I2D I2D marshall-2010-1 Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au Oncogene (0950-9232) 2010 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database marshall-2010-2 Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. human-sk_n_be(2) Human caucasian neuroblastoma cell line sk_n_be(2) Human neuroblastoma cell line anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marshall GM., Gherardi S., Xu N., Neiron Z., Trahair T., Scarlett CJ., Chang DK., Liu PY., Jankowski K., Iraci N., Haber M., Norris MD., Keating J., Sekyere E., Jonquieres G., Stossi F., Katzenellenbogen BS., Biankin AV., Perini G., Liu T. Cancer - Interactions investigated in the context of cancer Dual crosslinking ChIP and quantitative PCR were applied in Be(2)-C cells. tliu@ccia.unsw.edu.au Oncogene (0950-9232) 2010 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database sp1_human Transcription factor Sp1 SP1 TSFP1 protein protein human Homo sapiens Human MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF ccng2_human_gene gene gene human Homo sapiens Human mycn_human N-myc proto-oncogene protein MYCN NMYC BHLHE37 Class E basic helix-loop-helix protein 37 protein protein human Homo sapiens Human MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC hdac2_human Histone deacetylase 2 HDAC2 protein protein human Homo sapiens Human MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP sp1-ccng2 998506 n/a 998508 unspecified role unspecified role bait bait n/a 998509 unspecified role unspecified role prey prey association association false false false Fig. 5b n-myc-ccng2 998506 n/a 998510 unspecified role unspecified role bait bait n/a 998509 unspecified role unspecified role prey prey association association false false false Fig. 5b hdac2-ccng2 998506 n/a 998511 unspecified role unspecified role bait bait n/a 998509 unspecified role unspecified role prey prey association association false false false Fig. 5b n-myc-sp1-hdac2 998507 n/a 998510 unspecified role unspecified role bait bait n/a 998508 unspecified role unspecified role prey prey n/a 998511 unspecified role unspecified role prey prey physical association physical association false false false Fig. 5d hdac2-n-myc-sp1 998507 n/a 998510 unspecified role unspecified role prey prey n/a 998511 unspecified role unspecified role bait bait n/a 998508 unspecified role unspecified role prey prey physical association physical association false false false Fig. 5d