IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ yokoyama-2008-3 Menin critically links MLL proteins with LEDGF on cancer-associated target genes. human-hb1119 Homo sapiens acute lymphoblastic leukemia cell line HB1119 hb1119 Human acute lymphoblastic leukemia cell line HB1119 ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Yokoyama A., Cleary ML. Apoptosis - Interactions involving proteins with a function related to apoptosis The source of the MLL, MLL fusion protein, menin and LEDGF constructs could not be ascertained. Thus interactions involving these constructs could not be curated. ayokoyam@ncc.go.jp Cancer Cell (1535-6108) 2008 Only protein-protein interactions 1 imex curation Cancer - Interactions investigated in the context of cancer yokoyama-2008-2 Menin critically links MLL proteins with LEDGF on cancer-associated target genes. human-ml_2 Homo sapiens ML-2 acute myeloid leukemia-derived cell line ml_2 Human acute myeloid leukemia-derived cell line ML-2 ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Yokoyama A., Cleary ML. Apoptosis - Interactions involving proteins with a function related to apoptosis The source of the MLL, MLL fusion protein, menin and LEDGF constructs could not be ascertained. Thus interactions involving these constructs could not be curated. ayokoyam@ncc.go.jp Cancer Cell (1535-6108) 2008 Only protein-protein interactions 1 imex curation Cancer - Interactions investigated in the context of cancer yokoyama-2008-1 Menin critically links MLL proteins with LEDGF on cancer-associated target genes. human-reh Homo sapiens REH B cell precursor leukemia cells reh Human B cell precursor leukemia REH cells anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yokoyama A., Cleary ML. Apoptosis - Interactions involving proteins with a function related to apoptosis The source of the MLL, MLL fusion protein, menin and LEDGF constructs could not be ascertained. Thus interactions involving these constructs could not be curated. ayokoyam@ncc.go.jp Cancer Cell (1535-6108) 2008 Only protein-protein interactions 1 imex curation Cancer - Interactions investigated in the context of cancer hoxa7_human_gene gene gene human Homo sapiens Human psip1_human PC4 and SFRS1-interacting protein PSIP1 DFS70 LEDGF PSIP2 Lens epithelium-derived growth factor Transcriptional coactivator p75/p52 Dense fine speckles 70 kDa protein CLL-associated antigen KW-7 protein protein human Homo sapiens Human MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN hoxa9_human_gene Human HOXA9 gene gene gene human Homo sapiens Human men1_human Menin MEN1 SCG2 protein protein human Homo sapiens Human MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL kmt2a_human Histone-lysine N-methyltransferase 2A KMT2A ALL-1 ALL1 CXXC-type zinc finger protein 7 CXXC7 HRX HTRX MLL MLL1 Myeloid/lymphoid or mixed-lineage leukemia Myeloid/lymphoid or mixed-lineage leukemia protein 1 TRX1 Trithorax-like protein Zinc finger protein HRX Cysteine methyltransferase KMT2A protein protein human Homo sapiens Human MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN meis1_human_gene gene gene human Homo sapiens Human hoxa7-psip1-1 PSIP1 associates with the HOXA7 gene as shown by ChIP 756611 N/A-x 756614 unspecified role unspecified role prey prey N/A-x 756615 unspecified role unspecified role bait bait association association false false false S2 hoxa9-psip1-1 PSIP1 associates with the HOXA9 gene as shown by ChIP 756611 N/A 756615 unspecified role unspecified role bait bait N/A 756616 unspecified role unspecified role prey prey association association false false false S2 hoxa9-men1-1 Menin associates with the HOXA9 gene as shown by ChIP 756611 N/A-x 756616 unspecified role unspecified role prey prey N/A-x 756617 unspecified role unspecified role bait bait association association false false false S2 hoxa7-men1-1 Menin associates with the HOXA7 gene as shown by ChIP 756611 N/A 756614 unspecified role unspecified role prey prey N/A 756617 unspecified role unspecified role bait bait association association false false false S2 hoxa7-mll-1 MLL associates with the HOXA7 gene as shown by ChIP 756611 N/A-x 756618 unspecified role unspecified role bait bait N/A-x-x-x 756614 unspecified role unspecified role prey prey association association false false false S2 hoxa9-mll-1 MLL associates with the HOXA9 gene as shown by ChIP 756611 N/A 756616 unspecified role unspecified role prey prey N/A 756618 unspecified role unspecified role bait bait association association false false false S2 meis1-psip1 PSIP1 associates with the MEIS1 gene as shown by ChIP 756611 N/A 756619 unspecified role unspecified role prey prey N/A-x-x 756615 unspecified role unspecified role bait bait association association false false false S2 meis1-men1-2 Menin associates with the MEIS1 gene as shown by ChIP 756611 N/A 756619 unspecified role unspecified role prey prey N/A-x-x 756617 unspecified role unspecified role bait bait association association false false false S2 meis1-mll-2 MLL associates with the MEIS1 gene as shown by ChIP 756611 N/A-x-x 756618 unspecified role unspecified role bait bait N/A 756619 unspecified role unspecified role prey prey association association false false false S2 hoxa7-psip1 PSIP1 associates with the HOXA7 gene as shown by ChIP 756612 N/A 756614 unspecified role unspecified role prey prey N/A 756615 unspecified role unspecified role bait bait association association false false false 2 A hoxa9-psip1 PSIP1 associates with the HOXA9 gene as shown by ChIP 756612 N/A 756615 unspecified role unspecified role bait bait N/A 756616 unspecified role unspecified role prey prey association association false false false 2 A hoxa9-men1 Menin associates with the HOXA9 gene as shown by ChIP 756612 N/A 756617 unspecified role unspecified role bait bait N/A 756616 unspecified role unspecified role prey prey association association false false false 2 A hoxa7-men1 Menin associates with the HOXA7 gene as shown by ChIP 756612 N/A 756617 unspecified role unspecified role bait bait N/A 756614 unspecified role unspecified role prey prey association association false false false 2 A hoxa7-mll MLL associates with the HOXA7 gene as shown by ChIP 756612 N/A 756614 unspecified role unspecified role prey prey N/A 756618 unspecified role unspecified role bait bait association association false false false 2 A hoxa9-mll MLL associates with the HOXA9 gene as shown by ChIP 756612 N/A 756618 unspecified role unspecified role bait bait N/A 756616 unspecified role unspecified role prey prey association association false false false 2 A men1-mll Menin coimmunoprecipitates MLL and LEDGF (PSIP1) in REH lysates 756613 N/A 756615 unspecified role unspecified role prey prey N/A 756618 unspecified role unspecified role prey prey N/A 756617 unspecified role unspecified role bait bait association association false false false 1 D