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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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            <experimentDescription id="727392">
                <names>
                    <shortLabel>beyer-2008-1</shortLabel>
                    <fullName>Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.</fullName>
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                        <names>
                            <shortLabel>mouse-hepatocyte</shortLabel>
                            <fullName>Mouse hepatocyte</fullName>
                        </names>
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                                <shortLabel>hepatocyte</shortLabel>
                                <fullName>Liver  primary cell</fullName>
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                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">A hepatocyte is a cell of the main tissue of the liver.</attribute>
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                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                    <attribute name="author-list" nameAc="MI:0636">Beyer TA., Xu W., Teupser D., auf dem Keller U., Bugnon P., Hildt E., Thiery J., Kan YW., Werner S.</attribute>
                    <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="imex-exported">2009-01-08</attribute>
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                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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                    <shortLabel>p85a_mouse</shortLabel>
                    <fullName>Phosphatidylinositol 3-kinase regulatory subunit alpha</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha</alias>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016303" secondary="1-phosphatidylinositol-3-kinase activity" version="SP_209"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014065" secondary="phosphatidylinositol 3-kinase signaling" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-430116" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005942" secondary="phosphatidylinositol 3-kinase complex" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-512988" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9013106" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9013424" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007162" secondary="negative regulation of cell adhesion" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_209"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQQALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLEMIDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQELQSPEDCIQLLKKLIRLPNIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFPAASSDNTEHLIKAIEILISTEWNERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR</sequence>
            </interactor>
            <interactor id="727394">
                <names>
                    <shortLabel>irs1_mouse</shortLabel>
                    <fullName>Insulin receptor substrate 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">Irs1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Irs-1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P35569" version="SP_77" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043491" secondary="protein kinase B signaling" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005899" secondary="insulin receptor complex" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005080" secondary="protein kinase C binding" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-74749" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005068" secondary="transmembrane receptor protein tyrosine kinase adaptor activity" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014065" secondary="phosphatidylinositol 3-kinase signaling" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AXI" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-109704" version="SP_187"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034700.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002053" secondary="positive regulation of mesenchymal cell proliferation" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042327" secondary="positive regulation of phosphorylation" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-74713" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2428928" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011993" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-198203" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_187"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-32456N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008286" secondary="insulin receptor signaling pathway" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" secondary="regulation of gene expression" version="SP_187"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P35569"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-400825" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030879" secondary="mammary gland development" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031000" secondary="response to caffeine" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5673001" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032000" secondary="positive regulation of fatty acid beta-oxidation" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042169" secondary="SH2 domain binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001784" secondary="phosphotyrosine residue binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046676" secondary="negative regulation of insulin secretion" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090275" secondary="negative regulation of somatostatin secretion" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016042" secondary="lipid catabolic process" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043552" secondary="positive regulation of phosphatidylinositol 3-kinase activity" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071398" secondary="cellular response to fatty acid" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-112412" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036064" secondary="ciliary basal body" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1266695" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005901" secondary="caveola" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032869" secondary="cellular response to insulin stimulus" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034504" secondary="protein localization to nucleus" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046326" secondary="positive regulation of glucose import" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030159" secondary="signaling receptor complex adaptor activity" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046628" secondary="positive regulation of insulin receptor signaling pathway" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-6811558" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010907" secondary="positive regulation of glucose metabolic process" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1AYB" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1257604" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039011" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001849" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048009" secondary="insulin-like growth factor receptor signaling pathway" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045725" secondary="positive regulation of glycogen biosynthetic process" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070094" secondary="positive regulation of glucagon secretion" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043434" secondary="response to peptide hormone" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043548" secondary="phosphatidylinositol 3-kinase binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043231" secondary="intracellular membrane-bounded organelle" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005158" secondary="insulin receptor binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005159" secondary="insulin-like growth factor receptor binding" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046627" secondary="negative regulation of insulin receptor signaling pathway" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032868" secondary="response to insulin" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002404" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-112399" version="SP_187"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSASVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKEHSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-11529-1" id="727395">
                <names>
                    <shortLabel>irs1-pik3r1-4</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6381887" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-11529-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7723553" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>727392</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="727396">
                        <names>
                            <shortLabel>p85a_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">PI3K</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6381890" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7723562" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>727393</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>western blot</shortLabel>
                                    <fullName>western blot</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                                    <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                    <participant id="727397">
                        <names>
                            <shortLabel>irs1_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">Irs1</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6381889" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7723559" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>727394</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>western blot</shortLabel>
                                    <fullName>western blot</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                                    <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">Cells were stimulated with insulin.</attribute>
                    <attribute name="figure legend" nameAc="MI:0599">F7C F7D</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
