<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2013-02-01Z">
            <names>
                <shortLabel>mpidb</shortLabel>
                <fullName>The Microbial Protein Interaction Database</fullName>
            </names>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0903" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6390654" refType="identity" refTypeAc="MI:0356"/>
            </xref>
        </source>
        <experimentList>
            <experimentDescription id="1333924">
                <names>
                    <shortLabel>martinez_wi-2008-1</shortLabel>
                    <fullName>The vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18676667" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6403851" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-18220" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="83333">
                        <names>
                            <shortLabel>ecoli</shortLabel>
                            <fullName>Escherichia coli (strain K12)</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>phosphotransferase</shortLabel>
                        <fullName>phosphotransferase assay</fullName>
                        <alias typeAc="MI:1041" type="synonym">phosphotransferase</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0841" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218447" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>weight autoradiogra</shortLabel>
                        <fullName>molecular weight estimation by autoradiography</fullName>
                        <alias typeAc="MI:1041" type="synonym">weight autoradiogra</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0821" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218638" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Martinez-Wilson H.F., Tamayo R., Tischler A.D., Lazinski D.W., Camilli A.</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Bacteriol. (0021-9193)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="1333925">
                <names>
                    <shortLabel>a0a0h3al40_vibc3</shortLabel>
                    <fullName>Phosphorelay protein LuxU</fullName>
                    <alias typeAc="MI:0305" type="locus name">VC0395_A1259</alias>
                    <alias typeAc="MI:0301" type="gene name">vieS</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0H3AL40" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6403859" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A5F7M7" refType="uniprot-removed-ac"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019594"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ20966" version="TrEMBL_36" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ20966" version="TrEMBL_36" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004358"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="TrEMBL_36"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003594"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="TrEMBL_36"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003661"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005467"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036890"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035965"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001789"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" secondary="phosphoprotein phosphatase activity" version="TrEMBL_36"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000155" secondary="phosphorelay sensor kinase activity" version="TrEMBL_36"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036097"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="WP_001889586.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036641"/>
                    <secondaryRef db="ensemblbacteria" id="VC0395_A1259" version="TrEMBL_36" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004970" secondary="ionotropic glutamate receptor activity" version="TrEMBL_36"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001638"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011006"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="345073">
                    <names>
                        <shortLabel>vibc3</shortLabel>
                        <fullName>vibc3</fullName>
                    </names>
                </organism>
                <sequence>MPYWGGTGQEPIGIEHDFASGIAKELGINIEYKGFDTIEALLNAVSTGKADMAIGFGQTLAREGKFLFSKPLYENVRVIWLRDKAMEEKPFASLKWVCIQGTSYCEILKDRGYPNIIMARNYSSSVEMIRQGIADATVTNYVSLNHYLSQKRLALGKVIFDPDLGVQTNRILINNNEPLLLSAINKVIDADKQGLTENKLNSADVYFLNDQANLNILRNENVNPVVRYTIQDDLFPMSYWDEKEKKYKGYVHDLLERISTKSILKFEFVPAYGRDVEDMLRHGKVDLIPSFNMTYVDDRYFIHTGRYTDIQFGYIETTRPYTTPITGILDRTGKFNAYIAVQKNLSDVKVYRSMYDLEQALEKGDITHGLLNKVLINQMLLDGHQDAFKLSPLTEGQDLRADMTMLVRKDARGLQNMLQKVLATFSQQEIDEIKGAYDRVTVYFGYDKQKVLIYALIILCGLLSIGLILTLSLSRLRGKLRSSEQVAKLSTEQLRWLTELLDAIPSMIFISDEKDEVVLTNAAYRKIYHTCCEKGCVQPQPECSFLALPDQHEAEFSIIIQAPKSNCSIGEHYFHVTRRAISHPINQRKYYLTLFNDITELKETEQALRQSNEQALQAVEARNHFLAVVSHELRTPIAAMLGLMEILASRLKNSESQLLLTNAISSAERLKLHVNDILDFSKIEAQQLQLDIGLYNLTDELGPLLRGFEASAQLKEIEFDVIWSPNSLLLANFDALRFNQIVTNLLSNAIKFTDQGRVVFKIDVAPEMLTIVVEDTGCGMTQTQIESLFVPFAQADSTITRRFGGTGLGMSIVANLIELMNGKIEVKSEFEQGTQIQVNLPLVTQTCDEFRGQVVAMSYRSPYMLWAKALGMRVEENEEWVEQSGHNIYPDLLLNRLREVSNLTQAQTEPAHSRLLQGHVLVADDDAINRLLIKKQLSELGLSATLVSDGLQAFEKLSQHPEQYDLLITDCHMPHLDGFALTRKVKQEISLFKGAVVGCTAEDSRLAAEQALQAGMDKVIYKPYTLANLRKVLSRYLTTQWVALPEQSWLDAYQEEEREEMAMVVAESLAQDIALLNQPDCDVKALAHRIKGAAGSLQLQRLADLAKTVEKQNDPQQLVADKQQLINAMHEVVEQAQQWLHQYQSE</sequence>
            </interactor>
            <interactor id="1333926">
                <names>
                    <shortLabel>a0a0h3am52_vibc3</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">vieA</alias>
                    <alias typeAc="MI:0305" type="locus name">VC0395_A1258</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0H3AM52" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ21552" version="TrEMBL_31" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001633"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001789"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" secondary="regulation of transcription, DNA-templated" version="TrEMBL_31"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6403865" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035919"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" secondary="DNA binding" version="TrEMBL_31"/>
                    <secondaryRef db="ensemblbacteria" id="VC0395_A1258" version="TrEMBL_31" refType="gene"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ21552" version="TrEMBL_31" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000160" secondary="phosphorelay signal transduction system" version="TrEMBL_31"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000792"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A5F7M6" refType="uniprot-removed-ac"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011006"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016032"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036388"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="345073">
                    <names>
                        <shortLabel>vibc3</shortLabel>
                        <fullName>vibc3</fullName>
                    </names>
                </organism>
                <sequence>MKIMIVEDDRIQATSLKLKLRQLGLDDVILAENGFAALELCNKVGIDLMFCDIRMPQMDGISLLSQLSLQAPKLGVVILSAVEDTILELTHNMCSLAGFAYVDRLPKPYEVEDLQRVVEGFQKQTEPETSHKPAITLTCDEIEQAFLHDHIFNYYQPQFDFRSGAMVGVEALVRYEHPTHGMLSPAVFLPLIEQCGLHEKLFLTVLEKSVSALASIGADLQLSVNISQRNLQHSICDPILAICERYGFPASKLTLEMTEHEVYNRTPTSLANLARLRMYGVGLSIDDFGTGYASLGQLAQLPFTELKIDRSFVHDLATNYKHQQLTNMCLLLAQSLGLHCVVEGVENEETWQYLRQLGVDTCQGYYAAKPMPIAQLSELYTKNRRQCLGCQSMDDGWQILLVDNHMLSATALQKVLNKEENVSKVFVAQDIEQTLHKLRDLPINLLVVESRFLSTISPAAFHELLEPYYRGALLVLHDGLTAEAQEDEPKAIVVKANTLMETSSRILLQAQQSNVRPQAQQEELAQLSERELTVAKMLVEGLTNKEIALQLDINQKTVSTYKTRIMTKLGIKSAMELVRFVTLK</sequence>
            </interactor>
            <interactor id="1333927">
                <names>
                    <shortLabel>a0a0h3amj9_vibc3</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">cheY-3</alias>
                    <alias typeAc="MI:0305" type="locus name">VC0395_A1653</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0H3AMJ9" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ22016" version="TrEMBL_34" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4LX8"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ22016" version="TrEMBL_34" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001789"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000160" secondary="phosphorelay signal transduction system" version="TrEMBL_34"/>
                    <secondaryRef db="ensemblbacteria" id="VC0395_A1653" version="TrEMBL_34" refType="gene"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A5F6J9" version="TrEMBL_34" refType="uniprot-removed-ac"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="TrEMBL_34"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011006"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4JP1"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6503131" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="345073">
                    <names>
                        <shortLabel>vibc3</shortLabel>
                        <fullName>vibc3</fullName>
                    </names>
                </organism>
                <sequence>MEAILNKNMKILIVDDFSTMRRIVKNLLRDLGFNNTQEADDGLTALPMLKKGDFDFVVTDWNMPGMQGIDLLKNIRADEELKHLPVLMITAEAKREQIIEAAQAGVNGYIVKPFTAATLKEKLDKIFERL</sequence>
            </interactor>
            <interactor id="1333928">
                <names>
                    <shortLabel>a0a0h3akm6_vibc3</shortLabel>
                    <fullName>Phosphorelay protein LuxU</fullName>
                    <alias typeAc="MI:0301" type="gene name">cheA-2</alias>
                    <alias typeAc="MI:0305" type="locus name">VC0395_A1651</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0H3AKM6" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037006"/>
                    <secondaryRef db="ensemblbacteria" id="VC0395_A1651" version="TrEMBL_35" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036061"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A5F6J7" version="TrEMBL_49" refType="uniprot-removed-ac"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000155" secondary="phosphorelay sensor kinase activity" version="TrEMBL_35"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004105"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004358"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6503148" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006935" secondary="chemotaxis" version="TrEMBL_35"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036097"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="TrEMBL_35"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003594"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036641"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ20751" version="TrEMBL_35" refType="transcript"/>
                    <secondaryRef db="ensemblbacteria" id="ABQ20751" version="TrEMBL_35" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="WP_000119661.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002545"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR005467"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036890"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="345073">
                    <names>
                        <shortLabel>vibc3</shortLabel>
                        <fullName>vibc3</fullName>
                    </names>
                </organism>
                <sequence>MSYELDEDILQDFLVEAGEILELLSEQLVELENNPEDRDLLNAIFRGFHTVKGGAGFLALSELVETCHGAENVFDILRNGQRHVSPSLMDTMLKALDTVNEQFRAVQEREPLQPADPELLDELHRLSKPASEDEDEAAEAHFDEPEEELVEEIIEEVVEDVVEEAVPNVETEVTASASSGVIDKGSIDDINEDEFEKLLDELHGKGKAPGAQSPQAPASAPAKAASVTNSDLNGDITDDEFEKLLDQLHGKGKGPSIETAAPAAPVTPSTPKATETPKPAAAKSAPGGDDLMTDEEFEKLLDELHGSGKGPSVEELEMATRPVASSPVSSDAKASAEASAPSTKPAAKPVAKPAAAKPAVAKEEPAKAPAPAAVKDSDESREVAAAGGAKKAQTESTVRVDTSTLDTIMNMVGELVLVRNRLLSLGLNSNDEEMSKAVANLDVVTADLQGAVMKTRMQPIKKVFGRFPRVVRDLARSLNKEIDLELRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDERAKNGKSRTGKVILSASQEGDHIQLAIVDDGAGMDPDKLRGIAVKRGIMDEDAANRLTNKECFNLIFMPGFSSKEKITDISGRGVGMDVVKTAINTLNGSIDIDSTMGKGTKITIKVPLTLAILPTLMVGVAGHPFALPLASVNEIFHLDLRRTNVVDGQLTIIVREKSIPLFYLQNWLAPKKGKVQLRQGHGHVVIVQIGSQRVGLVVDTLIGQEEVVIKPLDKLLQGTPGMSGATITSDGHIALILDVPDLLKQYAAASRV</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-18220-1" id="1333929">
                <names>
                    <shortLabel>viea-vies</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mpidb" dbAc="MI:0903" id="MPIDB-INT-48" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-18220-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6403856" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1333924</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1333930">
                        <names>
                            <shortLabel>not-defined-1405636816</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6403872" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1333925</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>phosphate donor</shortLabel>
                                <fullName>phosphate donor</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0842" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218298" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1333931">
                                <names>
                                    <shortLabel>A0A0H3AL40:p.His1141Gln</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503176" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation decreasing rate</shortLabel>
                                        <fullName>mutation decreasing interaction rate</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation decreasing rate</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1130" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5528813" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1141"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="1141"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="1333932">
                                <names>
                                    <shortLabel>A0A0H3AL40:p.Asp1017Ala</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503174" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation increasing rate</shortLabel>
                                        <fullName>mutation increasing interaction rate</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation increasing rate</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1131" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14577292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5528809" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1017"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="1017"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="1333933">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503170" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mbp tag</shortLabel>
                                        <fullName>maltose binding protein tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">maltose binding protein tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">maltose binding protein tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">mbp tag</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0578" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-705364" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="1333934">
                        <names>
                            <shortLabel>not-defined-725733556</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6403871" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1333926</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>phosphate acceptor</shortLabel>
                                <fullName>phosphate acceptor</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0843" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218289" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1333935">
                                <names>
                                    <shortLabel>A0A0H3AM52:p.Asp52Ala</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503172" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation decreasing rate</shortLabel>
                                        <fullName>mutation decreasing interaction rate</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation decreasing rate</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1130" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-5528813" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="52"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="52"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>phosphotransfer</shortLabel>
                        <fullName>phosphotransfer reaction</fullName>
                        <alias typeAc="MI:1041" type="synonym">phosphotransfer</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0844" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="16712436" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218345" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 2</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-18220-2" id="1333936">
                <names>
                    <shortLabel>chea_2-chey_3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mpidb" dbAc="MI:0903" id="MPIDB-INT-48" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-18220-2" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6503145" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1333924</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1333937">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503169" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1333927</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>phosphate acceptor</shortLabel>
                                <fullName>phosphate acceptor</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0843" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218289" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="1333938">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6503168" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1333928</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>electron donor</shortLabel>
                                <fullName>electron donor</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0579" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-704954" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="562">
                                <names>
                                    <shortLabel>ecolx</shortLabel>
                                    <fullName>Escherichia coli</fullName>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>phosphotransfer</shortLabel>
                        <fullName>phosphotransfer reaction</fullName>
                        <alias typeAc="MI:1041" type="synonym">phosphotransfer</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0844" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="16712436" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218345" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 2</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
