Molecular Connections Molecular Connections Pvt. Ltd. 2/2, Kariappa Road, Basavanagudi, Bangalore -560 004 www.molecularconnections.com www.molecularconnections.com cao-2013a-1 The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. human-ren human mesothelioma cell line ren human mesothelioma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Cao X., Yap J.L., Newell-Rogers M.K., Peddaboina C., Jiang W., Papaconstantinou H.T., Jupitor D., Rai A., Jung K.Y., Tubin R.P., Yu W., Vanommeslaeghe K., Wilder P.T., MacKerell A.D., Fletcher S., Smythe R.W. Cancer - Interactions investigated in the context of cancer Species details of Bak peptide and Mcl-1 used in FPS assay is not mentioned in the article so thsi data has not been added. rsmythe@sw.org Mol. Cancer 2013 imex curation Molecular Connections Pvt. Ltd. Only protein-protein interactions bak_human Bcl-2 homologous antagonist/killer Apoptosis regulator BAK Bcl-2-like protein 7 BAK1 BAK BCL2L7 CDN1 protein protein human Homo sapiens Human MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS q07817-1 Bcl-2-like protein 1 BCLX Apoptosis regulator Bcl-X BCL2L1 BCL2L Bcl-xL protein protein human Homo sapiens Human MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK mcl1_human Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-related protein EAT/mcl1 mcl1/EAT MCL1 BCL2L3 Bcl-2-like protein 3 protein protein human Homo sapiens Human MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR bcl2l1-bak-5 1474912 n/a 1474913 unspecified role unspecified role prey prey n/a 1474914 unspecified role unspecified role bait bait physical association physical association false false false 2b JY-1-106 ABT-737 bak1-bcl2l1-6 1474912 n/a 1474914 unspecified role unspecified role prey prey n/a 1474913 unspecified role unspecified role bait bait physical association physical association false false false 2b JY-1-106 ABT-737 mcl1-bak1-6 1474912 n/a 1474915 unspecified role unspecified role bait bait n/a 1474913 unspecified role unspecified role prey prey physical association physical association false false false 2c JY-1-106 bak1-mcl1-1 1474912 n/a 1474915 unspecified role unspecified role prey prey n/a 1474913 unspecified role unspecified role bait bait physical association physical association false false false 2c JY-1-106