UniProt UniProt http://www.uniprot.org schilders-2007-3 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Schilders G., van Dijk E., Pruijn GJ. Apoptosis - Interactions involving proteins with a function related to apoptosis Source of MPP6 taken from previous work of the author (PMID: 16396833) G.Pruijn@ncmls.ru.nl Nucleic Acids Res. (0305-1048) 2007 mimix curation schilders-2007-1 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. human-hep_g2 Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt). hep_g2 human hepatocellular carcinoma (HCC) cells (p53-wt). confocal microscopy confocal microscopy tag fluorescence tag visualisation by fluorescence tag fluorescence Schilders G., van Dijk E., Pruijn GJ. Apoptosis - Interactions involving proteins with a function related to apoptosis G.Pruijn@ncmls.ru.nl Nucleic Acids Res. (0305-1048) 2007 mimix curation schilders-2007-2 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. human-hep_g2 Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt). hep_g2 human hepatocellular carcinoma (HCC) cells (p53-wt). anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Schilders G., van Dijk E., Pruijn GJ. Apoptosis - Interactions involving proteins with a function related to apoptosis G.Pruijn@ncmls.ru.nl Nucleic Acids Res. (0305-1048) 2007 mimix curation schilders-2007-4 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Schilders G., van Dijk E., Pruijn GJ. Apoptosis - Interactions involving proteins with a function related to apoptosis G.Pruijn@ncmls.ru.nl Nucleic Acids Res. (0305-1048) 2007 mimix curation c1d_human Nuclear nucleic acid-binding protein C1D C1D protein protein human Homo sapiens Human MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS exosx_human Exosome component 10 PMSCL2 EXOSC10 PMSCL Polymyositis/scleroderma autoantigen 2 Autoantigen PM/Scl 2 Polymyositis/scleroderma autoantigen 100 kDa P100 polymyositis-scleroderma overlap syndrome-associated autoantigen RRP6 protein protein human Homo sapiens Human MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEYDFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVILERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADFIHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVELNEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQLADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR mph6_human M-phase phosphoprotein 6 MPHOSPH6 MPP6 protein protein human Homo sapiens Human MAAERKTRLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRYETLVGTIGKKFARKRDHANYEEDENGDITPIKAKKMFLKPQD mtrex_human Exosome RNA helicase MTR4 MTREX DOB1 KIAA0052 MTR4 SKIV2L2 Superkiller viralicidic activity 2-like 2 TRAMP-like complex helicase ATP-dependent RNA helicase DOB1 ATP-dependent RNA helicase SKIV2L2 protein protein human Homo sapiens Human MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRDIVFAASLYL exos2_human Exosome complex component RRP4 EXOSC2 RRP4 Ribosomal RNA-processing protein 4 Exosome component 2 protein protein human Homo sapiens Human MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG exos9_human Exosome complex component RRP45 EXOSC9 PMSCL1 Exosome component 9 Polymyositis/scleroderma autoantigen 1 Autoantigen PM/Scl 1 Polymyositis/scleroderma autoantigen 75 kDa P75 polymyositis-scleroderma overlap syndrome-associated autoantigen protein protein human Homo sapiens Human MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKALENDQKVRKEGGKFGFAESIANQRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDLEDSEKEDDEGGGDQAIILDGIKMDTGVEVSDIGSQDAPIILSDSEEEEMIILEPDKNPKKIRTQTTSAKQEKAPSKKPVKRRKKKRAAN c1d-exosc10-3 1131359 n/a 1131363 unspecified role unspecified role bait bait n/a 1131364 unspecified role unspecified role prey prey direct interaction direct interaction false false false 2C mphosph6-exosc10 1131359 n/a 1131364 unspecified role unspecified role prey prey n/a 1131365 unspecified role unspecified role bait bait direct interaction direct interaction false false false 2C mphosph6-skiv2l2 1131359 n/a 1131365 unspecified role unspecified role bait bait n/a 1131366 unspecified role unspecified role prey prey direct interaction direct interaction false false false 2D c1d-exosc10-4 1131359 n/a 1131363 unspecified role unspecified role bait bait n/a 1131364 unspecified role unspecified role prey prey n/a 1131365 unspecified role unspecified role prey prey physical association physical association false false false 3 c1d-exosc10 1131360 n/a 1131363 unspecified role unspecified role neutral component neutral component n/a 1131364 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 1b exosc10-skiv2l2 1131360 n/a 1131364 unspecified role unspecified role neutral component neutral component n/a 1131366 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 1B exosc9-exosc10-1 1131361 n/a 1131367 unspecified role unspecified role prey prey n/a 1131364 unspecified role unspecified role prey prey n/a 1131368 unspecified role unspecified role bait bait association association false false false 2A c1d-exosc10-5 1131361 n/a 1131363 unspecified role unspecified role bait bait n/a 1131367 unspecified role unspecified role prey prey n/a 1131364 unspecified role unspecified role prey prey association association false false false 2A exosc10-c1d 1131362 n/a 1131363 unspecified role unspecified role prey prey n/a 1131364 unspecified role unspecified role bait bait direct interaction direct interaction false false false 2B exosc10-mphosph6-1 1131362 n/a 1131364 unspecified role unspecified role bait bait n/a 1131365 unspecified role unspecified role prey prey direct interaction direct interaction false false false 2B