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    <entry>
        <source releaseDate="2006-10-26+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
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            <attributeList>
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                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="506040">
                <names>
                    <shortLabel>borzacchiel-2006-1</shortLabel>
                    <fullName>Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours.</fullName>
                </names>
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                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-14406" refType="imex-primary" refTypeAc="MI:0662"/>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9913">
                        <names>
                            <shortLabel>bovin-urin_bladder_carcino</shortLabel>
                            <fullName>Bos taurus urinary bladder carcinoma</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>urinary_bladder_carcinoma</shortLabel>
                                <fullName>urinary bladder carcinoma</fullName>
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                            <xref>
                                <primaryRef db="brenda" dbAc="MI:0864" id="BTO:0000362" refType="identity" refTypeAc="MI:0356"/>
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                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Borzacchiello G., Russo V., Gentile F., Roperto F., Venuti A., Nitsch L., Campo MS., Roperto S.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Cancer - Interactions investigated in the context of cancer</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">borzacch@unina.it</attribute>
                    <attribute name="journal" nameAc="MI:0885">Oncogene (0950-9232)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="dataset" nameAc="MI:0875">BioCreative - Critical Assessment of Information Extraction systems in Biology</attribute>
                </attributeList>
            </experimentDescription>
            <experimentDescription id="506041">
                <names>
                    <shortLabel>borzacchiel-2006-2</shortLabel>
                    <fullName>Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours.</fullName>
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                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="16205631" refType="primary-reference" refTypeAc="MI:0358"/>
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                    <hostOrganism ncbiTaxId="9913">
                        <names>
                            <shortLabel>bovin-urin_bladder_carcino</shortLabel>
                            <fullName>Bos taurus urinary bladder carcinoma</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>urinary_bladder_carcinoma</shortLabel>
                                <fullName>urinary bladder carcinoma</fullName>
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                            </xref>
                        </tissue>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>confocal microscopy</shortLabel>
                        <fullName>confocal microscopy</fullName>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>immunostaining</shortLabel>
                        <fullName>immunostaining</fullName>
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                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
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                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="dataset" nameAc="MI:0875">BioCreative - Critical Assessment of Information Extraction systems in Biology</attribute>
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        </experimentList>
        <interactorList>
            <interactor id="506042">
                <names>
                    <shortLabel>q6xhb4_bpv2</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">E5</alias>
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                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q6XHB4" version="TrEMBL_12" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012555"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="TrEMBL_79"/>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="2758382">
                    <names>
                        <shortLabel>bpv2</shortLabel>
                        <fullName>Bovine papillomavirus type 2</fullName>
                    </names>
                </organism>
                <sequence>MPNLWFLLFLGLVAAMQLLLLLFLLLFFLVYWDHFECSCTGLPF</sequence>
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            <interactor id="506043">
                <names>
                    <shortLabel>q0vc10_bovin</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">PDGFRB</alias>
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                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                </interactorType>
                <organism ncbiTaxId="9913">
                    <names>
                        <shortLabel>bovin</shortLabel>
                        <fullName>Bos taurus (Bovine)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Bovine</alias>
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                </organism>
                <sequence>MWLPSAMQAVVLKGRVLLLPLLFLLGPQASWGLAIIPPGPELVLNLSSTFVLTCSGPAPVVWERMSQKPPQEMTETQDGTFSSVLTLVNVTGLDTGEYFCGYKRSHGLEASERKRLYIFVPDPSVGFLPVDPEELFIFLTEITETTIPCRVTDPRLVVMLHEKKVDVPLPIAYDPQRGFSGTFEDKTYICKTTIGDREVDSDAYHVYSLQGEPPFWPGAQPRQV</sequence>
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        </interactorList>
        <interactionList>
            <interaction imexId="IM-14406-1" id="506044">
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                    <shortLabel>q6xhb4-pdgfrb</shortLabel>
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                    <experimentRef>506040</experimentRef>
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                        <names>
                            <shortLabel>N/A</shortLabel>
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                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009572" refType="identity" refTypeAc="MI:0356"/>
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                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
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                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
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                            <shortLabel>N/A</shortLabel>
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                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
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                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
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                                    <shortLabel>region</shortLabel>
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                                        <shortLabel>phosres</shortLabel>
                                        <fullName>phosphorylated residue</fullName>
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                                        <alias typeAc="MI:1041" type="synonym">Phospho</alias>
                                        <alias typeAc="MI:1041" type="synonym">Phosphorylation</alias>
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                                                <shortLabel>undetermined</shortLabel>
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                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
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                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                </participantList>
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                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
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                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">3 A, 4 B</attribute>
                    <attribute name="comment" nameAc="MI:0612">Three different BPV-2-positive bovine bladder cancer samples were tested.</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-14406-2" id="506048">
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                    <shortLabel>q6xhb4-pdgfrb-1</shortLabel>
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                            <shortLabel>N/A</shortLabel>
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                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009579" refType="identity" refTypeAc="MI:0356"/>
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                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
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                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
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                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009578" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>506042</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">3 B</attribute>
                    <attribute name="comment" nameAc="MI:0612">Three different BPV-2-positive bovine bladder cancer samples were tested.</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-14406-3" id="506051">
                <names>
                    <shortLabel>q6xhb4-pdgfrb-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009598" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" refType="component" refTypeAc="MI:0354"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-14406-3" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>506041</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="506052">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009599" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>506043</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="506053">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009601" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>phosres</shortLabel>
                                        <fullName>phosphorylated residue</fullName>
                                        <alias typeAc="MI:1041" type="synonym">PhosRes</alias>
                                        <alias typeAc="MI:1041" type="synonym">Phospho</alias>
                                        <alias typeAc="MI:1041" type="synonym">Phosphorylation</alias>
                                        <alias typeAc="MI:1041" type="synonym">Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine)</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mod" dbAc="MI:0897" id="MOD:00696" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0170" refType="secondary-ac" refTypeAc="MI:0360"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6410650" refType="secondary-ac" refTypeAc="MI:0360"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456700" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="506054">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-1009600" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>506042</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">2 m-o</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
