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                    <shortLabel>bonnefoy_b_-1995-1</shortLabel>
                    <fullName>Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Bonnefoy-Bérard N., Liu YC., von Willebrand M., Sung A., Elly C., Mustelin T., Yoshida H., Ishizaka K., Altman A.</attribute>
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                    <attribute name="publication year" nameAc="MI:0886">1995</attribute>
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                    <shortLabel>bonnefoy-1995-1</shortLabel>
                    <fullName>Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.</fullName>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001263" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037702" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" secondary="cell migration" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035022" secondary="positive regulation of Rac protein signal transduction" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033031" secondary="positive regulation of neutrophil apoptotic process" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2029485" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000403" version="SP_201"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000289153" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016310" secondary="phosphorylation" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-512988" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-373753" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010508" secondary="positive regulation of autophagy" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046854" secondary="phosphatidylinositol phosphate biosynthetic process" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-114604" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198203" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8853659" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014065" secondary="phosphatidylinositol 3-kinase signaling" version="SP_201"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016862108.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-186763" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6811558" version="SP_201"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000418143" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048015" secondary="phosphatidylinositol-mediated signaling" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018936" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035005" secondary="1-phosphatidylinositol-4-phosphate 3-kinase activity" version="SP_201"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2609540" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036940" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051000" secondary="positive regulation of nitric-oxide synthase activity" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912631" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029071" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005942" secondary="phosphatidylinositol 3-kinase complex" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046934" secondary="phosphatidylinositol-4,5-bisphosphate 3-kinase activity" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010595" secondary="positive regulation of endothelial cell migration" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016303" secondary="1-phosphatidylinositol-3-kinase activity" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2219530" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006914" secondary="autophagy" version="SP_201"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000289153" version="SP_201" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001952" secondary="regulation of cell-matrix adhesion" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006897" secondary="endocytosis" version="SP_201"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="11797">
                <names>
                    <shortLabel>ywhaq-pik3cb</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16257" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553502" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>11793</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="11798">
                        <names>
                            <shortLabel>1433t_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505472" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553511" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>11795</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="11799">
                        <names>
                            <shortLabel>pk3cb_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505475" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553508" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>11796</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">Overexpressio of 14-3-3 Theta reduce the enzymatic activity of the tyrosine phosphorylated PI3-K from activated T cells.</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="11800">
                <names>
                    <shortLabel>ywhaq-pik3cb-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16256" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553521" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>11794</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="11801">
                        <names>
                            <shortLabel>pk3cb_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505486" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553530" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>11796</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="11802">
                        <names>
                            <shortLabel>1433t_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-1505483" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8553527" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>11795</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">Overexpressio of 14-3-3 Theta reduce the enzymatic activity of the tyrosine phosphorylated PI3-K from activated T cells.</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
