MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint bahar-2008-1 Structure and function of A41, a vaccinia virus chemokine binding protein. in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Bahar MW., Kenyon JC., Putz MM., Abrescia NG., Pease JE., Wise EL., Stuart DI., Smith GL., Grimes JM. Virus - Publications including interactions involving viral proteins PLoS Pathog. (1553-7366) 2008 rapid curation rapid curation a41_vaccw Protein A41 VACWR166 A41L protein protein vaccw vaccinia virus (stra Vaccinia virus (strain WR) VACV MYSLVFVILMCIPFSFQTVYDDKSVCDSDNKEYMGIEVYVEATLDEPLRQTTCESKIHKYGASVSNGGLNISVDLLNCFLNFHTVGVYTNRDTVYAKFASLDPWTTEPINSMTHDDLVKLTEECIVDIYLKCEVDKTKDFMKTNGNRLKPRDFKTVPPSNVGSMIELQSDYCVNDVTTYVKIYDECGNIKQHSIPTLRDYFTTKNGQPRKILKKKFDNC mint ccl21_human C-C motif chemokine 21 Small-inducible cytokine A21 Beta-chemokine exodus-2 6Ckine Secondary lymphoid-tissue chemokine CCL21 SCYA21 UNQ784/PRO1600 protein protein human Homo sapiens Human MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP cc21a_mouse C-C motif chemokine 21a Ccl21a Scya21 Scya21a Ccl21c Scya21c Small-inducible cytokine A21a Small-inducible cytokine A21c 6Ckine Thymus-derived chemotactic age Beta-chemokine exodus-2 protein protein mouse Mus musculus Mouse MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSIVRGYRKQEPSLGCPIPAILFLPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPGCRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs mint ccl28_human C-C motif chemokine 28 Mucosae-associated epithelial chemokine CCL28 SCYA28 Small-inducible cytokine A28 Protein CCK1 protein protein human Homo sapiens Human MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner mint ccl28_mouse C-C motif chemokine 28 Ccl28 Scya28 Small-inducible cytokine A28 protein protein mouse Mus musculus Mouse MQQAGLTLMAVAVCVAFQTSEAILPMASSCCTEVSHHVSGRLLERVSSCSIQRADGDCDLAAVILHVKRRRICISPHNRTLKQWMRASEVKKNGRENVCSGKKQPSRKDRKGHTTRKHRTRGTHRHEASR Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner mint ccl25_human C-C motif chemokine 25 CCL25 SCYA25 TECK Small-inducible cytokine A25 Thymus-expressed chemokine Chemokine TECK protein protein human Homo sapiens Human MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL mint Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1 ccl25_mouse C-C motif chemokine 25 Ccl25 Scya25 Teck Small-inducible cytokine A25 Thymus-expressed chemokine Chemokine TECK protein protein mouse Mus musculus Mouse MKLWLFACLVACFVGAWMPVVHAQGAFEDCCLGYQHRIKWNVLRHARNYHQQEVSGSCNLRAVRFYFRQKVVCGNPEDMNVKRAMRILTARKRLVHWKSASDSQTERKKSNHMKSKVENPNSTSVRSATLGHPRMVMMPRKTNN mint Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9 ccl26_human C-C motif chemokine 26 CCL26 SCYA26 UNQ216/PRO242 Macrophage inflammatory protein 4-alpha Small-inducible cytokine A26 Eotaxin-3 Thymic stroma chemokine-1 CC chemokine IMAC protein protein human Homo sapiens Human MMGLSLASAVLLASLLSLHLGTATRGSDISKTCCFQYSHKPLPWTWVRSYEFTSNSCSQRAVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL mint Chemotactic for eosinophils and basophils. Binds to CCR3 plf4_human Platelet factor 4 PF4 CXCL4 SCYB4 C-X-C motif chemokine 4 Oncostatin-A Iroplact protein protein human Homo sapiens Human MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES groa_mouse Growth-regulated alpha protein Platelet-derived growth factor-inducible protein KC Cxcl1 Gro Gro1 Mgsa Scyb1 C-X-C motif chemokine 1 Secretory protein N51 protein protein mouse Mus musculus Mouse MIPATRSLLCAALLLLATSRLATGAPIANELRCQCLQTMAGIHLKNIQSLKVLPSGPHCTQTEVIATLKNGREACLDPEAPLVQKIVQKMLKGVPK Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity mint cxl13_mouse C-X-C motif chemokine 13 Cxcl13 Blc Scyb13 Small-inducible cytokine B13 B lymphocyte chemoattractant CXC chemokine BLC protein protein mouse Mus musculus Mouse MRLSTATLLLLLASCLSPGHGILEAHYTNLKCRCSGVISTVVGLNIIDRIQVTPPGNGCPKTEVVIWTKMKKVICVNPRAKWLQRLLRHVQSKSLSSTPQAPVSKRRAA mint Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs ccl21-a41 742740 va41_vaccw 742741 unspecified role unspecified role prey prey ccl21_human CCL21 742742 unspecified role unspecified role bait bait physical association physical association false false false T1 T2 homomint mint ccl21a-a41 742740 cc21a_mouse 742743 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 mint ccl28-a41 742740 ccl28_human 742744 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 homomint mint ccl28-a41-1 742740 ccl28_mouse 742745 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 homomint mint ccl25-a41 742740 va41_vaccw 742741 unspecified role unspecified role prey prey ccl25_human 742746 unspecified role unspecified role bait bait physical association physical association false false false T1 T2 homomint mint ccl25-a41-1 742740 va41_vaccw 742741 unspecified role unspecified role prey prey ccl25_mouse 742747 unspecified role unspecified role bait bait physical association physical association false false false T1 T2 mint ccl26-a41 742740 ccl26_human 742748 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 homomint mint pf4-a41 742740 va41_vaccw 742741 unspecified role unspecified role prey prey plf4_human 742749 unspecified role unspecified role bait bait physical association physical association false false false T1 T2 homomint mint cxcl1-a41 742740 groa_mouse 742750 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 mint cxcl13-a41 742740 cxl13_mouse 742751 unspecified role unspecified role bait bait va41_vaccw 742741 unspecified role unspecified role prey prey physical association physical association false false false T1 T2 homomint mint