IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ dai-2020-2 in vitro In vitro cleavage cleavage assay cleavage predetermined predetermined participant predetermined Dai W. Virus - Publications including interactions involving viral proteins hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Science 2020 Only protein-protein interactions imex curation imex curation Dai W., Zhang B., Su H., Li J., Zhao Y., Xie X., Jin Z., Liu F., Li C., Li Y., Bai F., Wang H., Cheng X., Cen X., Hu S., Yang X., Wang J., Liu X., Xiao G., Jiang H., Rao Z., Zhang LK., Xu Y., Yang H., Liu H. Coronavirus - Interactions investigated in the context of Coronavirus Science (New York, N.Y.) dai-2020-1 in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Dai W. Virus - Publications including interactions involving viral proteins hliu@simm.ac.cn, yanght@shanghaitech.edu.cn, zhangleike@wh.iov.cn, ycxu@simm.ac.cn Science 2020 Only protein-protein interactions imex curation imex curation Dai W., Zhang B., Su H., Li J., Zhao Y., Xie X., Jin Z., Liu F., Li C., Li Y., Bai F., Wang H., Cheng X., Cen X., Hu S., Yang X., Wang J., Liu X., Xiao G., Jiang H., Rao Z., Zhang LK., Xu Y., Yang H., Liu H. Coronavirus - Interactions investigated in the context of Coronavirus Science (New York, N.Y.) mca-avlqsgfr-lys(dnp)-lys-nh2 MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) AVLQSGFR p0dtd1-pro_0000449623 3C-like proteinase nsp5 rep ORF1ab polyprotein 1a-1b protein protein SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 2019-nCoV SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ 3264 3569 inhibitor 11a Inhibitor 11A small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) inhibitor 11b inhibitor 11b small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) mca_avlqsgfr_lys(dnp)_lys_nh2-rep-1 3714984 N/A 3714986 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714987 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage false false false 2 A/B mca_avlqsgfr_lys(dnp)_lys_nh2-rep-2 3714984 N/A 3714988 inhibitor inhibitor neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714986 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714987 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage false false false 3714984 2 A inhibitor 11a-mca_avlqsgfr_lys(dnp)_lys_nh2-1 3714984 N/A 3714989 inhibitor inhibitor neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714986 enzyme target enzyme target substrate substrate neutral component neutral component n-terminal fluorophore fluorophore n-term range n-terminal range n-term range n-term range n-terminal range n-term range false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714987 enzyme enzyme neutral component neutral component purified purified ecoli Escherichia coli (strain K12) cleavage cleavage reaction cleavage false false false 3714984 2 B inhibitor 11a-rep-1 3714985 N/A 3714988 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714987 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 2.0 direct interaction direct interaction false false false Table S1 inhibitor 11a-rep-2 3714985 N/A 3714989 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3714987 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 2.0 direct interaction direct interaction false false false Table S1