MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint renatus-2000-1 Crystal structure of the apoptotic suppressor CrmA in its cleaved form. in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Renatus M., Zhou Q., Stennicke HR., Snipas SJ., Turk D., Bankston LA., Liddington RC., Salvesen GS. Virus - Publications including interactions involving viral proteins Structure (0969-2126) 2000 spi2_cwpxb Serine proteinase inhibitor 2 CRMA SPI-2 CPXV207 ICE inhibitor Cytokine response modifier protein A Hemorrhage-inducing 38 kDa protein protein protein cpv Cowpox virus (strain Brighton Red) MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSKYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQTVDFTDCRTVDAINKCVDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWCDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATCALVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTN mint Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B spi2_var67 Serine proteinase inhibitor 2 SPI-2 B13R B12R B14R protein protein varv Variola virus (isolate Human/India/Ind3/1967) VARV Smallpox virus MDIFREIASSTKGENVFISPATISSVLTILYYGANGSTAEQLSKYVEKEETMDKVSAQNISFKSMNKVYGRYSAVFKNSFLGKIGDNFQTVDFTDCRTIDAINKCVDVFTEGKINPLLTEQLSPNTCLLAISAVYFKAKWLIPFKKEFTSDYPFYVSPTEMVDVSMMSMYGESFNYASVKESFGNFSIIELPYVGNTSMMVILPDKIDGLESIKQNLTDTNFKKWCNSLEATFIDVHIPKFKVTGSYNLVDTLVKLGLTDVFYSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATSVLVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTN mint May be involved in the regulation of the complement cascade crma-spi_2 100365 spi2_cwpxb 100366 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role unspecified role unspecified role purified purified tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 spi2_varv 100367 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role unspecified role unspecified role purified purified tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 direct interaction direct interaction false false false In the xray complex 1f0c, P07385 is chain A and P33830 is chain B Resolution 2.260 homomint mint