UniProt UniProt http://www.uniprot.org li-2011d-1 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-2 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-skbr3 Homo sapiens SKBR3 skbr3 SKBR3 Species: human; Tissue: breast; Tumor: adenocarcinoma; Derived from: metastatic site: pleural effusion anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-11 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mda_mb_453 Human breast carcinoma cell line MDA-MB-453 mda_mb_453 Human breast carcinoma cell line MDA-MB-453 These cells do not express heregulin. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-12 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-bt474 Homo sapiens breast ductal carcinoma cell line bt474 Human breast ductal carcinoma cell line BT474 Human breast ductal carcinoma cell line established from a solid, invasive ductal carcinoma of the breast obtained from a 60-year-old woman. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-4 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mda_mb_453 Human breast carcinoma cell line MDA-MB-453 mda_mb_453 Human breast carcinoma cell line MDA-MB-453 These cells do not express heregulin. confocal microscopy confocal microscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-3 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-skbr3 Homo sapiens SKBR3 skbr3 SKBR3 Species: human; Tissue: breast; Tumor: adenocarcinoma; Derived from: metastatic site: pleural effusion confocal microscopy confocal microscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-5 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human Homo sapiens Human confocal microscopy confocal microscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-6 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human Homo sapiens Human electron microscopy electron microscopy Electron crystallography Electron cryomicroscopy Electron crystallography Electron cryomicroscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. The cell type in which this experiment was performed was not specified. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-7 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. The cell line in which this experiment is performed was not specified. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-8 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-9 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. Source of ERBB2 taken from mutant mapping of construct used in previous work by the author (PMID: 12049736) mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-10 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-13 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-bt474 Homo sapiens breast ductal carcinoma cell line bt474 Human breast ductal carcinoma cell line BT474 Human breast ductal carcinoma cell line established from a solid, invasive ductal carcinoma of the breast obtained from a 60-year-old woman. confocal microscopy confocal microscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation li-2011d-14 Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells confocal microscopy confocal microscopy immunostaining immunostaining Li L.Y., Chen H., Hsieh Y.H., Wang Y.N., Chu H.J., Chen Y.H., Chen H.Y., Chien P.J., Ma H.T., Tsai H.C., Lai C.C., Sher Y.P., Lien H.C., Tsai C.H., Hung M.C. mhung@mdanderson.org Cancer Res. (0008-5472) 2011 mimix curation erbb2_human Receptor tyrosine-protein kinase erbB-2 p185erbB2 MLN19 Proto-oncogene c-ErbB-2 Tyrosine kinase-type cell surface receptor HER2 Proto-oncogene Neu ERBB2 HER2 NEU NGL Metastatic lymph node gene 19 protein protein protein human Homo sapiens Human MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV actb_human Actin, cytoplasmic 1 ACTB Beta-actin protein protein human Homo sapiens Human MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF rpa1_human DNA-directed RNA polymerase I subunit RPA1 POLR1A DNA-directed RNA polymerase I subunit A DNA-directed RNA polymerase I largest subunit RNA polymerase I 194 kDa subunit A190 protein protein human Homo sapiens Human MLISKNMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLALGPADSKEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAVIHLLLCQLRVLEVGALQAVYELERILNRFLEENPDPSASEIREELEQYTTEIVQNNLLGSQGAHVKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVRKEHNSKLTITFPAMVHRTAGQKDSEPLGIEEAQIGKRGYLTPTSAREHLSALWKNEGFFLNYLFSGMDDDGMESRFNPSVFFLDFLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQKLPEEVATPTTDEEKDSLIAIDRSFLSTLPGQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEKKEGLFRKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTPATGAPKPQGTKIVCRHVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRGLTDKVGRVKLLSPSILKPFPLWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFTAYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRRGAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAAACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKWQRSLCEPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQESFCMEEKQNKFQVYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASAFRNVNTRRATQRDLDNAGELGRSRGEQEGDEEEEGHIVDAEAEEGDADASDAKRKEKQEEEVDYESEEEEEREGEENDDEDMQEERNPHREGARKTQEQDEEVGLGTEEDPSLPALLTQPRKPTHSQEPQGPEAMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHGAVIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATMLGSHDELRSPSACLVVGKVVRGGTGLFELKQPLR erbb2-actb 1175308 n/a 1175322 unspecified role unspecified role bait bait n/a 1175323 unspecified role unspecified role prey prey physical association physical association false false false 1A actb-erbb2 1175308 n/a 1175322 unspecified role unspecified role prey prey n/a 1175323 unspecified role unspecified role bait bait physical association physical association false false false 1A and 1B erbb2-polr1a 1175308 n/a 1175324 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false 2A polr1a-erbb2 1175308 n/a 1175324 unspecified role unspecified role bait bait n/a 1175322 unspecified role unspecified role prey prey physical association physical association false false false 2A erbb2-actb-1 1175309 n/a 1175322 unspecified role unspecified role bait bait n/a 1175323 unspecified role unspecified role prey prey physical association physical association false false false 1A actb-erbb2-1 1175309 n/a 1175323 unspecified role unspecified role bait bait n/a 1175322 unspecified role unspecified role prey prey physical association physical association false false false 1A erbb2-polr1a-1 1175309 n/a 1175324 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false 2A polr1a-erbb2-1 1175309 n/a 1175322 unspecified role unspecified role prey prey n/a 1175324 unspecified role unspecified role bait bait physical association physical association false false false 2A erbb2-actb-3 1175310 n/a 1175323 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false S1A actb-erbb2-4 1175310 n/a 1175322 unspecified role unspecified role prey prey n/a 1175323 unspecified role unspecified role bait bait physical association physical association false false false S1B erbb2-polr1a-8 1175310 n/a 1175322 unspecified role unspecified role bait bait n/a 1175324 unspecified role unspecified role prey prey physical association physical association false false false S2A erbb2-actb-4 1175311 n/a 1175323 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false S1A erbb2-polr1a-9 1175311 n/a 1175324 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false S2A polr1a-erbb2-2 1175311 n/a 1175322 unspecified role unspecified role prey prey n/a 1175324 unspecified role unspecified role bait bait physical association physical association false false false S2A and S2B actb-erbb2-3 1175312 n/a 1175322 unspecified role unspecified role neutral component neutral component n/a 1175323 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 1D and S1C erbb2-polr1a-12 1175312 n/a 1175322 unspecified role unspecified role neutral component neutral component n/a 1175324 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S2D actb-erbb2-2 1175313 n/a 1175323 unspecified role unspecified role neutral component neutral component n/a 1175322 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 1C erbb2-polr1a-2 1175314 n/a 1175322 unspecified role unspecified role neutral component neutral component n/a 1175324 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B The cell type in which this interaction occurred was not specified. erbb2-polr1a-3 1175315 n/a 1175324 unspecified role unspecified role neutral component neutral component n/a 1175322 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B erbb2-actb-2 1175316 n/a 1175322 unspecified role unspecified role bait bait n/a 1175323 unspecified role unspecified role prey prey n/a 1175324 unspecified role unspecified role prey prey association association false false false 2C erbb2-polr1a-5 1175317 n/a 1175322 unspecified role unspecified role bait bait n/a 1175324 unspecified role unspecified role prey prey physical association physical association false false false 3E erbb2-polr1a-6 1175318 n/a 1175324 unspecified role unspecified role prey prey n/a 1175322 unspecified role unspecified role bait bait physical association physical association false false false 3E erbb2-polr1a-7 1175319 n/a 1175322 unspecified role unspecified role bait bait n/a 1175324 unspecified role unspecified role prey prey physical association physical association false false false 3E erbb2-polr1a-10 1175320 n/a 1175322 unspecified role unspecified role neutral component neutral component n/a 1175324 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S2C erbb2-polr1a-11 1175321 n/a 1175324 unspecified role unspecified role neutral component neutral component n/a 1175322 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S2C