IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ tcherkezian-2010-4 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. density sedimentation cosedimentation through density gradient density sedimentation western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Sucrose velocity gradient UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-2 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-1 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-3 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. mouse-neuron Mus musculus neuronal cell neuron Neuron [Neuronal cell; Neural cell confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Mouse E10.5-11.5 commissural neurons UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-5 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. mouse-spinal-cord Mouse spinal cord spinal-cord spinal cord density sedimentation cosedimentation through density gradient density sedimentation western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Sucrose velocity gradient UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-6 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. mouse-spinal-cord Mouse spinal cord spinal-cord spinal cord anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-8 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. in vitro In vitro far western blotting far western blotting Affinity blotting Affinity blotting western blot western blot Immuno blot Immuno blot Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-9 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Tagged proteins visualised by tag fluorescence UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation tcherkezian-2010-7 Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. chick-neuron Chick neuron neuron Neuron [Neuronal cell; Neural cell confocal microscopy confocal microscopy immunostaining immunostaining Tcherkezian J., Brittis PA., Thomas F., Roux PP., Flanagan JG. Apoptosis - Interactions involving proteins with a function related to apoptosis Tagged proteins visualised by tag fluorescence UniProtKB protein Q9UI10 is now obsolete and the information supplied did not allow an unambiguous mapping to a single gene product so this protein has not been included in the dataset described in Figs. 2A. Data from Figs. 3C, 5D and 5E has not been captured as host cell type not stated. perry_brittis@hms.harvard.edu, flanagan@hms.harvard.edu Cell (0092-8674) 2010 Only protein-protein interactions imex curation rs6_human 40S ribosomal protein S6 RPS6 Phosphoprotein NP33 Small ribosomal subunit protein eS6 OK/SW-cl.2 protein protein human Homo sapiens Human MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK dcc_human Netrin receptor DCC DCC Tumor suppressor protein DCC Colorectal cancer suppressor IGDCC1 Immunoglobulin superfamily DCC subclass member 1 protein protein human Homo sapiens Human MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLNAITGSAF rl5_human 60S ribosomal protein L5 RPL5 Large ribosomal subunit protein uL18 MSTP030 protein protein human Homo sapiens Human MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES if2a_human Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 EIF2A Eukaryotic translation initiation factor 2 subunit alpha protein protein human Homo sapiens Human MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED rs23_human 40S ribosomal protein S23 RPS23 Small ribosomal subunit protein uS12 protein protein human Homo sapiens Human MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS dcc_rat Netrin receptor DCC Dcc Tumor suppressor protein DCC protein protein rat Rattus norvegicus (Rat) Rat MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLKCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSASKRKGSQKDLRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPIQSCQDLTPVSHSQSESQMGSKSASHSGQDTEEAGSSMSTLERSLAARRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTAQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF rl13_human 60S ribosomal protein L13 RPL13 BBC1 Breast basic conserved protein 1 Large ribosomal subunit protein eL13 OK/SW-cl.46 protein protein human Homo sapiens Human MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK eif3e_human Eukaryotic translation initiation factor 3 subunit E EIF3E INT6 EIF3S6 Eukaryotic translation initiation factor 3 subunit 6 eIF-3 p48 Viral integration site protein INT-6 homolog protein protein human Homo sapiens Human MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY rl28_human 60S ribosomal protein L28 RPL28 Large ribosomal subunit protein eL28 protein protein human Homo sapiens Human MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS ei2bb_human Translation initiation factor eIF-2B subunit beta eIF-2B GDP-GTP exchange factor subunit beta S20I15 S20III15 EIF2B2 EIF2BB protein protein human Homo sapiens Human MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL ei2bd_human Translation initiation factor eIF-2B subunit delta EIF2B4 EIF2BD eIF-2B GDP-GTP exchange factor subunit delta protein protein human Homo sapiens Human MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQVGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ if2g_human Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2 subunit gamma X EIF2S3 EIF2G protein protein human Homo sapiens Human MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD rl10a_human 60S ribosomal protein L10a RPL10A NEDD6 CSA-19 Neural precursor cell expressed developmentally down-regulated protein 6 Large ribosomal subunit protein uL1 protein protein human Homo sapiens Human MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY if2b_human Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit beta EIF2S2 EIF2B protein protein human Homo sapiens Human MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN rs13_human 40S ribosomal protein S13 RPS13 Small ribosomal subunit protein uS15 protein protein human Homo sapiens Human MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA net1_human Netrin-1 NTN1 NTN1L Epididymis tissue protein Li 131P protein protein human Homo sapiens Human MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA ezri_human Ezrin EZR VIL2 p81 Cytovillin Villin-2 protein protein human Homo sapiens Human MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL fak1_human Focal adhesion kinase 1 PTK2 FAK FAK1 pp125FAK Protein-tyrosine kinase 2 Focal adhesion kinase-related nonkinase Protein phosphatase 1 regulatory subunit 71 p125FAK protein protein human Homo sapiens Human MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH if4e3_human Eukaryotic translation initiation factor 4E type 3 EIF4E3 protein protein human Homo sapiens Human MALPPAAAPPAGAREPPGSRAAAAAAAPEPPLGLQQLSALQPEPGGVPLHSSWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH mk01_human Mitogen-activated protein kinase 1 MAPK1 ERK2 PRKM1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase isoform p42 ERT1 PRKM2 protein protein human Homo sapiens Human MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS if5a2_human Eukaryotic translation initiation factor 5A-2 Eukaryotic initiation factor 5A isoform 2 EIF5A2 protein protein human Homo sapiens Human MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK rs24_human 40S ribosomal protein S24 RPS24 Small ribosomal subunit protein eS24 protein protein human Homo sapiens Human MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE rl38_human 60S ribosomal protein L38 RPL38 Large ribosomal subunit protein eL38 protein protein human Homo sapiens Human MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK ei2ba_human Translation initiation factor eIF-2B subunit alpha eIF-2B GDP-GTP exchange factor subunit alpha EIF2B1 EIF2BA protein protein human Homo sapiens Human MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL rs10_human 40S ribosomal protein S10 RPS10 Small ribosomal subunit protein eS10 protein protein human Homo sapiens Human MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ rl23_human 60S ribosomal protein L23 RPL23 60S ribosomal protein L17 Large ribosomal subunit protein uL14 protein protein human Homo sapiens Human MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA rs6_mouse 40S ribosomal protein S6 Rps6 Phosphoprotein NP33 protein protein mouse Mus musculus Mouse MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK dcc_mouse Netrin receptor DCC Dcc Tumor suppressor protein DCC protein protein mouse Mus musculus Mouse MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISRTAKVTVAGPLRFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPTGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAKLMIPMEAQSSNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF eif2a_mouse Eukaryotic translation initiation factor 2A Eif2a D3Ertd194e protein protein mouse Mus musculus Mouse MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV rl5_mouse 60S ribosomal protein L5 Rpl5 protein protein mouse Mus musculus Mouse MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES eif3e_mouse Eukaryotic translation initiation factor 3 subunit E Eif3e Eif3s6 Int6 Eukaryotic translation initiation factor 3 subunit 6 eIF-3 p48 Mammary tumor-associated protein INT-6 Viral integration site protein INT-6 MMTV integration site 6 protein protein mouse Mus musculus Mouse MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY dcc_chick_protein Netrin receptor DCC protein protein chick Gallus gallus (Chicken) Chicken An amino acid sequence which is not represented in UniProt Similar to P43146 - does not appear to be in Ensembl dcc-rpl5-1 918389 n/a 918398 unspecified role unspecified role neutral component neutral component n/a 918399 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component n/a 918401 unspecified role unspecified role neutral component neutral component association association false false false Fig. 3A eIF4E was also observed but could not be assigned to a single gene product. rpl5-rs6-1 918389 n/a 918401 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component n/a 918398 unspecified role unspecified role neutral component neutral component n/a 918399 unspecified role unspecified role neutral component neutral component association association false false false Fig. 3A eIF4E was also observed but could not be assigned to a single gene product. dcc-rpl5-2 918389 n/a 918399 unspecified role unspecified role neutral component neutral component n/a 918402 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component physical association physical association false false false Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. rs23-rpl5-1 918389 n/a 918402 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component physical association physical association false false false Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rs23-1 918389 n/a 918399 unspecified role unspecified role neutral component neutral component n/a 918402 unspecified role unspecified role neutral component neutral component physical association physical association false false false Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rpl5-3 918389 n/a 918400 unspecified role unspecified role neutral component neutral component n/a 918399 unspecified role unspecified role neutral component neutral component physical association physical association false false false Supp. Fig. 3A DCC was in 40S, 60S and 80S fractions but was not seen prominently in the polysome fraction. S23 was in 40S, 80S and polysomal fractions; L5 was in 60S, 80S and polysomal fractions. In the presence of 25 mM EDTA to dissociate monosomes and polysomes, the 80S and polysome fractions were absent, while the 40S and 60S fractions were increased. Accordingly, L5, S23, and DCC bands were shifted to the 40S and 60S fractions, and were no longer seen in the 80S fraction. dcc-rpl5-5 918389 n/a 918403 unspecified role unspecified role neutral component neutral component cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range false n/a 918402 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 4D Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. dcc-rpl13-2 Interactors of DCC 918390 n/a 918400 unspecified role unspecified role prey prey n/a 918404 unspecified role unspecified role prey prey n/a 918399 unspecified role unspecified role bait bait n/a 918405 unspecified role unspecified role prey prey n/a 918406 unspecified role unspecified role prey prey n/a 918407 unspecified role unspecified role prey prey n/a 918408 unspecified role unspecified role prey prey n/a 918409 unspecified role unspecified role prey prey n/a 918410 unspecified role unspecified role prey prey n/a 918411 unspecified role unspecified role prey prey association association false false false Fig. 2B dcc-rpl5-4 918390 n/a 918400 unspecified role unspecified role prey prey n/a 918399 unspecified role unspecified role bait bait physical association physical association false false false Fig. 4B, Supp. 5A Expression of Netrin-1 ERK, eIF4e and S4x (small ribosomal subunit) were also observed in this interaction. dcc-rpl5-6 918390 n/a 918403 unspecified role unspecified role bait bait n/a 918400 unspecified role unspecified role prey prey physical association physical association false false false Supp. 5A ERK, eIF4e and S4x (small ribosomal subunit) were also observed in this interaction. The P1 domain of the cytoplasm was required for the interaction with eIF4e and S4x (small ribosomal subunit) but not with ERK. dcc-rpl13-1 Interactors of DCC 918391 n/a 918405 unspecified role unspecified role prey prey n/a 918412 unspecified role unspecified role prey prey n/a 918413 unspecified role unspecified role prey prey n/a 918414 unspecified role unspecified role prey prey n/a 918415 unspecified role unspecified role prey prey n/a 918416 unspecified role unspecified role prey prey n/a 918411 unspecified role unspecified role prey prey n/a 918417 unspecified role unspecified role prey prey n/a 918418 unspecified role unspecified role prey prey n/a 918419 unspecified role unspecified role prey prey n/a 918420 unspecified role unspecified role prey prey n/a 918406 unspecified role unspecified role prey prey n/a 918421 unspecified role unspecified role prey prey n/a 918422 unspecified role unspecified role prey prey n/a 918423 unspecified role unspecified role prey prey n/a 918409 unspecified role unspecified role prey prey n/a 918404 unspecified role unspecified role prey prey n/a 918399 unspecified role unspecified role bait bait n/a 918400 unspecified role unspecified role prey prey n/a 918410 unspecified role unspecified role prey prey n/a 918408 unspecified role unspecified role prey prey n/a 918407 unspecified role unspecified role prey prey association association false false false Fig. 2A dcc-rps6-1 Colocalisation of Dcc and Rps6 918392 n/a 918424 unspecified role unspecified role neutral component neutral component n/a 918425 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false Figs. 1A-D, Supp. Figs 1A-C dcc-rpl28-1 918393 n/a 918399 unspecified role unspecified role neutral component neutral component n/a 918406 unspecified role unspecified role neutral component neutral component association association false false false Fig. 3B dcc-rpl13-3 Interactors of DCC 918394 n/a 918426 unspecified role unspecified role prey prey n/a 918427 unspecified role unspecified role prey prey n/a 918428 unspecified role unspecified role prey prey n/a 918425 unspecified role unspecified role bait bait association association false false false Fig. 3B eIF4E was also observed but could ot be ascribed to a single gene product. rpl5-dcc-1 Direct interaction between Dcc and RPL5 918395 n/a 918400 unspecified role unspecified role bait bait region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 918403 unspecified role unspecified role prey prey cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 5C Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. rpl5-dcc-2 Colocalisation of Dcc and RPL5 918396 n/a 918403 unspecified role unspecified role neutral component neutral component cytoplasmic region sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis range range range range false p1 region required to bind necessary binding region required to bind range range certain certain sequence position certain false n/a 918400 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false colocalization colocalization false false false Fig. 5H Exact coordinates of the Dcc cytoplasmic domain were not given in the text so have been inferred from the UniProt KB entry. rpl5-dcc-3 Colocalisation of Dcc and RPL5 918397 n/a 918429 unspecified role unspecified role neutral component neutral component n/a 918400 unspecified role unspecified role neutral component neutral component region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false colocalization colocalization false false false Supp. Fig. 5B