UniProt UniProt http://www.uniprot.org aceto-2006-1 Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Aceto D., Beers M., Kemphues KJ. kjk1@cornell.edu Dev. Biol. (0012-1606) 2006 Only protein-protein interactions imex curation aceto-2006-2 Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. caeel-embryo Caenorhabditis elegans embryo embryo Embryo Defined as the development stage prior to the initiation of tissue differentiation. fluorescence imaging fluorescence microscopy fluorescence imaging tag visualisation tag visualisation Aceto D., Beers M., Kemphues KJ. kjk1@cornell.edu Dev. Biol. (0012-1606) 2006 Only protein-protein interactions imex curation kpc3_caeel Protein kinase C-like 3 F09E5.1 pkc-3 aPKC Atypical protein kinase C-3 protein protein caeel Caenorhabditis elegans MSSPTSLEEDGDIKLKTRFQGQVVVLYARPPLILDDFFALLKDACKQHKKQDITVKWIDEDGDPISIDSQMELDEAVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQCFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHCGQALQGPNIIPMAPASGSLKGARSNTSSSTTRSGGGIDNGAFHEHEIESPGSTSHDASRAMNGNGSSKWAVSLNDFRLLTVIGRGSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNPLQMSREDSV par6_caeel Partitioning defective protein 6 T26E3.3 par-6 protein protein caeel Caenorhabditis elegans MSYNGSYHQNHHSTLQVKSKFDSEWRRFSIPMHSASGVSYDGFRSLVEKLHHLESVQFTLCYNSTGGDLLPITNDDNLRKSFESARPLLRLLIQRRGESWEEKYGYGTDSDKRWKGISSLMAQKPPKRSYSISNPEDFRQVSAIIDVDIVPEAHRRVRLCKHGQERPLGFYIRDGTSVRVTERGVVKVSGIFISRLVDGGLAESTGLLGVNDEVLEVNGIEVLGKTLDQVTDMMVANAHNLIITVKPANQRNTLSRGPSQQGTPNASEMSAATAAATGGIQRPMKMNGSSDGSYHPKQHDANDSDSGED par3_caeel Partitioning defective protein 3 par-3 F54E7.3 Abnormal embryonic partitioning of cytoplasm protein 3 protein protein caeel Caenorhabditis elegans MSASSTSSSSTSCPEGGEPSGSCKSSDEGESTLKKRMQQYGIASGYANSSISTLDRSQYQSLPLNGTRRVTVQFGRMKIVVPWKESDQTVGQLADAALLRYKKARGMANEDRIHVHRLECASDGGILDMDDVLEEVFDLNYDQILAITDEANGGSTTPTYSQIQKQQHHYAQPLPYARKFDGGPSTPIASAFGSVTVNHQAHRAASPYNVGFARSNSRDFAPQPTHSKERRDSVVEVSSFDQIPQSGLRVSTPKPSRQSEDVIDGKPMNQPILRSSLRTEASGSRTEEATPVKQSRVTLSPEVEKKLAEQDERKSERRKHYDKNPGRFARGSDRKSRITDALLDARDRIADQLESQNPAEETKSQMIRVKIDQGPMPGTSLVTFPPIPEKSENEKQLGIEVNAVFDESSELPGTSEPTKLSSVQIMKIEDGGRIAKDGRIRVGDCIVAIDGKPVDQMSIIRVRASISDLAAVTSRPVTLIINRSLESFLEQESSAKPIQSALQQANTQYIGHTTVVELIKSSNGFGFTVTGRETAKGERLFYIGTVKPYGVALGHLKSGDRLLEINGTPTGQWTQSEIVEKLKETMVGEKIKFLVSRVSQSAIMSTSASSENKENEETLKVVEEEKIPQKLPLPALMTPPVPKDTPALSPSGASRFEIVIPFINGSSSAGLGVSLKARVSKKSNGSKVDCGIFIKNVMHGGAAFKEGGLRVDDRIVGVEDIDLEPLDNREAQAALAKKLKEVGMISSNVRLTISRYNECNPGQISRDLSRITVDASSPSPSSRMSSHTAPDSLLPSPATRGTSSSGADSSHSRQSSASSAVPAVPARLTERDSIVSDGTSRNDESELPDSADPFNREGLGRKSLSEKRGMGAAADPQHIKLFQDIKHQRQNSAPTSSTQKRSKSQPRSSSQRNYRSPMKLVDLPTTAAASASTNSQNLDDSDMLNRRSQSMESINRPVESILRGTGQIPTGSSSKVQFMQAASPDQHPFPPGAALLRLKNEESRSRDKSRRKSMGNPFSAMRNFFGFGSKSRDASPEKTPTESVQLRSVERPKSIIDERNNGSSERAPPPLPPHQSQRRGSGGNVFVDYGEPYGLIPQYPHNTTSGYESYADSELYDRYAAHRYHPRGGPIIDEDEYIYRQQSTSGNSPINTSSYVNYGLPASNAYHVGSRIPPQTSSGSISKTSGAMRRVYPAEYDEDVAYHQQIPQQSTRYQQGSGSGRGNADYHHMFNSWFAYTGGGAVGAAPVIKSSYGSSPVRIAAASAIERGESFVVEPVSGSSASATDRRGRSTSSGAVASGSSSTGFQYAAKEKYADARSGKFNGGSTRLFIPRHGGGLSAAAFATNFGGEAYETRGGGAGGSPSQYRRRDQGPPHRFPQY cdc42_caeel Cell division control protein 42 homolog cdc-42 R07G3.1 CDC42Ce protein protein caeel Caenorhabditis elegans MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVAPASFENVREKWVPEISHHCSKTPFLLVGTQVDLRDDPGMLEKLAKNKQKPVSTDVGEKLAKELKAVKYVECSALTQKGLKNVFDEAILAALDPPQQEKKKKCNIL par6-pkc3-1 765835 N/A 765837 unspecified role unspecified role prey prey N/A 765838 unspecified role unspecified role bait bait physical association physical association false false false Fig 1B par6-par3-1 765835 N/A 765839 unspecified role unspecified role prey prey N/A 765838 unspecified role unspecified role bait bait physical association physical association false false false Fig 1B par6-cdc42-1 765835 N/A 765838 unspecified role unspecified role bait bait Q9NAN2:p.[Pro135Ala;Asp137Ala;Phe138Ala;Arg139Ala] mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false Q9NAN2:p.[Val141Ala;Ser142Ala;Ile144Ala;Ile145Ala] mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false N/A 765840 unspecified role unspecified role prey prey Q05062:p.Gln61Leu mutation mutation certain certain sequence position certain certain certain sequence position certain false Q05062:p.Thr17Asn mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig 1B par6-cdc42-2 765836 N/A 765838 unspecified role unspecified role neutral component neutral component n-terminus cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A 765840 unspecified role unspecified role neutral component neutral component n-terminus yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Q05062:p.Gln61Leu mutation mutation certain certain sequence position certain certain certain sequence position certain false colocalization colocalization false false false Fig 5