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    <entry>
        <source releaseDate="2013-09-02+01:00">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
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            <attributeList>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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        <experimentList>
            <experimentDescription id="10227">
                <names>
                    <shortLabel>suzuki-2000-1</shortLabel>
                    <fullName>Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.</fullName>
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                        <names>
                            <shortLabel>in vivo</shortLabel>
                            <fullName>in vivo</fullName>
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                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Suzuki H., Chiba T., Suzuki T., Fujita T., Ikenoue T., Omata M., Furuichi K., Shikama H., Tanaka K.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2000</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="10228">
                <names>
                    <shortLabel>fbw1a_human</shortLabel>
                    <fullName>F-box/WD repeat-containing protein 1A</fullName>
                    <alias typeAc="MI:0301" type="gene name">BTRC</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">BTRCP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">FBW1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">FBXW1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">F-box and WD repeats protein beta-TrCP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">E3RSIkappaB</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">pIkappaBalpha-E3 receptor subunit</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Epididymis tissue protein Li 2a</alias>
                </names>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR</sequence>
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                    <shortLabel>ikba_human</shortLabel>
                    <fullName>NF-kappa-B inhibitor alpha</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">IKBA</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MAD3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">NFKBI</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">I-kappa-B-alpha</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Major histocompatibility complex enhancer-binding protein MAD3</alias>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169091" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010888" secondary="negative regulation of lipid storage" version="SP_227"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1NFI" version="SP_227"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R8L6" version="SP_113" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032495" secondary="response to muramyl dipeptide" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033209" secondary="tumor necrosis factor-mediated signaling pathway" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050729" secondary="positive regulation of inflammatory response" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1810476" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019899" secondary="enzyme binding" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5689880" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007253" secondary="cytoplasmic sequestering of NF-kappaB" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032088" secondary="negative regulation of NF-kappaB transcription factor activity" version="SP_227"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036770" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010745" secondary="negative regulation of macrophage derived foam cell differentiation" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045638" secondary="negative regulation of myeloid cell differentiation" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_227"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6Y1J" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_227"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020683" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-4755510" version="SP_227"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000216797" version="SP_227" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032270" secondary="positive regulation of cellular protein metabolic process" version="SP_227"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1IKN" version="SP_227"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5603029" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070417" secondary="cellular response to cold" version="SP_227"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_227"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL</sequence>
            </interactor>
            <interactor id="10230">
                <names>
                    <shortLabel>skp1_human</shortLabel>
                    <fullName>S-phase kinase-associated protein 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">SKP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EMC19</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">OCP2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SKP1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">TCEB1L</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cyclin-A/CDK2-associated protein p19</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">p19skp1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RNA polymerase II elongation factor-like protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Organ of Corti protein 2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Organ of Corti protein II</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SIII</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Transcription elongation factor B polypeptide 1-like</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P63208" version="SP_40" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8951664" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011333" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TTU" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AST" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5XYL" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5V4B" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6WNX" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5R" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6C16" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000429686" version="SP_187" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000429961" version="SP_187" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6M94" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FS1" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8939902" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016072" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051457" secondary="maintenance of protein location in nucleus" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174113" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5676590" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OVP" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5IBK" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000231487" version="SP_187" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-917937" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" secondary="protein domain specific binding" version="SP_187"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_008861.2"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VZU" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6M92" version="SP_187"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P63208" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2871837" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008013" secondary="beta-catenin binding" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6W66" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169091" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2894862" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904668" secondary="positive regulation of ubiquitin protein ligase activity" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OVR" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5M" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990756" secondary="ubiquitin ligase-substrate adaptor activity" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5K35" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6M90" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LDK" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2E32" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8TAY2" version="SP_40" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031146" secondary="SCF-dependent proteasomal ubiquitin-dependent protein catabolic process" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VCD" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-195253" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2644606" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P34991" version="SP_40" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-400253" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2ASS" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2122947" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2565942" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-187577" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9708530" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001232" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000517625" version="SP_187" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9604323" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FS2" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6BVA" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016073" version="SP_187"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31606N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000353411" version="SP_187" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6BYH" version="SP_187"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_733779.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610785" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DQ98" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6M93" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-180534" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610783" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031467" secondary="Cul7-RING ubiquitin ligase complex" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1170546" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000522855" version="SP_187" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3L2O" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5684264" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3WSO" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005813" secondary="centrosome" version="SP_187"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307486" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5L" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8854050" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VZT" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6O60" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4I6J" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6M91" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990444" secondary="F-box domain binding" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FQV" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1P22" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019005" secondary="SCF ubiquitin ligase complex" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6WCQ" version="SP_187"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DQ97" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OVQ" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JH5" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69231" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-68949" version="SP_187"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000113558" version="SP_187" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610780" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2644607" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607761" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036296" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_187"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983168" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000209" secondary="protein polyubiquitination" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035518" secondary="histone H2A monoubiquitination" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070936" secondary="protein K48-linked ubiquitination" version="SP_187"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016897" version="SP_187"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2E31" version="SP_187"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097602" secondary="cullin family protein binding" version="SP_187"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK</sequence>
            </interactor>
            <interactor id="10231">
                <names>
                    <shortLabel>fbw1b_human</shortLabel>
                    <fullName>F-box/WD repeat-containing protein 11</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">KIAA0696</alias>
                    <alias typeAc="MI:0301" type="gene name">FBXW11</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">BTRCP2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">FBW1B</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">FBXW1B</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">F-box/WD repeat-containing protein 1B</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">F-box and WD repeats protein beta-TrCP2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Homologous to Slimb protein</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UKB1" version="SP_71" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043161" secondary="proteasome-mediated ubiquitin-dependent protein catabolic process" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169091" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_205"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_387448.2"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000265094" version="SP_205" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007097" secondary="nuclear migration" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" secondary="protein dephosphorylation" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007281" secondary="germ cell development" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019005" secondary="SCF ubiquitin ligase complex" version="SP_205"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q9UKB1" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004842" secondary="ubiquitin-protein transferase activity" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983168" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9P2S9" version="SP_71" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000574" secondary="regulation of microtubule motor activity" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001680" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048511" secondary="rhythmic process" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031146" secondary="SCF-dependent proteasomal ubiquitin-dependent protein catabolic process" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021977" version="SP_205"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_036432.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031648" secondary="protein destabilization" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607761" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9P2S8" version="SP_71" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051010" secondary="microtubule plus-end binding" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008090" secondary="retrograde axonal transport" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005635" secondary="nuclear envelope" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904115" secondary="axon cytoplasm" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000209" secondary="protein polyubiquitination" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001810" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043025" secondary="neuronal cell body" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000072803" version="SP_205" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8951664" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042753" secondary="positive regulation of circadian rhythm" version="SP_205"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-355189" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005881" secondary="cytoplasmic microtubule" version="SP_205"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000265094" version="SP_205" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6WNX" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015943" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2565942" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" secondary="neuron projection" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046983" secondary="protein dimerization activity" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000151" secondary="ubiquitin ligase complex" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019775" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_205"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_387449.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016055" secondary="Wnt signaling pathway" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070840" secondary="dynein complex binding" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036322" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2RC98" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005875" secondary="microtubule associated complex" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036047" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045892" secondary="negative regulation of transcription, DNA-templated" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031023" secondary="microtubule organizing center organization" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000132" secondary="establishment of mitotic spindle orientation" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5684264" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048854" secondary="brain morphogenesis" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5676590" version="SP_205"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9Y4C6" version="SP_71" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005813" secondary="centrosome" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0047496" secondary="vesicle transport along microtubule" version="SP_205"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020472" version="SP_205"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-27593N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000776" secondary="kinetochore" version="SP_205"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2871837" version="SP_205"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045862" secondary="positive regulation of proteolysis" version="SP_205"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR</sequence>
            </interactor>
            <interactor id="10232">
                <names>
                    <shortLabel>cul1_human</shortLabel>
                    <fullName>Cullin-1</fullName>
                    <alias typeAc="MI:0301" type="gene name">CUL1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q13616" version="SP_70" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169091" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000473318" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-17013N"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005250117.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036388" version="SP_207"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q08AL6" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5L" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000663044" version="SP_207" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8854050" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000602748" version="SP_207" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000499277" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR019559" version="SP_207"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IYW1" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_207"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003583.2"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983168" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LDK" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610780" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000387160" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011514933.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O60719" version="SP_70" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607761" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69231" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3RTR" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5S" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8951664" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2644606" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097193" secondary="intrinsic apoptotic signaling pathway" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008283" secondary="cell population proliferation" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000665936" version="SP_207" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1170546" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2565942" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9708530" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006513" secondary="protein monoubiquitination" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016157" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4F52" version="SP_207"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011514932.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4P5O" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_207"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-359390" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610785" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000499255" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3TDU" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5684264" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016159" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-917937" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2122947" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610783" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174113" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2871837" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2894862" version="SP_207"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011514931.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000326804" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6WCQ" version="SP_207"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011514934.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3TDZ" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LDJ" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000325222" version="SP_207" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5M" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-195253" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009887" secondary="animal organ morphogenesis" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019005" secondary="SCF ubiquitin ligase complex" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031146" secondary="SCF-dependent proteasomal ubiquitin-dependent protein catabolic process" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036390" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000055130" version="SP_207" refType="gene"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000409469" version="SP_207" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004842" secondary="ubiquitin-protein transferase activity" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000082" secondary="G1/S transition of mitotic cell cycle" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-400253" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5V89" version="SP_207"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000499398" version="SP_207" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1U6G" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070936" secondary="protein K48-linked ubiquitination" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9604323" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5R" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-187577" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990452" secondary="Parkin-FBXW7-Cul1 ubiquitin ligase complex" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2644607" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001373" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-68949" version="SP_207"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DWG3" version="SP_105" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000662716" version="SP_207" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016567" secondary="protein ubiquitination" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016158" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8939902" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7B5N" version="SP_207"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q13616" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031461" secondary="cullin-RING ubiquitin ligase complex" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_207"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TTU" version="SP_207"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036317" version="SP_207"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5676590" version="SP_207"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="10233">
                <names>
                    <shortLabel>btrc-nfkbia</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-17059" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177724" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10234">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382280" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177733" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10235">
                        <names>
                            <shortLabel>ikba_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382283" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177730" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10229</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">This bind needs TNF-alfa stimulation</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10236">
                <names>
                    <shortLabel>btrc-skp1-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16900" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177736" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10237">
                        <names>
                            <shortLabel>skp1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382292" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177744" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10230</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10238">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382289" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177741" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10239">
                <names>
                    <shortLabel>fbxw11-skp1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16849" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177747" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10240">
                        <names>
                            <shortLabel>fbw1b_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382297" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177755" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10231</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10241">
                        <names>
                            <shortLabel>skp1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382300" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177752" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10230</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10242">
                <names>
                    <shortLabel>btrc-cul1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-14454" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177773" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10243">
                        <names>
                            <shortLabel>cul1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382308" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177781" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10232</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10244">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382305" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177778" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10245">
                <names>
                    <shortLabel>fbxw11-cul1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-13778" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177784" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10246">
                        <names>
                            <shortLabel>fbw1b_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382313" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177792" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10231</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10247">
                        <names>
                            <shortLabel>cul1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382316" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177789" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10232</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10248">
                <names>
                    <shortLabel>btrc-btrc</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16400" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177795" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10249">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382321" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177803" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="10250">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-382322" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177806" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="123"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10251">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382326" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177800" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="10252">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-382327" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177810" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="123"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="10253">
                <names>
                    <shortLabel>btrc-fbxw11</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-16173" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177814" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>10227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="10254">
                        <names>
                            <shortLabel>fbw1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382333" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177822" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10228</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="10255">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-382334" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177829" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="123"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="10256">
                        <names>
                            <shortLabel>fbw1b_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-382338" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177819" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>10231</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="10257">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-382339" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7177825" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="123"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
