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        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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            <experimentDescription id="635">
                <names>
                    <shortLabel>wei-1998-1</shortLabel>
                    <fullName>A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.</fullName>
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                            <shortLabel>in vivo</shortLabel>
                            <fullName>in vivo</fullName>
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                <interactionDetectionMethod>
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                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
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                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
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                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Wei P., Garber ME., Fang SM., Fischer WH., Jones KA.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">Cell (0092-8674)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1998</attribute>
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                    <shortLabel>cdk9_human</shortLabel>
                    <fullName>Cyclin-dependent kinase 9</fullName>
                    <alias typeAc="MI:0301" type="gene name">CDK9</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CDC2L4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cell division protein kinase 9</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Serine/threonine-protein kinase PITALRE</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cell division cycle 2-like protein kinase 4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">C-2K</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TAK</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Tat-associated kinase complex catalytic subunit</alias>
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                        <fullName>Homo sapiens</fullName>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" secondary="transcription cis-regulatory region binding" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_212"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A9XU13" version="SP_143" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167200" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167287" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070063" secondary="RNA polymerase binding" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-112382" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008024" secondary="cyclin/CDK positive transcription elongation factor complex" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BCF" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" secondary="cell cycle" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032786" secondary="positive regulation of DNA-templated transcription, elongation" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BCG" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016538" secondary="cyclin-dependent protein serine/threonine kinase regulator activity" version="SP_212"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O60581" version="SP_95" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2479671" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-167246" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097322" secondary="7SK snRNA binding" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-674695" version="SP_212"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-29891N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" secondary="DNA binding" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75955" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043923" secondary="positive regulation by host of viral transcription" version="SP_212"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001231.2"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028863" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BCI" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" secondary="transcription factor binding" version="SP_212"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR043198" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5L1Z" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" secondary="regulation of transcription by RNA polymerase II" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MI9" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4EC8" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9018519" version="SP_212"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000261900" version="SP_212" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2PK2" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BCH" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_212"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MIA" version="SP_212"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070691" secondary="P-TEFb complex" version="SP_212"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2173796" version="SP_212"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="638">
                <names>
                    <shortLabel>ccnt1-cdk9-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-15817" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8679485" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>635</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="639">
                        <names>
                            <shortLabel>cdk9_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1532859" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8679493" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>636</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="640">
                        <names>
                            <shortLabel>ccnt1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1532856" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8679490" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>637</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
