IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ li-2011c-5 Identification of cytochrome P450 2C2 protein complexes in mouse liver. mouse-liver Mus musculus liver liver anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li B., Yau P., Kemper B. Apoptosis - Interactions involving proteins with a function related to apoptosis CYP2D1 has been entered as CYP2D10:- the authors confirm that the antibody used to detect Mouse CYP2D10 was anti-Rat CYP2D1 (Millipore), as this antibody cross reacts with mouse CYP2D10 ( proteins have ~85% homology). byronkem@illinois.edu Proteomics (1615-9853) 2011 Only protein-protein interactions imex curation li-2011c-1 Identification of cytochrome P450 2C2 protein complexes in mouse liver. mouse-liver Mus musculus liver liver anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Li B., Yau P., Kemper B. Apoptosis - Interactions involving proteins with a function related to apoptosis CYP2D1 has been entered as CYP2D10:- the authors confirm that the antibody used to detect Mouse CYP2D10 was anti-Rat CYP2D1 (Millipore), as this antibody cross reacts with mouse CYP2D10 ( proteins have ~85% homology). Purified was by affinity to M2 agarose (Flag) and then further purification by affinity to Ni-NTA (Flag+His). The authors confirm that GI:1576133 should have been GI:576133 (GST Pi) and GI:20071598 should have been GI:20071589 (Bdh1). byronkem@illinois.edu Proteomics (1615-9853) 2011 Only protein-protein interactions imex curation li-2011c-2 Identification of cytochrome P450 2C2 protein complexes in mouse liver. mouse-liver Mus musculus liver liver anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Li B., Yau P., Kemper B. Apoptosis - Interactions involving proteins with a function related to apoptosis CYP2D1 has been entered as CYP2D10:- the authors confirm that the antibody used to detect Mouse CYP2D10 was anti-Rat CYP2D1 (Millipore), as this antibody cross reacts with mouse CYP2D10 ( proteins have ~85% homology). The authors confirm that the protein "PRD" is CPR- cytochrome P450 reductase. byronkem@illinois.edu Proteomics (1615-9853) 2011 Only protein-protein interactions imex curation li-2011c-3 Identification of cytochrome P450 2C2 protein complexes in mouse liver. mouse-liver Mus musculus liver liver density sedimentation cosedimentation through density gradient density sedimentation western blot western blot Immuno blot Immuno blot Li B., Yau P., Kemper B. Apoptosis - Interactions involving proteins with a function related to apoptosis CYP2D1 has been entered as CYP2D10:- the authors confirm that the antibody used to detect Mouse CYP2D10 was anti-Rat CYP2D1 (Millipore), as this antibody cross reacts with mouse CYP2D10 ( proteins have ~85% homology). Different distribution patterns at higher molecular weights were observed for different proteins, indicating multiple complexes. Mouse liver M2 affinity-purified protein complexes were analyzed in step sucrose gradients from 5% to 45% sucrose. byronkem@illinois.edu Proteomics (1615-9853) 2011 Only protein-protein interactions imex curation cp3ab_mouse Cytochrome P450 3A11 Cyp3a11 Cyp3a-11 CYPIIIA11 Cytochrome P-450IIIAM1 Cytochrome P-450UT protein protein mouse Mus musculus Mouse MDLVSALSLETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPRDAVITGA dhi1_mouse Corticosteroid 11-beta-dehydrogenase isozyme 1 Hsd11b1 Hsd11 11-beta-hydroxysteroid dehydrogenase 1 11beta-HSD1A protein protein mouse Mus musculus Mouse MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN hyep_mouse Epoxide hydrolase 1 Ephx1 Epoxide hydratase Microsomal epoxide hydrolase protein protein mouse Mus musculus Mouse MWLELILASVLGFVIYWFVSRDKEETLPLEDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSSYLKKVVSFWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKTHGLSDEHVFEVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGFQKFYIQGGDWGSLICTNIAQMVPNHVKGLHLNMSFISRNIYSLTPLLGQRFGRFLGYTEKDLELLYPFKEKVFYNIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLEDLLTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ fmo5_mouse Flavin-containing monooxygenase 5 Fmo5 Dimethylaniline oxidase 5 Hepatic flavin-containing monooxygenase 5 Dimethylaniline monooxygenase [N-oxide-forming] 5 NAPDH oxidase protein protein mouse Mus musculus Mouse MAKKRIAVIGAGASGLTCIKCCLEEGLEPVCFERSGDIGGLWRFQEAPEEGRASIYQSVVINTSKEMMCFSDYPIPDHYPNYMHNSQVLEYFRMYAKEFDLLKYIQFKTTVCSVKKQPDFSTSGQWQVVTECEGKQQVDVFDGVLVCTGHHTDAHLPLESFPGIEKFKGKYFHSRDYKNPVEFTGKRVIVIGIGNSGGDLAVEISHTAKQVFLSTRRGAWILNRVGKHGYPIDLLLSSRIMYYLSRICGPSLKNNYMEKQMNQRFDHEMFGLKPKHRALSQHPTVNDDLPNRIIAGLVKVKGNVKEFTETAAVFEDGSREDGIDVVIFATGYSFAFPFLEDSVKVVKNKVSLYKKVFPPNLEKPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKKLPSQSEMMAEINKAREEMAKRYVDSQRHTIQGDYIDTMEEIADLVGVRPNILPLVFTDPRLALRLLLGPCTPVQYRLQGPGKWAGARKTILTTEDRVRKPLMTRVVERDSSGGSLVTVRVLMLAVAFFAVILAYF pgrc1_mouse Membrane-associated progesterone receptor component 1 Pgrmc1 Pgrmc protein protein mouse Mus musculus Mouse MAAEDVVATGADPSELEGGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDETARKNE acsl1_mouse Long-chain-fatty-acid--CoA ligase 1 Acsl1 Acsl2 Facl2 Long-chain acyl-CoA synthetase 1 Arachidonate--CoA ligase Phytanate--CoA ligase protein protein mouse Mus musculus Mouse MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWYATRPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVYYYDDVRTMYDGFQRGIQVSNNGPCLGSRKPNQPYEWISYKEVAELAECIGSGLIQKGFKPCSEQFIGLFSQNRPEWVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIFADKPEKAKLLLEGVENKLTPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAIICFTSGTTGNPKGAMITHQNIINDCSGFIKATESAFIASTDDVLISFLPLAHMFETVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSLKRWLLDFASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTALGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNYLASKGEGEVCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAVVVPDVESLPSWAQKRGLQGSFEELCRNKDINKAILDDLLKLGKEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYATIKI cp2da_mouse Cytochrome P450 2D10 Cyp2d10 Cyp2d-10 CYPIID10 Cytochrome P450-16-alpha Cytochrome P450CB Testosterone 16-alpha hydroxylase protein protein mouse Mus musculus Mouse MELLTGAGLWSVAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYKLQNRYGDVFSLQMGWKPMVVINGLKAMKEVLLTCGEDTADRPQVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEARHLCDAFTAQAGQPINPNTMLNNAVCNVIASLIFARRFEYEDPYLIRMQKVLEDSLTEISGLIPEVLNMFPILLRIPGLPGKVFQGQKSLLAIVENLLTENRNTWDPDQPPRNLTDAFLAEIEKVKGNAESSFNDENLRMVVLDLFTAGMVTTSTTLSWALLLMILHPDVQRRVQQEIDAVIGQVRHPEMADQARMPYTNAVIHEVQRFGDIAPLNLPRITSRDIEVQDFLIPKGSILIPNMSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQHFSFSVPNGQPRPRNLGVFPFPVAPYPYQLCAVMREQGH bdh_mouse D-beta-hydroxybutyrate dehydrogenase, mitochondrial 3-hydroxybutyrate dehydrogenase Bdh1 Bdh protein protein mouse Mus musculus Mouse MLAARLSRPLSQLPGKALSVRDRENGTRHTLLFYPASFSPDTRRTYASQADAASGKAILITGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGDAGVKELDSLKSDRLRTIQLNVCNSEEVEKAVETIRSGLKDPEKGMWGLVNNAGISTFGEVEFTSMETYKEVAEVNLWGTVRTTKSFLPLLRRAKGRVVNISSMLGRMANPARSPYCITKFGIEAFSDCLRYEMHPLGVKVSVVEPGNFIAATSLYSPERIQAIAKKMWDDLPEVVRKDYGRKYFDEKIAKMETYCNSGSTDTSSVINAVTHALTAATPYTRYHPMDYYWWLRMQIMTHFPGAISDKIYIH gstp1_mouse Glutathione S-transferase P 1 Gstp1 Gstpib GST YF-YF GST-piB GST class-pi Preadipocyte growth factor protein protein mouse Mus musculus Mouse MPPYTIVYFPVRGRCEAMRMLLADQGQSWKEEVVTIDTWMQGLLKPTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKNQREAAQMDMVNDGVEDLRGKYVTLIYTNYENGKNDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPEHVNRPINGNGKQ cp2c2_rabit Cytochrome P450 2C2 CYP2C2 CYPIIC2 Cytochrome P450 PBc2 Cytochrome P450 PHP2 Laurate omega-1 hydroxylase protein protein rabit Oryctolagus cuniculus (Rabbit) Rabbit MDLVVVLGLCLSCLLLPSLWKQSHGGGKLPPGPTPFPILGNVLQLDFKDLSKSLTNLSKVYGPVFTVYLGMKPTVVVHGYEAVKEALVDLGHELSGRSRFLVTAKLNKGFGVIFSNGKRWTETRRFSLMTLRNFGMGKRSIEERVQEEAHCLVEELRKTNASPCDPTFILGAAPCNVICSVIFQNRFDYTDQDFLSLMGKFNENFKILNSPWVQFCNCFPILFDYFPGSHRKAVKNIFYVKNYITEQIKEHQKSLDINNPRDFIDCFLIKMEQEKCNQQSEFTIENLLTTVSDVFMAGTETTSTTLRYGLLLLMKHPEVIAKVQEEIERVIGRHRSPCMQDRSRMPYTDATVHEIQRYINLIPNNVPHTTICNLKFRNYLIPKGTDVLTSLSSVLHDDKEFPNPDRFDPGHFLDASGNFRKSDYFMPFSTGKRVCVGEALARMELFLFLTAILQNFTPKPLVNPNNVDENPFSSGIVRVPPLYRVSFIPV dhb13_mouse 17-beta-hydroxysteroid dehydrogenase 13 Hsd17b13 Alcohol dehydrogenase PAN1B-like Scdr9 Short-chain dehydrogenase/reductase 9 protein protein mouse Mus musculus Mouse MNLILEFLLLVGVIIYSYLESLVKFFIPRRRKSVTGQTVLITGAGHGIGRLTAYEFAKQKSRLVLWDINKRGVEETADKCRKLGAVVHVFVVDCSNRAEIYNSVDQVKREVGDVEIVVNNAGAIYPADLLSAKDEEITKTFEVNILGHFWIIKALLPSMLRRNSGHIVTVASVCGHGVIPYLIPYCSSKFAAVGFHRALTAELDTLGKTGIQTSCLCPVFVNTGFTKNPSTRLWPVLEPEEVARSLINGILTNKKMIFVPSYINISLILEKGPGFSSKHPHGGSQQPVTPIPGDLTPSSDFLKH hsp7c_mouse Heat shock cognate 71 kDa protein Heat shock 70 kDa protein 8 Hspa8 Hsc70 Hsc73 protein protein mouse Mus musculus Mouse MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD q811m6_mouse Igtp protein protein mouse Mus musculus Mouse MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYSSQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFINALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEMQISTYHLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQVCDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKVFGVDDGSLQQVARSTGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRVLESSWWYGLWNVVTRYFRHQRHKLVIEIVAENTKTSLRKALKDSVLPPEIH q3unw2_mouse Cytochrome P450 Cyp2d9 protein protein mouse Mus musculus Mouse MELLTGTDLWPVAIFTVIFILLVDLTHQRQRWTSRYPPGPVPWPVLGNLLQVDLGNMPYSLYKLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTSTTLSWALVLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAGRRSCLGEALARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVRDQGH bip_mouse Endoplasmic reticulum chaperone BiP Immunoglobulin heavy chain-binding protein Hspa5 Grp78 78 kDa glucose-regulated protein Binding-immunoglobulin protein Heat shock protein 70 family protein 5 Heat shock protein family A member 5 protein protein mouse Mus musculus Mouse MMKFTVVAAALLLLGAVRAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSGGPPPTGEEDTSEKDEL rtn3_mouse Reticulon-3 Rtn3 protein protein mouse Mus musculus Mouse MAESSAATQSPSVSSSSSGAEPSALGGGGGSPGACPALGAKSCGSSCADSFVSSSSSQPVSIFSTSQAGLSSLCSDEPPSKSMTSSFLSSSEIHNPDPTTPLGEKSETLGSQFVLAKGKDPLVLLDKKKLDSPQGTNKDRVDAPVSLATGIPCSHPSIPDSFPEQPAFLSKEIGPAEEWVVKDQEPKNPNKVPDGEDRSALDFGQSKAEHICTYSLSPSELPVASVEKDSPESPFEVIIDKATFDREFKDLYKENPNDLGGWAAHGDRESPADLLEMNDKLFPLRNKEAGRYPSSVLLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQANKTSCTTESTGLDRSELRSEIPVINLKTNPQQKMPVCSFNGSTPITKSTGDWTEAFTEGKPVRDYLSSTKEAGGNGVPGSSQLHSELPGSMPEKWVSGSGAATVEVTLPNLRGAWPNSVMGEVTEVDSSGESDDTVIEDITEKPDSLPSAAAKTSEREIKETPSRETVRSEMCENSEQPQAQPETPTQKSLEGEVASQVPNTLNEVTPEKLDMTNNPKVCSAAPPSVLNETGFSLTVPASAKLESLLGKYVEDTDGSSPEDLMAVLTGAEEKGIVDKEEGDVLEAVLEKIADFKNTLPVELLHESELSGSETKNIKSKYSEDSRETTGGAPTMSPDLEQEQLTIRAIKELGERQAEKVQDEGISSGGKLKQTFAPQSGPQSSSDILEHTDVKTGSDLGIPKNPTIIKNTRIDSISSLTKTEMVNKNVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE rdh7_mouse Retinol dehydrogenase 7 Rdh7 Crad2 Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2 Cis-retinol/androgen dehydrogenase type 2 protein protein mouse Mus musculus Mouse MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGICVFAINEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVNISSSMGRVSLCGGGYCISKYGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERLSHSIEKLWDQTSSEVKEVYDKNFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYMPTFLVDAMLYWSSVKPAQAL cp2dq_mouse Cytochrome P450 2D26 Cyp2d26 Cyp2d-26 CYPIID26 protein protein mouse Mus musculus Mouse MGLLVGDDLWAVVIFTAIFLLLVDLVHRRQRWTACYPPGPVPFPGLGNLLQVDFENIPYSFYKLQNRYGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHIGYGHKSKGVILAPYGPEWREQRRFSVSTLRDFGLGKKSLEQWVTEEAGHLCDAFTKEAEHPFNPSPLLSKAVSNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEVLNAIPMLLHIPGLPDKAFPKLNSFIALVNKMLIEHDLTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDKNLRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPYTNAVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYPEHFLDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSDYGIYTMPVTPEPYQLCAVAR met7b_mouse Thiol S-methyltransferase METTL7B Mettl7b Methyltransferase-like protein 7B protein protein mouse Mus musculus Mouse MDALVLFLQLLVLLLTLPLHLLALLGCWQPICKTYFPYFMAMLTARSYKKMESKKRELFSQIKDLKGTSGNVALLELGCGTGANFQFYPQGCKVTCVDPNPNFEKFLTKSMAENRHLQYERFIVAYGENMKQLADSSMDVVVCTLVLCSVQSPRKVLQEVQRVLRPGGLLFFWEHVAEPQGSRAFLWQRVLEPTWKHIGDGCHLTRETWKDIERAQFSEVQLEWQPPPFRWLPVGPHIMGKAVK apoe_mouse Apolipoprotein E Apoe protein protein mouse Mus musculus Mouse MKALWAVLLVTLLTGCLAEGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIITPVAQENQ ud19_mouse UDP-glucuronosyltransferase 1A9 Ugt1a9 Ugt1 Ugt1a12 UDP-glucuronosyltransferase 1-7 UGT1A12 UGTP4 UDP-glucuronosyltransferase 1-9 protein protein mouse Mus musculus Mouse MAPVAFPTSFFLCLLLASGLAQAGRLLVVPMDGSHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKKLVEYLKQRFFDAVFLDPFDVCGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSKTH ktn1_mouse Kinectin Ktn1 protein protein mouse Mus musculus Mouse MELYESTYFIVLIPSVVITVIFLFFWLFMKETLYDEVLAKQKREQKLISTKTDKKKAEKKKNKKKEIQNGTLRESDSEHVPRDFKLSDASPAEDEQFVPAPLNVAETSSSVRERQKKEKKQKPSLEEQVIKESDASKIPGKKVEPVLVTKQPAPPPPLEAAALKKKAGQKKSKNGSEEQDKKVEMLMAPSKEQDVLLSHQDTKQEGGLGKKKGLSKKQKSENVAVLVDEPLIHATTYMPLDNANSNLMMDKREIIDMIKPDHVEGIQKSGTKKLKIETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIKEALKKSNKGELSGLLHQLQEKERLLSAMKEDAAASKERCKRLTQEMMTEKERSSVVIARMKDRIGTLEKEHNIFQNKMHASYQETQQMQMKFQQVQEQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDCGRLVSELNEKTGKLQQEGVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRASKEESLQIQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQLKQTEDSLANEQDHLASKEEELKDVQNMNFLLKAEVQKWQALANEQAATAHEVEKMQKSIHVKEDEIRLLEEQLQHEVASKMEELKILSEQNKALQSEVRKLQTAVSQQPNKDVVEQMEKCIQEKDEKLRTVEELLETGLIQVATREEELSAIRTENSTLTREVQELKAKQSDQVSFVSLIEDLKRVIHEKDGQIKSVEELLEVELLKVANKEKTVQALKQEIEVLKEEIGNAQLEKAHQLSVTSQVQELQNLLRGKEEQVNSMKAALEDRDRGLTGRGTCAQVCSTPQFEELESVLKEKDNEIKRIEVKLKDTESDVSKMSELLKEVQEENKFLKCQLSHQKHQQASFPSQEELQTVISEKEKEITDLCNELESLKNAVEHQRKKNNDLREKNWEAMEALASTEKMLQDRVNKTSKERRQHVEAIELESKDLLKRLFPTVSVPSNLNYSEWLRGFEKKAKACVAGTSDAEAVKVLEHRLKEASEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEESKWKIKADESQRMIKQMQSSFTASERELERLRQENKDMENLRREREHLEMELEKAEMERSTYVMEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKTQLNETHSKLQNEQTERKKVADDLHKAQQSLNSIHSKISLKAAGDTVVIENSDISPEMESPEKETMSVSLNQTVTQLQQLLQEVNQQLTKET bap31_mouse B-cell receptor-associated protein 31 Bcap31 Bap31 p28 protein protein mouse Mus musculus Mouse MSLQWTTVATFLYAEVFAVLLLCIPFISPKRWQKVFKSRLVELVVTYGNTFFVVLIVILVLLVIDAVREILKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAEDGDKLDIGNTEMKLEENKSLKNDLRKLKDELASTKKKLEKAENEALAMQKQSEGLTKEYDRLLEEHAKLQASVRGPSVKKEE ncpr_mouse NADPH--cytochrome P450 reductase Por protein protein mouse Mus musculus Mouse MGDSHEDTSATVPEAVAEEVSLFSTTDIVLFSLIVGVLTYWFIFKKKKEEIPEFSKIQTTAPPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDKEHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS nb5r3_mouse NADH-cytochrome b5 reductase 3 Cyb5r3 Dia1 Diaphorase-1 protein protein mouse Mus musculus Mouse MGAQLSTLSHVVLSPVWFIYSLFMKLFQRSTPAITLENPDIKYPLRLIDKEVISPDTRRFRFALPSPQHILGLPIGQHIYLSTRIDGNLVIRPYTPVSSDDDKGFVDLVVKVYFKDTHPKFPAGGKMSQYLENMKIGDTIEFRGPNGLLVYQGKGKFAIRADKKSNPVVRTVKSVGMIAGGTGITPMLQVIRAVLKDPNDHTVCYLLFANQSEKDILLRPELEELRNEHSARFKLWYTVDKAPDAWDYSQGFVNEEMIRDHLPTPGEEPLILMCGPPPMIQFACLPNLERVGHPKERCFTF fmo5 1172517 n/a 1172521 unspecified role unspecified role prey prey n/a 1172522 unspecified role unspecified role prey prey n/a 1172523 unspecified role unspecified role prey prey n/a 1172524 unspecified role unspecified role bait bait n/a 1172525 unspecified role unspecified role prey prey association association false false false Fig 4B The fraction of PGRMC1 and mEH coprecipitating from the M2-bound fractions was much greater than from the M2-unbound fraction. acsl1-hyep 1172517 n/a 1172525 unspecified role unspecified role prey prey n/a 1172526 unspecified role unspecified role bait bait n/a 1172523 unspecified role unspecified role prey prey association association false false false Fig 4B-2 Coimmunoprecipitation with ACSL1 of PGRMC1 and mEH occurs, but not with 11beta-HSD1 in the M2-bound fraction. hsd1-dhi1 1172517 n/a 1172524 unspecified role unspecified role prey prey n/a 1172522 unspecified role unspecified role bait bait n/a 1172525 unspecified role unspecified role prey prey n/a 1172527 unspecified role unspecified role prey prey association association false false false Fig 4B-3 PGRMC1 selectively coimmunoprecipitated in the M2-bound fraction compared with the M2-unbound fraction, whereas FMO5 and Cyp3a11 did not coimmunoprecipitate efficiently in the M2-bound fraction. meh-hyep 1172517 n/a 1172527 unspecified role unspecified role prey prey n/a 1172523 unspecified role unspecified role bait bait n/a 1172525 unspecified role unspecified role prey prey association association false false false Fig 4B-4 mEH coimmunoprecipitated in the M2-bound fraction with PGRMC1 and Cyp2d10, but not with Cyp3a11. cyp2d1 1172517 n/a 1172527 unspecified role unspecified role bait bait n/a 1172522 unspecified role unspecified role prey prey association association false false false Fig 4B-5 cyp2c2-acsl1-9 1172518 n/a 1172528 unspecified role unspecified role prey prey n/a 1172529 unspecified role unspecified role prey prey n/a 1172530 unspecified role unspecified role bait bait region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1172531 unspecified role unspecified role prey prey n/a 1172526 unspecified role unspecified role prey prey n/a 1172532 unspecified role unspecified role prey prey n/a 1172523 unspecified role unspecified role prey prey n/a 1172533 unspecified role unspecified role prey prey n/a 1172534 unspecified role unspecified role prey prey n/a 1172535 unspecified role unspecified role prey prey n/a 1172536 unspecified role unspecified role prey prey n/a 1172525 unspecified role unspecified role prey prey n/a 1172522 unspecified role unspecified role prey prey n/a 1172521 unspecified role unspecified role prey prey n/a 1172537 unspecified role unspecified role prey prey n/a 1172538 unspecified role unspecified role prey prey n/a 1172539 unspecified role unspecified role prey prey n/a 1172540 unspecified role unspecified role prey prey n/a 1172524 unspecified role unspecified role prey prey n/a 1172527 unspecified role unspecified role prey prey n/a 1172541 unspecified role unspecified role prey prey association association false false false Fig 1, Table 1 , Supplementary Table S1. cyp2c2-acsl1-10 1172519 n/a 1172523 unspecified role unspecified role prey prey n/a 1172524 unspecified role unspecified role prey prey n/a 1172542 unspecified role unspecified role prey prey n/a 1172543 unspecified role unspecified role prey prey n/a 1172526 unspecified role unspecified role prey prey n/a 1172522 unspecified role unspecified role prey prey n/a 1172541 unspecified role unspecified role prey prey n/a 1172530 unspecified role unspecified role bait bait region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1172521 unspecified role unspecified role prey prey n/a 1172527 unspecified role unspecified role prey prey n/a 1172544 unspecified role unspecified role prey prey association association false false false Fig 2A cyp2c2-acsl1-7 1172520 n/a 1172525 unspecified role unspecified role neutral component neutral component n/a 1172545 unspecified role unspecified role neutral component neutral component n/a 1172530 unspecified role unspecified role neutral component neutral component region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1172524 unspecified role unspecified role neutral component neutral component n/a 1172523 unspecified role unspecified role neutral component neutral component n/a 1172543 unspecified role unspecified role neutral component neutral component n/a 1172526 unspecified role unspecified role neutral component neutral component n/a 1172521 unspecified role unspecified role neutral component neutral component n/a 1172522 unspecified role unspecified role neutral component neutral component n/a 1172527 unspecified role unspecified role neutral component neutral component association association false false false Fig 3