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        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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        <experimentList>
            <experimentDescription id="986286">
                <names>
                    <shortLabel>liu-1996a-1</shortLabel>
                    <fullName>Activation-modulated association of 14-3-3 proteins with Cbl in T cells.</fullName>
                </names>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-3">
                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
                        </names>
                    </hostOrganism>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">coip</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Liu YC., Elly C., Yoshida H., Bonnefoy-Berard N., Altman A.</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1996</attribute>
                    <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="986287">
                <names>
                    <shortLabel>cbl_human</shortLabel>
                    <fullName>E3 ubiquitin-protein ligase CBL</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Signal transduction protein CBL</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proto-oncogene c-Cbl</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Casitas B-lineage lymphoma proto-oncogene</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RING finger protein 55</alias>
                    <alias typeAc="MI:0301" type="gene name">CBL</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CBL2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RNF55</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RING-type E3 ubiquitin transferase CBL</alias>
                </names>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
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                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT</sequence>
            </interactor>
            <interactor id="986288">
                <names>
                    <shortLabel>1433t_human</shortLabel>
                    <fullName>14-3-3 protein theta</fullName>
                    <alias typeAc="MI:0301" type="gene name">YWHAQ</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">14-3-3 protein tau</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">14-3-3 protein T-cell</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein HS1</alias>
                </names>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_225"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2BTP" version="SP_225"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KZH" version="SP_225"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023409" version="SP_225"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023410" version="SP_225"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5TZU8" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000238081" version="SP_225" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006605" secondary="protein targeting" version="SP_225"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042584" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" secondary="protein C-terminus binding" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045202" secondary="synapse" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" secondary="negative regulation of transcription, DNA-templated" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034766" secondary="negative regulation of ion transmembrane transport" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_225"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5628897" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0021762" secondary="substantia nigra development" version="SP_225"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5625740" version="SP_225"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6BCR" version="SP_225"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75035" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_225"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000238081" version="SP_225" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1445148" version="SP_225"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P27348" version="SP_225"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-359854" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UP48" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6BD2" version="SP_225"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000134308" version="SP_225" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036815" version="SP_225"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9614399" version="SP_225"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000308" version="SP_225"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000371267" version="SP_225" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-27584N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000381844" version="SP_225" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044325" secondary="transmembrane transporter binding" version="SP_225"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111447" version="SP_225"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q567U5" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071889" secondary="14-3-3 protein binding" version="SP_225"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_006817.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D6W4Z5" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0047485" secondary="protein N-terminus binding" version="SP_225"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IQP" version="SP_225"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_225"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KZG" version="SP_225"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="986289">
                <names>
                    <shortLabel>cbl-ywhaq-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005023" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8682982" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>986286</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="986290">
                        <names>
                            <shortLabel>cbl_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">CBL_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005027" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P22681" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8682991" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>986287</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="986291">
                        <names>
                            <shortLabel>1433t_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">1433T_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8005024" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P27348" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8682987" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>986288</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">domino</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
