IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ liccardi-2014-3 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-4 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-5 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-6 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-1 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Irradiation with X rays - 4 Gy Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-2 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. anti bait coip anti bait coimmunoprecipitation anti bait coip sequence tag sequence tag identification sequence tag Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Irradiation with X rays - 4 Gy Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-7 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-8 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-9 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-10 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-11 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059j M059J-Human glioblastoma cell line m059j M059J-Human glioblastoma cell line http://www.lgcstandards-atcc.org/products/all/CRL-2366.aspx lacks DNA-dependent protein kinase activity. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-12 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-m059k Human glioblastoma M059JK cells m059k Human glioblastoma M059K cells These cells express DNA-dependent protein kinase (DNA-PK) http://www.lgcstandards-atcc.org/products/all/CRL-2365.aspx?geo_country=gb#generalinformation pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-13 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-qgp1 Human QGP1; pancreatic islet cell carcinoma/somatostatinoma qgp1 Human QGP1 cell line derived from a pancreatic islet cell carcinoma/somatostatinoma produces (CEA) and Somatostatin pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-14 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-bon1 BON1 Human pancreatic Carcinoid tumor cell line bon1 BON1 Human pancreatic Carcinoid tumor cell line derived from a lymph node metastasis Secretes chromogranin A (which is cleaved into 13 chains including vasostatin peptides, SP-I peptide, Pancreastatin and others.) pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-15 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. liccardi-2014-16 Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. human-a_431 Homo sapiens epidermoid carcinoma a_431 Human epidermoid carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Liccardi G., Hartley J.A., Hochhauser D. Cancer - Interactions investigated in the context of cancer d.hochhauser@ucl.ac.uk Clin. Cancer Res. (1078-0432) 2014 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. ercc1_human DNA excision repair protein ERCC-1 ERCC1 protein protein human Homo sapiens Human MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVDTSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKVP egfr_human Epidermal growth factor receptor ERBB1 EGFR Receptor tyrosine-protein kinase erbB-1 Proto-oncogene c-ErbB-1 ERBB HER1 protein protein human Homo sapiens Human MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA xpf_human DNA repair endonuclease XPF ERCC4 ERCC11 XPF DNA excision repair protein ERCC-4 DNA repair protein complementing XP-F cells Xeroderma pigmentosum group F-complementing protein protein protein human Homo sapiens Human MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLTDRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEKMEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQLRDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERASTKERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSSDAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDFIHTSFAEVVSKGKGKK xrn2_human 5'-3' exoribonuclease 2 XRN2 DHM1-like protein protein protein human Homo sapiens Human MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN fus_human RNA-binding protein FUS FUS TLS Oncogene FUS Oncogene TLS Translocated in liposarcoma protein POMp75 75 kDa DNA-pairing protein protein protein human Homo sapiens Human MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY lmna_human Prelamin-A/C LMNA LMN1 protein protein human Homo sapiens Human METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM apex1_human DNA-(apurinic or apyrimidinic site) endonuclease Apurinic-apyrimidinic endonuclease 1 APEX nuclease APE1 APEX1 APE APEX APX HAP1 REF1 REF-1 Redox factor-1 protein protein human Homo sapiens Human MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL nucl_human Nucleolin NCL Protein C23 protein protein human Homo sapiens Human MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE mcm4_human DNA replication licensing factor MCM4 MCM4 CDC21 CDC21 homolog P1-CDC21 protein protein human Homo sapiens Human MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL parp1_human Poly [ADP-ribose] polymerase 1 PARP1 ADPRT PPOL NAD(+) ADP-ribosyltransferase 1 Poly[ADP-ribose] synthase 1 ADP-ribosyltransferase diphtheria toxin-like 1 DNA ADP-ribosyltransferase PARP1 Protein poly-ADP-ribosyltransferase PARP1 protein protein human Homo sapiens Human MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW npm_human Nucleophosmin NPM1 NPM Nucleolar phosphoprotein B23 Numatrin Nucleolar protein NO38 protein protein human Homo sapiens Human MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL tif1b_human Transcription intermediary factor 1-beta TRIM28 KAP1 RNF96 TIF1B Tripartite motif-containing protein 28 Nuclear corepressor KAP-1 KRAB-associated protein 1 KRAB-interacting protein 1 RING finger protein 96 E3 SUMO-protein ligase TRIM28 RING-type E3 ubiquitin transferase TIF1-beta protein protein human Homo sapiens Human MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP ercc2_human General transcription and DNA repair factor IIH helicase subunit XPD ERCC2 XPD XPDC Basic transcription factor 2 80 kDa subunit CXPD DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells TFIIH basal transcription factor complex 80 kDa subunit Xeroderma pigmentosum group D-complementing protein protein protein human Homo sapiens Human MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL mcm3_human DNA replication licensing factor MCM3 MCM3 DNA polymerase alpha holoenzyme-associated protein P1 RLF subunit beta p102 P1-MCM3 protein protein human Homo sapiens Human MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI ilf2_human Interleukin enhancer-binding factor 2 PRO3063 NF45 ILF2 Nuclear factor of activated T-cells 45 kDa protein protein human Homo sapiens Human MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE ilf3_human Interleukin enhancer-binding factor 3 ILF3 MPHOSPH4 NF90 Nuclear factor of activated T-cells 90 kDa Double-stranded RNA-binding protein 76 Translational control protein 80 Nuclear factor associated with dsRNA M-phase phosphoprotein 4 DRBF protein protein human Homo sapiens Human MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR fen1_human Flap endonuclease 1 Flap structure-specific endonuclease 1 Maturation factor 1 DNase IV FEN1 RAD2 protein protein human Homo sapiens Human MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK mcm6_human DNA replication licensing factor MCM6 MCM6 p105MCM protein protein human Homo sapiens Human MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED baba2_human BRISC and BRCA1-A complex member 2 BABAM2 BRCA1-A complex subunit BRE BRCA1/BRCA2-containing complex subunit 45 BRCC45 BRE Brain and reproductive organ-expressed protein protein protein human Homo sapiens Human MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL top1_human DNA topoisomerase 1 DNA topoisomerase I TOP1 protein protein human Homo sapiens Human MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF dhx9_human ATP-dependent RNA helicase A DHX9 DDX9 NDH2 DExH-box helicase 9 RNA helicase A LKP Nuclear DNA helicase II DEAH box protein 9 Leukophysin protein protein human Homo sapiens Human MGDVKNFLYAWCGKRKMTPSYEIRAVGNKNRQKFMCEVQVEGYNYTGMGNSTNKKDAQSNAARDFVNYLVRINEIKSEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALKAENNSEVGASGYGVPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAKARLNQYFQKEKIQGEYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYHLGVVEAYSGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGINLMIGSTRYGDGPRPPKMARYDNGSGYRRGGSSYSGGGYGGGYSSGGYGSGGYGGSANSFRAGYGAGVGGGYRGVSRGGFRGNSGGDYRGPSGGYRGSGGFQRGGGRGAYGTGYFGQGRGGGGY egfr-ercc1 1766849 n/a 1766865 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait physical association physical association false false false 2 A/B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-1 1766849 n/a 1766865 unspecified role unspecified role bait bait n/a 1766866 unspecified role unspecified role prey prey n/a 1766867 unspecified role unspecified role prey prey association association false false false 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. ercc1-egfr-2 1766849 n/a 1766865 unspecified role unspecified role bait bait n/a 1766867 unspecified role unspecified role prey prey physical association physical association false false false 2C-2 this interaction was seen in the presence or absence of irradiation ercc1-egfr-3 1766850 n/a 1766865 unspecified role unspecified role bait bait n/a 1766867 unspecified role unspecified role prey prey physical association physical association false false false 2C-2 this interaction was seen in the presence or absence of irradiation egfr-ercc1-1 1766850 n/a 1766865 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait physical association physical association false false false 2 A/B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-3 1766850 n/a 1766867 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role bait bait association association false false false 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. ercc1-egfr-4 1766851 n/a 1766867 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role bait bait n/a 1766866 unspecified role unspecified role prey prey association association false false false 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. egfr-ercc1-2 1766851 n/a 1766866 unspecified role unspecified role bait bait n/a 1766865 unspecified role unspecified role prey prey physical association physical association false false false 2 B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-4 1766851 n/a 1766867 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role bait bait physical association physical association false false false 2C-2 this interaction was seen in the presence or absence of irradiation egfr-ercc1-3 1766852 n/a 1766866 unspecified role unspecified role bait bait n/a 1766865 unspecified role unspecified role prey prey physical association physical association false false false 2 B Irradiation:- 4Gy XRays for 1 minute there is a time-dependent association of EGFR and ERCC1, peaking at 20 minutes following 4 Gy IR. ercc1-egfr-5 1766852 n/a 1766867 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role bait bait physical association physical association false false false 2C-2 this interaction was seen in the presence or absence of irradiation ercc1-egfr-5 1766852 n/a 1766866 unspecified role unspecified role prey prey n/a 1766867 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role bait bait association association false false false 2C Irradiation:- 4Gy XRays for 1 minute The complex did not include EGFR when irradiation was absent. egfr-apex1 1766853 n/a 1766868 unspecified role unspecified role prey prey n/a 1766869 unspecified role unspecified role prey prey n/a 1766870 unspecified role unspecified role prey prey n/a 1766871 unspecified role unspecified role prey prey n/a 1766872 unspecified role unspecified role prey prey n/a 1766873 unspecified role unspecified role prey prey n/a 1766874 unspecified role unspecified role prey prey n/a 1766875 unspecified role unspecified role prey prey n/a 1766876 unspecified role unspecified role prey prey n/a 1766877 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait association association false false false Supp Table 1 No egfr-apex1-2 1766853 n/a 1766878 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role prey prey n/a 1766879 unspecified role unspecified role prey prey n/a 1766867 unspecified role unspecified role prey prey n/a 1766880 unspecified role unspecified role prey prey n/a 1766876 unspecified role unspecified role prey prey n/a 1766875 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait n/a 1766873 unspecified role unspecified role prey prey n/a 1766871 unspecified role unspecified role prey prey n/a 1766872 unspecified role unspecified role prey prey n/a 1766881 unspecified role unspecified role prey prey n/a 1766870 unspecified role unspecified role prey prey n/a 1766868 unspecified role unspecified role prey prey n/a 1766869 unspecified role unspecified role prey prey n/a 1766882 unspecified role unspecified role prey prey association association false false false Supp Table 1 Yes egfr-apex1-5 1766854 n/a 1766874 unspecified role unspecified role prey prey n/a 1766883 unspecified role unspecified role prey prey n/a 1766884 unspecified role unspecified role prey prey n/a 1766885 unspecified role unspecified role prey prey n/a 1766871 unspecified role unspecified role prey prey n/a 1766882 unspecified role unspecified role prey prey n/a 1766880 unspecified role unspecified role prey prey n/a 1766881 unspecified role unspecified role prey prey n/a 1766879 unspecified role unspecified role prey prey n/a 1766868 unspecified role unspecified role prey prey n/a 1766875 unspecified role unspecified role prey prey n/a 1766873 unspecified role unspecified role prey prey n/a 1766872 unspecified role unspecified role prey prey n/a 1766878 unspecified role unspecified role prey prey n/a 1766867 unspecified role unspecified role prey prey n/a 1766876 unspecified role unspecified role prey prey n/a 1766869 unspecified role unspecified role prey prey n/a 1766865 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait n/a 1766870 unspecified role unspecified role prey prey association association false false false Supp Table 1 No egfr-apex1-7 1766854 n/a 1766867 unspecified role unspecified role prey prey n/a 1766872 unspecified role unspecified role prey prey n/a 1766876 unspecified role unspecified role prey prey n/a 1766870 unspecified role unspecified role prey prey n/a 1766866 unspecified role unspecified role bait bait n/a 1766865 unspecified role unspecified role prey prey n/a 1766880 unspecified role unspecified role prey prey n/a 1766873 unspecified role unspecified role prey prey n/a 1766879 unspecified role unspecified role prey prey n/a 1766884 unspecified role unspecified role prey prey n/a 1766868 unspecified role unspecified role prey prey n/a 1766869 unspecified role unspecified role prey prey n/a 1766875 unspecified role unspecified role prey prey n/a 1766874 unspecified role unspecified role prey prey n/a 1766871 unspecified role unspecified role prey prey association association false false false Supp Table 1 Yes egfr-ercc1-4 1766855 n/a 1766865 unspecified role unspecified role neutral component neutral component n/a 1766866 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3A egfr-ercc1-5 1766856 n/a 1766866 unspecified role unspecified role neutral component neutral component n/a 1766865 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3A egfr-ercc1-6 1766857 n/a 1766866 unspecified role unspecified role neutral component neutral component n/a 1766865 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3A egfr-ercc1-7 1766858 n/a 1766866 unspecified role unspecified role neutral component neutral component n/a 1766865 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3A egfr-ercc1-8 1766859 n/a 1766865 unspecified role unspecified role neutral component neutral component n/a 1766866 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 3B, Supp 3 Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-9 1766860 n/a 1766865 unspecified role unspecified role neutral component neutral component n/a 1766866 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 3B, Supp 3 Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-10 1766861 n/a 1766866 unspecified role unspecified role neutral component neutral component n/a 1766865 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 3B Irradiation; X Rays 4Gy, I minute egfr-ercc1-11 1766862 n/a 1766865 unspecified role unspecified role neutral component neutral component n/a 1766866 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 3B, Supp 3B Irradiation; X Rays 4Gy, I minute Gefitinib; selective inhibitor of the EGFR tyrosine kinase domain. egfr-ercc1-12 1766863 n/a 1766866 unspecified role unspecified role bait bait n/a 1766865 unspecified role unspecified role prey prey physical association physical association false false false Supp 2 Irradiation:- 4Gy XRays for 1 minute egfr-ercc1-13 1766864 n/a 1766866 unspecified role unspecified role bait bait n/a 1766865 unspecified role unspecified role prey prey physical association physical association false false false Supp 2 Irradiation:- 4Gy XRays for 1 minute