IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ tao-2007-1 mouse-t-cell Mouse T cell t-cell Peripheral blood T-lymphocytes ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Tao R., de Zoeten EF., Ozkaynak E., Chen C., Wang L., Porrett PM., Li B., Turka LA., Olson EN., Greene MI., Wells AD., Hancock WW. IBD - Inflammatory bowel disease CD4+ CD25+ T cells whancock@mail.med.upenn.edu Nature medicine 2007 Only protein-protein interactions imex curation imex curation foxp3_mouse Forkhead box protein P3 Foxp3 Scurfin protein protein mouse Mus musculus Mouse MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP il2_mouse_gene Interleukin-2 Il2 Il-2 gene gene mouse Mus musculus Mouse foxp3-il2-3 1857142 N/A 1857143 unspecified role unspecified role bait bait Q99JB6:p.[Lys382His;Lys393His] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false undefined mutation mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false N/A 1857144 unspecified role unspecified role prey prey promoter_region sufficient to bind sufficient binding region sufficient to bind undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false association association false false false 4 C/H CHEBI:46024 ; TSA-trichostatin A - an HDAC inhibitor CHEBI:46024 increases binding of Q99JB6 to ENSMUSG00000027720 mutation mapping has been entered using the sequence given in Figure 4D rather than from the main body of the text, hence the K383 mutation is entered as K382. Q99JB6 decreases expression at the protein level of ENSMUSG00000027720 CHEBI:46024 increases expression at the protein level of Q99JB6