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                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
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                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                    <shortLabel>xiong-2004a-1</shortLabel>
                    <fullName>A novel adaptation of the integrin PSI domain revealed from its crystal structure.</fullName>
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                        <shortLabel>predetermined</shortLabel>
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                    <attribute name="author-list" nameAc="MI:0636">Xiong JP., Stehle T., Goodman SL., Arnaout MA.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">PDBe - Data obtained from the Protein Data Bank Europe</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2004</attribute>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RN0" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043235" secondary="receptor complex" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AVR" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070527" secondary="platelet aggregation" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050748" secondary="negative regulation of lipoprotein metabolic process" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3ZDZ" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" secondary="glutamatergic synapse" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G1E" version="SP_275"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-114608" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038027" secondary="apolipoprotein A-I-mediated signaling pathway" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RMZ" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035866" secondary="alphav-beta3 integrin-PKCalpha complex" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6BXF" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035868" secondary="alphav-beta3 integrin-HMGB1 complex" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2MTP" version="SP_275"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1566948" version="SP_275"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007160" secondary="cell-matrix adhesion" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1U8C" version="SP_275"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2VDN" version="SP_275"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT</sequence>
            </interactor>
            <interactor id="514940">
                <names>
                    <shortLabel>itav_human</shortLabel>
                    <fullName>Integrin alpha-V</fullName>
                    <alias typeAc="MI:0301" type="gene name">ITGAV</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">VNRA</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Vitronectin receptor subunit alpha</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MSK8</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Vitronectin receptor</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">VTNR</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P06756" version="SP_101" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NET" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q59EB7" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015026" secondary="coreceptor activity" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DPG8" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E7EWZ6" version="SP_162" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008305" secondary="integrin complex" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028994" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1U8C" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MK0" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AVR" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OM1" version="SP_246"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P06756" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7ZLX0" version="SP_176" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-298282" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0AV67" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000138448" version="SP_246" refType="gene"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000261023" version="SP_246" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905598" secondary="negative regulation of low-density lipoprotein receptor activity" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001618" secondary="virus receptor activity" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007204" secondary="positive regulation of cytosolic calcium ion concentration" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4O02" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010745" secondary="negative regulation of macrophage derived foam cell differentiation" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002201.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" secondary="cell migration" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034684" secondary="integrin alphav-beta5 complex" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0LPF4" version="SP_127" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002020" secondary="protease binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902533" secondary="positive regulation of intracellular signal transduction" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JV2" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NAJ" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q53SK4" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IJE" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-445144" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7Z883" version="SP_162" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013649" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034685" secondary="integrin alphav-beta6 complex" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990430" secondary="extracellular matrix protein binding" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJB" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NER" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0085017" secondary="entry into host cell by a symbiont-containing vacuole" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001968" secondary="fibronectin binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071604" secondary="transforming growth factor beta production" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4UM8" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032369" secondary="negative regulation of lipid transport" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001237" secondary="negative regulation of extrinsic apoptotic signaling pathway" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007229" secondary="integrin-mediated signaling pathway" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4MMX" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034683" secondary="integrin alphav-beta3 complex" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138472.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2129379" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050431" secondary="transforming growth factor beta binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" secondary="external side of plasma membrane" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032695" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-216083" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038027" secondary="apolipoprotein A-I-mediated signaling pathway" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FFO" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035866" secondary="alphav-beta3 integrin-PKCalpha complex" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035579" secondary="specific granule membrane" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007160" secondary="cell-matrix adhesion" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901388" secondary="regulation of transforming growth factor beta activation" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138471.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1L5G" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4MMZ" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NEM" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" secondary="integrin binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033627" secondary="cell adhesion mediated by integrin" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031258" secondary="lamellipodium membrane" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051057" secondary="positive regulation of small GTPase mediated signal transduction" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035867" secondary="alphav-beta3 integrin-IGF-1-IGF1R complex" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000536" secondary="negative regulation of entry of bacterium into host cell" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045335" secondary="phagocytic vesicle" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3000178" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035987" secondary="endodermal cell differentiation" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G1E" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032587" secondary="ruffle membrane" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010888" secondary="negative regulation of lipid storage" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018184" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070371" secondary="ERK1 and ERK2 cascade" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046718" secondary="viral entry into host cell" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050748" secondary="negative regulation of lipoprotein metabolic process" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJA" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035868" secondary="alphav-beta3 integrin-HMGB1 complex" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" secondary="cell adhesion" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031527" secondary="filopodium membrane" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005245" secondary="voltage-gated calcium channel activity" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050840" secondary="extracellular matrix binding" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5NEU" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033690" secondary="positive regulation of osteoblast proliferation" version="SP_246"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10984285" refType="intact-secondary"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6OM2" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1566948" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AVU" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070588" secondary="calcium ion transmembrane transport" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-4420097" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1236973" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3000157" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UJC" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4UM9" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034446" secondary="substrate adhesion-dependent cell spreading" version="SP_246"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31785N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001846" secondary="opsonin binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031589" secondary="cell-substrate adhesion" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045785" secondary="positive regulation of cell adhesion" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6DJP" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6LD15" version="SP_101" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034686" secondary="integrin alphav-beta8 complex" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005080" secondary="protein kinase C binding" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FFG" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043277" secondary="apoptotic cell clearance" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097192" secondary="extrinsic apoptotic signaling pathway in absence of ligand" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4MMY" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050919" secondary="negative chemotaxis" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1M1X" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MSU" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3000170" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" secondary="cell surface" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G1M" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-210990" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050764" secondary="regulation of phagocytosis" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013519" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6MSL" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013517" version="SP_246"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000261023" version="SP_246" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001570" secondary="vasculogenesis" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031528" secondary="microvillus membrane" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000413" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6AVQ" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034113" secondary="heterotypic cell-cell adhesion" version="SP_246"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="514941">
                <names>
                    <shortLabel>itgav-itgb3-3</shortLabel>
                    <fullName>A novel adaptation of the integrin psi domain revealed from
   its crystal structure</fullName>
                </names>
                <xref>
                    <primaryRef db="rcsb pdb" dbAc="MI:0460" id="1U8C" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1039821" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>514938</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="514942">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1039825" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>514939</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="514943">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-1039826" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="27"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="718"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7108">
                                <names>
                                    <shortLabel>spofr</shortLabel>
                                    <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="514944">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1039822" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>514940</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="514945">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-1039823" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>sufficient to bind</shortLabel>
                                        <fullName>sufficient binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">sufficient to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608899" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="31"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="987"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="7108">
                                <names>
                                    <shortLabel>spofr</shortLabel>
                                    <fullName>Spodoptera frugiperda (Fall armyworm)</fullName>
                                    <alias typeAc="MI:1041" type="synonym">Fall armyworm</alias>
                                </names>
                            </hostOrganism>
                        </hostOrganismList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="assembly">dimeric, multimeric</attribute>
                    <attribute name="3d-r-factors" nameAc="MI:0631">working 70.700%, free 63.300%</attribute>
                    <attribute name="3d-resolution" nameAc="MI:0632">3.1A</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
