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        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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            <experimentDescription id="1171949">
                <names>
                    <shortLabel>mahalingam-2011-1</shortLabel>
                    <fullName>Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts.</fullName>
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                            <shortLabel>human-imr_90</shortLabel>
                            <fullName>Homo sapiens embryonic fetal lung fibroblast</fullName>
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                            <names>
                                <shortLabel>imr_90</shortLabel>
                                <fullName>human, Caucasian female 16 fetal weeks; Tissue: lung, embryonic fibroblast</fullName>
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                    <names>
                        <shortLabel>fluorescence imaging</shortLabel>
                        <fullName>fluorescence microscopy</fullName>
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                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Mahalingam D., Tay LL., Tan WH., Chai JH., Wang X.</attribute>
                    <attribute name="journal" nameAc="MI:0885">FEBS J. (1742-464X)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2011</attribute>
                    <attribute name="imex-exported"/>
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                    <shortLabel>h2ax_human</shortLabel>
                    <fullName>Histone H2AX</fullName>
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                        <fullName>Homo sapiens</fullName>
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                <sequence>MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTSATVGPKAPSGGKKATQASQEY</sequence>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904354" secondary="negative regulation of telomere capping" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BU8" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031848" secondary="protection from non-homologous end joining at telomere" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001005" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032214" secondary="negative regulation of telomere maintenance via semi-conservative replication" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905778" secondary="negative regulation of exonuclease activity" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110331" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013867" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9670095" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" secondary="cell cycle" version="SP_216"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-706651" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031627" secondary="telomeric loop formation" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000773" secondary="negative regulation of cellular senescence" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1VF9" version="SP_216"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-706637" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032210" secondary="regulation of telomere maintenance via telomerase" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR031902" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009057" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003691" secondary="double-stranded telomeric DNA binding" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090398" secondary="cellular senescence" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903824" secondary="negative regulation of telomere single strand break repair" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1XG1" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SJM" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1W0U" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001673" secondary="male germ cell nucleus" version="SP_216"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q15554" version="SP_216"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000254942" version="SP_216" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070198" secondary="protein localization to chromosome, telomeric region" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036507" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1221632" version="SP_216"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017930" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174430" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559586" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-171306" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174411" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-110329" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-171319" version="SP_216"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174437" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1VFC" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903770" secondary="negative regulation of beta-galactosidase activity" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006278" secondary="RNA-dependent DNA biosynthetic process" version="SP_216"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4M7C" version="SP_216"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6J67" version="SP_216"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN</sequence>
            </interactor>
            <interactor id="1171952">
                <names>
                    <shortLabel>tp53b_human</shortLabel>
                    <fullName>TP53-binding protein 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">TP53BP1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q12888" version="SP_82" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045830" secondary="positive regulation of isotype switching" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MXY" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042162" secondary="telomeric DNA binding" version="SP_224"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5FWZ3" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4X34" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035064" secondary="methylated histone binding" version="SP_224"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2M1Z7" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2LVM" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005657" secondary="replication fork" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VA5" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042393" secondary="histone binding" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MXX" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VIP" version="SP_224"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693571" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003684" secondary="damaged DNA binding" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2MWP" version="SP_224"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-396540" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6IU7" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051091" secondary="positive regulation of DNA-binding transcription factor activity" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3LGF" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MY0" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GZH" version="SP_224"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001135451.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5Z78" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2MWO" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3LH0" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6RMM" version="SP_224"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q4LE46" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5ECG" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KZY" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4CRI" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5ZCJ" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7LIO" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2G3R" version="SP_224"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693565" version="SP_224"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-5978N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6IUA" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003712" secondary="transcription coregulator activity" version="SP_224"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="F8VY86" version="SP_158" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014722" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000781" secondary="chromosome, telomeric region" version="SP_224"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69473" version="SP_224"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000263801" version="SP_224" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MXZ" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" secondary="cellular response to DNA damage stimulus" version="SP_224"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036420" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000776" secondary="kinetochore" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7LIN" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000077" secondary="DNA damage checkpoint signaling" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4RG2" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KGF" version="SP_224"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015125" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035861" secondary="site of double-strand break" version="SP_224"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001135452.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061629" secondary="RNA polymerase II-specific DNA-binding transcription factor binding" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CO2" version="SP_224"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3232118" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006303" secondary="double-strand break repair via nonhomologous end joining" version="SP_224"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693607" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2IG0" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051260" secondary="protein homooligomerization" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016604" secondary="nuclear body" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061649" secondary="ubiquitin modification-dependent histone binding" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002039" secondary="p53 binding" version="SP_224"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q12888" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CO1" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1XNI" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990391" secondary="DNA repair complex" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6RML" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071481" secondary="cellular response to X-ray" version="SP_224"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000067369" version="SP_224" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001357" version="SP_224"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7Z3U4" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3LGL" version="SP_224"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000042" secondary="negative regulation of double-strand break repair via homologous recombination" version="SP_224"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002999" version="SP_224"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UPT" version="SP_224"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_005648.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000263801" version="SP_224" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5J26" version="SP_224"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDPTGSQLDSDFSQQDTPCLIIEDSQPESQVLEDDSGSHFSMLSRHLPNLQTHKENPVLDVVSNPEQTAGEERGDGNSGFNEHLKENKVADPVDSSNLDTCGSISQVIEQLPQPNRTSSVLGMSVESAPAVEEEKGEELEQKEKEKEEDTSGNTTHSLGAEDTASSQLGFGVLELSQSQDVEENTVPYEVDKEQLQSVTTNSGYTRLSDVDANTAIKHEEQSNEDIPIAEQSSKDIPVTAQPSKDVHVVKEQNPPPARSEDMPFSPKASVAAMEAKEQLSAQELMESGLQIQKSPEPEVLSTQEDLFDQSNKTVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQRSLVQDSLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQEGRQDKPMDTSVLSEEGGEPFQKKLQSGEPVELENPPLLPESTVSPQASTPISQSTPVFPPGSLPIPSQPQFSHDIFIPSPSLEEQSNDGKKDGDMHSSSLTVECSKTSEIEPKNSPEDLGLSLTGDSCKLMLSTSEYSQSPKMESLSSHRIDEDGENTQIEDTEPMSPVLNSKFVPAENDSILMNPAQDGEVQLSQNDDKTKGDDTDTRDDISILATGCKGREETVAEDVCIDLTCDSGSQAVPSPATRSEALSSVLDQEEAMEIKEHHPEEGSSGSEVEEIPETPCESQGEELKEENMESVPLHLSLTETQSQGLCLQKEMPKKECSEAMEVETSVISIDSPQKLAILDQELEHKEQEAWEEATSEDSSVVIVDVKEPSPRVDVSCEPLEGVEKCSDSQSWEDIAPEIEPCAENRLDTKEEKSVEYEGDLKSGTAETEPVEQDSSQPSLPLVRADDPLRLDQELQQPQTQEKTSNSLTEDSKMANAKQLSSDAEAQKLGKPSAHASQSFCESSSETPFHFTLPKEGDIIPPLTGATPPLIGHLKLEPKRHSTPIGISNYPESTIATSDVMSESMVETHDPILGSGKGDSGAAPDVDDKLCLRMKLVSPETEASEESLQFNLEKPATGERKNGSTAVAESVASPQKTMSVLSCICEARQENEARSEDPPTTPIRGNLLHFPSSQGEEEKEKLEGDHTIRQSQQPMKPISPVKDPVSPASQKMVIQGPSSPQGEAMVTDVLEDQKEGRSTNKENPSKALIERPSQNNIGIQTMECSLRVPETVSAATQTIKNVCEQGTSTVDQNFGKQDATVQTERGSGEKPVSAPGDDTESLHSQGEEEFDMPQPPHGHVLHRHMRTIREVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDISSFSSKASSLHRTSSGTSLSAMHSSGSSGKGAGPLRGKTSGTEPADFALPSSRGGPGKLSPRKGVSQTGTPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETAVPGPLGIEDISPNLSPDDKSFSRVVPRVPDSTRRTDVGAGALRRSDSPEIPFQAAAGPSDGLDASSPGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQGNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNVSSPATPTASSSSSTTPTRKITESPRASMGVLSGKRKLITSEEERSPAKRGRKSATVKPGAVGAGEFVSPCESGDNTGEPSALEEQRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLPDGPTGSSEEEEEFLEIPPFNKQYTESQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIPCVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQNFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLPVVSQEWVIQCLIVGERIGFKQHPKYKHDYVSH</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-16775-1" id="1171953">
                <names>
                    <shortLabel>h2afx-terf2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202883" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000781" secondary="chromosome, telomeric region" refType="go-definition-ref" refTypeAc="MI:0242"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16775-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066011" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1171949</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1171954">
                        <names>
                            <shortLabel>h2ax_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">H2AX</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202885" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066018" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1171950</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                    <participant id="1171955">
                        <names>
                            <shortLabel>terf2_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">TRF2</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202886" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066021" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1171951</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="figure legend" nameAc="MI:0599">f3 sf2</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-16775-2" id="1171956">
                <names>
                    <shortLabel>terf2-tp53bp1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202894" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16775-2" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035861" refType="go-definition-ref" refTypeAc="MI:0242"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066024" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1171949</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1171957">
                        <names>
                            <shortLabel>terf2_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">TRF2</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202897" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066034" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1171951</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                    <participant id="1171958">
                        <names>
                            <shortLabel>tp53b_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">53BP1</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8202899" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7066031" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1171952</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="figure legend" nameAc="MI:0599">f4 sf3</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
