IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ hale-2009-1 RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. pyrfu Pyrococcus furiosus chromatography chromatography technology column chromatography chromatography de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Cell (0092-8674) 2009 Only protein-protein interactions 2 imex curation hale-2009-2 RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. in vitro In vitro ribonuclease assay ribonuclease assay weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Cell (0092-8674) 2009 Only protein-protein interactions 2 imex curation hale-2009-3 RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex. pyrfu Pyrococcus furiosus chromatography chromatography technology column chromatography chromatography de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Hale CR., Zhao P., Olson S., Duff MO., Graveley BR., Wells L., Terns RM., Terns MP. Archaea - Interaction dataset based on Archaea proteins Gel filtration and affinity chromatography followed by native gel electrophoresis rterns@bmb.uga.edu, mterns@bmb.uga.edu Cell (0092-8674) 2009 Only protein-protein interactions 2 imex curation vora_pyrfu Ketoisovalerate oxidoreductase subunit VorA vorA 2-oxoisovalerate oxidoreductase alpha chain 2-oxoisovalerate ferredoxin reductase subunit alpha PF0969 protein protein pyrfu Pyrococcus furiosus MEYKPIRKVVSGNYAAAYAALHARVQVVAAYPITPQTSIIEKIAEFIANGEADIQYIPVESEHSAMAACIGASATGARTFTATSAQGLALMHEMLHWAAGARLPIVMVDVNRAMAPPWSVWDDQTDSLSQRDTGWMQFYAENNQEVYDGVLMAYKVAETVNVPAMVVESAFILSHTYDVVEMIPQELVDEFLPPRKPLYSLANFDEPIAVGALATPNDYYEFRYKLAKAHEEAKKVIKEVGKEFGERFGRDYSQMIETGYIDDADFVFMGMGSLMGTVKEAVDLLRKEGYKVGYAKVRWFRPFPKEELVEIAESVKGIAVLDRNFSFGQEGILFTESKGALYNSSAHPLMKNYIVGLGGRDVTVKDIKAIADDMKKVIESGKVDKEVVWYHLKR acda1_pyrfu Acetate--CoA ligase [ADP-forming] I subunit alpha acdAI ADP-forming acetyl coenzyme A synthetase I subunit alpha PF1540 protein protein pyrfu Pyrococcus furiosus MSLEALFNPKSVAVIGASAKPGKIGYAIMKNLIEYGYEGKIYPVNIKGGEIEINGRKFKVYKSVLEIPDEVDMAVIVVPAKFVPQVLEECGQKGVKVVPIISSGFGELGEEGKKVEQQLVETARKYGMRILGPNIFGVVYTPAKLNATFGPTDVLPGPLALISQSGALGIALMGWTILEKIGLSAVVSVGNKADIDDADLLEFFKDDENTRAILIYMEGVKDGRRFMEVAKEVSKKKPIIVIKAGRSERGAKAAASHTGSLAGSDKVYSAAFKQSGVLRAYTIGEAFDWARALSNLPEPQGDNVVIITNGGGIGVMATDAAEEEGLHLYDNLEELKIFANHMPPFGSYKNPVDLTGMADGKSYEGAIRDALAHPEMHSIAVLYCQTAVLDPRELAEIVIREYNESGRKKPLVVAIVGGIEAKEAIDMLNENGIPAYPEPERAIKALSALYKWSKWKAKHKEK otca_pyrfu Ornithine carbamoyltransferase, anabolic argF PF0594 protein protein pyrfu Pyrococcus furiosus MVVSLAGRDLLCLQDYTAEEIWTILETAKMFKIWQKIGKPHRLLEGKTLAMIFQKPSTRTRVSFEVAMAHLGGHALYLNAQDLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVPVINGLSDFSHPCQALADYMTIWEKKGTIKGVKVVYVGDGNNVAHSLMIAGTKLGADVVVATPEGYEPDEKVIKWAEQNAAESGGSFELLHDPVKAVKDADVIYTDVWASMGQEAEAEERRKIFRPFQVNKDLVKHAKPDYMFMHCLPAHRGEEVTDDVIDSPNSVVWDQAENRLHAQKAVLALVMGGIKF 14404FBDC2ECCB95 if5a_pyrfu Translation initiation factor 5A eif5a eIF-5A Hypusine-containing protein PF1264 protein protein pyrfu Pyrococcus furiosus MGDKTKVQVSKLKPGRYIIIDDEPCRIVNITVSSPGKHGSAKARIEAVGIFDGKVRSIVKPTSAEVDVPIIDKRTAQVIAVTPDTVQIMDMETYEMFEVPLDTGVEEEIKDKIKEGINVEYWETLGRIKIMRIKGEEE q8u124_pyrfu PF1405 protein protein pyrfu Pyrococcus furiosus MTILIKRETMVEEILKEIREKVAQKIPKEAKITEIEFEGPELVIYVKNPEVVMKDGELIKELAKILKKRISIRPDPDVLLPPEEAEKLILEIVPKEAEITNISFDPSVGEVLIEAKKPGLVIGKNGETLRLITEKVRWAPKVVRTPPLQSQTIYLIRQILQTESKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESFVLVDFGINVAALNDPYKAFPHFDAPEFQYVLKEGLLDAIVITHAHLDHSGMLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFVEIQQSNGQEPLYKPKDIKEVIKHTITLDYGEVRDISPDVRLTLHNAGHILGSAIVHLHIGNGLHNIAVTGDFKFIPTRLLEPASYRFPRLETLVMESTYGGANDIQMPREEAEKRLIEVIHQTIRRGGKVLIPAMAVGRAQEIMMVLEEYARVGGIDVPIYLDGMIWEATAIHTAYPEYLSKTLREQIFKEDYNPFLSEIFHPVANSKERQDIIDSNEPAIIIASSGMLVGGPSVEYFKQLASDKRNSIIFVSYQAEGTLGRQVQSGVREIPMIGESGRTEVIKVNMEVHTIDGFSGHADRKELMNYVAKVRPRPERVITVHGEPQKCLDLATSIHKKFGLSTRAPNNLDTIRLR top6b_pyrfu Type 2 DNA topoisomerase 6 subunit B top6B Type II DNA topoisomerase VI subunit B PF1579 protein protein pyrfu Pyrococcus furiosus MAEARDLFKEFKVQSVSEFFRRNAAMLGYTGSIRSLTTVIHEAVTNSLDACEEAGILPYVRVEIEELGKEHYKVIVEDNGPGIPEDYIPHVFGKMLAGTKAHRNIQSRGQQGIGISGAVMFAQITSGKATRVITSTGDDEIVEAWVKIDVQKNEGKIVKKIKHPNPKRWRGTRIELEVKNVKYVRSKQGVYWYLKLTAIANPHAHIELVEPDGKLIVFPRSSEDIPEPPVEMKPHPKGVMTDDVYTMAHRSKRSTVRRFLVSEFSRISDKKVDELVLYIAALRLINREVTDQNLKSQLIERLANGEVEKVLKSFGRKWKKVVEEVEKIMEKPPEKLTWHEAEEIVEAFKLMKFLAPPTYGLRPIGEENIEKGLSSILRPEFVTAVTRPPKVYSGGIPFQVEVGIAYGGEITNSEILRYANRVPLLFDAGSCVITSAVRSIDWRRYRVESFDNAPLVVLVNVVSVHVPYTSTGKQSIASIDEIYNEIRLALMEAARRLAAYLGGKYRRLYQIRRKKIFEKYLPEIARSLHILTGEPEEKIKEYFLRLIESKITVAQEGVSEVEVEEGEA q8u472_pyrfu 3-hexulose-6-phosphate synthase PF0220 protein protein pyrfu Pyrococcus furiosus MASPVDGYYQILWSSKFFSLFSYLSPSDNTTNIKTLKEHPLKQKRVCVMILQVALDLTDIEQAISIAEKAARGGAHWLEVGTPLIKKEGMRAVELMKRRFPDRKIVADLKTMDTGALEVEMAARHGADVVSILGVADDKTIKDALAVARKYGIKVMVDLIGVKDKVKRAKELEEMGVHYILVHTGIDEQAQGKSPLEDLEKVVKAVKIPVAVAGGLNLETIPKVIELGATIIVVGSAITKAKDPEEVTRKIIDLFWDEYMRTIKKAMKDITEHINEVADKLKLEEVRGLVDAMIGANKIFIYGAGRSGLVGKAFAMRLMHLDFNVYVVGETITPAFEEGDLLIAISGSGETKTIVDAAEIAKQQGGKVVAITSYRDSTLGKLADVVVEIPGRTKTDVPTDYIARQMLTQYKWTAPMGTLFEDSTMVFLDGVIAC q8u3d5_pyrfu Indolepyruvate oxidoreductase subunit IorA Indolepyruvate ferredoxin oxidoreductase subunit alpha PF0533 protein protein pyrfu Pyrococcus furiosus MVKVTDIVLWDKPGERVLLLGNQAIVRGALEGNIAVFAAYPGTPSSEVTDTMAAVAKRAGVYMEYSTNEKVAFETALSASWAGLRAMTAMKHVGLNVAMDSFMTVSYMGVNGGFIVMVADDPSMWSSQNEQDTRAIGKFANIPVLEPSSVQEAKDIVKYGFEISEKYGQMVILRTTTRSSHMRGDVVLGELPEEIKQGKRKFGEFKKNPERYVDIPAFQRKKHLWLLETIEKYRKEFESSPFNWIEGDGKVGIIAPGLSYAYVKEALAWLGMENIRILKLGTPFPVPYALLEKFFDGLEKVLIVEELEPVVEEQVKLWAYDNDVRIPIHGKDLVPRVYEMTTRRAVEAIAKFLGVSTPIKFEEIDEKYKKVQEIVPPRPPSLCPACPHRNTFFAIRKAAGPKAIYPSDIGCYTLGVLPPLKTVDTTIAMGGSIGIAHGLSIALNGALSEEQRKTGKEKKVIVATIGDSTFFHTGLPALANAIYNRSNVLIVVMDNLVTAMTGDQPNPGTGETPHGEGRRILIEEVAAAMGADFVAVVDPYDIKATYETIKKALEVEGVSVVVSRRACALYRIGQLRREGKQWPIYQVNEEKCTGCKVCINAYGCPAIYWDAEKKKARVDPLMCWGCGGCAQVCPFGAFEKVREGEL rgyr_pyrfu Reverse gyrase rgy PF0495 protein protein pyrfu Pyrococcus furiosus MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS ndrz_pyrfu Vitamin B12-dependent ribonucleoside-diphosphate reductase rnr Ribonucleotide reductase PF0440 protein protein pyrfu Pyrococcus furiosus MAVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGIRDEKKLDEVVKSIVQRINELYDGKIPHIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINALRVLASRYLKKDENGNIVESPRELFERVAILAVIPDLLYDERVFDKNGNYSQDLKRVEYYLEHFEEFDRKYSIGKYKLNKYHFERMVNLYKELAEQGKMKVSIDEFLAMLEKGEFNEYEKEINEYFRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGGGCIDGKAKIIFENEGEEHLTTMEEMYERYKHLGEFYDEEYNRWGIDVSNVPIYVKSFDPESKRVVKGKVNVIWKYELGKDVTKYEIITNKGTKILTSPWHPFFVLTPDFKIVEKRADELKEGDILIGGMPDGEDYKFIFDYWLAGFIAGDGCFDKYHSHVKGHEYIYDRLRIYDYRIETFEIINDYLEKTFGRKYSIQKDRNIYYIDIKARNITSHYLKLLEGIDNGIPPQILKEGKNAVLSFIAGLFDAEGHVSNKPGIELGMVNKRLIEDVTHYLNALGIKARIREKLRKDGIDYVLHVEEYSSLLRFYELIGKNLQNEEKREKLEKVLSNHKGGNFGLPLNFNAFKEWASEYGVEFKTNGSQTIAIINDERISLGQWHTRNRVSKAVLVKMLRKLYEATKDEEVKRMLHLIEGLEVVRHITTTNEPRTFYDLTVENYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEVDPKTLFEELAYMAWAKADPGVIFFDVINRRNVLKKAKGGPIRATNPCVVGDTRILTPEGYLKAEEIFSLAKERGKKEAVAVEGIAEEGEPYAYSVEILLPGEEKVEYETVHGKVLAVADPVAVPAYVWKVGRKKVARVKTKEGYEITATLDHKLMTPEGWKEVGKLKEGDKILLPRFEVEEEFGSESIGEDLAFVLGWFIGDGYLNVNDKRAWFYFNAEKEEEIAVRIRDILVKHFGIKAELHRYGNQIKLGVRGEAYRWLENIVKNNEKRIPEIVYRLKPREIAAFLRGLFSADGYVDKDMAIRLTSKSRELLREVQDLLLLFGILSKIYEKPYESEFHYTTKNGEERIYRSKGYYELVITNYSRKLFAEKIGLEGYKMEKLSLKKTKVDQPIVTVESVEVLGEEIVYDFTVPNYHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYDKTEYPEGKLPVEGFYHPEIWNLPWDKLVEEIKKYGLRNAMVTTCPPTGSVSMIADTSSGIEPVYALVYKKSVTVGEFYYVDPVFEEELKKRGLYSEELLKKISDNYGSVQGLEEIPEDMQRVFVTALDIHWLDHIIAQASIQMWLTDSASKTINMINEATVEDVKAAYLIARFLGCKGVTVYRDGSLSVQVYSVEGEKKKRRFKPKPSEYAKKILLEIVEKEPWIKNFINVDEILNGKKEQLLFSLRPANESKLKVPGREEEVRPGNIPEEKIRELLGVVYCPVCYEKEGKLVELKMESGCATCPVCGWSKCVIS q8u1k3_pyrfu Aldehyde ferredoxin oxidoreductase PF1203 protein protein pyrfu Pyrococcus furiosus MNVKMVDSMYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEGEKAEKVEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE atgt_pyrfu tRNA-guanine(15) transglycosylase tgtA Archaeal tRNA-guanine transglycosylase PF1046 7-cyano-7-deazaguanine tRNA-ribosyltransferase protein protein pyrfu Pyrococcus furiosus MSRGDSMLRFEIKDRDAAGRIGKLEVNGKKIETPAIMPVVNPKQLIVEPKELKRMGFDIIITNSYIIYKDKKLREKALEKGIHRLLDYDGIIEVDSGSFQLMRYGKVEVTNREIVEFQHKIGVDIGTFLDIPTPPDAPREKAEQDLKITLERAKEAESIKQIPMNATVQGSTYLDLRKLAARKLSEMNFEIHPIGAVVPLLESYRFKDVVDIVIASKMGLRPDRPVHLFGAGHPMVFALAVAMGVDLFDSASYALYAKDDRYLTPQGTKRLEELEYFSCSCPVCSKYTPQELREMPKEEREKLLALHNLWVIREEINRVKQAIKEGELWRLVDERARAHPKLYAAYKRLLEYYHYLEEYEPITKKSAFFKISEESLKWPIARRAKERAEKVKAKFPESIPHPIFGEIPKYLSLTYPFAQSESEEDFQIEKPTRENAILYIMAIAEYQFGEGAGEAFRDAEVEIAKTGMPRQVKKNGKRLATVRAEDGLLTLGIEGAKRLHELLPYPVMRVVVNKEAEPFARKGKDVFAKFVEFADPKIRPYDEVLIVNENDELLATGQALLSGREMVLFSSGRAVKTRRGVEEKK q8u049_pyrfu PF1768 protein protein pyrfu Pyrococcus furiosus MIIRGDEPEQKALLRKLYRAGNYFMMGDEAIAYGAIFAGCRFYAGYPITPSSEIAETMARELPKVGGYYLQMEDEIASIAAIIGASWTGLKAMTATSGPGFSLMQENIGYAVMTETPVVIVDVQRSGPSTGQATKGAQGDFFQARWGTHGDHPIIAVSPISVEDAFWETIRAFNIAEQLRTPVIVLFDGILGHTREQIRIPDPDEVEISYRKLPRNEEEAKLPFGDPHGDGVPPMPIFGKGYFTHVTGSTHKENGLRDVYTPEVHDRLVRRLHKKIEKNRHIYEKYNEYFTDDAEILVVSWGVSARPSLGAVKKAREEGIKAGLFVPKTVHPFPGEKMRELGKKVRAILVPEMNLGQLILEVQRFVNDDVILKGVNKIGGVPITVEEILREIRGVA gapor_pyrfu Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase gor Tungsten-containing glyceraldehyde-3-phosphate ferredoxin oxidoreductase PF0464 protein protein pyrfu Pyrococcus furiosus MKFSVLKLDVGKREVEAQEIEREDIFGVVDYGIMRHNELRTYEVDPYDPRNIVIFGIGPFAGSVLPGSHRLVFFFRSPLYGGLFPSTMGGAGYQFKNVGVDFVEIHGKAEKPTVIILKNDGEKLSVDFYEIELEKLLDVWKEYKGEEGVYALTQYLLDNLASVFEGMEFRIAVVGPAALNTNMGAIFSQALRNGKRAVGSEDWAARGGPGSVLLRAHNVVAIAFGGKKRKREFPGEDISDVKVAKRVVEGIHKKAQRDVINESTVKYRYNPKLNTGGTFGGNYPAEGDLVPVLNWQMPYIPKEERIKIHELIMKYYWEPFNKESIQPKNWTTCGEPCPVVCKKHRKGHHVEYEPYEANGPLSGSIYLYASDISVHAVDAMGFDAIEFGGTAAWVLELVHKGLLKPAEVGISDVPEFTKDDLITKPVEASEKNAKLVAELAHSIAFGKTEVARIIGMGKRKASKILDEKFKDRLSYGESFKDYGVYTPLGDDGEINPTMYWAIGNFIPLPIQGRYWTFYQFGVFLEPEELAQKIVSSALWEFWYDNVGWCRFHRGWMKKVLKALFMEAYGVSIDMEEHAKKQIRKLIDYLKKAGYEPVFWDSMRVIDLVAKGSEEFGNENWAKKFKEDKIGTAKEYLKRVLDAYSQLIGTEWTL rtcb_pyrfu RNA-splicing ligase RtcB 3'-phosphate/5'-hydroxy nucleic acid ligase PF1615 rtcB protein protein pyrfu Pyrococcus furiosus MIILRVVNVAVPLKRIDKIRWEIPKFDKRMKVPGRVYADDVLIEKMRQDRTLEQAANVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDIKEGVISPGGIGYDINCLAPGTKVLTEHGYWLKIEEMPEKFKLQRLRLYNIEEGHNDFSRVAFVAERNIEKDETAIRIVTETGTLIEGSEDHPVLTPQGYVYLKNIKEGDYVIVYPFEGVPYEEKKGIIIDESAFEGEDPQVIKFLKERNLLPLRWEDPKIGTLARILGFALGDGHLGEMGGRLVLAFYGREETLRELKKDLESLGIKANLYVREKNYRIKTESGEYSGKTVLAELRVSSRSFALLLEKLGMPRGEKTKKAYRIPVWIMEAPLWVKRNFLAGFFGADGSIVEFKGTTPLPIHLTQAKDVALEENLKEFLYDISRILEEFGVKTTIYKVNSKKSVTYRLSIVGEENIRNFLGKINYEYDPKKKAKGLIAYAYLKFKESVKKERRKAMEISKKIYEETGNIDRAYKAVKDIVNRRFVERTIYEGERNPRVPKNFLTFEEFAKERGYEGGFVAEKVVKVERIKPEYDRFYDIGVYHEAHNFIANGIVVHNCGVRLIRTNLTEKDVRPKIKQLVDTLFKNVPSGVGSQGKVRLHWTQIDDVLVDGAKWAVDQGYGWERDLERLEEGGRMEGADPDAVSQRAKQRGAPQLGSLGSGNHFLEVQVVDKIFDEEIAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMERAIRKYGIPWPDRELVSVPFQSEEGQRYFSAMKAAANFAWANRQMITHWVRESFQEVFRQDPEGDLGMEIVYDVAHNIGKVEEHEVDGKKVKVIVHRKGATRAFPPGHEAIPKIYRDVGQPVLIPGSMGTASYVLAGTEGAMAETFGSTCHGAGRVLSRAAATRQYRGDRIRDELLRRGIYVRAASMRVVAEEAPGAYKNVDNVVKVVSEAGIAKLVARMRPIGVAKG q9hgz8_pyrfu PF1746 protein protein pyrfu Pyrococcus furiosus MSVILSYNGAFAVTRQNGDMKDGYDGFYIFDTRFLKGVKLKLDKNSVLIGSSQDGPRKAYSHFSIEDEVVLLRKREIKDNWAYREELQFYNTSKRKVHLRVEYSFKVPIEDIFEVRKFGGQKIRRRIKSSLGDENEYSYTGKDKIKRNLKIKTNMRTEKGLAFAEITLEPLEKETLYLEFIPKISKEGLEIFLTEKPLLLPNVVSTNLTWLDRVFERAIEDLTALTAYTNYGMVPFAGIPYYACPFGRDSIITSWFLLPYYPQYAEGTLKFFAKIQGKKFNPLNEEEPGKIPHEFRFGELSHSRKMPFAPYYGTVDATPLYVILAAEYLRWTGDRELIERLKPNLTAAVEWILRRLDEGGGYIRYKGGLLANQGWKDSKEGIPTEEGTPTKPPVALVEVQGYAYKALMDAASLGLTSLDPKMLKKEAEELKKRFNKDFWCDGFYALALDGDNVPSKVVSSNMGHLLFTGIAEHQEKIAERLFEEDMFSGWGIRTLSSKEKAYNPFSYHNGSIWPHDNAVIAIGLASIGEKEKARMLAEAIFKTAKFLPNSQLPELFSGLESEYPLLCPRANAPQAWSAASVFALLTALLGLKAEKELTVSPLLPKNFKVSALVRFRRKAYLIESQEKEVVRFEERDI cca_pyrfu CCA-adding enzyme cca tRNA nucleotidyltransferase tRNA adenylyl-/cytidylyl- transferase tRNA CCA-pyrophosphorylase tRNA-NT PF0026 CCA tRNA nucleotidyltransferase protein protein pyrfu Pyrococcus furiosus MDIEEVIEEALQKIVPKEEEERFVKTLMSEIEEKARETIEELNLNAKPYFVGSLAKNTYLAGDHDLDLFIAFPLDTSLEKLREKGLEAGKVLGKKLGRYELAYAEHPYVRAEYKGVKVDIVPCYDVKSWKDVRTAVDRSILHTKWVIENLKGKNNEVRLFKRFLKGIKAYGSEIYVRGFSGYLAEILVIEFGSFLSVLEKADFMLKKKIIDTGKWMKKESEITMKTIKREAEEDKPLIVIDPVDPRRNVAANLSWERFGLFYFSSMQFLEKPSLEFFFPGEKRGNYREELKRKGTHLVTLLFTPPKLVDDLLLPQVEKTAKGLAKALEIEGFKVFGIDYGRNFIFLEVDRVEKPRIEIKRGPLYFTSHGRRFYEKNEKVWIEGKDLMAEKKVGGFIVEVLEEIFKKGQFSAGKNVKEVIKSSDILIDFVPKPLANEAYLFLSREKFNVKRSTS q8u1h0_pyrfu PF1238 protein protein pyrfu Pyrococcus furiosus MLIRGKVKESKIPKFKHRWFGVLEVEANGETYRLYMSGIAQWFLEGDEVEIKILRPPREKEGIKILEFNDYELYKFYNGEKIKVWPVWEKIYKTKRFSPLTAELLYEYEIRAREATYESDFEAIAELEQYHYASQKEKVALWRCEKCGIIIEANTKPICPKCKTDKHVHILEIKGSTPASRFLLLELVKREEYEPRVLAYVRVDPPIPLMHRKLPNGEIDKNIREKVFPKDCLSLASGRKRLMYELFVELRKKYPKKIARSLLWEKAKERALRESNTAGARIARVVVHPDYRSDGLGQLSVKAALEWIAERRIPEMRKKKHFVETIAQMARYNPFFEKVGFRYVWETASGRPVLIYPLTEEAKEYLENYFKNDPYAPKEPLWKPSYGKVEPLNGPIVFKNVSKVFESELDIKGLPEEIQDLLKAFGVRHRVIQRPVLRNLNFEIKPGEVIVVVGASGAGKTTLLRLILGAIMKYWEEKYRPTNGEIKVPDNAKVSVLIPGEFEPEFGSESILEHVYRKIRDLNAAVEVLNRAGLSDAVLYRAKFSELSTGQKERAKIASLLAEKPNLILIDEFAAHLDTLTAMRVARKVAEIIREAGITAVIITHRPEVVKALDPDRILFVGYGTAIMKDKL q8u444_pyrfu PUA domain-containing protein PF0251 protein protein pyrfu Pyrococcus furiosus MVARVIVDAQAARAIGKGAMIVFKKGVVRTEGEIKPGDIVEVYTRGGKFLGKGFANPNSNIMVRIVTRDKDVEINKELFKERIRKANEYRKKVLKYTNVYRMVYGESDYLPGLIVDRFNDIASLQISSAGMERFKLEVAEAIMEVEPEIETVFEKNTGRSRRREGLPEIERVLLGKEKYRTIIQEGRAKFIVDMRGQKTGFFLDQRENRLALEKWVEPGDRVLDVFTYTGGFAIHAAIAGAEEVIAIDKSPRAIETAKENAKLNGVEDRIKFIVGSAFEEMEKLQKKGEKFDIVILDPPAFVQHEKDLQAGMRAYFNVNFAGLNLVKDGGILVTCSCSQHVDLQMFKDMIIAAGAKAGKFLKMLEPYRTQAPDHPILMASKDTEYLKCLFLYVEDMKH q8u3v4_pyrfu PF0351 protein protein pyrfu Pyrococcus furiosus MDDNKPRRFWFSSKTRGRKFESTNAEGDVTLNFTKFDSLKKFSQELSNVVSQFNKAIRELDIKFEQSGREKEHYPNYPTFDQENSLVFTNEEWAASGKKETWIKALDNFGRWYLGRRRGRKFIDGFRFKFADYTLSHALEKVKEDSIIKTVNSEPLKEKRYYLGLPIRYANYGTTVSGWSGDLPLENKKLKKDNIVHRRASGYWLSLIDINGTIYPTVTVFAYQFYPNYRGAFYFEKQDNKTKARGLIYIYEDNYSAYLFYKRWIENIVQNSDKGKFVVLWPKKS tmbl2_pyrfu Putative HTH-type transcriptional regulator TrmBL2 trmBL2 PF0496 protein protein pyrfu Pyrococcus furiosus MSKDRMVELLQEHFELNLYEARAYVALVAFGVLTPAELASVSEVPAPRTYDVLRSLEKKGFAMTQPGKTNKYRPVHPANVLEKFIQDWQERVKEELEAKKKAKEELLELMAPLIETEVPKYGVERVWVVRGIKNSTLKTKEMLEEAQNEILLADDGFIAVNLEDDIIKAVDRGVKTKILLTKNLLPRLKASKIIDYAKEGKLELRALDKFDLPMLICDEEVFFALEDLAARYFNYETQVWIKDHRVVALFKEKFNEYWEKAEKV top6a_pyrfu Type 2 DNA topoisomerase 6 subunit A top6A Type II DNA topoisomerase VI subunit A PF1578 protein protein pyrfu Pyrococcus furiosus MKLKRGKPKEKFSYDPQKVLKKLEDLAYKILEEVKAGKNPYFDVPTRGLSNVYFDEEARLIKLGDKLSRRYFLNVAHARKFMQTLILMAYVKRLVSEGKHASLREAYYANKHTIPGTHENTFEDQSESDPIIEDLERMLGVLREEMHITADRRGYVYGDIVIKDGEDEFNASKLGMGGWAVPGTVEHIQFPEINVDYVLVVETAAMADRLIEEKYPKRERALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSEKLATPDAKFVGMTMDDIKEYGLEHVTEKLKGIPPDKKGGPTGDYKRLIEELNYPWFQNKEWQRQLKLALKWGVRIEQQALANKSLEFVAKEYLPEKIREGKLLP q8u310_pyrfu PF0666 protein protein pyrfu Pyrococcus furiosus MEAEKEKKLSIPPRGIRAIIEAVRLGEVIKPSQYAKREAFKKHDIKEAWLNRVLTMIFYDIMKKQGLIDKAIKDVVGVTPLILDPWLRAALRVAFDVVLFHDPNQNTLKNLKWKASDFISSKTHPYVGMYYWDIFERILEYKPNPKTELERLEWEYLAPAWLIERVRKLLGDETKAFFEAVNRKHEWISIRVNTLKTTPEEVIKEFEEEGVEVVQSKRIPVVLKIKGPYDFDSSYLFRKGKIIVQEEASAVASVILDPKPGEVVVDLAAAPGGKTTHMAELMKNRGKIFAFDIDKARMKRLKDFVSRMGIKIVKPIVKDARKAPEILGEEVADRVMLDAPCTSSGTIGKNPELRWRLREQKIEEMAQLQRELLESAAKLVKPGGRLLYTTCSIFIEEDEDNVSWFLETYKEFRLVKLSGPYDPGFLEGTMRAWPHRHETIGFFYALFEKVTQ if2a_pyrfu Translation initiation factor 2 subunit alpha eif2a eIF-2-alpha aIF2-alpha PF1140 protein protein pyrfu Pyrococcus furiosus MPRRAREYPEEGELVVATVKRVHNYGAFLDLDEYPGKEGFMHISEVASTWVKNIRDYLREGQKVVAKVIRVDPKKGHIDLSLRRVTQQQRKAKLQEFKRAQKAENLLKLAAEKLGKDFEEAWREVWVPLENEWGEVYAAFEDAARNGIEVLKGYVPDEWLPVLKEIIDSYVEVPTVTIDAEFEITVPKPNGIEIIKEALIKARDRANQEKDIEVKFTYLGAPRYRIDITAPDYYKAEEVLEDIAEEILRVIKEAGGEATLLRKEKRIRKVKKRKK nadb_pyrfu L-aspartate oxidase nadB Quinolinate synthase B PF1976 protein protein pyrfu Pyrococcus furiosus MKVAVVGSGLAGLTAAMSLAKKGIEVTVFGPKPKESNSYLAQAGIAFPISDGDSIISHVTDTIRGGKYLNDVTVVWNVISKSTEAYHFLTSLGIEFTSRELEGGHSFPRIFTIKNETGKYIIPVLEKHAKEMGVNFIRKFAEEVAIHNKKIVGVFVEGELLYFDAVIIASGGFSGLYKFTAGNPWNLGIPIGDLALKGVPLRDIEFIQFHPTGFIGKRTYLISEAVRGAGAKLVTGEGERFVNELETRDVVAREIYRKMLEGKGVFLDATGIEDFKRRFPYIYSFLRREGINPKRDLIPVTPVAHYTIGGISVDIFYRTPIKGLYAIGEAACNGFHGANRLASNSLLECIVSGIEVSRTVIREKPRGERKEAKYHGYEPGNVDEVRDIMWNHAGIIRREESLRLGLKKLEKVEADPRVKILAEAVLKCALAREESRGAHYREDYPYSREEFRRPSIFRVENCML ef1a_pyrfu Elongation factor 1-alpha tuf Elongation factor Tu PF1375 protein protein pyrfu Pyrococcus furiosus MPKDKPHVNIVFIGHVDHGKSTTIGRLLYDTGNIPEQIIKKFEEMGEKGKSFKFAWVMDRLKEERERGITIDVAHTKFETPHRYITIIDAPGHRDFVKNMITGASQADAAVLVVAATDGVMPQTKEHAFLARTLGIKHIIVAINKMDMVNYNQKRFEEVKAQVEKLLKMLGYKDFPVIPISAWEGENVVKKSDKMPWYNGPTLIEALDQIPEPEKPVDKPLRIPIQDVYSIKGVGTVPVGRVETGKLRVGEVVIFEPASTIFHKPIQGEVKSIEMHHEPLEEALPGDNIGFNVRGVSKNDIKRGDVAGHTTNPPTVVRTKDTFKAQIIVLNHPTAITVGYSPVLHAHTAQVPVRFEQLLAKLDPKTGNIVEENPQFIKTGDAAIVILRPMKPVVLEPVKEIPQLGRFAIRDMGMTIAAGMVISIQRGE sys_pyrfu Serine--tRNA ligase serS Seryl-tRNA(Ser/Sec) synthetase PF1204 Seryl-tRNA synthetase protein protein pyrfu Pyrococcus furiosus MLDINLIRNNPELVKNDLKKRGELDKIAWIDEILRLDEEWRKKLKEINRLRHERNKIAIEIGKRKKAGEPVEDLLAKSKEIVKRIEELEKEVEELRKRIDYYLWRLPNITHPSVPVGKDENDNVPIRFWGKAKVWKGHLESFLEQSQGKMEYEVLEWRPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIEKGFTPVIPPYMVRRFVEEGSTTFEDFEDVIYKVEGEDLYLIPTAEHPLAGMHANEILDGKDLPLLYVAFSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWHERLVRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGRFREVVSASNCTDWQARRLNIRFRDRTDEKPRYVHTLNSTAIATSRAIVAILENHQQEDGTVKIPRALWKYTGFKEIVPVEKKEGCCKA q8u3c3_pyrfu cobW domain-containing protein PF0547 protein protein pyrfu Pyrococcus furiosus MAEKKRRRVVILGAAGRDFHNFNVFFRDNPDYEVVAFTATQIPDIEGRIYPPELAGELYPNGIPILPEDDLEKIIKEHDVDIVVFAYSDVSHEHVMHLASRAHSAGADFWLLGPKSTMLKSSKPVVAVTAVRTGCGKSQTSRKVAQILQEMGFKVVAVRHPMPYGDLRKQVVQRFATFEDLDRYECTIEEREEYEPYLERGMVVYAGVDYEKILREAEKEADIILWDGGNNDFPFFEPDLWIVVTDPHRPGHELTHHPGETNFRSADVIIINKIDTAPPENIQKIRENIEKINPNAIVIEAASPIFVDKPELIKGKRVLVVEDGPTLTHGGMSFGAGYIAAKKFGAKEIVDPRPYAVGSIIETYKKYPHLSNILPAMGYGKKQIKELEETINRADADVVVMGTPVDLRRFMNLNKPAVRVKYELEEIGKPKLRDVLEEWVKKCEKLKK cmr1b_pyrfu CRISPR system Cmr subunit Cmr1-2 cmr1-2 CRISPR type III-B/RAMP module RAMP protein Cmr1-2 PF0352 protein protein pyrfu Pyrococcus furiosus MYEAIFDLEAITPLFMRGADARSPEFSSASVKGVMRWWFRALAGGYFGNNIEALKEVEEKIFGSTRNKSRVFVRAEVEDVKKGNIYRQASSWADKTIIVWSEYVDYFFFSVLDKRRNRKTKKIDIKTRFEYFDVGSKFSISLSSTDERYFRLAEASLWMTINLGGFGFRARRGAGSLKVQMLREMLL cmr1a_pyrfu CRISPR system Cmr subunit Cmr1-1 cmr1-1 CRISPR type III-B/RAMP module RAMP protein Cmr1-1 PF1130 protein protein pyrfu Pyrococcus furiosus MFIEEFEIESITSTHLLEVLTREYPEVRSPSIKGAMRWWFRALAGSYFGDDAQKLKEIENQVFGSTKERSRVKISVTPLSSPKRLNLKEFKDKNVGYIWFSINLLGKRGTITHYYPPGSRFRVVLESPSERVIKLATLSLWALVSLGSVGFRSRRGTGSMKIVRASSEVLEDLGLTTEFNSIDEFKDSLKRVLDVTGEILGVKNSETNKSLPSYATLKFSDVEVFGPGKNTWEVLAQFNNSYKEYLRRRIKKYQRIIFGLPRFKLRGVRKDLRRASPLWFGVVEIGGKPYGRIIKFFQSTFHPEVRSKHIVDWNVLSNFDWFISSRLPVTKVWGGWSG cmr4_pyrfu CRISPR system Cmr endoribonuclease Cmr4 cmr4 CRISPR type III-B/RAMP module RAMP protein Cmr4 Target RNase Cmr4 PF1126 protein protein pyrfu Pyrococcus furiosus MKAYLVGLYTLTPTHPGSGTELGVVDQPIQRERHTGFPVIWGQSLKGVLRSYLKLVEKVDEEKINKIFGPPTEKAHEQAGLISVGDAKILFFPVRSLKGVYAYVTSPLVLNRFKRDLELAGVKNFQTEIPELTDTAIASEEITVDNKVILEEFAILIQKDDKGILESVVKAIEQAFGNEMAEKIKGRIAIIPDDVFRDLVELSTEIVARIRINAETGTVETGGLWYEEYIPSDTLFYSLILVTPRAKDNDMALIKEVLGKINGKYLQIGGNETVGKGFVKVTLKEVTNNGGTHAK cmr3_pyrfu CRISPR system Cmr subunit Cmr3 cmr3 CRISPR type III-B/RAMP module-associated protein Cmr3 PF1128 protein protein pyrfu Pyrococcus furiosus MIEVTFTPYDVLLFRESRPFDAGSESVARSIIPLPQTVAGAIRTLLFYKGLKNCVGVGEEEPEFTLVGIAIGTEKGRIYPLPFNIIKSEKFYKVVNPGRFLGKLILPPKGKYKSGYVTESILEKYLKGELKEVEENKVIRIEKEKRIGIKLSREKKVVEEGMLYTVEFLRIEKIYAWIEDPGCGIKDILSSYEFLTLGGESRVAFVEVDDKTPDIFNRELGSTKKALFYFSTPTIGKVGEIVQELEKRLNAKIDDYLLVSSRPTAISGWDMHEKKPKGTKFAIPPGSVLFVEFKEEVEVPPYIKLGKLKKLGYGLALGGIWE cmr2_pyrfu CRISPR system Cmr subunit Cmr2 cmr2 CRISPR-associated protein Cas10/Cmr2, subtype III-B PF1129 protein protein pyrfu Pyrococcus furiosus MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNIQYSRTDKVKQADALSSKTQRFIIRTKENKEPVIDFLGRSSGKYFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFYPVKLKEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSALSVKDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKIEEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSKKLKNKKEIDEEKVKEVVDFLNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHPNIRDYVEIPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHPLYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKKLLEEKGGVGKRFIYHVLREVDTWPKVGIDEMLKFEVIRHIRGRNKEETKELREKIYGEIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP cmr5_pyrfu CRISPR system Cmr subunit Cmr5 cmr5 CRISPR type III-B/RAMP module-associated protein Cmr5 PF1125 protein protein pyrfu Pyrococcus furiosus MEVHMLSKDNKKSIRKTLEQRRGEYAYYVIKEVADLNDKQLEEKYASLVKKAPVMILSNGLLQTLAFLLAKAETSPEKANQILSRVNEYPPRFIEKLGNDKDEHLLLYLHIVYWLRENVDRNIDVKTLLSQDYSKVLWATKEAIALLNWMRRFAVAMLKEEGKENEGSS cmr6_pyrfu CRISPR system Cmr subunit Cmr6 cmr6 CRISPR type III-B/RAMP module RAMP protein Cmr6 PF1124 protein protein pyrfu Pyrococcus furiosus MKEVVKLVLLGERQNSLNLSLYFNKYPPTIIYPEVLEDRNKKLASPSGSQRKISLLVLNQGVLQFNKIKETIEKSLPIETKVKLPQKAYELYKKYYQDYTDMLNSLHAITGKFKTQSRLVVGLGDESVYETSIRLLRNYGVPYIPGSAIKGVTRHLTYYVLAEFINEGNDFYKRAKTVQDAFMKGDPKEILSNAKVPERCSRLCKEFLRIFGEKKVPEIIDELIRIFGTQKKEGEVVFFDAIPIAEEIADKPILELDIMNPHYGPYYQSGEKNVPPPGDWYDPIPIFFLTVPKDVPFLVAVGGRDRELTEKAFSLVKLALRDLGVGAKTSLGYGRLVEYV pora_pyrfu Pyruvate synthase subunit PorA porA Pyruvate oxidoreductase alpha chain Pyruvic-ferredoxin oxidoreductase subunit alpha PF0966 protein protein pyrfu Pyrococcus furiosus MPIRKVMKANEAAAWAAKLAKPKVIAAFPITPSTLIPEKISEFVANGELDAEFIKVESEHSAISACVGAAAAGVRTFTATASQGLALMHEILFIAAGMRLPIVMAIGNRALSAPINIWNDWQDTISQRDTGWMQFYAENNQEALDLILIAYKVAEDERVLLPAMVGFDAFILTHTVEPVEIPDQEVVDEFLGEYEPKHAYIDPARPITQGSLAFPAHYMESRYTVWEAMERAKKVIDEAFAEFEKKFGRKYQKIEEYKTEDADIIFVTMGSLAGTLKEWIDKKREEGYKVGAAKITVYRPFPVEEIRELAKKAKVLAFLEKNITIGLYGAVFTDASAALINESEKPLMVDFIVGLGGRDVTFNQLDEALEIAEKALKEGKVENPINWIGLRWELVK smc_pyrfu Chromosome partition protein Smc PF1843 smc protein protein pyrfu Pyrococcus furiosus MPYIEKLELKGFKSYGNKKVVIPFSKGFTAIVGANGSGKSNIGDAILFVLGGLSAKAMRASRISDLIFAGSKNEPPAKYAEVAIYFNNEDRGFPIDEDEVVIRRRVYPDGRSSYWLNGRRATRSEILDILTAAMISPDGYNIVLQGDITKFIKMSPLERRLLIDDISGIAEYDSKKEKALEELKQAEENLARVDLLIKEVKKQLDKLEKERNDALRYLDLKDKLEKAKVSLLLGEIKILETQIKEGEKRRAEIEEEIQKIEKEIEKIGKEIVEKVKVLREIEERIEKESGEEAIQITKKIGEVTSKIELTKRNIEVAKEELEDAQRRLAKTKEELRKVLSEIEKSKGAITRWKKRRDALINEIKKKEEERNVLVVKLGEIDKTFGAAREEFDSVVKELEETTRKMYEIEGNIRRLQEEKEKLHSRILFLRAKLPGIKEKINEFKAVVEDKRAEISEIEGKLSTIQAKRIKVEKEIEAKSNELEKVSKELESSERELIAAEAQREVRGNRAAEELKRSGIGGIYGTLAELIKVKDEAYALAIEVALGNRADNVVVEDELVAEKAIKYLKEHKLGRLTFLPLNKIKPKHVDSSVGLPAVDVIEYDQKIENAVKFALGDTVIVNSMEEARPHIGKVRMVTIEGELYERSGAITGGHFRARGLAVDTTKLREKVESLRRRKEALEGELNSLKIELRSLENASFELRIKLSDEKKELELASKDLNRLLEEENAVKEEIEESERKIQEIEQKIENEKSELAKLRGRIQRLERKKEKLKKALENPEARELMEKIRIIDGEISSLKEELSRIESRIESLESRLNEELLPRKASLEEEIEGLVNKINALKNNISENEKALELLNKELEKLKSIEENIKGEIRTLREKRKKLEEDISKLREKKEVLQRKLQELEIEANTLKVRDAQLNAQLEEKKYQLTHYDKNLIKSIKEIPLDLEKVKKEIEKMEEEIRSLEPVNMKAIEDFEIVERRYLELKSKREKLEAEKESIIEFINEIEKEKKNVFMRTFEAISRNFSEIFAKLSPGGSARLILENPEDPFSGGLEIEAKPAGKDVKRIEAMSGGEKALTALAFVFAIQKFKPAPFYLFDEIDAHLDDANVKRVADLIKESSKESQFIVITLRDVMMANADKIIGVSMRDGVSKVVSLSLEKAMKILEEIRKKQGWEHGN lysj_pyrfu Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase lysJ PF1685 protein protein pyrfu Pyrococcus furiosus MSLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAGPMFDHEEKYEMLEELEKFVTYEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGRTMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAITTETAAVIFEPIQGEGGVVPANEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSLTLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGKGLMIGIVMKKPVAKVVEELQNRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVINDIYGRKN alba_pyrfu DNA/RNA-binding protein Alba albA PF1881 protein protein pyrfu Pyrococcus furiosus MAEEHVVYIGKKPVMNYVLAVITQFNEGAKEVSIKARGRAISRAVDVAEIVRNRFLKDTVDIKEIKIGTEELPTADGRTTNTSTIEIVLERKV syfb_pyrfu Phenylalanine--tRNA ligase beta subunit pheT Phenylalanyl-tRNA synthetase beta subunit PF0990 protein protein pyrfu Pyrococcus furiosus MPKFDVAKSDLERLVGREFSVEEWEDLVLYAKCELDDVWEEDGKIYFKLDSKDTNRPDLWSAEGVARQIRWALGLAKGLPKYEVEESDVVVYVDKKLRNIRPYGVYAVVEGLKLDEEALSQLIQLQEKVALTYGRRRREVAIGIFDFDKVKPPIYYRAAEKTEKFVPLGYSEEMTLEEILEKHEKGREYGHLIRDKPYYPLLVDSEGNVLSMPPIINSELTGRVTTETKNVFVDVTGWDLRKVMLALNVIVTALAERGGKIKRVKVIYPDFEITTPDLTPKEFEVSFEYIRKLSGLELSNEEIKELLERMMYEVEILSENKAKVKYPAFRDDIMHTRDVLEDVLIAYGYNNIDPEEPKLAVQGRGDPFKDFEDAIRDLMVGFGLQEVMTFNLTSKEVQFDKMNIPEEEIVEIANPISSRWSALRKWLLPSLMEFLSNNTHEEYPQRIFEVGLATLIDESRETKTVSEPKLAVALAGSGYTFTNAKEILDSLMRHLGIEYDIEETVHGSFIPGRVGKILVDGKEIGIIGEIHPQVLENWNIQVPVVAFEIFLKPLYR lysy_pyrfu Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase lysY PF1683 protein protein pyrfu Pyrococcus furiosus MIKAAVVGASGYIGGELVRLLAMHPEVEITAITSRQYAGKKVHKVHPNLRGLDLRFTNDYNFDADVIFLAVPHGTSMKIIEEFLGSAKIIDMSADFRIKKELYEKYYGPHEKPELIDRFTYGLPELHRKEIKKAELVANPGCNATATILGLYPFKDLTQEAIVDLKVSSSAGGRRENIASIHPERSNVVRVYKPYHHRHEAEVLQETRVKAMFTVHSVDLVRGLLATIYFRYEGNERELLRKLLMYKDEPFVRIVTDKGGLQRYPDPKYVIGSNFIDIGFAYDSENSRVMVFSAIDNLIKGGAGQAVQNMNIMFGLKETTGLEYYPVYPV q8tzz6_pyrfu PF1827 protein protein pyrfu Pyrococcus furiosus MKVKTIMTPNPVTITLPATRNYALELFRKHKVRSFPVVNKEGKLVGIISIKRVLTNVDEEQLAMLVKRDVPTVKPDDTLKKAAKLMLEYDYRRVVVIDEEGKPVGILTVGDIIRRYLAKSEKYKDVEIEPYYQRYVSVVWRGTPLMAALKALLLSNAMALPVIDDDGKLIGIVDETDLLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEKFELKLPNKPVEDIMTRDVIVATPHMTVHEVARKMVKYKIEQLPVIRGDGDLVGLIRDFDLLKVLVK tmbl1_pyrfu HTH-type sugar sensing transcriptional regulator TrmBL1 trmBL1 PF0124 protein protein pyrfu Pyrococcus furiosus MLEEEILQKLQKFGLTKYESLAYLTLLKLGPSKATDVTKESGIPHTRIYDVLSSLARKGFVDIVHGTPRLYAPVNPEIVLEKIREDLISDIERLKKAFQELYREVHGEELPEIWTVHGFENTIDRAQHIIRSAKHDILINTPYEFLEYLRGVLEKRNDVLIIVISNFSEIPLWLRNKNNVILARSGQAPWLLGTWVIGDINYALFFGTLPEDKGKERFYSFWVKSTRLIQNYVHWFYTMYFDNSEIVKPLNYERMEKPLTLSHIRTVITVLKQAGLPRNIEVIGRSLADKKQVTIKGKVIDYEYTPLTANITVKTDNKKIKVGGLGSYLEDIEGESFILLD if2g_pyrfu Translation initiation factor 2 subunit gamma eif2g eIF-2-gamma aIF2-gamma PF1717 protein protein pyrfu Pyrococcus furiosus MGEKRKTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEIRRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGASLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALENYRQIKEFIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRDSNKPPKMLVLRSFDVNKPGTPPEKLVGGVLGGSIVQGKLKVGDEIEIRPGVPYEEHGRIKYEPITTEIVSLQAGGQFVEEAYPGGLVGIGTKLDPYLTKGDLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQELNVEPIKRKEVLLLNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSRWRLIGYGIIKE if2b_pyrfu Translation initiation factor 2 subunit beta eif2b eIF-2-beta aIF2-beta PF0481 protein protein pyrfu Pyrococcus furiosus MEIDYYDYEKLLEKAYQELPENVKHHKSRFEVPGALVTIEGNKTIIENFKDIADALNRDPQHLLKFLLREIATAGTLEGRRVVLQGRFTPYLIANKLKKYIKEYVICPVCGSPDTKIIKRDRFHFLKCEACGAETPIQHL syfa_pyrfu Phenylalanine--tRNA ligase alpha subunit pheS Phenylalanyl-tRNA synthetase alpha subunit PF0989 protein protein pyrfu Pyrococcus furiosus MLGYNEKLVLLKLNEVKKARIEELVKLTGLEQVAIMRALLTLEKEGLAKISERKERIIRLTDLGRKYIQMGLPEIRALNVLKSKKKVKLDELRGVLTEDELKPIVGILRKEGWVKVEKTPEGLVLEITERGENPEERPIDKALKILSEKEYATSEEISKIVPINELKRRKVAQEEEVVERIAEITEKGVELVKKGIELKREVTSLTPELIASGKWREVEFKPFNIKAPVKKIYPGKKQPYRVFLDKIRRKLIEMGFIEITVDSLIETQFWNFDALFQPQNHPAREWTDTYQLKYPEKGYLPNRELVERVKEAHERGLAGSRGWGYVWSPERAMFLMPRAHATALSARQLAKGIEIPGKYFTIQRVFRPDVLDRTHLIEFNQIDGFVAAEDLTFRHLLGILKKFAIEIAGAKKVKFFPDYYPFTEPSVQLSAYHPELGWVEFGGAGVFREEMTKALGIDVPVIAWGIGIDRLAMFRLGIDDIRYLFSYDLKWLREAKLIW psirna701 P. furiosus psiRNA 7.01 rna ribonucleic acid RNA rna pyrfu Pyrococcus furiosus CUGAAGGUGCUCUCAGCCGCAAGGACCGCAUACUACAA q8u4i5_pyrfu KaiC domain-containing protein PF0102 protein protein pyrfu Pyrococcus furiosus MPLQPIRRVKSGIPGFDELIEGGFPEGTTVLLTGGTGTGKTTFAAQFIYKGAEEYGEPGVFVTLEERAKDLRREMAAFGWDFEKYEKEGKIAIIDGVSSIAGIPSEEKFVLEDRFNVENFLRYVYRVVKAINAKRLVIDSIPSIAMRLEEENRIREVLLKLNTILLEMGVTTILTTEAPDPQHGRISRYGIEEFIARGVVILDLQERNIELKRYILIRKMRGTRHSMKKYPFEIGPNGIVVYPSGEIY y1931_pyrfu UPF0273 protein PF1931 PF1931 protein protein pyrfu Pyrococcus furiosus MVRRVKTGIPGMDEILHGGIPERNVVLLSGGPGTGKSIFSQQFLWNGLQMGEPGIYVALEEHPVQVRQNMAQFGWDVRKYEEEGLFAMVDAFTAGVGKSKEYEKYIVHDLTDIREFIEVLRQAIRDINAKRVVVDSVTTLYINKPAMARSIILQLKRVLAGTGCTSIFVSQISVGERGFGGPGVEHGVDGIIRLDLDEIDGELKRSLIVWKMRGTSHSMKRHPFDITDKGIIVYPDKVLKRGRIYEL q8u1g3_pyrfu PF1245 protein protein pyrfu Pyrococcus furiosus MRNLRPLDLTEKKKKKVRIYFEGKELEAYEGEKLPVALLANGIYWLTTSLEGRKRGAFTFGPVPMIINGVKGVDARKTKVKDGMKVQRQTYGDFHEEPLPQDGEVKQVVVDVLVIGGGPAGLGAVLEMQEHLNVALVEEKGWLGGDMFLKTSTAEGFEESSRKVVDKLAKEVKANVYLGTVALGVFDKGEYFLVPATKGNNLIEFLAKRVVLATGAVDNIMLFENNDMPGVFRRDFALEVMNVWEVAPGWNVAVTGSKAEEVIYELERWGIDYVEVPSVKRVEGKEKVEKVIDFNGNEYKVDAIIFADGKRPDINPITQAGGKLHFRRGYYRPVVNEYNQIREGVYVAGSAVTIKPHYTNYLEGRLVGAYILREFGIDSEPCIYKEKLKEFEPEALPVPKIPINKLNLDDVQICGCDVSLRKVYDVVEKGITDLQIIKRLTHLAMGFCQGRFCLFNGAAVVSQVTGIKLGEIDLPVARPPIKTVKLGILSRR trm1_pyrfu tRNA (guanine(26)-N(2))-dimethyltransferase trm1 tRNA(guanine-26,N(2)-N(2)) methyltransferase tRNA 2,2-dimethylguanosine-26 methyltransferase tRNA(m(2,2)G26)dimethyltransferase PF1871 protein protein pyrfu Pyrococcus furiosus MSMELFEVHEGKAKVLVPKAKTIYDSPVFYNPRMAPNRDVVVLLLNVLKPKIVLDALSATGIRGIRFALETPAEEIWMNDINELAYELMKKNVLLNFKGTLKENAKRAIFEGEKTIVINNDDANRLMAEKHRYFHFIDLDPFGSPMEFLDTALRSVKRKGILGVTATDGAPLCGAHPKACLRKYLAVPLRGELCHEVGTRILVGVIARYAAKYDLGMEVLLAYYKDHYFRAFVKLKDGAKKGDETLENLGYVYFDEKTGRFEVEKSFLSTRPNAYGPLWLGPLKNEKVVGEMLELLVSGFEVANYREVLKLLHMLHEELDIPLFYDTHALGKRLKIEPKKLGEIIKELKSMGYEATRTHFSPTGIKTNAPYEVFVEVMRKN q8u487_pyrfu Glutamine amidotransferase type-2 domain-containing protein PF0204 protein protein pyrfu Pyrococcus furiosus MLKYRDEKDISACGIFGIMDRKGRRFNGKLVIEAMSQMKVRGNGLGAGFAVYGLYKKFKEYYAFHVMIYDKDGREKLEKFLSTNFDIVYVDEIPVNDKAKVIDPPKFMRYFVAPRKKGTEKVLNDDDFVVKKVMYINRAIPGVYVISSGKNMGVFKGVGFPEDIADYFMIEEYKGYIWTAHTRFPTNTPGWWGGAHPFSILDWSVVHNGEISSYGTNKRYLEMYGYYSTLQTDTEVITYIFDLLVRRQGLPIEVVSKILAPPMWEEIDRMPEKEKKFYKALRMVYSPILLNGPWAIIVARHGEMIGLTDRIRLRPLTVAEKKSFLIISSEEAPIRYLFRDVDRIYTPYGGELVVGKLEEDIKKFVGESQ q8u0n8_pyrfu PF1548 protein protein pyrfu Pyrococcus furiosus MSESINNITKPKERRDFVVMAGMRKDGTIDFIKVYALNEKLAIEVLEAFLKENNIHPSDFIVIQRGYEDVKDKKAITTRSEEELSAMLGRLGLRLVSNGVLYTDGIDKLYQITAISRELFESLQKEKREIFEDVQEKITFNFSKVDLPEKYVKKLRLLELMEDTIIFNMAELEIPNLLKAIVEGTVLIPRFLEKEDLIIRIFDEELHEYRGSYFDKVLIKPPIIHWDFYLDSLEDFSFKKVEESIYIAPLFLRATGGFLILTEPPEDLVKTLLKLKKRGEVRTILEGKRITIPINFTLIVDTRHPERYAGLKFPIRINLPPLDDETFLKVLETNLGITPPTEIVRIFPPDYKTFLGVELIKNLFEKLKLTEKGKDEVSLLKEAATIITGGTP rad50_pyrfu DNA double-strand break repair Rad50 ATPase rad50 pfRad50 PF1167 protein protein pyrfu Pyrococcus furiosus MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS q9p9k5_9eury protein protein 9eury Pyrococcus furiosus MVRRIRRWDIWDPFDLIREIQEEIDAMFDEFFSRPRLWTYRRWSEPAMYEERVGEVWREPFVDIFDNGDEFVITAELPGVRKEDIKVRVTEDTVYIEATVKREKELEREGAVRIERYFTGYRRAIRLPEEVIPEKAKAKYNNGVLEIRVPKKHPTKKESEGFEVKVE q8u4c6_pyrfu PF0162 protein protein pyrfu Pyrococcus furiosus MEINEFISQLKLGETVLVEHSSYSKPELLFYGIIKESRMPVVIDDILDTLFEYYNKLKVWGYDLTVFDKVYVIKAGGNEVIGNLLGKLEVGKYVIEAREYTKIIKEVNPPIINPVLGVHKLILLGNLLENLRLLKEISTYVGNENRVAIYFVNRDVVESHSPAALKLLEEISTSVFQLNEENKIKRMK cmr2-syfa-1 Purification by gel filtration 866712 n/a 866715 unspecified role unspecified role neutral component neutral component n/a 866716 unspecified role unspecified role neutral component neutral component n/a 866717 unspecified role unspecified role neutral component neutral component n/a 866718 unspecified role unspecified role neutral component neutral component n/a 866719 unspecified role unspecified role neutral component neutral component n/a 866720 unspecified role unspecified role neutral component neutral component n/a 866721 unspecified role unspecified role neutral component neutral component n/a 866722 unspecified role unspecified role neutral component neutral component n/a 866723 unspecified role unspecified role neutral component neutral component n/a 866724 unspecified role unspecified role neutral component neutral component n/a 866725 unspecified role unspecified role neutral component neutral component n/a 866726 unspecified role unspecified role neutral component neutral component n/a 866727 unspecified role unspecified role neutral component neutral component n/a 866728 unspecified role unspecified role neutral component neutral component n/a 866729 unspecified role unspecified role neutral component neutral component n/a 866730 unspecified role unspecified role neutral component neutral component n/a 866731 unspecified role unspecified role neutral component neutral component n/a 866732 unspecified role unspecified role neutral component neutral component n/a 866733 unspecified role unspecified role neutral component neutral component n/a 866734 unspecified role unspecified role neutral component neutral component n/a 866735 unspecified role unspecified role neutral component neutral component n/a 866736 unspecified role unspecified role neutral component neutral component n/a 866737 unspecified role unspecified role neutral component neutral component n/a 866738 unspecified role unspecified role neutral component neutral component n/a 866739 unspecified role unspecified role neutral component neutral component n/a 866740 unspecified role unspecified role neutral component neutral component n/a 866741 unspecified role unspecified role neutral component neutral component n/a 866742 unspecified role unspecified role neutral component neutral component n/a 866743 unspecified role unspecified role neutral component neutral component n/a 866744 unspecified role unspecified role neutral component neutral component n/a 866745 unspecified role unspecified role neutral component neutral component n/a 866746 unspecified role unspecified role neutral component neutral component n/a 866747 unspecified role unspecified role neutral component neutral component n/a 866748 unspecified role unspecified role neutral component neutral component n/a 866749 unspecified role unspecified role neutral component neutral component n/a 866750 unspecified role unspecified role neutral component neutral component n/a 866751 unspecified role unspecified role neutral component neutral component n/a 866752 unspecified role unspecified role neutral component neutral component n/a 866753 unspecified role unspecified role neutral component neutral component n/a 866754 unspecified role unspecified role neutral component neutral component n/a 866755 unspecified role unspecified role neutral component neutral component n/a 866756 unspecified role unspecified role neutral component neutral component n/a 866757 unspecified role unspecified role neutral component neutral component n/a 866758 unspecified role unspecified role neutral component neutral component n/a 866759 unspecified role unspecified role neutral component neutral component n/a 866760 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 1E, Supp. Table 1 A number of prokaryotic silencing (psi)RNAs were purified with this complex pf1130-pf1128-1 RNase activity of a reconstituted CMR complex 866713 n/a 866761 enzyme target enzyme target substrate substrate neutral component neutral component n/a 866748 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) n/a 866749 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) n/a 866745 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) n/a 866747 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) n/a 866746 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) n/a 866744 unspecified role unspecified role neutral component neutral component ecoli Escherichia coli (strain K12) rna cleavage rna cleavage false false false It is unclear which of the subunits has catalytic activity so the biological role 'enzyme' could not be assigned. 5A psiRNA cleaved at 2 sites to generate 14- and 20-nucleotide 5′ end-labeled products. pf1130-pf1128-2 Affinity purification by hydroxy apatite chromatography 866714 n/a 866762 unspecified role unspecified role neutral component neutral component n/a 866763 unspecified role unspecified role neutral component neutral component n/a 866764 unspecified role unspecified role neutral component neutral component n/a 866765 unspecified role unspecified role neutral component neutral component n/a 866766 unspecified role unspecified role neutral component neutral component n/a 866767 unspecified role unspecified role neutral component neutral component n/a 866751 unspecified role unspecified role neutral component neutral component n/a 866768 unspecified role unspecified role neutral component neutral component n/a 866769 unspecified role unspecified role neutral component neutral component n/a 866756 unspecified role unspecified role neutral component neutral component n/a 866770 unspecified role unspecified role neutral component neutral component n/a 866745 unspecified role unspecified role neutral component neutral component n/a 866749 unspecified role unspecified role neutral component neutral component n/a 866747 unspecified role unspecified role neutral component neutral component n/a 866746 unspecified role unspecified role neutral component neutral component association association false false false Supp. Table 1