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                <shortLabel>IntAct</shortLabel>
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                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
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                <names>
                    <shortLabel>kesselring-2016-1</shortLabel>
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                        <names>
                            <shortLabel>human-colorectal_cancer</shortLabel>
                            <fullName>human</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
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                                <shortLabel>colorectal_cancer</shortLabel>
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                        <shortLabel>antibody detection</shortLabel>
                        <fullName>identification by antibody</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Kesselring R., Glaesner J., Hiergeist A., Naschberger E., Neumann H., Brunner SM., Wege AK., Seebauer C., Köhl G., Merkl S., Croner RS., Hackl C., Stürzl M., Neurath MF., Gessner A., Schlitt HJ., Geissler EK., Fichtner-Feigl S.</attribute>
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                    <attribute name="contact-email" nameAc="MI:0634">stefan.fichtner@ukr.de</attribute>
                    <attribute name="journal" nameAc="MI:0885">Cancer cell</attribute>
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                    <shortLabel>stat3_human</shortLabel>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905618" secondary="positive regulation of miRNA mediated inhibition of translation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" secondary="cytokine-mediated signaling pathway" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036535" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020933" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9673767" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257674.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060396" secondary="growth hormone receptor signaling pathway" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2586552" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6783783" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006606" secondary="protein import into nucleus" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000678044" version="SP_231" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040014" secondary="regulation of multicellular organism growth" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8849474" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000503181" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099527" secondary="postsynapse to nucleus signaling pathway" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033210" secondary="leptin-mediated signaling pathway" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AX3" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000503102" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" secondary="transcription cis-regulatory region binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061629" secondary="RNA polymerase II-specific DNA-binding transcription factor binding" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013800" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031730" secondary="CCR5 chemokine receptor binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072538" secondary="T-helper 17 type immune response" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523447.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" secondary="positive regulation of angiogenesis" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_231"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33584N"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016880464.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" secondary="DNA-binding transcription factor activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008283" secondary="cell population proliferation" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9008059" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019827" secondary="stem cell population maintenance" version="SP_231"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM</sequence>
                <attributeList>
                    <attribute name="crc64">6C00632211C8012D</attribute>
                </attributeList>
            </interactor>
            <interactor id="1936573">
                <names>
                    <shortLabel>irak3_human</shortLabel>
                    <fullName>Interleukin-1 receptor-associated kinase 3</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">IL-1 receptor-associated kinase M</alias>
                    <alias typeAc="MI:0301" type="gene name">IRAK3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Inactive IL-1 receptor-associated kinase 3</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q9Y616" version="SP_54" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042698" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042177" secondary="negative regulation of protein catabolic process" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032720" secondary="negative regulation of tumor necrosis factor production" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070555" secondary="response to interleukin-1" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_181"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001135995.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000488" version="SP_181"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_181"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000261233" version="SP_181" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZIW" version="SP_181"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-166058" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046982" secondary="protein heterodimerization activity" version="SP_181"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000090376" version="SP_181" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010933" secondary="positive regulation of macrophage tolerance induction" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" secondary="negative regulation of MAP kinase activity" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001819" secondary="positive regulation of cytokine production" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000287" secondary="magnesium ion binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043244" secondary="regulation of protein-containing complex disassembly" version="SP_181"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5UKE" version="SP_181"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6RUU" version="SP_181"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-447690" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032496" secondary="response to lipopolysaccharide" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" secondary="intracellular signal transduction" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032715" secondary="negative regulation of interleukin-6 production" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032088" secondary="negative regulation of NF-kappaB transcription factor activity" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043330" secondary="response to exogenous dsRNA" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_181"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_009130.2"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DQ57" version="SP_90" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032695" secondary="negative regulation of interleukin-12 production" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="SP_181"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000261233" version="SP_181" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034122" secondary="negative regulation of toll-like receptor signaling pathway" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009615" secondary="response to virus" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045824" secondary="negative regulation of innate immune response" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001960" secondary="negative regulation of cytokine-mediated signaling pathway" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032494" secondary="response to peptidoglycan" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002755" secondary="MyD88-dependent toll-like receptor signaling pathway" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033610" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010936" secondary="negative regulation of macrophage cytokine production" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" secondary="cytokine-mediated signaling pathway" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043242" secondary="negative regulation of protein-containing complex disassembly" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR042747" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070498" secondary="interleukin-1-mediated signaling pathway" version="SP_181"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-25361-1" id="1936574">
                <names>
                    <shortLabel>23423-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-11790103" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-25361-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1936571</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1936575">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-11790107" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1936572</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1936576">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-11790106" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1936573</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>proximity</shortLabel>
                        <fullName>proximity</fullName>
                        <alias typeAc="MI:1041" type="synonym">close-contact colocalization</alias>
                        <alias typeAc="MI:1041" type="synonym">neighbourhood interaction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">4F, Supp 4D</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
