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        <source releaseDate="2013-09-02+01:00">
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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                <names>
                    <shortLabel>bouchier_ha-2001-1</shortLabel>
                    <fullName>CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.</fullName>
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                            <shortLabel>in vivo</shortLabel>
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                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Bouchier-Hayes L., Conroy H., Egan H., Adrain C., Creagh EM., MacFarlane M., Martin SJ.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2001</attribute>
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            </experimentDescription>
        </experimentList>
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                <names>
                    <shortLabel>card8_human</shortLabel>
                    <fullName>Caspase recruitment domain-containing protein 8</fullName>
                    <alias typeAc="MI:0301" type="gene name">CARD8</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">KIAA0955</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">NDPP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CARD-inhibitor of NF-kappa-B-activating ligand</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">DACAR</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Tumor up-regulated CARD-containing antagonist of CASP9</alias>
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                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
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                <sequence>MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFFQAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL</sequence>
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                    <alias typeAc="MI:0302" type="gene name synonym">IkB kinase-associated protein 1</alias>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006955" secondary="immune response" version="SP_230"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000611071" version="SP_230" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070530" secondary="K63-linked polyubiquitin modification-dependent protein binding" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" secondary="inflammatory response" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169091" version="SP_230"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032419" version="SP_230"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001093326.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008385" secondary="IkappaB kinase complex" version="SP_230"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5LDE" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5357956" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5689896" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990459" secondary="transferrin receptor binding" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5602636" version="SP_230"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-356130" refType="intact-secondary"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CL3" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" secondary="cellular response to DNA damage stimulus" version="SP_230"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q7Z7F1" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-445989" version="SP_230"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BRT" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_230"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BWN" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_230"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001308325.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MI3" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-168638" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-933542" version="SP_230"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000269335" version="SP_230" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021063" version="SP_230"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-81279" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003630.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043276" secondary="anoikis" version="SP_230"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BRV" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009615" secondary="response to virus" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5357905" version="SP_230"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-27528N"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-4755510" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990450" secondary="linear polyubiquitin binding" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1236974" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043122" secondary="regulation of I-kappaB kinase/NF-kappaB signaling" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_230"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000471166" version="SP_230" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2JVX" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5684264" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5603029" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5603027" version="SP_230"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0065003" secondary="protein-containing complex assembly" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1810476" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5689880" version="SP_230"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001093327.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034735" version="SP_230"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450302" version="SP_230"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000594239" version="SP_230" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-937041" version="SP_230"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="6032">
                <names>
                    <shortLabel>card8-ikbkg</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-17746" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7968341" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>6029</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="6033">
                        <names>
                            <shortLabel>card8_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">CARD8</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-586690" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7968350" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>6030</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="6034">
                        <names>
                            <shortLabel>nemo_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">NEMO</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-586693" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7968346" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>6031</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
