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    <entry>
        <source releaseDate="2014-03-31+01:00">
            <names>
                <shortLabel>Molecular Connections</shortLabel>
                <fullName>Molecular Connections Pvt. Ltd.</fullName>
            </names>
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            <attributeList>
                <attribute name="postal address">2/2, Kariappa Road, Basavanagudi, Bangalore -560 004</attribute>
                <attribute name="url" nameAc="MI:0614">www.molecularconnections.com</attribute>
                <attribute name="url">www.molecularconnections.com</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="1521067">
                <names>
                    <shortLabel>luan-2014-1</shortLabel>
                    <fullName>Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.</fullName>
                </names>
                <bibref>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-aspc-1</shortLabel>
                            <fullName>Human caucasian pancreas adenocarcinoma cell line</fullName>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>aspc-1</shortLabel>
                                <fullName>Human caucasian pancreas adenocarcinoma cell line</fullName>
                            </names>
                            <xref>
                                <primaryRef db="intact" dbAc="MI:0469" id="IA:2800" refType="identity" refTypeAc="MI:0356"/>
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                                <shortLabel>pancreas</shortLabel>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Luan Z., He Y., Alattar M., Chen Z., He F.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Cancer - Interactions investigated in the context of cancer</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">zschen@tjh .tjmu.edu.cn</attribute>
                    <attribute name="journal" nameAc="MI:0885">Mol. Cancer</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2014</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="external curation">Molecular Connections Pvt Ltd.</attribute>
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                    <fullName>Prohibitin</fullName>
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                        <fullName>Homo sapiens</fullName>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802948" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NTC" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003116" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5673000" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5621575" version="SP_249"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R5N3" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005265412.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030878" secondary="thyroid gland development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NTD" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" secondary="signal transduction" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5674135" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031434" secondary="mitogen-activated protein kinase kinase binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3O8I" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045595" secondary="regulation of cell differentiation" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IHL" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6802955" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031143" secondary="pseudopodium" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042981" secondary="regulation of apoptotic process" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048538" secondary="thymus development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010856" secondary="adenylate cyclase activator activity" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9660537" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FAR" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007507" secondary="heart development" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035023" secondary="regulation of Rho protein signal transduction" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-430116" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3KUD" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G0N" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902042" secondary="negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060324" secondary="face development" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000251849" version="SP_249" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IEA" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000132155" version="SP_249" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031333" secondary="negative regulation of protein-containing complex assembly" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OMV" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007190" secondary="activation of adenylate cyclase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004709" secondary="MAP kinase kinase kinase activity" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045104" secondary="intermediate filament cytoskeleton organization" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XGU" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FAQ" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GUA" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000145" secondary="regulation of cell motility" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_249"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4G3X" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071550" secondary="death-inducing signaling complex assembly" version="SP_249"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UC20" version="SP_114" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1C1Y" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" secondary="mitochondrial outer membrane" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_249"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9649948" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3NKX" version="SP_249"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000251849" version="SP_249" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6PTW" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7JHP" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000186" secondary="activation of MAPKK activity" version="SP_249"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6XHA" version="SP_249"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048011" secondary="neurotrophin TRK receptor signaling pathway" version="SP_249"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-22263-1" id="1521070">
                <names>
                    <shortLabel>phb1-raf1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-9257863" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-22263-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1521067</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1521071">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-9257866" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1521068</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1521072">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-9257865" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1521069</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">3d</attribute>
                    <attribute name="antagonist" nameAc="MI:0626">RocA</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
