HPIDb Host Pathogen Interaction database http://www.agbase.msstate.edu/hpi/main.html http://www.agbase.msstate.edu/hpi/main.html ghosh-2011-5 Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org J. Viral Hepat. (1352-0504) 2011 imex curation Only protein-protein interactions imex curation ghosh-2011-1 Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org J. Viral Hepat. (1352-0504) 2011 imex curation Only protein-protein interactions imex curation ghosh-2011-3 Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org J. Viral Hepat. (1352-0504) 2011 imex curation Only protein-protein interactions imex curation ghosh-2011-4 Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. human-huh-7.5 Human Huh-7.5 cells huh75 Huh-7.5 cells confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org J. Viral Hepat. (1352-0504) 2011 imex curation Only protein-protein interactions imex curation ghosh-2011-2 Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. human-liver Homo sapiens liver liver liver confocal microscopy confocal microscopy immunostaining immunostaining Ghosh S., Ahrens W.A., Phatak S.U., Hwang S., Schrum L.W., Bonkovsky H.L. Virus - Publications including interactions involving viral proteins 9-13 cell line sriparna.ghosh@carolinashealthcare.org J. Viral Hepat. (1352-0504) 2011 imex curation Only protein-protein interactions imex curation q9wmx2-pro_0000037548 Serine protease/helicase NS3 protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNAVAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMSADLEVVT 1027 1657 flna_human Filamin-A FLNA FLN FLN1 Alpha-filamin Filamin-1 Endothelial actin-binding protein Actin-binding protein 280 Non-muscle filamin protein protein human Homo sapiens Human MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP q9wmx2-pro_0000037551 Non-structural protein 5A protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC 1973 2419 calx_human Calnexin CANX Major histocompatibility complex class I antigen-binding protein p88 p90 IP90 protein protein human Homo sapiens Human MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE q9wmx2-pro_0000037541 Core protein precursor protein protein hcvco Hepatitis C virus genotype 1b (isolate Con1) (HCV) STNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARQPEGRAWAQPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLALLSCLTIPASA 2 191 vime_human Vimentin VIM protein protein human Homo sapiens Human MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE flna-q9wmx2_pro-2 1420011 n/a NS3 1420016 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false Fig. 2A flna-q9wmx2_pro-1 1420011 n/a NS5A 1420018 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2a canx-q9wmx2_pro-2 1420011 n/a NS3 1420016 unspecified role unspecified role neutral component neutral component n/a Calnexin 1420019 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 6 canx-q9wmx2_pro-1 1420011 n/a Calnexin 1420019 unspecified role unspecified role neutral component neutral component n/a NS5A 1420018 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 6 flna-core-1 1420011 n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component n/a Core 1420020 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 CNS3 cell line core-vim-1 1420011 n/a Vimentin 1420021 unspecified role unspecified role neutral component neutral component n/a Core 1420020 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 CNS3 cell line ns3-fila-3 1420012 n/a NS3 1420016 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false Fig. 2A fila-ns5a-3 1420012 n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component n/a NS5A 1420018 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2a core-fila-2 1420012 n/a Core 1420020 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 9-13 cell line core-vim-4 1420012 n/a Core 1420020 unspecified role unspecified role neutral component neutral component n/a Vimentin 1420021 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 9-13 cell line flna-ns3-2 1420013 n/a NS3 1420016 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma n/a Filamin-A 1420017 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association false false false 3 flna-ns5a-1 1420013 n/a NS5A 1420018 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma n/a Filamin-A 1420017 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association false false false 3 flna-ns3-1 1420013 n/a Filamin-A 1420017 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma n/a NS3 1420016 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association false false false 3 ns5a-flna-1 1420013 n/a NS5A 1420018 unspecified role unspecified role bait bait human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma n/a Filamin-A 1420017 unspecified role unspecified role prey prey human-huh7 Homo sapiens hepatoma cell line established from a hepatocellular carcinoma huh7 Human hepatoma cell line established from a hepatocellular carcinoma physical association physical association false false false 3 ns3-fila-2 1420014 n/a NS3 1420016 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2b CON1 cell fila-ns5a-2 1420014 n/a NS5A 1420018 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2b CON1 cell core-fila-1 1420014 n/a Core 1420020 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 and 2b CON1 cell core-vim-2 1420014 n/a Vimentin 1420021 unspecified role unspecified role neutral component neutral component n/a Core 1420020 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false S3 and 2b CON1 cell fila-ns5a-1 1420015 n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component n/a NS5A 1420018 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2c ns3-fila-1 1420015 n/a NS3 1420016 unspecified role unspecified role neutral component neutral component n/a Filamin-A 1420017 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2c