UniProt UniProt http://www.uniprot.org yoda-2005-1 Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. caeel Caenorhabditis elegans anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Yoda A., Kouike H., Okano H., Sawa H. sawa@cdb.riken.jp Development (0950-1991) 2005 Only protein-protein interactions imex curation med6_caeel Mediator of RNA polymerase II transcription subunit 6 mdt-6 med-6 Y57E12AL.5 Mediator complex subunit 6 CeMED6 c-MED6 protein protein caeel Caenorhabditis elegans MMPRMGPPAAARQDNPLHVSFRNPQWPPNFINKDNVLDYFCNQANAFYEMNSCNQQIRMQNIVNRTVEECLRTMPGIQYVLWYSQPPLFIICKQRRNNVTNVSPIAYYYVINGSVHQAPDMYSLVQSRLLGALEPLRNAFGEVTNYSRYNTAKGYYWEFKNKPNVKKREEEKKEDEEEKLEDRSTNFQKTRTMMLLNQLFSEMPAEDALEREEKEEVEEEEEETLKTEEPTTSTDEPKFAEPTARTTSKQ med23_caeel Mediator of RNA polymerase II transcription subunit 23 sur-2 F39B2.4 mdt-23 Mediator complex subunit 23 Mediator complex subunit sur-2 protein protein caeel Caenorhabditis elegans MTDKPGSAEDTIEMDDTCSPQFVQEVNRIKSQIKSLVEENHTRKFFRPLTSNIGDETAILRIQFNNMMSKMEEKEKQSLVKELIKMVHHVAEKNSPDRVFVGTNYERVVDQLLRYAHQKGAISTNLCAEGLIMTSDFRLCSRICQEKWKFINDCIPKIDYKGIRNILRYILESQLRRLPYSLSPEQVNEIRIVENVILHIVDRDSNLMPPLITLSEIMRGMPKQALMLPRLTEKLASLSVHFRPIADLSHVCGRGFVYPIPLHPSFYPLTSCWEEHGLNASNTIVQPHHTLPYRPEHTSTYLYTLYMILRQPLGKDSLHPPSKTKTKTNWEMLISVMICESMAEAESLPETEPIPRYQWDNIVNIVIYGITQHLLVPKTFFNVLKNLIKRCKYTRARDEVMWIVFQVVGSLSNLTRLDDAVTEIVELYNELFDGDVVWMGASDHPALFARFLAAAGTWMILEKDFADKMPPANETIKSHIKFIQDGVDNFDSSNTAMLAVLSNIYRTDTKMGKLIVPTLQQMLESIDDTKSLFELSYKRMAVNCFSAFPVEFMEALTFRSKKTLLIQCFQPLRSFSTVRLPSPAVFETVAKICESEDYEMAVKDMEHLAQRSLHVATAADRSSGEHQNVQAKDQCYFLFDFLVYRLPHLHAYSKYSSTVNALSYFTQHIPNNPQNHQIYRLMEQFLMRRWCWAGFHGCITAHTQMFGTSYKDNTMMRHMAYPKTFSVPDQYPFAINPEIFKMAIYSFLRAVKITAQDIAIEKTMFPTIINGFGWPEKSTSYFPKWALDAIKASDTSNAVNTEEILSDVRNTARMHTSLTPNQFVIRYGEDRDPATSHCMLAVLFHFAYNSVDSTYNITSEFYEVMEKKTPKEIVVMGNYLVDYIIADAKTQDCNEKTFKNIAKAAALLVFQFQVLRADRLLLSLIMHPATDEDALICIQIANEFILTPEFQERIRWYHQNVPKKDHFPTEYIKAIVKYHDAFPEFEACELVRSYDSSSNVHMPTYYGCLIERLLPIMDQYLHVALEQQGYKLNPQILQSVSMLYKFHAMPIHFMYSVLFTSHGLMSGPDAKSFVLAFATQIEECHLTEAFEKFNHQKSSREQLIMELIDRMSASLDFILTPPPFVAKDWKIAELSPGAQTLYLACIELMASPHSPETLVAAMINVMQMKPHARPFNIVNLTALLLTALPAAYSNALHDEFVAVFVNGETANLKFEEIVFDNYEESLLLNLPNRARTINVISQQYWLHCSLSLLNFFSHEYVPRILEHVKTEKDLWYTLRLVMPYLRRYYENWDTAKQMRSQRENFGPLHIVKLVFQKLGSMAEEGVEIVYEQHLCDLFYNCKYFFAGDFLRNTAITEFAKLPEKMRDRLKFYVSQSEPTAEQETPPEKEKSPEKEKEQEQEQHVKAHQPLESTPSVSSLPQMQHHLQQAPLLPSHQMMPPPQQHSSSLQHHLQHHTSTHQMMDTSQHQTIQQQSNHPTQQQLQHQIPNMSMHQQMGPQYPGAVFHHPSGPVGHVPMQYGMGHHMQQHPHLPHHQQMPAPMHTMNPMMQNMTPQQQYLYMQQLQQHQQHQQYMQQQQQHHHQHQQQPH med13_caeel Mediator of RNA polymerase II transcription subunit 13 let-19 K08F8.6 mdt-13 psa-7 Mediator complex subunit 13 Lethal protein 19 CeTRAP240 protein protein caeel Caenorhabditis elegans MSSAKDSDKDASRKMKLQKRPEWNNGGSLEDCISNVYALLELPGIKWKCYRTKPNAPRGVALTADFVLKAYSKCLLDGILCTWRRKPLPPTDNKETPKLTNFSNDAPKELWVFWYDDEPALLQKNCEGLDNDDELSSANQMNIVSYEVRTIIFKALHVVLERDLTKDGFVRFGRWFTVPYDARENYLHFTYPSHSPAIRFNFFVHGSSTICASVQAQRQPTLITLARRHLECKTKRVVVVVGPWSMRGQLVQDQIALLADPKIQESAEKEWNQWKDYLQMEEKEPENVSEERQKSPDSDPPAPPQTTRVLLADSSDEEQSQSFEAIDESKKDDIPQRLRWMYEPDYRQEKSKEETPEEKEKREQSREVRKQRRKLREERRKEVERQRTEVKNPDDYDSDVVTDEDVGEKEECVNNDVPKMVLLDIDGVRLLYPSKFLCVTIDEDRQMLESIGLKTNQQPPELQAQNRRPRNKLVVNVANPILSTMAVYQYCENERLISKENVPQKSATSGQLLPPLKEKFLNWKFTAKKYGCRGDVSCRHCAEAEYQGESDGQVILDVDRHNRFLKYGPYTENSIRWHKIRSRIQKKFDFHAYHKKHPIGPITPRKAGDSVKQTKQLSAVKRRRRARRERAQKKRRDKKRPTGSTRADSEDDSFRMDKLSQDDWANFEGEHPKGIPEIEVDKDFELHNDIKIPKVPNDDNYKPKSFLPITYLTNNVDNNDFESMPGDDDMSEERFNQIFKDKYNRWKPGMSRAEKIEHAHYQFDPSNQMTGSPREYHLKDLPKKIQKYESILPTPKGNKFFKGSICRKGLRGYDEICADQDEKEMMRKAKWLKKARRKVSKQQIKKAGQYHIDMQKQIVKRSLKRAIRKLKLTTKKDSQSKGTKQQKLVLLSYKKKKVDEKKFQQYLKEVENVLDKLDVNSFCKKNEKAGFSEKAIPSGYIIPDYESSIHCGMEEESDSEIDEPRHGLGEGTCGQYLEGESVDLADMEHHHNELPMEVTSIGHIRTVGEHIGPDGMLSPPASNEMPKGGPLSVGPPSIESQGLNQIYPTPPSVQMLLGDAAQAHSPVMHTKSRYAMNTLEDDVERIAVPGGVGSLVEIEADDIETKNMQKWSKLSNQSKLSKFIALSCKDPFLKSKKKKYDTPVTSKFKIENEPPSMSAELVYAPMVTRNFYSAPHRTFGTLAQKVVDKRPSQFAIPSTSTAAHPGLTTPMASIFQSPTMPPPHTPSPFSAGPMSHHPMGPPAYPGTPGSFPPTTPTYPGMTPRPGPNFGPPGPVYPNSQQMMGPGGYPPQMGMINSQRHFQNQQMYQQQMVRMQQMRQMGGPPGYGAPGVSPYQQVNAITSPAGFGMPPNGPSSVQRLNNFVNQSQFGPNNGHPTPPYGYMQQMIPQSPNFNQQYNGMGNQLMSPIHQHQFHQQQMVQQQQQQQMQMHRQQMQMQNQNMSQPFQPPTAQMLQMQQNEQMRIAFSTLSERDKAKFQKRQGQLRSGIMPKSLQPAVLKNLKNPPDANIPYMKQDALFRPPESNSLQGESLTIAIVLSDTLLDLHFDSVFDACPICSCSVSIRSRDIGMYITPHTVLYSTERGHTNMREHTTGPWSGFNVNSATNCTCGFSAIRHRYLSCCSGLFEEDADEATASEHAVAPVIPPLDYPKKSTARDMSWFDSKSVHDLALLDQIRQMAFSNSLGKAVSHMATIKEHNRNLAIAVDLGNDVTVPSEYILSHVDALELLMLGNSVLGPMKNTSIANQVASHNKFLGFFHPWGIQIANGMTELEASEWVDLLGVVTPTLEGSMKQARHIPAETPFELDGPMTWKQIVTKSNRGKPPADDEEDFSLPEPVPAIMRALTKEAIRAAPNIEQYYEQAGLGPVDQPKDVMYITVIPDDDDIYSRTVEFMDTLTRTYEKMRLGRHIPFPVSTGTATRFREAFKSCQSQFPFQEQQHLAYTNQTLRNMPQTLADTPDPVNSDPKVWSRRAKRKLDFEEELKLPEAGSETIDESDDDEENEEVSKEENNELIDSEDVMDEVPKGFYEREGILRVGAPMEPSRSPHTVTNTPEFDNMTKYLSDENGFVSRLRLYLQQMEDLVHFALSENPEAFDRRGYRYQLAVEGRLKRQKHKMDIIEERLRFEASKDFDEQSDRKEPLEENDPEITPGIVISNNPVESWIDDELEEKRQQRQKENEQYPPEAQQAPSPVPAGMIHIPETLSKEERAVQPTLEMILADPATVAPINAQNIVWKQRDTRVPNPFPSSNQPPVAFEAAGSPDTDAYSTLPHVIVVYVVNPFSYGPEGHSALHMRIAILAFIRAFNSIMCKIPYEKRPQLQLEIVGMEGMDNVAKPIPDYFNDAKIPFDLLNDRPIRVERPGESVQGELARSLSIAVYTHPRVFFPDVYKSASARCMTAFGPGSQLMNTINKIEALNKDSFARMAKRSKTTLDTMDMYRHPGMIQAQQSTEKKNYIAYRVPSNIAVLAPPPMVYQMDEKGKAIMNQLDEQTLFISYCLVGTDFLVATATDAQGKLIDNCISNIKPRRQSNQVYRYRNKTQILDGMGKLWSFILGIMASETKNWRLVVGRLGRIGHGEFRAWTHLLNKTSLLRYSGSLKDICGACRSMPSVIGTPAILSACLITLEPEPSIRIMPEFHDQELSTKKSFLFQTPGDLSCTHILTFPVGTEINLEVQDQTADTKADENWEFGDLDIMEGLDDGDTEIMKDLGLETPSSAAIRQTGGPSMFFSEDSSSIEIQNQPLASGYYISTAPAPELPAWFWATCPSAKRHSPVHLKSSLHIHISEVKNDDIAMESTKEKEKDKEKDEKDAHPLESRQTEEVLRHVLESYNALSWLNLNRQTGDRYSCLPIHIQHLLRLYHSVARLLA med6-med13-1 668032 N/A 668033 unspecified role unspecified role prey prey N/A 668034 unspecified role unspecified role prey prey c-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false N/A 668035 unspecified role unspecified role bait bait c-terminus gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range false association association false false false Fig 6