#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48506	uniprotkb:P48507	intact:EBI-2832840|uniprotkb:Q14399|ensembl:ENSP00000497574	intact:EBI-1051387|uniprotkb:Q6FHC1|uniprotkb:Q9NPX9|uniprotkb:Q9NU74|uniprotkb:A8K334|uniprotkb:M5A959|uniprotkb:D3DT45|ensembl:ENSP00000359258	psi-mi:gsh1_human(display_long)|uniprotkb:GCLC(gene name)|psi-mi:GCLC(display_short)|uniprotkb:GLCL(gene name synonym)|uniprotkb:GLCLC(gene name synonym)|uniprotkb:GCS heavy chain(gene name synonym)|uniprotkb:Gamma-ECS(gene name synonym)|uniprotkb:Gamma-glutamylcysteine synthetase(gene name synonym)	psi-mi:gsh0_human(display_long)|uniprotkb:Gamma-glutamylcysteine synthetase regulatory subunit(gene name synonym)|uniprotkb:Gamma-ECS regulatory subunit(gene name synonym)|uniprotkb:GCS light chain(gene name synonym)|uniprotkb:Glutamate--cysteine ligase modifier subunit(gene name synonym)|uniprotkb:GCLM(gene name)|psi-mi:GCLM(display_short)|uniprotkb:GLCLR(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Misra et al. (1998)	imex:IM-29410|pubmed:9675072	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996567|imex:IM-29410-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0097069"(cellular response to thyroxine stimulus)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:2000490"(negative regulation of hepatic stellate cell activation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR004308(Glutamate-cysteine ligase catalytic subunit)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-174403|reactome:R-HSA-5578999|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0016595"(glutamate binding)|go:"GO:0017109"(glutamate-cysteine ligase complex)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|ensembl:ENSG00000001084(gene)|ensembl:ENST00000650454(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004357"(glutamate-cysteine ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006534"(cysteine metabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0009408"(response to heat)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0014823"(response to activity)|refseq:NP_001184044.1|refseq:NP_001489.1	refseq:NP_002052.1|refseq:NP_001295182.1|ensembl:ENSG00000023909(gene)|ensembl:ENST00000370238(transcript)|go:"GO:0004357"(glutamate-cysteine ligase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006534"(cysteine metabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0014823"(response to activity)|go:"GO:0017109"(glutamate-cysteine ligase complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0035226"(glutamate-cysteine ligase catalytic subunit binding)|go:"GO:0035229"(positive regulation of glutamate-cysteine ligase activity)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0042493"|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0097069"(cellular response to thyroxine stimulus)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR023210|interpro:IPR032963|interpro:IPR036812|reactome:R-HSA-174403|reactome:R-HSA-5578999	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2022/01/12	2022/01/12	rogid:EcbMKzIB2YBbUBswkGfUFZUPC9s9606	rogid:arU12Xm86K7yRxElliA31V7z5d89606	rigid:SSKmJFjxxHzYXeIdjiVnKd+gb1w	false	-	-	-	-	psi-mi:"MI:0433"(partial identification of protein sequence)	psi-mi:"MI:0433"(partial identification of protein sequence)