IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ von-2007-1 yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined von Brunn A., Teepe C., Simpson JC., Pepperkok R., Friedel CC., Zimmer R., Roberts R., Baric R., Haas J. Coronavirus - Interactions investigated in the context of Coronavirus vonbrunn@lmb.uni,haas@lmb.uni-muenchen.de PloS one 2007 Only protein-protein interactions imex curation imex curation This entry was curated with the special contribution of Edoardo, Filippo and Elisa. von-2007-2 human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western von Brunn A., Teepe C., Simpson JC., Pepperkok R., Friedel CC., Zimmer R., Roberts R., Baric R., Haas J. Coronavirus - Interactions investigated in the context of Coronavirus vonbrunn@lmb.uni,haas@lmb.uni-muenchen.de PloS one 2007 Only protein-protein interactions imex curation imex curation This entry was curated with the special contribution of Edoardo, Filippo and Elisa. ap3a_sars ORF3a protein Protein 3a Accessory protein 3a Protein U274 Protein X1 3a protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGDGISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLVKDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVPL p0c6x7-pro_0000037309 Host translation inhibitor nsp1 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 1 180 p0c6x7-pro_0000283841 Non-structural protein 4 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus KIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 2741 3240 p0c6x7-pro_0000037310 Non-structural protein 2 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG 181 818 p0c6x7-pro_0000037313 Non-structural protein 6 ORF1ab polyprotein 1a-1b rep protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3547 3836 p0c6x7-pro_0000037315 Non-structural protein 8 ORF1ab polyprotein 1a-1b rep protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus AIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQ 3920 4117 p0c6u8-pro_0000338265 Non-structural protein 11 ORF1a polyprotein 1a protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus SADASTFLNGFAV 4370 4382 p0c6x7-pro_0000037322 2'-O-methyltransferase nsp16 ORF1ab polyprotein 1a-1b rep protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus ASQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPRTKHVTKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMGHFSWWTAFVTNVNASSSEAFLIGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSSDILVNN 6776 7073 p0c6x7-pro_0000037311 Papain-like protease nsp3 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus APIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG 819 2740 orf9b_sars ORF9b protein Protein 9b 9b Accessory protein 9b ORF-9b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MDPNQTNVVPPALHLVDPQIQLTITRMEDAMGQGQNSADPKVYPIILRLGSQLSLSMARRNLDSLEARAFQSTPIVVQMTKLATTEELPDEFVVVTAK p0c6x7-pro_0000037314 Non-structural protein 7 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQ 3837 3919 p0c6x7-pro_0000037312 3C-like proteinase nsp5 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ 3241 3546 p0c6x7-pro_0000037316 Non-structural protein 9 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus NNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4118 4230 p0c6x7-pro_0000037317 Non-structural protein 10 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ 4231 4369 p0c6x7-pro_0000037318 RNA-directed RNA polymerase nsp12 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus SADASTFLNRVCGVSAARLTPCGTGTSTDVVYRAFDIYNEKVAGFAKFLKTNCCRFQEKDEEGNLLDSYFVVKRHTMSNYQHEETIYNLVKDCPAVAVHDFFKFRVDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQSLLKTVQFCDAMRDAGIVGVLTLDNQDLNGNWYDFGDFVQVAPGCGVPIVDSYYSLLMPILTLTRALAAESHMDADLAKPLIKWDLLKYDFTEERLCLFDRYFKYWDQTYHPNCINCLDDRCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVETPHLMGWDYPKCDRAMPNMLRIMASLVLARKHNTCCNLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYRNRDVDHEFVDEFYAYLRKHFSMMILSDDAVVCYNSNYAAQGLVASIKNFKAVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTNDNTSRYWEPEFYEAMYTPHTVLQ 4370 5301 p0c6x7-pro_0000037319 Helicase nsp13 ORF1ab polyprotein 1a-1b rep protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKIGILCIMSDRDLYDKLQFTSLEIPRRNVATLQ 5302 5902 p0c6x7-pro_0000037320 Proofreading exoribonuclease nsp14 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus AENVTGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVGTNLPLQLGFSTGVNLVAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKGLSDRVVFVLWAHGFELTSMKYFVKIGPERTCCLCDKRATCFSTSSDTYACWNHSVGFDYVYNPFMIDVQQWGFTGNLQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSVEYPIIGDELRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYDAQPCSDKAYKIEELFYSYATHHDKFTDGVCLFWNCNVDRYPANAIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQFDTYNLWNTFTRLQ 5903 6429 p0c6x7-pro_0000037321 Uridylate-specific endoribonuclease nsp15 rep ORF1ab polyprotein 1a-1b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus SLENVAYNVVNKGHFDGHAGEAPVSIINNAVYTKVDGIDVEIFENKTTLPVNVAFELWAKRNIKPVPEIKILNNLGVDIAANTVIWDYKREAPAHVSTIGVCTMTDIAKKPTESACSSLTVLFDGRVEGQVDLFRNARNGVLITEGSVKGLTPSKGPAQASVNGVTLIGESVKTQFNYFKKVDGIIQQLPETYFTQSRDLEDFKPRSQMETDFLELAMDEFIQRYKLEGYAFEHIVYGDFSHGQLGGLHLMIGLAKRSQDSPLKLEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVISKVVKVTIDYAEISFMLWCKDGHVETFYPKLQ 6430 6775 vemp_sars Envelope small membrane protein E sM 4 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPTVYVYSRVKNLNSSEGVPDLLV ns3b_sars ORF3b protein Accessory protein 3b Protein X2 3b Non-structural protein 3b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQVR ns7b_sars Protein non-structural 7b Accessory protein 7b 7b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MNELTLIDFYLCFLAFLLFLVLIMLIIFWFSLEIQDLEEPCTKV vme1_sars Membrane protein M E1 glycoprotein Matrix glycoprotein Membrane glycoprotein 5 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MADNGTITVEELKQLLEQWNLVIGFLFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVTLACFVLAAVYRINWVTGGIAIAMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLNVPLRGTIVTRPLMESELVIGAVIIRGHLRMAGHSLGRCDIKDLPKEITVATSRTLSYYKLGASQRVGTDSGFAAYNRYRIGNYKLNTDHAGSNDNIALLVQ q19qw5_sars Accessory protein 6 ORF6 sars6 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP spike_sars Spike glycoprotein S E2 Peplomer protein 2 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MFIFLLFLTLTSGSDLDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTINHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAILTAFSPAQDIWGTSAAAYFVGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT ns7a_sars ORF7a protein Accessory protein 7a Protein U122 Protein X4 7a protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MKIILFLTLIVFTSCELYHYQECVRGTTVLLKEPCPSGTYEGNSPFHPLADNKFALTCTSTHFAFACADGTRHTYQLRARSVSPKLFIRQEEVQQELYSPLFLIVAALVFLILCFTIKRKTE ns8a_sars ORF8a protein Accessory protein 8a Protein non-structural 8a 8a protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MKLLIVLTCISLCSCICTVVQRCASNKPHVLEDPCKVQH ns8b_sars ORF8b protein Accessory protein 8b Non-structural protein 8b 8b protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MCLKILVRYNTRGNTYSTAWLCALGKVLPFHRWHTMVQTCTPNVTINCQDPAGGALIARCWYLHEGHQTAAFRDVLVVLNKRTN y14_sars Uncharacterized protein 14 ORF14 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MLPPCYNFLKEQHCQKASTQREAEAAVKPLLAPHHVVAVIQEIQLLAAVGEILLLEWLAEVVKLPSRYCC ncap_sars Nucleoprotein N 9a Nucleocapsid protein protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAADMDDFSRQLQNSMSGASADSTQA mint Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid rep-ap3a_cvhsa-1 3680468 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP1 3680471 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-23 3680468 N/A NSP4 3680472 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-24 3680468 N/A NSP6 3680474 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-25 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-pro_0000338265-1 3680468 N/A NSP11 3680476 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-26 3680468 N/A NSP16 3680477 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-ap3a_cvhsa-2 3680468 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-27 3680468 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP3 3680478 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Nsp3C sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig.1 rep-ap3a_cvhsa-3 3680468 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP3 3680478 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false nsp3C sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig.1 rep-orf9b_cvhsa-1 3680468 N/A NSP3 3680478 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Nsp3C sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-28 3680468 N/A NSP7 3680480 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP5 3680481 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-29 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP5 3680481 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-30 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP6 3680474 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-31 3680468 N/A NSP7 3680480 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP7 3680480 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-32 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP7 3680480 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-2 3680468 N/A NSP7 3680480 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-33 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP8 3680475 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-3 3680468 N/A NSP8 3680475 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-34 3680468 N/A NSP6 3680474 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP9 3680482 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-35 3680468 N/A NSP7 3680480 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP9 3680482 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-36 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP9 3680482 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-ap3a_cvhsa-4 3680468 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP10 3680483 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-4 3680468 N/A NSP10 3680483 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-37 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP12 3680484 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-38 3680468 N/A NSP13 3680485 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP12 3680484 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-ap3a_cvhsa-5 3680468 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP12 3680484 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-5 3680468 N/A NSP12 3680484 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-39 3680468 N/A NSP7 3680480 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-40 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-41 3680468 N/A NSP12 3680484 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-42 3680468 N/A NSP13 3680485 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-6 3680468 N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-43 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A NSP14 3680486 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-7 3680468 N/A NSP14 3680486 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-orf9b_cvhsa-8 3680468 N/A NSP15 3680487 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-rep-1 3680468 N/A NSP1 3680471 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-rep-2 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-pro_0000338265-1 3680468 N/A NSP11 3680476 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-e-1 3680468 N/A E 3680488 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-ns3b_cvhsa-1 3680468 N/A ORF3B 3680489 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-ns7b_cvhsa-1 3680468 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 e-orf9b_cvhsa-1 3680468 N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ap3a_cvhsa-m-1 3680468 N/A M 3680491 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF3A 3680470 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-ns7b_cvhsa-1 3680468 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF6 3680492 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns7a_cvhsa-s-1 3680468 N/A S 3680493 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF7A 3680494 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8a_cvhsa-rep-1 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8A 3680495 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8a_cvhsa-rep-2 3680468 N/A NSP15 3680487 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8A 3680495 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8a_cvhsa-ns8b_cvhsa-1 3680468 N/A ORF8B 3680496 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8A 3680495 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8a_cvhsa-orf9b_cvhsa-1 3680468 N/A ORF8A 3680495 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-rep-1 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-s-1 3680468 N/A S 3680493 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-ns7b_cvhsa-1 3680468 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-ns8a_cvhsa-1 3680468 N/A ORF8A 3680495 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-orf9b_cvhsa-1 3680468 N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-y14_cvhsa-1 3680468 N/A ORF14 3680497 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF8B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-rep-1 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-rep-2 3680468 N/A NSP14 3680486 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-ns7b_cvhsa-1 3680468 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-orf9b_cvhsa-1 3680468 N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 y14_cvhsa-rep-1 3680468 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 y14_cvhsa-orf9b_cvhsa-1 3680468 N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 y14_cvhsa-y14_cvhsa-1 3680468 N/A ORF14 3680497 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-rep-4 3680468 N/A ORF7B 3680478 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A ORF9B 3680496 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 orf9b_cvhsa-rep-5 3680468 N/A ORF7B 3680478 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A ORF9B 3680494 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 ns8b_cvhsa-rep-2 3680468 N/A ORF7B 3680478 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A ORF9B 3680492 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association false false false Fig.1 rep-rep-44 3680469 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1, Fig.2A rep-rep-45 3680469 N/A NSP6 3680474 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-46 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-pro_0000338265-2 3680469 N/A NSP11 3680476 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-47 3680469 N/A NSP16 3680477 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-ap3a_cvhsa-6 3680469 N/A ORF3A 3680470 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-48 3680469 N/A NSP5 3680481 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP5 3680481 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-orf9b_cvhsa-9 3680469 N/A NSP5 3680481 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-49 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP7 3680480 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1, Fig.2A rep-rep-50 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP8 3680475 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1, Fig.2B rep-rep-51 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP9 3680482 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-52 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP12 3680484 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1, Fig.2B rep-rep-53 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP13 3680485 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-rep-54 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP14 3680486 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1, Fig.2B e-rep-3 3680469 N/A NSP1 3680471 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 e-rep-4 3680469 N/A NSP8 3680475 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 e-e-2 3680469 N/A E 3680488 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 e-ns7b_cvhsa-2 3680469 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A E 3680488 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 m-n-1 3680469 N/A N 3680498 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A M 3680491 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 rep-ns7b_cvhsa-2 3680469 N/A ORF7B 3680490 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF6 3680492 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 orf9b_cvhsa-rep-3 3680469 N/A NSP14 3680486 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 1 orf9b_cvhsa-orf9b_cvhsa-2 3680469 N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig.1, Fig. S1 y14_cvhsa-orf9b_cvhsa-2 3680469 N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig.1, Fig. S1 y14_cvhsa-y14_cvhsa-2 3680469 N/A ORF14 3680497 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig.1, Fig. S1 orf9b_cvhsa-orf9b_cvhsa-3 3680469 N/A ORF9B 3680479 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. S1 orf9b_cvhsa-y14_cvhsa-1 3680469 N/A ORF14 3680497 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF9B 3680479 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. S1 y14_cvhsa-y14_cvhsa-3 3680469 N/A ORF14 3680497 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A ORF14 3680497 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. S1 rep-rep-55 3680469 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP6 3680474 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 2A rep-rep-56 3680469 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP8 3680475 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 2A rep-rep-57 3680469 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680473 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false physical association physical association false false false Fig. 2A rep-rep-58 3680469 N/A NSP2 3680473 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed HA tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false N/A NSP2 3680478 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed c-Myc tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false Nsp3N sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Fig. 1, Fig.2A