UniProt UniProt http://www.uniprot.org bae-2010-1 Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. human-ea.hy926 Homo sapiens EA.hy926 ea.hy926 EA.hy926 http://www.lgcstandards-atcc.org/LGCAdvancedCatalogueSearch/ProductDescription/tabid/1068/Default.aspx?ATCCNum=CRL-2922&Template=cellBiology This cell line was established by fusing primary human umbilical vein cells (HUVEC) with a thioguanine-resistant clone of A549 by exposure to polyethylene glycol (PEG). anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Bae J.S., Yang L., Rezaie A.R. rezaier@slu.edu rezaiear@slu.edu J. Biol. Chem. (0021-9258) 2010 Only protein-protein interactions imex curation bae-2010-2 Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1. human-uvec Human Umbilical Vein Endothelial Cells (HUVEC) huvec umbilical_vein_endothelium Umbilical vein endothelial cell [Umbilical vein endothelium] anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Bae J.S., Yang L., Rezaie A.R. rezaier@slu.edu rezaiear@slu.edu J. Biol. Chem. (0021-9258) 2010 Only protein-protein interactions imex curation epcr_human Endothelial protein C receptor Endothelial cell protein C receptor Activated protein C receptor PROCR EPCR protein protein human Homo sapiens Human MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC cav1_human Caveolin-1 CAV1 CAV protein protein human Homo sapiens Human MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI par1_human Proteinase-activated receptor 1 CF2R PAR1 TR Coagulation factor II receptor Thrombin receptor F2R protein protein human Homo sapiens Human MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT par2_human Proteinase-activated receptor 2 F2RL1 GPR11 PAR2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 protein protein human Homo sapiens Human MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY q14868_human EPR-1 protein protein human Homo sapiens Human MTSRGFQRSCNNPPCSSMTGRRANQIHHLTPDFSLRELLPPKKAGTWADCVSPPCGERDRCEGWADRHTACSSPASTCQVHTQDCDSLNNMRSRHIHCGRLCHANKAVSSSKRDTAFFLPHFSPGKPGNQNSKNEPPKKRERERSSHCYPAAPAAQAEAPLVPLSRQNKSTVETSNLKMLISFPKTLLRGPQEGWWHQGINPGSGAATLGPGSSERPQSIEASCSMARRTFFAVSSNSFFLLLVSFAILFLALSLSSFKNSPRVNSSNCFLTERKAQPDECFLCSSMGSSSGSQPSSSLKQKKHWAKSGSFSVGQWMKPASAIRSGVQRSPPRRASS f2r-cav1 1170061 n/a 1170063 unspecified role unspecified role prey prey n/a 1170064 unspecified role unspecified role prey prey n/a 1170065 unspecified role unspecified role bait bait association association false false false 5a cav1-f2r 1170061 n/a 1170064 unspecified role unspecified role bait bait n/a 1170065 unspecified role unspecified role prey prey n/a 1170063 unspecified role unspecified role prey prey association association false false false 5b procr-cav1 1170061 n/a 1170065 unspecified role unspecified role prey prey n/a 1170064 unspecified role unspecified role prey prey n/a 1170063 unspecified role unspecified role bait bait association association false false false 5c procr-cav1-1 1170061 n/a 1170065 unspecified role unspecified role prey prey n/a 1170063 unspecified role unspecified role bait bait physical association physical association false false false 5c When endothelial cells were pretreated with Factor FX (Ser195Ala), EPCR and caveolin-1 were not co-immunoprecipitated. cav1-f2r-1 1170061 n/a 1170065 unspecified role unspecified role prey prey n/a 1170064 unspecified role unspecified role bait bait association association false false false 5b When endothelial cells were pretreated with Factor FX (Ser195Ala), EPCR and caveolin-1 were not co-immunoprecipitated. epr1-f2rl1-1 1170061 n/a 1170066 unspecified role unspecified role prey prey n/a 1170067 unspecified role unspecified role bait bait physical association physical association false false false 6c f2rl1-epr1-1 1170061 n/a 1170067 unspecified role unspecified role prey prey n/a 1170066 unspecified role unspecified role bait bait physical association physical association false false false 6c epr1-f2rl1 1170062 n/a 1170066 unspecified role unspecified role prey prey n/a 1170067 unspecified role unspecified role bait bait physical association physical association false false false 6c f2rl1-epr1 1170062 n/a 1170067 unspecified role unspecified role prey prey n/a 1170066 unspecified role unspecified role bait bait physical association physical association false false false 6c