IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ farhoud-2005-1 Protein complexes in the archaeon Methanothermobacter thermautotrophicus analyzed by blue native/SDS-PAGE and mass spectrometry. metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum bn-page blue native page bn-page de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Farhoud MH., Wessels HJ., Steenbakkers PJ., Mattijssen S., Wevers RA., van Engelen BG., Jetten MS., Smeitink JA., van den Heuvel LP., Keltjens JT. Archaea - Interaction dataset based on Archaea proteins M. thermautotrophicus (DSM1053) was cultured in a 12-liter fed-batch fermentor containing 10 liters of medium. Cells were cultured under two different conditions. In one treatment cells (MCR 1) were cultured in N medium (15) at 65 �C with a gas flow of 2.0 liters/min of 80% H2, 20% CO2 (v/v) and harvested at an optical density at 600 nm of 5. In the other treatment (MCR II) cells were grown at 55 �C with a gas flow of 5.0 liters/min of 80% H2, 20% CO2 (v/v) and harvested at an optical density at 600 nm of 1.8. Table 1. Table 2. Figure 1. Figure 2. P.Steenbakkers@science.ru.nl Mol. Cell Proteomics (1535-9476) 2005 adhs_metth 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase aroA' MTH_579 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MIGKRIRIERIINRKTDRTVIVPLDHGVSIGPVRGIIDMAGTIDEVASGGANAVLMHKGMVRSGHRGYGRDIGLIIHLSASTGLGPDPNHKVLVTSVEKALKLGADAVSVHVNVGSEREPEMLIKLGTVAEICDDWGMPLIAMMYPRGKKIDDEHDPEVVKLAARAGAELGADIIKTNYTGDPDTFRDVVKGCPVPVVIAGGPKIETEEELLQMVSDSVEAGGAGVAIGRNIFQADSPANMTGAIAGIVHDGLSVEEAVRILKGGE o26729_metth MTH_632 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MITVTGDITVDWIQWSVKGDSDVSEFNWKNHLGFKRKALEGGALLTARMLKNFTEVNHPSIGDEPGNTDPSEFIHSFAELKATGDGYHVKKFMGYTGPDSGLPSMPFSLKEHESPIIVIDDAGNGFREMEERWPSQIMGGDPLIVLKMSSPLFRGSLWEHLLEEHPEKLIVIITADDLREHGANITRRLSWERTAEDFIWQMENNRSLEDLRDLNVVVRIGLEGAINYNRGDVRLFYHPQFFEGDLTERAPGKMQGCGSAFTAAFTAALSEGREMDECIRRGITAAARLLERGFSSEPDYPISDVFMSADDEIGAVEIPQHPRGLWTIASSPPLFDIESVSRYIVINGYSRKKCPLPVAHFGKLITADRREIEGYQSIRNLMVEYMKNDNPERPLCIGVFGPPGAGKSFAVSQLAASVDPERIKHLNFNISQFRCEDDLIDAFHQIRDAVLEGMVPQAFFDEFDSPIGEKKLGWVKYFLAPMQDGEFREGDSMHPLGKCILVFAGGTSSTFQEFESQDPEVLKEAKVRDFISRLRGYVNIIGPDPQHRRDKFFMLRRAILLRSMFERKAPHLFDASGRLRIDEGVLNAFLMIPEYRHGVRSMEAILDMSILQDVRKFEKASLPSAGQLDLHVDGELFHRMAMD hem2_metth Delta-aminolevulinic acid dehydratase Porphobilinogen synthase hemB MTH_744 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSDNMEFPTKRMRRLRKSPQIRNILRETRLHPSDLIYPMFVSEKLGRGDVEAIDTMPGQFRYSVDDAVSEASRLEDEGLSSVLIFGMPSAKDELASAAHDPHGVVQRTVRRLKEETDLVVMTDVCLCQYTSHGHCGIVVDGEIVNDETLEVLSRIALSHAEAGADVVAPSDMMDGRVAAIRRSLDDAGFQDTLIMSYAVKYASAFYAPFRGAVSSAPAFGDRRSYQMDPANIDEALIEAELDLREGADILMVKPALAYLDVIGKVRERFSVPLAAYNVSGEYSMLKAAIKSGYLTDEAIYESILSIKRAGADLIISHFAPDLLGVI fpaa_metth Type A flavoprotein FprA Flavoprotein A fpaA fprA MTH_1350 FMN protein FprA protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MKARAEKIADGLYWTGVLDWDIRNYHGYTLQGTTYNAYLVFGDEGVALIDNSYPGTFQELMARMEDAFNREGREMRVDFIVQNHVERDHSGVLVELHRRFPEAEIHCTEVAVEGLLKHYPALEGTEFRTVKTGDSIDLGGRTLTFLEAPLLHWPDSMFTFLDTGILFSNDAFGQHLCYPQRLDTEIPEYILMDAAKKFYANLITPLSKLVLRKFDEVKELGLLDKIGMIAPSHGQIWTEPMKIIEAYTAWATGKVKKKVTVIYDTMHHSTAMMAHAIAEGAMSEGADVRVYYLHEDDRSEIVKDILDSHAIALGAPAIYDEPYPSVGDLLMYLRGLKFNRTGQRRAMVFGSMGGRGGATGTMQKLLADAGFDVMEADEIYYVPNNEELDACFEAGRRLAGDLNE risb_metth 6,7-dimethyl-8-ribityllumazine synthase ribH MTH_1390 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDEIDAVITLGAVIEGATDHDQIVVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDYAKRAVEAAVKMYRRLKEDI mtd_metth F420-dependent methylenetetrahydromethanopterin dehydrogenase Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase MTH_1464 mtd protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDRDFVIFISPNPGAPGPAKARELLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGKAPELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKLAVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE trpb2_metth Tryptophan synthase beta chain 2 trpB2 MTH_1476 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MMNKIVLDENEIPKKWYNINPDLPSPLPEPKNPEGGKNIENLPRVFSRGVLEQEMSMERWIKIPREVMDVYKMIGRPTPLFRAKGLEEMLDTPARIYYKREDYSPTGSHKLNTAIAQAYYARKDGAERLTTETGAGQWGTALSLACSLMDLQCKVYMVRVSFNQKPFRKTIMQLYGGEVVPSPSNHTEFGRRMLKEDPEHPGSLGIAISEAMEEALQEENVYYSLGSVLNHVLLHQTVIGLETKKQLEIAGETPDIMIGCVGGGSNFGGAIFPFVKDKLDGKLDCEFIAAEPKSCPTLTAGEYRYDFGDTAGMTPLLKMYTLGHDFVPPSVHAGGLRYHGMSPQVALLVREGVINARAVPQHTIFESGVKFAKAEGVVPAPETCHAISVAIDEARKCRETGEEKTIVISFSGHGLLDLKGYGDYLEGKI o27556_metth MTH_1512 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQILMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKEIKNLMGGKAAEGTIRRCMRKMFE mcrb_metth Methyl-coenzyme M reductase I subunit beta Coenzyme-B sulfoethylthiotransferase beta mcrB MTH_1168 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAKFEDKVDLYDDRGNLVEEQVPLEALSPLRNPAIKSIVQGIKRTVAVNLEGIENALKTAKVGGPACKIMGRELDLDIVGNAESIAAAAKEMIQVTEDDDTKVELLGGGKRALVQVPSARFDVAAEYSAAPLVTATAFVQAIINEFDVSMYDANMVKAAVLGRYPQSVEYMGANIATMLDIPQKLEGPGYALRNIMVNHVVAATLKNTLQAAALSTILEQTAMFEMGDAVGAFERMHLLGLAYQGMNADNLVFDLVKANGKEGTVGSVIADLVERALEDGVIKVEKELTDYKVYGTDDLAMWNAYAAAGLMAATMVNQGAARAAQGVSSTLLYYNDLIEFETGLPGVDFGKVEGTAVGFSFFSHSIYGGGGPGIFNGNHIVTRHSKGFAIPCVAAAMALDAGTQMFSPEATSGLIKEVFSQVDEFREPLKYVVEAAAEIKNEI mcrg_metth Methyl-coenzyme M reductase I subunit gamma Coenzyme-B sulfoethylthiotransferase gamma mcrG MTH_1165 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAQYYPGTSKVAQNRRNFCNPEYELEKLREISDEDVVKILGHRAPGEEYPSVHPPLEEMDEPEDAIREMVEPIDGAKAGDRVRYIQFTDSMYFAPAQPYVRSRAYLCRYRGADAGTLSGRQIIETRERDLEKISKELLETEFFDPARSGVRGKSVHGHSLRLDEDGMMFDMLRRQIYNKDTGRVEMVKNQIGDELDEPVDLGEPLDEETLMNKTTIYRVDGEAYRDDTDAVEIMQRIHVLRSQGGYNPE mcra_metth Methyl-coenzyme M reductase subunit alpha Coenzyme-B sulfoethylthiotransferase alpha mcrA MTH_1164 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MADKLFINALKKKFEESPEEKKTTFYTLGGWKQSERKTEFVNAGKEVAAKRGIPQYNPDIGTPLGQRVLMPYQVSTTDTFVEGDDLHFVNNAAMQQMWDDIRRTVIVGLNHAHAVIEKRLGKEVTPETITHYLETVNHAMPGAAVVQEHMVETHPALVADSYVKVFTGNDEIADEIDPAFVIDINKQFPEDQAETLKAEVGDGIWQVVRIPTIVSRTCDGATTSRWSAMQIGMSMISAYKQAAGEAATGDFAYAAKHAEVIHMGTYLPVRRARGENEPGGVPFGYLADICQSSRVNYEDPVRVSLDVVATGAMLYDQIWLGSYMSGGVGFTQYATAAYTDNILDDFTYFGKEYVEDKYGLCEAPNTMDTVLDVASEVTFYGLEQYEEYPALLEDQFGGSQRAAVVAAAAGCSTAFATANAQTGLSGWYLSMYLHKEQHSRLGFYGYDLQDQCGASNVFSIRGDEGLPLELRGPNYPNYAMNVGHQGEYAGISQAPHAARGDAFVFNPLVKIAFADDNLVFDFTNVRGEFAKGALREFEPAGERALITPAK mcry_metth Methyl-coenzyme M reductase II subunit beta Coenzyme-B sulfoethylthiotransferase beta mrtB MTH_1132 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MPMYEDRIDLYGADGKLLEEDVPLEAVSPLKNPTIANLVSDVKRSVAVNLAGIEGSLKKAALGGKSNFIPGREVELPIVENAEAIAEKVKRLVQTSEDDDTNIRLINNGQQILVQVPTTRMGVAADYTVSALVTGAAVVQAIIDEFDVDMFDANAVKTAVMGRYPQTVDFTGANLSTLLGPPVLLEGLGYGLRNIMANHVVAITRKNTLNASALSSILEQTAMFETGDAVGAFERMHLLGLAYQGLNANNLLFDLVKENSKGTVGTVIASLVERAIEDRVIKVASEMKSGYKMYEPADWALWNAYAATGLLAATIVNVGAARAAQGVASTVLYYNDILEYETGLPGVDFGRAMGTAVGFSFFSHSIYGGGGPGIFHGNHVVTRHSKGFALPCVAAAMCLDAGTQMFSVEKTSGLIGSVYSEIDYFREPIVNVAKGAAEIKDQL mcrz_metth Methyl-coenzyme M reductase II subunit gamma Coenzyme-B sulfoethylthiotransferase gamma mrtG MTH_1130 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MTYKAQYTPGETQIAENRRKHMDPDYEFRKLREVSDEDLVKVLGHRNPGESYKSVHPPLDEMDFEEDIVRDMVEPIQGAKEGVRVRYIQFADSMYNAPAQPYDRARTYMWRYRGVDTGTLSGRQVIEMRELDLEGVSKELVETELFDPATTGIRGATVHGHSLRLDENGLMFDALQRYVFDEEKGHVVYVKDQVGRPLDEPVDMGQPLGEDELKKITTIYRKDNIAMRDDKEAIEVVENIHTGRTMGGFGMDVFKDDLRKRLGDD mcrx_metth Methyl-coenzyme M reductase II subunit alpha Coenzyme-B sulfoethylthiotransferase alpha mrtA MTH_1129 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MDEKKLFLTALKKKFEVEDPDEKYTNFYCFGGWEQSARKKEFTEYAKKAAEKRGGIPFYNPDIGVPLGQRKLMAYRVSGTDAYVEGDDLHFVNNAAIQQMVDDIKRTVIVGMDTAHAVLEKRLGVEVTPETINEYMEAINHALPGGAVVQEHMVEVHPGLVEDCYAKIFTGDDNLADELDKRILIDINKEFPEEQAEQLKSYIGNRTYQVNRVPTIVVRTCDGGTVSRWSAMQIGMSFISAYKLCAGEAAIADFSYAAKHADVIEMGTIMPARRARGPNEPGGVAFGTFADIVQASRVSDDPAKISLEVIAGAAALYDQVWLGSYMSGGVGFTQYATAAYTDDILDDFVYYGMEYVDDKYGICGTKPTMDVVRDISTEVTLYSLEQYEEYPTLLEDHFGGSQRAAVAAAAAGCSTAFATGNSNAGINGWYLSQILHKEAHSRLGFYGYDLQDQCGASNSLSIRSDEGLIHELRGPNYPNYAMNVGHQPEYAGIAQAPHAARGDAFCTNPLIKVAFADKDLSFDFTSPRKSIAAGALREFMPEGERDLIIPAGK o27599_metth MTH_1557 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHIAGAKVNVGRMYRPEDSRRDAEKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPLLARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDACAAYASWLLRATKGYAIKIVNPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGNYETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRNDHVVIDVGQITLDETTTMTADGPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVPAVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIAWLMSNKYRMNLIEGELHKWAQRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPSADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKFKQYYSVNFANYPVQDEYLPKSAPVKGVML o27601_metth MTH_1559 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MEVIIMEYVKNVVCPFCGTLCDDIICKVEGNEIVGTINACRIGHSKFVHAEGAMRYTKPLIRKNGEFVEVSYDEAIDKAAKILAESKRPLMYGWSCTECEAQAVGVELAEEAGAVIDNTASVCHGPSVLALQDVGYPICTFGEVKNRADVVVYLGCNPMHAHPRHMSRNVFARGFFRERGRSDRTLIVVDPRKTDSAKLADIHLQLDFDHDYELLDAMRSCLLGHEILYDEVAGVPREQIEEAVEVLKNAQFGILFFGMGITHSRGKHRNIDTAIMMVQDLNDYAKWTLIPMRGHYNVTGFNQVCTWESGYPFCVDFSEGEPRYNPGETGANDLLQNREADSMMVIASDPGAHFPQRALERMAEIPVIAIEPHRTPTTEMADIIIPPAIVGMEAEGTAYRMEGVPIRMKKVVDTDLLSDREILEKLLEKVREYKASK fwdc_metth Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C Tungsten-containing formylmethanofuran dehydrogenase II subunit C fwdC MTH_1558 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSEIILTPKEQPEVPLEAPNIKPDVFAGKSIDEIRNIQIMHGNEVVKLGDFFEVSGEPADSAADIKIIIDGDVYNTKRIGQDMTAGEILVKGNVNMYVGAGMKGGKITVEGNAKSWAGQDMRGGELEIFGDAGDYVGSSYRGDWRGMSGGVITVHGNAGNEIGEYMNGGKIIIKGDVNIMPGIHMNNGLIIIEGNAVARVGGEMAGGTIVVKGMIEEFLPGFKYLGVEKDIEVNGETFPGAYYKFEGDHAIKGAKGMVYAAVGCNGHIEP mtrh_metth Tetrahydromethanopterin S-methyltransferase subunit H N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H mtrH MTH_1156 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MFRFDKEQIVLDIAGTKIGGQPGEYPTVLAGTIFYGGHSIIEDEKAGVFDKDKAEALIKTQEEMSDVTGNPHIVQTFGQTPEAIVKYLEFVGDVTDAPFFIDSTSGEARIAGANYASEVGLEDRAIYNSVNMAADEAELEALKETKLSASIVLGFNPMDPTVDGKIGIWEDGAGTIDKGLLEMAAECGIDKYLMDVAVTPLGQGAGVAVRTSFAVKSKWGYPVGSGIHNVPSAWDWLREYKKDHKEAWPVCDVGSNLIQQMAGGDFVLYGPIENAKMAFPACAMADIFISEAAKDIGTEPVEDHPFFKLL mtre_metth Tetrahydromethanopterin S-methyltransferase subunit E N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E mtrE MTH_1163 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MDPMITGLGVVALMGAAATIAGAAEDLESDVGSQSNPNSQVQLAPQMGHLHRIINKAVSGEPVAYGTWCGIAGSVAYVLMQSMQLPVIMAIAVGAVIAAMVHTTYAVTSHMGRIVSQSQFNQPLFMDMLVQHLGPIAGHGFIVTFCIVGLSYLMTLPIPGFAHPFPLPLLAVLWGITIGAIGSSTGDVHYGAEREYQQYPFGGGIPVAIHGDITTKAELGARNSMDVVHFCAKYGGPLTGFAFGAIVFLSFWNTIVFGITGGIISGLIIVLLLIILNNRLEVFARNRYGPYKEDE mtrd_metth Tetrahydromethanopterin S-methyltransferase subunit D N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D mtrD MTH_1162 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MDPLLLIGAITAGGVLIGGGVHFVPVGGAPAAMATATGVGTGTAMLAAGAGLTGLITAAAMTGQSPLMIMAAGAVGSMLMIGITMLVGNLIYVYGVGTVPVSAKVAVDPLTGMEQEKYVTPGTEGHGLPTVCFVSGIIGGALGGIGGGLIYWALNEALKTLSYGAIGAAGVAAIFAVGIFFINAVIASYNIGGTIEGFHDPKFKRIGRGIVACLIASIVAGALSTLLVYGGVF mtra1_metth Tetrahydromethanopterin S-methyltransferase subunit A 1 mtrA1 N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit A 1 MTH_1159 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MVEKKSPAEGWPVVNGDYIVGDPESPVAATTLASHIEDVPVEAGAAIAGPCKTENLGIEKMIANLISNPNIRFLILCGSEVQGHITGQSIEALHQNGVDPDKRNIIGATGAIPYIENIPDEGIERFQKQLEIVNLIDVEDADAIKAKVKECIEKDPGAFEEEAMVIKVEEGGEEEEGEEVKPVAPETALIEARMRNIQTQVKMIGSTNRMFAGMYSGKVQGIMIGLAFTLTLGILLLV mtrg_metth Tetrahydromethanopterin S-methyltransferase subunit G N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G mtrG MTH_1157 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSEEDKTTIPRVLVSADEFNKANERLDDIEEKVEFTVGEYSQRIGQQIGRDIGILYGIVIGLIILAVTNILFAGLLKGLLKSLFGL mtrf_metth Tetrahydromethanopterin S-methyltransferase subunit F N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit F mtrF MTH_1158 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MIILSNKPNIRGIKRVVEDIKYRNQLIGRDGRLFAGLIATRISGIAIGFLLAVLLVGVPAMMSILGVI mtrc_metth Tetrahydromethanopterin S-methyltransferase subunit C N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C mtrC MTH_1161 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSVAAGGPAGAAIPESRLMALGIIGGLGGIYASTVNPVIGPVFASLGAVCAIIWGADAIRRVASYGLGTGVPSIGYMSVSIGIVGVVAGLASVFTLPALAAPVVGLILAMILGVVVAVLGKKIVKMKIPILEKCTAEISGAAALSVLGFSAAIAGSYTMQAVLTSVIATGFIGLLFILNTMAIQHPFNACLGPNENQTRTLKLAASTGFISMAIAGLLGIGLNPGWWLVSLVGALCWVVAFKSFVSASFEEAASVKWSGLWPKEEEQ hdra_metth H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit A hdrA CoB--CoM heterodisulfide reductase iron-sulfur subunit A MTH_1381 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAEEKKEETMEEPRIGVYVCHCGVNIGGVVDIEAVRDYAAKLPNVVVSKDYKYYCSDPGQLEIQKDIKELGLNRVVVAACSPRLHEPTFRRCVEEAGLNQFLFEFANLREQDSWVHMDDPEGATEKAKDLVRMAVAKARLLEPLEASKVSVDDKALVIGGGVAGIQTALDLADMGFKTYMVEKRPSISGRMGQLDKTFPTLDCSMCILAPKMVDVGKHDNIELITYAEVKEVDGYIGNFKVKIEKKPRYIDEDLCTGCGSCVEVCPIEMPNYFDEGIGMTKAVYIPFPQAVPLCATIDKDYCIECMLCDEICERGAVKHDQEPEEIEIEVGTIIVATGYDAYDPTEKLEYGYGRHTNVITGLELERMINASGPTDGKVIKPSDGEKPKRVAFIHCVGSRDEQIGKPYCSRVCCMYIMKNAQLIKDKMPDTEVTLYYMDIRAFGKGFEEFYKRSQEKYGIKFIRGRPAEILENPDLTLTVRSEDTLLGKVTEYDYDMVVLGVGLVPPEGSEKLRQTIGLSKSADGFLMEAHPKLRPVDTLTDGVYLAGVAQGPKDIPDAVAQASGAAARAAIPMVKGEVEIEPIVAVTDSDVCGGCEVCIELCPFGAISIEEGHANVNVALCKGCGTCVAACPSGAMDQQHFRTEQIMAQIEAALNEQAK hdrc_metth H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit C hdrC CoB--CoM heterodisulfide reductase iron-sulfur subunit C MTH_1878 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MTLLQREENIIRKGNIDKEFSEKIKAAGGDSLEYCFQCGTCTGSCPSGRRTPYRVRQIIRKANVGLKDEIISDPALWMCTTCYSCQERCPRKVKIVDVVKLARNEAAKAGFMAPAHKAVGSFVIKTGHGVPINDATMELRKAVGLGELPPTTHQFPEALEEVQKIIKATGFDQLIGYNWETGELE hdrb_metth H(2):CoB-CoM heterodisulfide,ferredoxin reductase subunit B hdrB CoB--CoM heterodisulfide reductase subunit B MTH_1879 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MEIAYFLGCIMNNRYPGIEKATRVLFDKLGIELKDMEGAFCCPAPGVFGSFDKTTWAAIAARNITIAEEMGSDVMTECNGCFGSLFEANHLLKEDEEMRAKINEILKEAGREYKGEINVRHLAEILYNDVGLDKLSEVVEKPLNLNVAVHYGCHFLKPSEEINIDNPERPTILDELVEVTGAKSVDYKDKMMCCGAGGGVRSRDLDVALDFTMEKLRNMKEAGVDAIVNVCPFCHLQFDVGQMEIKDKFGEEFDIPVLHLAQLLGLAMGLPKEDLVVDAHQVCVDECLEKLEELDRLAPGSG mvha_metth F420-non-reducing hydrogenase subunit A Methyl viologen-reducing hydrogenase subunit alpha mvhA MTH_1134 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MVKLTMEPVTRIEGHAKITVHLDDAGNVEDTRLHVMEFRGFEKFLQGRPIEEAPRIVPRICGICDVQHHLAAAKAVDACFGFEPEDVLPAAYKMREIMNWGSYMHSHGLHFYFLAAPDFIAGKDRKTRNVFQIIKDAPDIALQAIELRKNALELVRATGGRPIHPTSSTPGGISTELDDETQKDLLKKAQRNVELAEATLELAVPIFEENIDLVNSLGNIETYHTGLVKDGVWDVYDGIVRIKDKEGNMFREFKPADYADTIAEHVKPYSWLKFPYIKDLGYPDGVYRVSPLSRLNVADKMPDAAPKAQEHFKEFRENFGYAQQTLLYHWARLIELLACAECAADALEGDLSGEKFPDSLERQAGDGVGIVEAPRGTLTHHYTCDENGLITKANIVVATIQNNPAMEMGIQKVAQDYIKPGVEVDDKIFNLMEMVIRAYDPCLSCATHTIDSQMRLATLEVYDSEGDLVKRI mvhg_metth F420-non-reducing hydrogenase subunit G Methyl viologen-reducing hydrogenase subunit gamma mvhG MTH_1135 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAEKIKIGTMWLGGCSGCHLSIADFHEKIIDVMEHADFEFSPVLMDTKYDEIPELDVVIIEGGIVNDENREFAEELREKAKFVISYGTCAVYGGIPGLRNLWDKDEVIEEAYINSITTPNEEGVIPSEDVPHLEGRVKPLGEVIDVDFEVPGCPPRSDVAAEAVMALLTGEEIELPETNLCEVCPREKPPEGLAMDFIKRQFEVGKPEDDLCLIPQGLICMGPATVSICGAECPSIAIPCRGCYGPTARVEDQGAKMISAIASDYKVEEDKTVDPEEVAEQLDDIVGTFYTFTLPAALIPMKIQKEGK mvhd_metth F420-non-reducing hydrogenase iron-sulfur subunit D Methyl viologen-reducing hydrogenase subunit delta mvhD MTH_1136 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAEDDIKIVMFCCNWCSYGGADTAGTARMQYPTNIRVIRVMCSGRIEPQFVLKAFREGADGVLVTGCHHGDCHYDAGNYKLDRRMRLIYKLADELGIGRERIHHDWISASEGEKFAETVKMMVNRIKDLGPSPIKKQLAEA frhg_metth Coenzyme F420 hydrogenase subunit gamma 8-hydroxy-5-deazaflavin-reducing hydrogenase subunit gamma frhG MTH_1298 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAEENAKPRIGYIHLSGCTGDAMSLTENYDILAELLTNMVDIVYGQTLVDLWEMPEMDLALVEGSVCLQDEHSLHELKELREKAKLVCAFGSCAATGCFTRYSRGGQQAQPSHESFVPIADLIDVDLAIPGCPPSPEIIAKAVVALLNNDMEYLQPMLDLAGYTEACGCDLQTKVVNQGLCTGCGTCAMACQTRALDMTNGRPELNSDRCIKCGICYVQCPRSWWPEEQIKKELGL frhb_metth Coenzyme F420 hydrogenase subunit beta 8-hydroxy-5-deazaflavin-reducing hydrogenase subunit beta frhB MTH_1297 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MVLGTYKEIVSARSTDREIQKLAQDGGIVTGLLAYALDEGIIEGAVVAGPGKEFWKPEPMVAMTSDELKAAAGTKYTFSPNVLMLKKAVRQYGIEKLGTVAIPCQTMGIRKAQTYPFGVRFVADKIKLLVGIYCMENFPYTSLQTFICEKLGLNMELVEKMDIGKGKFWVYTQDDVYTLPLKETHGYEQAGCKICKDYVAELADVSTGSVGSPDGWSTVITRTDSGDSILKQAVEAGIFETKPIEEVKPGLGLLEKLSAQKKEKAEKNIAARKEMGLPTPY frha_metth Coenzyme F420 hydrogenase subunit alpha 8-hydroxy-5-deazaflavin-reducing hydrogenase subunit alpha frhA MTH_1300 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSERIVISPTSRQEGHAELVMEVDDEGIVTKGRYFSITPVRGLEKIVTGKAPETAPVIVQRICGVCPIPHTLASVEAIDDSLDIEVPKAGRLLRELTLAAHHVNSHAIHHFLIAPDFVPENLMADAINSVSEIRKNAQYVVDMVAGEGIHPSDVRIGGMADNITELARKRLYARLKQLKPKVDEHVELMIGLIEDKGLPKGLGVHNQPTLASHQIYGDRTKFDLDRFTEVMPESWYDDPEIAKRACSTIPLYDGRNVEVGPRARMVEFQGFKERGVVAQHVARALEMKTALARAIEILDELDTSAPVRADFDERGTGKLGVGAIEGPRGLDVHMAQVENGKIQFYSALVPTTWNIPTMGPATEGFHHEYGPHVIRAYDPCLSCATHVMVVDDEDRSVIRDEMVRL vatf_metth V-type ATP synthase subunit F atpF MTH_956 V-ATPase subunit F protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSSNIAVVGDRDTVTGFRLGGVREGYVVETPDEAEETIRNLIRDGFSIIIVTEKIGDELREFIEETTSSSALPMIIEIPDKTGPSERETDPLRDLIKRVIGVEMVK vatd_metth V-type ATP synthase subunit D atpD MTH_953 V-ATPase subunit D protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAQEMIEGINPTRMELLKLKQREKLAVKGYSLLKEKRNALIMEFFNILERVKGSREKVEEHLKEAFSDLTEAQVLMGDTAVERAAMSVRESVEVDIDSRSIMGVVVPVVDARATQRTVVERGYGLVDTSVKLDEAARKFEESLALIIELGEIEKTIRLLAGEIESTKRRVNALEHIIIPRLKNTVKYIEMRLEEMERENFVRLKMIKKSMEME vatb_metth V-type ATP synthase beta chain atpB MTH_954 V-ATPase subunit B protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MNVNIKTREYTTVTEVSGPLMIVEGVEGVAYSEIVEIETPTGEKRRGQVLEVREDLAVVQVFEGTSDLNTETTKIRFTGETAKIGVSLDMMGRIFDGTGKPIDGGPEIIPEKELDINGSPMNPAAREFPAEFIQTGISTIDGMNTLVRGQKLPIFSGSGLPHNELAAQIARQAKVLAEESEFAVIFAAMGITHEEANYFMRDFERTGALERVTVFMNLADDPAIERIITPRMALTTAEYFAFEHDMHVLVILTDLTNYCEALREISAAREEVPGRRGYPGYMYTDLASLYERAGRIVGKEGSITQMPILVMPQDDITHPIPDLTGYITEGQIVLSRDLHRKGIYPPVDVLPSLSRLMSGGIGEGRTREDHSGVSDQLYSAYAEGRDLRDLMAVVGEEALTERDRKFLKFADEFEKRFITQARDEDRSIEETLNLGWELLSLLPRSELKRVREEHIPKYLPGAE vata_metth V-type ATP synthase alpha chain atpA MTH_955 V-ATPase subunit A protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MTQEGRIIKIAGPVIIAEGMRGSQMYEMVKVGEDKLIGEIIELEGDTATIQVYEETAGIKPGETVERTGGPLSVELGPGILGSIFDGIQRPLENIKALTGDYIERGVDVPSLPKDKKWTFKPTAREGQMVKGGDIIGEVEETSSITHRIMIPPNVEGKLTMIAPQGEYTVLDDIAEVETESGTEKIQMLQKWPVRKGRPYKKKLDPDVPLVTGQRAQDTFFSVAKGGTAAIPGPFGSGKTVTQQQLAKWADADIIVYVGCGERGNEMTEVLKEFPELEDPKTGNPLMDRTVLIANTSNMPVAAREACVYTGITIAEYFRDMGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVTTIGSEDKIASVSVVGAVSPPGGDLSEPVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYIDSVQEWWASNVDPEWRKFRDEAMALLQKEAELQEIVQLVGPDALPDRERITLETTRMIREDFLQQNAYHEVDTYCSPSKQFEMLRTIIMFHRNATAALEKGAPAADIISLPVKEDIGRMKYIPEEEFPARIKEIQERIVKECSEV vatc_metth V-type ATP synthase subunit C atpC MTH_957 V-ATPase subunit C protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MADSITTIVTALGFPSIESFIGVLLLGGAIIGAIVVIATIRPILDLFPFAYPNARVRARIGRLLNEKQLSEILETESMEEFKNYLRGLPDYAKYIDRFPIEKALESQLAETYEMVSQIAPASIRDPFRANLKRWDVRNIKSLITAKAAGLSAEETVNLLVPGGEVYEIIEGLADASSVQEVVTGLEATEYAGVLEDALSGYEETGMLLPIEAALDRKFLEGLIRTVGSPSDDNTKILHTYFGTMVDISNLKIILRAKADGLSYDDISPYIVPHGYQIREWKLKDLMESEDVSGVVSGLEGTDYGQMLSEALSEYTSTGSVAVFERVLEDNLNRMARNFALKKPFGVGPMIGFLSRKEVEVKNLKVIARSKREPGFPEAMVKEMLA vati_metth V-type ATP synthase subunit I atpI MTH_960 V-ATPase subunit I protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSDMFLPARMRKLKIITLDQYSDSVVRSLHEEGVTQIDDISERIQQDAEWRQILKPSRATPYTGRVSSLLMKTSGILDFLGSVAAEEKGLRDTIREFINPPIFEKREVEELDTESLIERAEETLGRVESETRVMEEKLNELDSERSAVESSLSVAEKLKDFDIDFSDLQDSEYITGIAGRITAENLPELRDKLADITDELVISDREGENKAERILIIVTLKKHADSIASVLRRMEFERFEISELQGRPSEIISSSKTRLEEISRERKEIISKLRDINAEWEDELLVLREQLEIEKERNEVFSLFGETRKTVMLEAWVPLKEADRVIAVVEESSEGTALTDLEDPDPEEVPVLLDNPRFAKPYETFVEMYSPLKYNEIDPTIFMAFVFPFFFGFCLTDAGYGIIDALIGFILYRGLGKVNNFMRNFGIIMMSCGVWAFILGMVTNGFIGDFFPRFFNITLPTVIPAIDAFVNPQNILIMALTVGVLHINFGLILGARNNIRLGNMREALGSQIVWLILELGIILYLVGGMIFGAPLIILAFAMLLYYNGLFGLMDVSGFLGTLLSYARLLALCLSTGGIAMTVNILTGLSYEMIPVIGVVLAPIIFVFGHIANNAFQSLGAFINSLRLHYVEFFAQFYMGGKNKFNAFRAERNFTKIRR vate_metth V-type ATP synthase subunit E atpE MTH_958 V-ATPase subunit E protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MSSGAEKIVSSIMSEAQAKADAIIREAEDEAAGIVDEGEKRARMASERILESARKQADMRYQQIISEAKMNARRAELEAREEVIQEAFKKAEEELKNLASTSQEEYVSALRGMIKEAAVEIGGGDLVVSMREDDRSLDLGLDKIAAEVEAETGKKTTLKVGDSIRTIGGAVVRTEDGLIEVNNTIEARMSRFRKALRSEVARVLFE o27042_metth MTH_961 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MIHMTTISEAITTIKKAENDADRLIQEAREKSSQLLDDARNRSAELLEKAEREASEKGDEIIAEAEERARKEAIEISGKAKREVETMKSAAMGKVPEAASIIVKSIL acda_metth Acetyl-CoA decarbonylase/synthase complex subunit alpha cdhA ACDS complex carbon monoxide dehydrogenase subunit alpha MTH_1708 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMKLLERYEPFYAPFCDMCCLCTYGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPATLGDLREVMDYAEEQMSHLLSACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDTEKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQLRFIRSGVADVIVVDEQCVRTDVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDIDEIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDEKYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYIVVTTGCGAMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGIPVVLGPHGSKYRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMKLSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER acdb_metth Acetyl-CoA decarbonylase/synthase complex subunit beta ACDS complex acyltransferase cdhC MTH_1710 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MFEDIPVDVSPMHEGERIRSANMFVELAGPKSIGAELVQVKDEVEDGKVEVKGPEIDEMEQGQVYPFAINVEVAGSELEEELESVIERRLHELCNYVKGFMHLNQRDQIWCRVSTEAKDAGFRLEHLGKALSVLFREEFPIIESIAVTLMTDEAAVQEFLETAREKYETRDSRARELSDEDVDVFYGCLMCQSFAPTHVCIVTPDRTALCGAINWFDCRAAYKMDPDGPIFEIEKGEVLDPERGEYANVNAAVEENSQGTTDRVYLHSVFGYPHTSCGCFEAVAFYIPELDGIGIVNRDFRGETPLGIPFSAMAGQCSGGKQVEGFSGLSLEYMRSPKFLQADGGYHRVIWMPRELKESVLEFIPEDVRDKIATEEDATSIKDLRRFLRDNEHPVLERAAVEETEPEEEEVEEAYPEETPIPEGVPVMAAPEMTLPAAGGFRIVLKNAKIYAEKVIIKRK acdg_metth Acetyl-CoA decarbonylase/synthase complex subunit gamma ACDS complex methyltransferase Corrinoid/iron-sulfur component large subunit cdhE MTH_1713 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPAVKEITFGPEENQVVVGGDEVLYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFERTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLCTFDVEAMKAALEVLGDQKPLLYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEGIGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYADILILAGTEIWEIMPVLTLRQGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYYTVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVADLIKETGIEERVRDKVMIIPGLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE y793_metth Uncharacterized protein MTH_793 MTH_793 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQEHISSLIADHAGLTPIPSTRVEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVDPTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTREQLAMVSVINHENASNNPRAQFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQASGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVEKGEGGRAFEDGMTRIDGDIPVNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEGAEIGMTHNIGGTGGTAAVHIFSR y792_metth UPF0219 protein MTH_792 MTH_792 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEAARNALRRSQIDPSEIGAVYVGSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTAGIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAGGAAYVIGGKNCLADIKETYSFTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPNGKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSGAGSDAFIIEVNDLIEERRDLAPSVAEIIKNKRYVDYALYAKFKGKLRMA syfb_metth Phenylalanine--tRNA ligase beta subunit pheT Phenylalanyl-tRNA synthetase beta subunit MTH_770 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MPVITFDYDDLKELGIDIDREKLLDVLPMMGSDIEDFDDESIKVEFFPNRPDLLSVEGVARSLRGFLGIEKGMPSYDVHDSGVEVTVDESVLDVRPYLGMAVIEDVQFTDKKLKQVMEFQEDLHWVIGRDRRKVAIGIHDLDRVEPPFLYSGVEPEGVTFTPLDSVCEMTPHEILEEHPKGVSYAHLLRDHDRYPLITDKNGDVLSMPPIINGELTKLTVNTRRILVDVTGTDDRAVRQTLNIICTSFAEAGGRIGSVRVKRPDGELHLPDLTPREMRVSVSEASRITGLELSADEVMDLLMKARMDARRTSDDEVVAVIPAYRVDILHEVDLVENIAVQHCIGRIEPELPDIATIAEEDTWSRADASIREVMVGLGFQEVMSLMLTSEESHYRRMRLEEDERVEVAQPISQDRTMIRKSLLNGLLEFFEDNKHEDLPQKIFEVGDVVYINPESETRSRVVTKLACAVTHSSAGFTEIKSLAAAVVENLGYEFRIEPLEHPSFIEGRCAAIESEGKSSAIGGFFGEVHPEVVTNFNLEYPVIALEIEFK syfa_metth Phenylalanine--tRNA ligase alpha subunit pheS Phenylalanyl-tRNA synthetase alpha subunit MTH_742 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MMDLDRIIDQLHIYEKKVLKAFEGSDKPLKPEEIAESQKIDIKSVMSASGALESRGFVRVMKDADEVVSLTEDGESCAREGLPERRLIEALKGEEELEMSELSRRAGLDKKEAGIGIGWLMRKGWGRISQGMVSAVSDETPERGADERLLELLLERGSVRIRELPDELRGALKDLKGRKGIVDIRKIKRHTIELTTEGRKLLERGIEIVEEATQVTHEHLKSGAWRKLHYRGYNIDAEYPLVYPGKMHPLRRIIDEIRSIFLKLGFTESRGPIVESAFWNFDCLFQPQDHAAREMQDTFYVKNPAVTDLPCEDLVRAVQDAHETGGSTGSEGWQYEWDRDVARQSVLRTHTTCVSARFLSENEPPLKMFSVGRVFRRETITYKHLPEFHQVEGIVAGDEVNFRNLLGILREFYRKLGFEVRFRPAYFPYTYLSTECEIYLPEKKSWIELGGAGMFRPEVLEPLGVETPVAAFGLGIERLAMIRFDIKDIRMLYQSDLGWLRGLPVTGDLEL o27217_metth MTH_1149 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MLLEITDLAVEVSGKQVLKDIDLYIDRGETHVLLGPNGSGKSTLFMTILGFPKYRVTNGQIIFKGEDITDLSTTERVRMGIGVSFQNPPAIRGVKLMDLLKVESGLETEDELTPELRGLAAKMKFDESFLERDVNLGFSGGEVKRSEILQLLAQKPDFIMFDEPDSGVDIENVELLAEEINVLLDKDKKPGLRKKAGLLITHLGYILNFVSADTAHVLMDGRIACSGNPQEIIEDIRKDGFKGCVECCGIH yb50_mettw UPF0051 protein MTH1150 homolog ORF2 protein protein mettw Methanobacterium thermoautotrophicum (strain Winter) MLRDTLKKAEKARDKKALYGEDIDLERFIKEEAGEHEEVPRAREVPKKVQETLLKVGVDPEERERAGTFIQVDQSGICTTCASESIEIMGMNVALDRYSWLKDYMWKAVAVDTDKYTATTALREAEGEMGGYFIRSMPGSREVFPLQACMFIGDENVMQTAHNIIIAEENSELHIITGCATGQDVSSALHVGVSEFYLKKGAKITFTMVHNWAEQVEVRPRTGIMVGDDATYISNYILTSPVKSIQSYPTAYCTGENSRVVFQSILGGQKDSVLDMGSRVILEGRGSSAEMVSRAVSKDASQIYSRGHLAGRVPEVKGHLECHGLVLSDDSMIYAVPELEGSATELEMSHEAAVGKIAEEEVMYLTSRGLTEDEAASMIVRGFLSMDITGLPPELAAETKRMLDMSLKGM psa_metth Proteasome subunit alpha 20S proteasome alpha subunit psmA MTH_686 Proteasome core protein PsmA protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MQPLQSAGYDRAITVFSPDGRLFQVEYAREAVKRGTTSLGVKSKEGIVLVVDKRPTSKLVEPKSIEKIFQIDEHIGAATSGLVADARAIIEKARLEAQINRITYNEPIRVESLAKKICDMKQMYTQHGGVRPFGTALIIGGVNGRGCRLFETDPSGALIEYKATAIGAGRPAAMEEFEKKYSDDMNLNQAIELALDAVYEATEGKTTPESVEIAVIEAADKKYRRLPDDEIRDHVEELLIRKEKEEEE psb_metth Proteasome subunit beta 20S proteasome beta subunit psmB MTH_1202 Proteasome core protein PsmB protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVADAQSLMKYLKAEAALYRMRNSEKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKIYSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDEAVDVAIRAIKSAMERDTYSGNGILVATVTEEEGFRMLSEEEIQKRIENLN pan_metth Proteasome-activating nucleotidase Proteasomal ATPase pan MTH_728 Proteasome regulatory ATPase Proteasome regulatory particle protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MENNSQNVLKKIEDLKKEVRMLKEENSKTKRNLMWKIRKLEKDKLLIENERTRLDREVKSLRGEIERFRTPPLVIATVTEVLDDHRVAVKSTTGPHFVINYSRFIDRKQLEPGARVALNQQTFSIVDVLPSEKDPVVTGMEVEEKPDVSYEQIGGLEEQVREVKETVELPLKKPELFEKIGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIKIVASEFVRKYIGEGARLVRGVFELAKEKSPSIIFIDEIDAVAAKRLKSSTSGDREVQRTLMQLLAELDGFESRGNVGIVAATNRPDILDPALLRPGRFDRFIEVPLPNEDGRREILKIHTSGMALAEEVDIELLARITDGASGADLKAICTEAGMFAIRDERDEVTMADFMDAVDKIMGVEKEEEYKQETGVMFG rad50_metth DNA double-strand break repair Rad50 ATPase rad50 MTH_540 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MIIRSLELKNIRSYESGRVEFDDGVTLFEGDIGSGKTTLLLAVEFALFGLGDQRGDSLLRATSNSGSVKLTFTVDGEEYTVYRELKRGSSGVQQGELYIRKQGVVKKLSAKELKAEVLEILGYREPLNPRARSRIYRYAVFTPQEQMKSIIEAPKNDRLERLRKAFDLEKYSRAADNANLVSRRIRRESESLEDRSYDLEDKKRELEGLLGEKEKLESEKKQLDSDIEGIEAEIAKLKSEMEVLQREKNRIESAEREIESLQNEIETLRSSSERLMERNRSIEEEYRRSLDELQKCSDIREKLQEELNSLGERISALELKRESLMDDSRRFREASIQYRNLVSELENLIKTGRDLEDEISGLEDYTDRIKSKIESMESIEDPGYTEDEVEAGIRKLEVEVSDLQQELGGIHGKIEDYESIGRRGVCPTCDQEVNPDYINDKLSSARERKGSVESRIADLRNEIMNKNELMKRIAEYKRSREELRLLREDLEKRIKECHRRRESLDNIRERIRQIEEGKAESEKLIEELKDAESDFNKVEHELKSLREMESGYSSKLAAASGRMDQLRTRITELNPETSREYRDNLKKIDENESNIAEKRAKIRENEEALKNRDEVESSIHDLTQSICEMENLRDEKRDRRAAVEGKIEEKQRQIGNLESEIAKKRELRKRARELGNYVTWLNEYFIPAMDDIETHVMAQINHEFNERFQKWFRVLVDDPGKSVRIDEDFTPIVEQDGYEQNLEYLSGGERTSIALAYRLALNMVVQRLTDVRSDILILDEPTDGFSKEQLYKLRDIFDELESRQIILVSHEEELENLADHIYRVEKSDGTSIIEKTG enda_metth tRNA-splicing endonuclease tRNA-intron endonuclease endA MTH_250 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MRVEGQLGDEVVTIKATSIARRLHGKSHYGKMYEDRLQLSLIEAAYLMERGKLKLMKDDDEVSPEEFISLLGERGLYSKYLVYRDLRNRGYIVKTGFKYGAEFRLYERGGAPGRTHSAYLVRVISENDTIHALDFSSYVRVAHGVNKKLLMAFLDDEEDITYYLVDWIRP dnag_metth DNA primase DnaG dnaG MTH_891 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MGKEEISTTKYLIHAQINANGIVEKPDVVGAIFGQTEGLLSNDLDLREFQKTGRIGRIKVNITSRGGKSKGEIIIPSSLDRVETAILAASLETINRVGPCEAYIQVTKVEDVRAVKRKRVVERAKEIYASMMEEVTPESLKMIEEVKEAMRVHEITEYGEEKLPAGPNVETSDAILVVEGRSDVLNLLKYGIKNAIAVEGVSVPKTVADLTRKKTVTAFVDGDRGGELILKELLQVGEIDYVTRAPKGKEVEDLEKDEIMMALRNKVPVEQFYHDLGMKKEKKKTEDKMVLLRNILKELEGTGNAEILDDALNILREVKVENLYDELSRVNNHPYAVVFDGVITQRLVDLSFEKGLRYLVAVRSGDIVKKPHNLKLITGHT rrp41_metth Exosome complex component Rrp41 rrp41 MTH_683 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MITIITQDQLKTSPSVREDGRAFDELRPLKIEAGILERADGSSYLEFGGNKILVAVYGPREAQIRKLQRPDRAVIRCRYNMAPFSVEERKRPGPDRRSVEISKITAEALRPALILEKFPRSVIDVFIEVLEAEGGTRCAGITAASVALADAGIPMRDMVVACAAGKVGDQVVLDLSEEEDKEGQADVPVAILPRTREITLLQSDGNLTPEEFERALDLAVEGCLRIHEVQKEALRKRYGE rrp42_metth Exosome complex component Rrp42 rrp42 MTH_682 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MVNKMDIIPEITRKSITDLINNKERIDGRSLHEFRDISIETGVISKAEGSSRVKLGNTQIIVGVKPQIGEPFPDTPEMGVILTNSELLPMASPTFEPGPPDERSVELSRVVDRCIRESRMIDLEKLCIIEGSKVWMLFLDLHIIDYDGNLFDAAVLATVAALLDTRIPAAEVEDGEVVINREKMQPLPVNRKALMCTFAKIGNEIVLDPSLEEEDILTARISIGVTEEGSICAMQKGGEGPLTRDDVLKAVSIAVEKVPQLIEYLDKSMTP rrp4_metth Exosome complex component Rrp4 rrp4 MTH_684 protein protein metth Methanobacterium thermoautotrophicum Methanobacterium thermoautotrophicum MLLVNEKDLVVPGQVLAENEYFPGRGTFKEDNRICSSFVGLVSVRNKKINVIPLQSKYIPKRGDVVIGEITDIRFSMWGLDINSPYTGLLPASEVFGKDKRELESVFDIVDVLLLRVVDVDEVKKVKLGLKGRGLGKFRDGILVYITPTKVPRLIGKRGSMINMVKEKTHCDIVVGQNGVVWIKGEPDMERIAEKVVLMIDREAHTSGLTDRVRELLDRLTGVEPEIQVEESEGTEKPETPESEDFEEASDYSEDVEVSPESEDIEEVSDESEDLEVESEDVEEGTDTPAAEEDDGEAGDAEVKDENNSER mth579-mth579 Fructose-1-6-bisphosphate aldolase complex 256311 N/A 256312 unspecified role unspecified role neutral component neutral component Stoichiometry: 10.0 physical association physical association false false false The Fructose-1-6-bisphosphate aldolase homomeric complex was reported as having 10 subunits A 300kDa Fructose-1-6-bisphosphate aldolase homomeric complex was detected. Reaction catalsed by complex D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate annotated by amino acid sequence similarity to characterised proteins in other species. mth632-mth632 Putative phosphofructo-(sugar) kinase complex 256311 N/A 256313 unspecified role unspecified role neutral component neutral component Stoichiometry: 10.0 physical association physical association false false false Putative phosphofructo-(sugar) kinase homomeric complex was reported as having 10 subunits A 700 kDa putative phosphofructo-(sugar) kinase complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. Function unknown. mth744-mth744 Porphobilinogen synthase complex 256311 N/A 256314 unspecified role unspecified role neutral component neutral component Stoichiometry: 8.0 physical association physical association false false false Porphobilinogen synthase homomeric complex was reported as having 8 subunits A 300 kDa porphobilinogen synthase complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. fpaa-fpaa Flavoprotein A1 complex 256311 N/A 256315 unspecified role unspecified role neutral component neutral component Stoichiometry: 4.0 physical association physical association false false false Flavoprotein A1 homomeric complex was reported as having 4 subunits A 150 kDa flavoprotein A1 complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. mth1390-mth1390 Riboflavin synthase beta subunit complex 256311 N/A 256316 unspecified role unspecified role neutral component neutral component Stoichiometry: 50.0 physical association physical association false false false Riboflavin synthase beta subunit homomeric complex was reported as having 50 subunits A 800 kDa Riboflavin synthase beta subunit complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. mtd-mtd F420-dependent methylenetetrahydromethanopterin dehydrogenase complex 256311 N/A 256317 unspecified role unspecified role neutral component neutral component Stoichiometry: 6.0 physical association physical association false false false F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD) homomeric complex was reported as having 6 subunits A 100 kDa flavoprotein A1 complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. trpb2-trpb2 Tryptophan synthase beta chain 2 (TrpB2) complex 256311 N/A 256318 unspecified role unspecified role neutral component neutral component Stoichiometry: 2.0 physical association physical association false false false Tryptophan synthase beta chain 2 complex was reported as having 2 subunits A 100 kDa tryptophan synthase beta chain 2 complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. mth1512-mth1512 H(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase homolog complex 256311 N/A 256319 unspecified role unspecified role neutral component neutral component Stoichiometry: 3.0 physical association physical association false false false H(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase homolog homomeric complex was reported as having 3 subunits A 100 kDa H(2)-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase homolog complex was detected. Annotated by amino acid sequence similarity to characterised proteins in other species. unc_22mrcb Methyl coenzyme M reductase 1 complex 256311 N/A 256320 unspecified role unspecified role neutral component neutral component N/A 256321 unspecified role unspecified role neutral component neutral component N/A 256322 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 250kDa methyl coenzyme M reductase 1 complex was detected. Reaction catalsed by complex reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide. There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I. unc_22mrcb-1 Methyl coenzyme M reductase II complex 256311 N/A 256323 unspecified role unspecified role neutral component neutral component N/A 256324 unspecified role unspecified role neutral component neutral component N/A 256325 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 250kDa methyl coenzyme M reductase II complex was detected. Reaction catalsed by complex reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and an heterodisulfide. There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I. fwdc-mth1558 Tungsten-dependent formylmethanofuran dehydrogenase complex 256311 N/A 256326 unspecified role unspecified role neutral component neutral component N/A 256327 unspecified role unspecified role neutral component neutral component N/A 256328 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 100kDa tungsten-dependent formylmethanofuran dehydrogenase complex was detected. Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidise formylmethanofuran. This enzyme is oxygen-labile fwdc-mth1558-1 Methyltransferase complex 256311 N/A 256329 unspecified role unspecified role neutral component neutral component N/A 256330 unspecified role unspecified role neutral component neutral component N/A 256331 unspecified role unspecified role neutral component neutral component N/A 256332 unspecified role unspecified role neutral component neutral component N/A 256333 unspecified role unspecified role neutral component neutral component N/A 256334 unspecified role unspecified role neutral component neutral component N/A 256335 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 900kDa methyltransferase complex was detected. The complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin hdra-hdrb Heterodisulphide reductase complex 256311 N/A 256336 unspecified role unspecified role neutral component neutral component N/A 256337 unspecified role unspecified role neutral component neutral component N/A 256338 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 300kDa and a 400kDa heterodisulphide reductase complex was detected. a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Subunit A (O27434) may act as the catalytic subunit (By similarity). Cells cultured under MCR I conditions (N medium (15) at 65 �C with a gas flow of 2.0 liters/min of 80% H2, 20% CO2 (v/v) and harvested at an optical density at 600 nm of 5) had a 3-fold increase in the complex than cells grown under MCR II conditions (55 �C with a gas flow of 5.0 liters/min of 80% H2, 20% CO2 (v/v) and harvested at an optical density at 600 nm of 1.8). Auhors state that the higher molecular weight complex detected represented an association between of the heterosulphide reductase and methylviologen-reducing hydrogenase complexes. mvha-mvhd Methylviologen-reducing hydrogenase complex 256311 N/A 256339 unspecified role unspecified role neutral component neutral component N/A 256340 unspecified role unspecified role neutral component neutral component N/A 256341 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 100 kDa Methylviologen-reducing hydrogenase complex was detected. A complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase (By similarity). frhb-frhg F420 reducing hydrogenase complex 256311 N/A 256342 unspecified role unspecified role neutral component neutral component N/A 256343 unspecified role unspecified role neutral component neutral component N/A 256344 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 1000 kDa F420-reducing hydrogenase complex was detected. A complex that reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. atpa-atpb A1 subcomplex ATP synthase complex 256311 N/A 256345 unspecified role unspecified role neutral component neutral component N/A 256346 unspecified role unspecified role neutral component neutral component N/A 256347 unspecified role unspecified role neutral component neutral component N/A 256348 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 400 kDa subcomplex of the ATP synthase complex was detected. A complex that produces ATP from ADP in the presence of a proton gradient across the membrane. atc-atpe-1 A0 subcomplex ATP synthase complex 256311 N/A 256349 unspecified role unspecified role neutral component neutral component N/A 256350 unspecified role unspecified role neutral component neutral component N/A 256351 unspecified role unspecified role neutral component neutral component N/A 256352 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 600 kDa subcomplex of the ATP synthase complex was detected. A complex that produces ATP from ADP in the presence of a proton gradient across the membrane. o27042 is annotated as A0 subcomplex ATP synthase subunit H by authors cdha-cdhc Acetyl-CoA decarbonylase/synthase complex 256311 N/A 256353 unspecified role unspecified role neutral component neutral component N/A 256354 unspecified role unspecified role neutral component neutral component N/A 256355 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 1200 kDa acetyl-CoA decarbonylase/synthase complex was detected. A complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) . mth792-mth793 Lipid biosynthesis precursor complex 256311 N/A 256356 unspecified role unspecified role neutral component neutral component N/A 256357 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 300 kDa lipid biosynthesis precursor complex was detected. A complex that converts acetyl-CoA to hydroxy-3-methylglutaryl-CoA , a precursor of lipid biosynthesis. phes-phet Phenylalanyl-tRNA synthetase complex 256311 N/A 256358 unspecified role unspecified role neutral component neutral component N/A 256359 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 300 kDa Phenylalanyl-tRNA synthetas complex was detected. A complex that catalyses the following reaction ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). mth1149-mth1150 Fe-S cluster assembly complex 256311 N/A 256360 unspecified role unspecified role neutral component neutral component N/A 256361 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 200 kDa Fe-S cluster assembly complex was detected. A complex that may be involved in protection of iron sulphur clusters of proteins under oxidative stress. Proteins O27217 and Q50519 is annotated by authors as homologues of E.coli proteins SufC and SufB respectively which are involved in the bacterial iron uptake system. psma-psmb Proteasome complex 256311 N/A 256362 unspecified role unspecified role neutral component neutral component N/A 256363 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 800 kDa proteasome complex was detected. A complex that may be involved in protein degradation. rad50-pan Proteasome regulation complex 256311 N/A 256364 unspecified role unspecified role neutral component neutral component N/A 256365 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 800 kDa peoteasome regulatory complex was detected. A complex that may be involved in regulation of protein degradation. mth682-mth683 Exosome complex 256311 N/A 256366 unspecified role unspecified role neutral component neutral component N/A 256367 unspecified role unspecified role neutral component neutral component N/A 256368 unspecified role unspecified role neutral component neutral component N/A 256369 unspecified role unspecified role neutral component neutral component N/A 256370 unspecified role unspecified role neutral component neutral component physical association physical association false false false A 900 kDa exosome complex was detected. A complex that may be involved in the 3'->5' degradation of a variety of RNA species fwdc-mth1558-2 Methyltransferase/ATP synthase supercomplex 256311 N/A 256349 unspecified role unspecified role neutral component neutral component N/A 256350 unspecified role unspecified role neutral component neutral component N/A 256330 unspecified role unspecified role neutral component neutral component N/A 256331 unspecified role unspecified role neutral component neutral component N/A 256333 unspecified role unspecified role neutral component neutral component N/A 256335 unspecified role unspecified role neutral component neutral component physical association physical association false false false A putative supercomplex containing subunits of the methyltransferase complex and subunits of the ATP synthase complex was detected.