Established from the late embryo of Drosophila melanogaster Mixture of diploid and tetraploid. Originally had some XY cells now predominantly XX. ch-ip chromatin immunoprecipitation assay ch-ip nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-5 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-4 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip ms participant Identification by mass spectrometry ms participant Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-6 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. drome-salivary_gland Drosophila melanogaster Salivary gland salivary_gland Salivary gland fluorescence imaging fluorescence microscopy fluorescence imaging immunostaining immunostaining Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-1 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Drosophila embryonic cDNA Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-2 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation reddy-2010-3 Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Reddy B.A., Bajpe P.K., Bassett A., Moshkin Y.M., Kozhevnikova E., Bezstarosti K., Demmers J.A., Travers A.A., Verrijzer C.P. c.verrijzer@erasmusmc.nl Mol. Cell. Biol. (0270-7306) 2010 Only protein-protein interactions imex curation ark_drome_gene Apaf-1 related killer DARK gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly ttkb_drome Protein tramtrack, beta isoform ttk FTZ-F2 Repressor protein fushi tarazu Tramtrack p69 CG1856 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MKMASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSDGNDSDGEGLDTSYMEPQLMLDEYDEPVEFKYNPLTDNSSPTQDHTDGSHLNEQARQQAFLIAAQRKHQVETAAAAAASGIKLNIIGMAAGGAQVKSMVSIPKLTPIGKVNAASTPLVSPAGSFSTATVKPRVQKRPKLGKQNGDVKPAVFSSQEYLDIYNSNDGFKLKAAGLSGSTPNLSAGLGTPSVKTKLNLSSNVGEGEAEGSVRDYCTKEGEHTYRCKVCSRVYTHISNFCRHYVTSHKRNVKVYPCPFCFKEFTRKDNMTAHVKIIHKIENPSTALATVAAANLAGQPLGVSGASTPPPPDLSGQNSNQSLPATSNALSTSSSSSTSSSSGSLGPLTTSAPPAPAAAAQ hair_drome_gene Hairy gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly hmen_drome_gene Segmentation polarity homeobox protein engrailed gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly chdm_drome Chromodomain-helicase-DNA-binding protein Mi-2 homolog Mi-2 CG8103 ATP-dependent helicase Mi-2 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MASEEENDDNFQEEEEAQEDNAPAAELSNDSDAPLKPNNDEDDDYDPEDSRRKKKGKKRKTRKGEEKGRKKKKRKKNESEEDSDFVQHDEEVEYPSTSKRGRKRKEEKQAAKEKESASSGMPSVEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCESNPHIQQEGGAAGSGGSAGQARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKDGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWANEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEEKAAVPGREYEIWHRRHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDVGKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQDPSHPAMSLNARFAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKSDVSRLPATLARIPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQGTTLPAFTSGPAGNFANFRPQFSVPGQLSNNSGV q0e8j0_drome MEP-1 Dmel\CG1244 MEP1 Q0E8J0_DROME anon-EST:Liang-1.37 anon-WO0118547.584 clone 1.37 dMEP-1 Dmel_CG1244 CG1244 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MTEVDVVLPEGVAEPTTKLASASSSPKQSKPSADDVEQQVTTVEDDEEQVVEEQQEEDVHLPEAPSNEKLELLSAGGKDISKEDVAQASPQAPVADEIMEVDGTEDVEENEVENDDEDSQITSSSSKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAEDPLGAVTVPDDELASGKKAHLDGEESVASEGVVEEEPPAKQENGFGASPNQKENGQASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDAVLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRKSDLDDLQLQQPSHKRQRSSTPSGMGQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVTGAATNLGVVPPKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMFVLEAPSFIVPYIYEKPPRENICEVVKAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQADESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEANDDLSALKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKMRKAQVQNSKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYETPHMNGVLYKCNFCTFEIRNATEIVYHMEAVHNIKARLIKPLPYHQCPNCGFEDNGKAKLARHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQKAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLPNSYQLAAGQLVQASKKPMAGQPSISITPLPRQSSVGAGAGASSSKAPQAAAGMKPGQSPSGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKVKIHPKMIYNRPPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGKDAGRCPVCGRMYQWKLLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAHSTVARKAMDSKKNSAQSSGSGSGAGMSRSSLGAANDSLLKPLKINDEITIIPQPASKPRITNMESHVID sk1_drome_gene Sphingosine kinase 1 gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly q9biw6_drome Bap111 dalao CG7055 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MALPSNYKQIAVGGQGSATPLQGGGGGSGGGSRSRSSGGGGGGDRNKDQTPIFTHSNYGNPAFTPQKVTKSSSSKNQNESRLPKPPKPPEKPILPYMRYSKRVWDSVKAKHPELKLWELGKKIGAMWKLLPEDEKTEFIDEYEAEKLEYEKSLKAYHQTPAYQAYMSAKSKVKTDVDMHETPSRGGGSKSQHERRIDIQPAEDEDDQDEGYTTKHLAYARYLHNHRLINEIFSEAVVPDVRSVVTTTRMQVLKRQVSSLTMHQTKLEAELQQMEEKFEAKKQRMVESSEAFQEELKRHCKPAVDEETFQKMVLRMYEDIKRDRQRLDEPNANANSAANPAAAAATAAAAPVTRSEEAVKPPTQPGQPAATPAGQEPASAVPAPAAPPKETPPAVKPATLNPTPSSTPTPAPAVHVHETASKTDPEPMDIEPPPKPSVPPPPIKPEKLEMAAALPPQSTLVEPPKTEPAKVVAQPGKVPTPVPTPTPPPEVAPAAGAVTAATTTTRRTPTPPPVPQQVPLPQQQGGPAPPPGMPQMHPHPGHPPPGHSLMPPHMGPHQPPPGMPGLPPPPPHTGYANYGGPPHGPPPGPPGGPARPYYQPQYGGHPTPQPYYAPFSPYQQSYGPPPGSHYMSPRPPPPQHNGNPGHPYAPEHGSNPPPPQQQQQQQPPPGHLHEPSGGGPGAPGGGAGAAAAAAPGAGVYPTPGAGAGPGAPPGPAGGAPLGEAAVAGGVGPPAATALGKHPEAEKHEAD kcnq_drome_gene KCNQ potassium channel gene gene drome Drosophila melanogaster (Fruit fly) Fruit fly q9vz27_drome CDK2AP1 CG18292-RA DOC1 Dmel\CG18292 anon-WO03040301.144 Dmel_CG18292 CG18292 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MDIMDIQAVESKLSDVTVTPIPRSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSVGGGGGSNSSNAATDYSTSSGGKRERDRSSASDYSSSSSKQSSAAAANAAAAAAAVAALQYSPQFLQAQLALLQQQSNTTATPAAVAAAALSLANMCSSNGGQRNSGAGVSSTSSGSNGQSMGLNLSSSQLKYPPPSTSPVVVTTQTSANITTPLTSTASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAARQ q9vnf6_drome MTA1-like Dmel\CG2244 MTA MTA-like MTA1 dMTA dMTA-1 dMTA1-like p120 Dmel_CG2244 CG2244 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPAAPEPSSRPIESQIVILD hdac1_drome Histone deacetylase HDAC1 HDAC1 Rpd3 CG7471 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSYKGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGDGADGEESTASNTNSNNNSNNKSDNDAGATANAGSGSGSGSGAGAKGAKENNI caf1_drome Chromatin assembly factor 1 p55 subunit Caf1-55 CAF-1 Caf1 Nucleosome-remodeling factor 55 kDa subunit CG4236 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNTA q0e8g1_drome simj 68-like Dmel\CG32067 SIMJ anon-WO0118547.361 dp66 l(3)01814 l(3)j4A5 l(3)rN672 p66 Dmel_CG32067 CG7983 CG8000 CG32067 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MAKMEVDDVVDLSLGSGRDPALTITPAPPPAALSNRDLRALTANNAGLTITPSASPATNNGTTSNSSNTNSNSSSTTTTTNNNNNSSSNTNSSSANNNNNNNSINASDGVTGATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQQNGNIDSETDDEEMPPYVPIKELSHAELKEREKSLRKLRQDLRNEETKLMLLKKLKQSQQVMKENLVVTPTSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAHSKGSRSSLSGSGGPAVSISATNSRTGSSSSAAAAASAIAAAAMSGQHRSGSNSILPPPRSSLPAGATLAAGTTITPATSSSHRSSNLPPRTNLPNLTITPSVTITPTSAPPSSLKPRNVPGTISNSVSITPALPLSQSHQNQHNDQKNDRSTPREDAQTPAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDFVYLLGLETVVDYLTVNKKANAVAAPFRCAQCKIDFTPVWKWEKQTNKDPKVICEQCVTSNVKKALKAEHTNRLKQAFVKALQQEQEIEQRLASQSSPSPVDNHGSSGGGNSLSVSAVSSNSSSSHMQREREQLQASHASAAAALVNLPPSVTVIPTKCQTPTPATPRPTPPPPQSQATPPPSSGGSRSSRAAATAAAAAIAAQQAGILSPGPSPAHHHEPTTSSRSSRNDRLDHHHQSQQQQQRDQRERDQQQRDQQSQQQAQNYDKYSAATLAAAAHLSALGGMGGLNINSLASLGNLGNLGNLSQLGNLAALGGLGNFGGASTGSANPAAGLSGSSPAATAAAMQAFQQQLFRALGQGLGGNPQHMMQFAPLLYSYQMAMAQAAQVAAFNNNNKKSSSSSGSAKNSSSSNSMAEVQRAAELQRQYLLEMIPPQQQSGASGSRQNNWKA q9w321_drome Histone acetyltransferase nej CBP CBP_ Cbp Crbp Dmel\CG15319 Nej Nejire anon-WO0147981.11 anon-WO03040301.89 cbp dCBP dKAT3 dmCBP l(1)G0112 l(1)G0350 l(1)G0470 nej CBP p300 CG15321 Dmel_CG15319 CG15319 P300 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MMADHLDEPPQKRVKMDPTDISYFLEENLPDELVSSNSGWSDQLTGGAGGGNGGGGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMTQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQIQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRAAPSASPRAQPSPHHVMSSHSPAPQGPPHDGMHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVNVNVGNVGVGNAGGALPDASDQLTKFVERL q9v424_drome CG8208 MBD-like 3 Dm Mbd2 DmMbd2 Dmel\CG8208 MBD2 MBD2-3 MBD3 dMBD-like dMBD2 dMbD2 Dmel_CG8208 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT ctbp_drome C-terminal-binding protein CtBP CG7583 dCtBP protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGALHHRAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSSQSPLSAPDPNNHLSSSIKTEVKAESTEAP q9vhb7_drome 3 Dm Mbd2 DmMbd2 Dmel\CG8208 MBD2 MBD2-3 MBD3 dMBD-like dMBD2 dMbD2 Dmel_CG8208 MBD-like CG8208 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSPTGKRAEGKPQDIAIPDFQPGKMPHCALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT q9w4w7_drome MAD Dmel\CG2662 EG:100G10.6 snuts CG2662 Dmel_CG2662 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MKQSKDEDKEESPVQPTTHNSSAGSNGHDAKSPVVTTAPAATCSVSVSDASGAGASVRTTGRVKKPKQVYDPSDNYVSRASSNRNSLSSVPATSNVQSPPVKEATDSQDSTTSPVSEQQQQQLQQAAQLRNFDTCQKCGKSEPKRGSGHKSNFLTCKGCMQKWHFPCLPITFHNQSTARKKFKCDKCRYCRLCNVRGPGLSICSLCVDAYHPDCNDPTLKQSKAVEANPNWRCFRCEACNIGGSTSASSEEQTGARKSTASREDQAQPVVPRKSNAGRKKRVQSEPTGQEKAAKIEKLAKRRQPLKTEKKKEYKKEEDEEPAQIKVKVEKVEPVDMETEQIENNDLPGPEQESLSLRLTPITAVERRSHPVSTWSVEQVVQFVAKRYPKEANVFRYQDIDGASLLLLNRHDVMNGFGLKLGPALRVFELVMSLQTQSNDVGLAWLD ttk-ark 1300929 n/a 1300936 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role bait bait association association false false false Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. ttk-hair 1300929 n/a 1300937 unspecified role unspecified role bait bait n/a 1300938 unspecified role unspecified role prey prey association association false false false Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. ttk-hmen 1300929 n/a 1300939 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role bait bait association association false false false Fig. 6B Depletion of either MEP1 or Mi2 did not affect TTK69 binding to the gene loci. mi_2-ark 1300929 n/a 1300940 unspecified role unspecified role bait bait n/a 1300936 unspecified role unspecified role prey prey association association false false false Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mi_2-hair 1300929 n/a 1300940 unspecified role unspecified role bait bait n/a 1300938 unspecified role unspecified role prey prey association association false false false Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mi_2-hmen 1300929 n/a 1300939 unspecified role unspecified role prey prey n/a 1300940 unspecified role unspecified role bait bait association association false false false Fig. 6C Depletion of either MEP1 or TTK69 caused reduced MI-2 binding to the gene loci. mep_1-ark 1300929 n/a 1300936 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role bait bait association association false false false Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. mep_1-hair 1300929 n/a 1300938 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role bait bait association association false false false Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. mep_1-hmen 1300929 n/a 1300941 unspecified role unspecified role bait bait n/a 1300939 unspecified role unspecified role prey prey association association false false false Fig. 6D MEP1 binding was strictly dependent on TTK69 however, loss of Mi2 only modestly affected MEP1 recruitment to the gene loci. dalao-sk1 1300929 n/a 1300942 unspecified role unspecified role prey prey n/a 1300943 unspecified role unspecified role bait bait association association false false false Fig. 6E BAP111 binding to its targets SK1 and KCNQ was unaffected by the knockdown of TTK69, MEP1, or Mi2 dalao-kcnq 1300929 n/a 1300943 unspecified role unspecified role bait bait n/a 1300944 unspecified role unspecified role prey prey association association false false false Fig. 6E BAP111 binding to its targets SK1 and KCNQ was unaffected by the knockdown of TTK69, MEP1, or Mi2 mi_2-chdm-1 1300930 n/a 1300940 unspecified role unspecified role bait bait n/a 1300945 unspecified role unspecified role prey prey n/a 1300946 unspecified role unspecified role prey prey n/a 1300947 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role prey prey association association false false false Fig. 2C mep_1-caf1-1 1300930 n/a 1300946 unspecified role unspecified role prey prey n/a 1300940 unspecified role unspecified role prey prey n/a 1300945 unspecified role unspecified role prey prey n/a 1300947 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role bait bait association association false false false Fig. 2C mi_2-cg18292_ra 1300930 n/a 1300947 unspecified role unspecified role prey prey n/a 1300940 unspecified role unspecified role prey prey n/a 1300945 unspecified role unspecified role bait bait n/a 1300941 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role prey prey n/a 1300946 unspecified role unspecified role prey prey association association false false false Fig. 2D, 2E Immunodepletion of CDK2AP1/DOC1resulted in the concomitant loss of Mi2, MEP1, MTA1, and, to a somewhat lesser extent, RPD3 mep_1-caf1-3 1300931 n/a 1300948 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role bait bait n/a 1300937 unspecified role unspecified role prey prey n/a 1300947 unspecified role unspecified role prey prey n/a 1300949 unspecified role unspecified role prey prey n/a 1300950 unspecified role unspecified role prey prey n/a 1300951 unspecified role unspecified role prey prey n/a 1300952 unspecified role unspecified role prey prey n/a 1300945 unspecified role unspecified role prey prey n/a 1300953 unspecified role unspecified role prey prey n/a 1300954 unspecified role unspecified role prey prey n/a 1300940 unspecified role unspecified role prey prey n/a 1300946 unspecified role unspecified role prey prey association association false false false Fig. 2A, Table 1 mi_2-caf1 1300931 n/a 1300951 unspecified role unspecified role prey prey n/a 1300940 unspecified role unspecified role bait bait n/a 1300946 unspecified role unspecified role prey prey n/a 1300941 unspecified role unspecified role prey prey n/a 1300948 unspecified role unspecified role prey prey n/a 1300953 unspecified role unspecified role prey prey n/a 1300937 unspecified role unspecified role prey prey n/a 1300945 unspecified role unspecified role prey prey n/a 1300947 unspecified role unspecified role prey prey n/a 1300949 unspecified role unspecified role prey prey association association false false false Fig. 2B, Table 1 mep_1-ttk-1 1300932 n/a 1300937 unspecified role unspecified role neutral component neutral component n/a 1300941 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false Fig. 4 mi_2-ttk-1 1300932 n/a 1300940 unspecified role unspecified role neutral component neutral component n/a 1300937 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false Fig. 4 ttk-mep_1 1300933 n/a 1300941 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1300937 unspecified role unspecified role bait bait physical association physical association false false false text, fig 1A ttk-mep_1-1 1300934 n/a 1300941 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1300937 unspecified role unspecified role bait bait region required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false 1301048 1301046 physical association physical association false false false Fig. 1B mep_1-ttk 1300935 n/a 1300937 unspecified role unspecified role prey prey in vitro In vitro n/a 1300941 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) physical association physical association false false false Fig. 1C