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                    <shortLabel>kobayashi-2010-1</shortLabel>
                    <fullName>Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.</fullName>
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                </organism>
                <sequence>MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN</sequence>
            </interactor>
            <interactor id="984896">
                <names>
                    <shortLabel>araf_human</shortLabel>
                    <fullName>Serine/threonine-protein kinase A-Raf</fullName>
                    <alias typeAc="MI:0301" type="gene name">ARAF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PKS</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PKS2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ARAF1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proto-oncogene A-Raf-1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proto-oncogene Pks</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proto-oncogene A-Raf</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P10398" version="SP_100" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029071" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802946" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001645.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006464" secondary="cellular protein modification process" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000377039"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5H9B2" version="SP_157" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000366244"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020454" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9660537" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5673000" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001243125.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5675221" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000377045" version="SP_231" refType="transcript"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28988863" refType="intact-secondary"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802952" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9656223" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004709" secondary="MAP kinase kinase kinase activity" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9649948" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P07557" version="SP_100" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001243126.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_231"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31374N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000078061" version="SP_231" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1WXM" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003116" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000366244" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P10398" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032006" secondary="regulation of TOR signaling" version="SP_231"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-365961" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674135" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032434" secondary="regulation of proteasomal ubiquitin-dependent protein catabolic process" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011542210.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5H9B3" version="SP_100" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001245" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002219" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802955" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000366238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2MSE" version="SP_231"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP</sequence>
            </interactor>
            <interactor id="984897">
                <names>
                    <shortLabel>raf1_human</shortLabel>
                    <fullName>RAF proto-oncogene serine/threonine-protein kinase</fullName>
                    <alias typeAc="MI:0301" type="gene name">RAF1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RAF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proto-oncogene c-RAF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Raf-1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P04049" version="SP_108" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P04049" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PTS" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001245" version="SP_249"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1048N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" secondary="nuclear speck" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9656223" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4FJ3" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002219" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3KUC" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VJJ" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_249"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011532276.1"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-365996" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15278" version="SP_114" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IQV" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802946" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674499" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1RFA" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035773" secondary="insulin secretion involved in cellular response to glucose stimulus" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042060" secondary="wound healing" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XI7" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CU8" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035994" secondary="response to muscle stretch" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008179" secondary="adenylate cyclase binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035019" secondary="somatic stem cell population maintenance" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2672351" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XGV" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-392517" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802952" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IQJ" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XHB" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IQU" version="SP_249"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0LPH8" version="SP_114" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002871.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029071" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020454" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043154" secondary="negative regulation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5675221" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NTC" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003116" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5673000" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5621575" version="SP_249"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R5N3" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005265412.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030878" secondary="thyroid gland development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NTD" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" secondary="signal transduction" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674135" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031434" secondary="mitogen-activated protein kinase kinase binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3O8I" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045595" secondary="regulation of cell differentiation" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IHL" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802955" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031143" secondary="pseudopodium" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042981" secondary="regulation of apoptotic process" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048538" secondary="thymus development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010856" secondary="adenylate cyclase activator activity" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9660537" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FAR" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007507" secondary="heart development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035023" secondary="regulation of Rho protein signal transduction" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-430116" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3KUD" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G0N" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902042" secondary="negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060324" secondary="face development" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000251849" version="SP_249" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IEA" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000132155" version="SP_249" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031333" secondary="negative regulation of protein-containing complex assembly" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OMV" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007190" secondary="activation of adenylate cyclase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004709" secondary="MAP kinase kinase kinase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045104" secondary="intermediate filament cytoskeleton organization" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XGU" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FAQ" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GUA" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000145" secondary="regulation of cell motility" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G3X" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071550" secondary="death-inducing signaling complex assembly" version="SP_249"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC20" version="SP_114" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1C1Y" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" secondary="mitochondrial outer membrane" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9649948" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3NKX" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000251849" version="SP_249" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PTW" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7JHP" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000186" secondary="activation of MAPKK activity" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XHA" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048011" secondary="neurotrophin TRK receptor signaling pathway" version="SP_249"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="984898">
                <names>
                    <shortLabel>araf-ywhaz-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009569" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702412" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>984894</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="984899">
                        <names>
                            <shortLabel>1433z_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">1433Z_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009570" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63104" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702421" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>984895</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="984900">
                        <names>
                            <shortLabel>araf_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">ARAF_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009573" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702417" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P10398" refType="original identifier" refTypeAc="MI:0869"/>
                        </xref>
                        <interactorRef>984896</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">domino</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="984901">
                <names>
                    <shortLabel>raf1-ywhaz-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009701" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702466" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>984894</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="984902">
                        <names>
                            <shortLabel>1433z_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">1433Z_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009702" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63104" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702475" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>984895</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="984903">
                        <names>
                            <shortLabel>raf1_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">RAF1_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8009705" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P04049" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7702471" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>984897</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">domino</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
