#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2D6	uniprotkb:Q8BTI8	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-8328602|uniprotkb:E9QNB0|uniprotkb:Q3TBY5|uniprotkb:Q569P9|uniprotkb:Q80U37|intact:MINT-4112373|uniprotkb:Q8K383|ensembl:ENSMUSP00000139842	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:srrm2_mouse(display_long)|uniprotkb:Srrm2(gene name)|psi-mi:Srrm2(display_short)|uniprotkb:Kiaa0324(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_780438.2|refseq:XP_006525139.1|refseq:XP_006525140.1|ensembl:ENSMUSG00000039218(gene)|ensembl:ENSMUST00000190686(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q8BTI8|reactome:R-MMU-72163	-	-	function:Part of pre- and post-splicing multiprotein mRNP complexes. May be involved in pre-mRNA processing events. Binds to RNA|comment:mint	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:PTLJsCjqGftaxq5deG19BhEASWo10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:P97868	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-8329311|uniprotkb:P70287|uniprotkb:Q8R399|uniprotkb:Q3TTR9|uniprotkb:Q4U217|uniprotkb:Q3UMP7|intact:MINT-4106375|uniprotkb:Q3TUM7|uniprotkb:Q7TT06|uniprotkb:Q8BNY8|ensembl:ENSMUSP00000049528	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:rbbp6_mouse(display_long)|uniprotkb:Rbbp6(gene name)|psi-mi:Rbbp6(display_short)|uniprotkb:P2pr(gene name synonym)|uniprotkb:Pact(gene name synonym)|uniprotkb:p53-associated cellular protein of testis(gene name synonym)|uniprotkb:Proliferation potential-related protein(gene name synonym)|uniprotkb:Protein P2P-R(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RBBP6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_035377.2|refseq:NP_778188.1|refseq:XP_006507533.1|ensembl:ENSMUSG00000030779(gene)|ensembl:ENSMUST00000052135(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006397"(mRNA processing)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0048568"(embryonic organ development)|go:"GO:0061053"(somite development)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014891(DWNN domain)|interpro:IPR025829|interpro:IPR033489|interpro:IPR036875|mint:P97868|reactome:R-MMU-9013422|reactome:R-MMU-983168	-	-	comment:mint	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:mpPVAoOa4h9lRTIZhKfpI5Po5cg10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8BG05	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2735601|uniprotkb:Q8BHF8|ensembl:ENSMUSP00000088298|ensembl:ENSMUSP00000107595	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:roa3_mouse(display_long)|uniprotkb:Hnrnpa3(gene name)|psi-mi:Hnrnpa3(display_short)|uniprotkb:Hnrpa3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_444493.1|refseq:NP_666242.2|refseq:NP_932758.1|ensembl:ENSMUSG00000059005(gene)|ensembl:ENSMUST00000090792(transcript)|ensembl:ENSMUST00000111964(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:Q8BG05|reactome:R-MMU-72163|reactome:R-MMU-72203|refseq:XP_011237818.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:KcZjXvHON9QZSqHWi4nWSDz/HtE10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O88569	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-299636|ensembl:ENSMUSP00000110103|ensembl:ENSMUSP00000145028|uniprotkb:Q3UVJ5|uniprotkb:Q6PCV9|uniprotkb:Q8C2A0|uniprotkb:Q8CJ71|uniprotkb:Q91ZR9|uniprotkb:Q9R204|uniprotkb:B9EJ02	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:roa2_mouse(display_long)|uniprotkb:Hnrnpa2b1(gene name)|psi-mi:Hnrnpa2b1(display_short)|uniprotkb:Hnrpa2b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000004980(gene)|ensembl:ENSMUST00000114459(transcript)|ensembl:ENSMUST00000203954(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0050658"(RNA transport)|go:"GO:0005634"(nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:0016233"(telomere capping)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0016363"(nuclear matrix)|interpro:IPR034486|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR034489|interpro:IPR035979|mint:O88569|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0043005"(neuron projection)|refseq:NP_058086.2|refseq:NP_872591.1|refseq:XP_006506436.2|refseq:XP_006506437.2	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:spiQ4bW/9iuXf5NMz/cdsgIWQLE10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:P09405	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O08810	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2550333|ensembl:ENSMUSP00000102675	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:u5s1_mouse(display_long)|uniprotkb:Eftud2(gene name)|psi-mi:Eftud2(display_short)|uniprotkb:Snrp116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000020929(gene)|ensembl:ENSMUST00000107060(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:O08810|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_001103465.1|refseq:NP_035561.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:BXx/oB92nIw8mcrZHvpWc+E+DFA10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:P41230	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-26619093|ensembl:ENSMUSP00000108203|uniprotkb:O54995|uniprotkb:Q3TYU8|uniprotkb:Q3U1X6|uniprotkb:Q3U282|uniprotkb:Q6ZQF8|uniprotkb:Q80XQ9|uniprotkb:Q9CVI4|uniprotkb:Q9D0C3|uniprotkb:Q9QVR8|uniprotkb:Q9R039	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:kdm5c_mouse(display_long)|uniprotkb:Histone demethylase JARID1C(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1C(gene name synonym)|uniprotkb:Protein SmcX(gene name synonym)|uniprotkb:Protein Xe169(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5C"(gene name synonym)|uniprotkb:Kdm5c(gene name)|psi-mi:Kdm5c(display_short)|uniprotkb:Jarid1c(gene name synonym)|uniprotkb:Kiaa0234(gene name synonym)|uniprotkb:Smcx(gene name synonym)|uniprotkb:Xe169(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	go:"GO:0048511"(rhythmic process)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|mint:P41230|reactome:R-MMU-3214842|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000025332(gene)|ensembl:ENSMUST00000112584(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|refseq:NP_038696.2|refseq:XP_006528832.1|refseq:XP_006528835.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:Cz2SLt7G4flnRV/dGUoqKlwpIK410090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8BTW8	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-26619062|ensembl:ENSMUSP00000028990|ensembl:ENSMUSP00000105353|uniprotkb:Q9D6Q4	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:ck5p1_mouse(display_long)|uniprotkb:CDK5 activator-binding protein C42(gene name synonym)|uniprotkb:CDK5 regulatory subunit-associated protein 1(gene name synonym)|uniprotkb:mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase(gene name synonym)|uniprotkb:"mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase"(gene name synonym)|uniprotkb:Cdk5rap1(gene name)|psi-mi:Cdk5rap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000027487(gene)|ensembl:ENSMUST00000028990(transcript)|ensembl:ENSMUST00000109731(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0035597"(N6-isopentenyladenosine methylthiotransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0070900"(mitochondrial tRNA modification)|interpro:IPR002792(Deoxyribonuclease/rho motif-related TRAM)|interpro:IPR005839(Protein of unknown function UPF0004)|interpro:IPR006463("tRNA-i(6)A37 modification enzyme MiaB")|interpro:IPR006638(Elongator protein 3/MiaB/NifB)|interpro:IPR007197(Radical SAM)|interpro:IPR013848(Protein of unknown function UPF0004, N-terminal)|interpro:IPR020612|interpro:IPR023404|interpro:IPR038135|mint:Q8BTW8|refseq:NP_080152.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:yWH0WrDyUzl1RdwJBTy+JpOjvrY10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q9JIX8	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-3043817|uniprotkb:B8JJ87|ensembl:ENSMUSP00000022793|uniprotkb:Q9CSN7|uniprotkb:Q9CSR9|uniprotkb:Q9CSX7|uniprotkb:Q9R046|uniprotkb:Q9R047	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:acinu_mouse(display_long)|uniprotkb:Acin1(gene name)|psi-mi:Acin1(display_short)|uniprotkb:Acinus(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|ensembl:ENSMUSG00000022185(gene)|ensembl:ENSMUST00000022793(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032552|interpro:IPR034257|interpro:IPR035979|interpro:IPR036361|reactome:R-MMU-111465|mint:Q9JIX8|refseq:NP_001078942.2|refseq:NP_001229534.1|refseq:NP_062513.3|refseq:NP_075679.2|refseq:XP_006519361.1|refseq:XP_006519367.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:U5PP/rm/ISlOu/33tl61lOBoSBQ10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q9Z321	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-16728364|ensembl:ENSMUSP00000023465|ensembl:ENSMUSP00000156132	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:top3b_mouse(display_long)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)|uniprotkb:Top3b(gene name)|psi-mi:Top3b(display_short)|uniprotkb:Top3b1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000022779(gene)|ensembl:ENSMUST00000023465(transcript)|ensembl:ENSMUST00000232581(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:Q9Z321|refseq:NP_001313505.1|refseq:NP_035754.1|refseq:XP_006522054.1|refseq:XP_006522055.1|refseq:XP_006522057.1|refseq:XP_006522058.1|refseq:XP_017172426.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:9m6mpZ7aIV3fx3bU6opc3sFN3SA10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q04750	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-6666222|ensembl:ENSMUSP00000105094|uniprotkb:A2A4B7	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:top1_mouse(display_long)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:Top-1(gene name synonym)|uniprotkb:DNA topoisomerase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000070544(gene)|ensembl:ENSMUST00000109468(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|reactome:R-MMU-4615885|mint:Q04750|refseq:NP_033434.2	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:nY84yAtfGCI/k+B2u3mM151r+zU10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8VIJ6	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-6094576|uniprotkb:A2A7U6|uniprotkb:Q9ERW2|ensembl:ENSMUSP00000030623	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:sfpq_mouse(display_long)|uniprotkb:Sfpq(gene name)|psi-mi:Sfpq(display_short)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:Psf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_076092.1|ensembl:ENSMUSG00000028820(gene)|ensembl:ENSMUST00000030623(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:Q8VIJ6|reactome:R-MMU-8849468	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:9mciNgfKrEvyAv7kjs55FHlUtRY10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:P51448	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-1169722|uniprotkb:P70283|uniprotkb:P97741|uniprotkb:P97773|uniprotkb:Q923G1|ensembl:ENSMUSP00000034766	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:rora_mouse(display_long)|uniprotkb:Retinoid-related orphan receptor-alpha(gene name synonym)|uniprotkb:Nuclear receptor RZR-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group F member 1(gene name synonym)|uniprotkb:Rora(gene name)|psi-mi:Rora(display_short)|uniprotkb:Nr1f1(gene name synonym)|uniprotkb:Rzra(gene name synonym)|uniprotkb:RAR-related orphan receptor A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_038674.1|refseq:NP_001276845.1|ensembl:ENSMUSG00000032238(gene)|ensembl:ENSMUST00000034766(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0008142"(oxysterol binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046068"(cGMP metabolic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072539"(T-helper 17 cell differentiation)|go:"GO:0098531"(ligand-activated transcription factor activity)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003079(Nuclear receptor ROR)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044101|mint:P51448|reactome:R-MMU-383280|reactome:R-MMU-4090294|dip:DIP-35351N	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:1wN5T6JsFmE3jJ3Nps7EfwUp5ho10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q99PV0	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2551815|ensembl:ENSMUSP00000018449|ensembl:ENSMUSP00000099568|uniprotkb:A5D6Q4|uniprotkb:Q7TQK2|uniprotkb:Q8BRZ5|uniprotkb:Q8K001|uniprotkb:Q5ND30|uniprotkb:Q5ND31	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:prp8_mouse(display_long)|uniprotkb:Prp8(gene name synonym)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:Prpf8(gene name)|psi-mi:Prpf8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000020850(gene)|ensembl:ENSMUST00000018449(transcript)|ensembl:ENSMUST00000102510(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q99PV0|reactome:R-MMU-72163|reactome:R-MMU-72165|interpro:IPR037518|refseq:NP_619600.2	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:vHccw48piO1PjsNcxDszzscPO8010090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:P08551	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8C854	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-4285350|uniprotkb:Q6ZPT3|uniprotkb:Q8QZZ1|uniprotkb:Q60690|uniprotkb:Q6P930|ensembl:ENSMUSP00000123088	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:myef2_mouse(display_long)|uniprotkb:Myef2(gene name)|psi-mi:Myef2(display_short)|uniprotkb:Kiaa1341(gene name synonym)|uniprotkb:Mef2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_001155889.1|refseq:XP_006498947.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034630|interpro:IPR034631|interpro:IPR034632|interpro:IPR035979|interpro:IPR000504(RNA recognition motif, RNP-1)|mint:Q8C854|ensembl:ENSMUSG00000027201(gene)|ensembl:ENSMUST00000152367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|refseq:XP_017171620.1|refseq:XP_017171621.1|refseq:XP_017171623.1	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:ZnM8NqQUhlLdO7gzhs09ckrZUPw10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q6PGF3	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-6260816|uniprotkb:E9QM81	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:med16_mouse(display_long)|uniprotkb:Mediator complex subunit 16(gene name synonym)|uniprotkb:Thrap5(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 5(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 95 kDa component(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 92 kDa component(gene name synonym)|uniprotkb:Med16(gene name)|psi-mi:Med16(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|interpro:IPR001680(WD40 repeat)|interpro:IPR011041(Soluble quinoprotein glucose dehydrogenase)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR021665|interpro:IPR036322|rcsb pdb:6W1S|reactome:R-MMU-212436|mint:Q6PGF3|dip:DIP-48408N	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:7RYpXMMTPBtLxPGifdlY+MdwlEM10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q6IE82	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-12553408|ensembl:ENSMUSP00000048529|uniprotkb:A1L3T5|uniprotkb:Q6ZQG2	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:jade3_mouse(display_long)|uniprotkb:Jade3(gene name)|psi-mi:Jade3(display_short)|uniprotkb:Kiaa0215(gene name synonym)|uniprotkb:Phf16(gene name synonym)|uniprotkb:Jade family PHD finger protein 3(gene name synonym)|uniprotkb:PHD finger protein 16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000037315(gene)|ensembl:ENSMUST00000043693(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019542|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|interpro:IPR039550|mint:Q6IE82|reactome:R-MMU-3214847|refseq:NP_955021.2	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:O+nRJbSNBRCfhyNq2ssifkGxK7g10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8VEK3	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-529674|uniprotkb:Q9R205|uniprotkb:G3XA10|ensembl:ENSMUSP00000047571	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:hnrpu_mouse(display_long)|uniprotkb:Hnrpu(gene name synonym)|uniprotkb:Hnrnpu(gene name)|psi-mi:Hnrnpu(display_short)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:XP_017177162.1|refseq:XP_017177163.1|refseq:NP_058085.2|refseq:XP_017177161.1|dip:DIP-34257N|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q8VEK3|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000039630(gene)|ensembl:ENSMUST00000037748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:ONBrFPHIT3aP6XnUgJMf4qiu8VQ10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q9D0E1	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-773789|uniprotkb:Q6P1B2|uniprotkb:Q99JQ0|ensembl:ENSMUSP00000120115	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:hnrpm_mouse(display_long)|uniprotkb:Hnrpm(gene name synonym)|uniprotkb:Hnrnpm(gene name)|psi-mi:Hnrnpm(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_001103383.1|refseq:NP_084080.1|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:Q9D0E1|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000059208(gene)|ensembl:ENSMUST00000148178(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0048306"(calcium-dependent protein binding)	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:VpoWJwPx1uDzAsBxM3/TfiCMGok10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O35668	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-473704|uniprotkb:O35636|ensembl:ENSMUSP00000133356	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:hap1_mouse(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_034534.1|refseq:NP_817090.1|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000138603(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|mint:O35668|go:"GO:0030425"(dendrite)|dip:DIP-32510N	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:mrrVufzrFAAiuT8yarD5JfWlRbc10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O70133	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q61656	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-643076|uniprotkb:E9Q105	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q62167	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q501J6	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-911206|uniprotkb:Q6P5G1|uniprotkb:Q8BIN2|ensembl:ENSMUSP00000155307	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:ddx17_mouse(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:Ddx17(gene name)|psi-mi:Ddx17(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_001035277.1|refseq:NP_951061.1|refseq:NP_951062.1|ensembl:ENSMUSG00000055065(gene)|ensembl:ENSMUST00000229877(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0061614"(miRNA transcription)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q501J6|reactome:R-MMU-3899300	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:uGXMsVmy7MWcTaJPNlkof05dS8I10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q61687	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2657527|intact:EBI-2658449|uniprotkb:A2ADH4|ensembl:ENSMUSP00000109203	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:atrx_mouse(display_long)|uniprotkb:Xnp(gene name synonym)|uniprotkb:ATP-dependent helicase ATRX(gene name synonym)|uniprotkb:HP1 alpha-interacting protein(gene name synonym)|uniprotkb:HP1-BP38 protein(gene name synonym)|uniprotkb:Heterochromatin protein 2(gene name synonym)|uniprotkb:X-linked nuclear protein(gene name synonym)|uniprotkb:Atrx(gene name)|psi-mi:Atrx(display_short)|uniprotkb:Hp1bp2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619053|imex:IM-28803-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_033556.2|interpro:IPR038718|interpro:IPR041430|mint:Q61687|reactome:R-MMU-9670095|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900112"(regulation of histone H3-K9 trimethylation)|go:"GO:1901581"(negative regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1901582"(positive regulation of telomeric RNA transcription from RNA pol II promoter)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR025766|interpro:IPR027417|ensembl:ENSMUSG00000031229(gene)|ensembl:ENSMUST00000113573(transcript)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030900"(forebrain development)|go:"GO:0031297"(replication fork processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035128"(post-embryonic forelimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070615"|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0072711"(cellular response to hydroxyurea)|dip:DIP-55974N	-	-	-	figure legend:Fig. 5A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:dZfE7Or8WAgkuHkmUcqC3UlWi7U10090	rigid:C0BImPm44oVBitH5lrdQzj+UOWk	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q8BTI8	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-8328602|uniprotkb:E9QNB0|uniprotkb:Q3TBY5|uniprotkb:Q569P9|uniprotkb:Q80U37|intact:MINT-4112373|uniprotkb:Q8K383|ensembl:ENSMUSP00000139842	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:srrm2_mouse(display_long)|uniprotkb:Srrm2(gene name)|psi-mi:Srrm2(display_short)|uniprotkb:Kiaa0324(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_780438.2|refseq:XP_006525139.1|refseq:XP_006525140.1|ensembl:ENSMUSG00000039218(gene)|ensembl:ENSMUST00000190686(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q8BTI8|reactome:R-MMU-72163	-	-	function:Part of pre- and post-splicing multiprotein mRNP complexes. May be involved in pre-mRNA processing events. Binds to RNA|comment:mint	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:PTLJsCjqGftaxq5deG19BhEASWo10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O08810	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2550333|ensembl:ENSMUSP00000102675	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:u5s1_mouse(display_long)|uniprotkb:Eftud2(gene name)|psi-mi:Eftud2(display_short)|uniprotkb:Snrp116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000020929(gene)|ensembl:ENSMUST00000107060(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:O08810|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_001103465.1|refseq:NP_035561.1	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:BXx/oB92nIw8mcrZHvpWc+E+DFA10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q9JIX8	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-3043817|uniprotkb:B8JJ87|ensembl:ENSMUSP00000022793|uniprotkb:Q9CSN7|uniprotkb:Q9CSR9|uniprotkb:Q9CSX7|uniprotkb:Q9R046|uniprotkb:Q9R047	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:acinu_mouse(display_long)|uniprotkb:Acin1(gene name)|psi-mi:Acin1(display_short)|uniprotkb:Acinus(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|ensembl:ENSMUSG00000022185(gene)|ensembl:ENSMUST00000022793(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032552|interpro:IPR034257|interpro:IPR035979|interpro:IPR036361|reactome:R-MMU-111465|mint:Q9JIX8|refseq:NP_001078942.2|refseq:NP_001229534.1|refseq:NP_062513.3|refseq:NP_075679.2|refseq:XP_006519361.1|refseq:XP_006519367.1	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:U5PP/rm/ISlOu/33tl61lOBoSBQ10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q04750	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-6666222|ensembl:ENSMUSP00000105094|uniprotkb:A2A4B7	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:top1_mouse(display_long)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:Top-1(gene name synonym)|uniprotkb:DNA topoisomerase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000070544(gene)|ensembl:ENSMUST00000109468(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0003682"(chromatin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|reactome:R-MMU-4615885|mint:Q04750|refseq:NP_033434.2	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:nY84yAtfGCI/k+B2u3mM151r+zU10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q99PV0	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2551815|ensembl:ENSMUSP00000018449|ensembl:ENSMUSP00000099568|uniprotkb:A5D6Q4|uniprotkb:Q7TQK2|uniprotkb:Q8BRZ5|uniprotkb:Q8K001|uniprotkb:Q5ND30|uniprotkb:Q5ND31	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:prp8_mouse(display_long)|uniprotkb:Prp8(gene name synonym)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:Prpf8(gene name)|psi-mi:Prpf8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000020850(gene)|ensembl:ENSMUST00000018449(transcript)|ensembl:ENSMUST00000102510(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q99PV0|reactome:R-MMU-72163|reactome:R-MMU-72165|interpro:IPR037518|refseq:NP_619600.2	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:vHccw48piO1PjsNcxDszzscPO8010090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q6IE82	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-12553408|ensembl:ENSMUSP00000048529|uniprotkb:A1L3T5|uniprotkb:Q6ZQG2	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:jade3_mouse(display_long)|uniprotkb:Jade3(gene name)|psi-mi:Jade3(display_short)|uniprotkb:Kiaa0215(gene name synonym)|uniprotkb:Phf16(gene name synonym)|uniprotkb:Jade family PHD finger protein 3(gene name synonym)|uniprotkb:PHD finger protein 16(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000037315(gene)|ensembl:ENSMUST00000043693(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019542|interpro:IPR019786|interpro:IPR019787|interpro:IPR034732|interpro:IPR039550|mint:Q6IE82|reactome:R-MMU-3214847|refseq:NP_955021.2	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:O+nRJbSNBRCfhyNq2ssifkGxK7g10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:O35668	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-473704|uniprotkb:O35636|ensembl:ENSMUSP00000133356	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:hap1_mouse(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26852395|imex:IM-28803-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_034534.1|refseq:NP_817090.1|ensembl:ENSMUSG00000006930(gene)|ensembl:ENSMUST00000138603(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016234"(inclusion body)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006933(HAP1, N-terminal)|mint:O35668|go:"GO:0030425"(dendrite)|dip:DIP-32510N	-	-	-	figure legend:Fig. 5A|agonist:RNAse|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/03/01	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:mrrVufzrFAAiuT8yarD5JfWlRbc10090	rigid:6btjdlLvZIx4UJfYvFr27efZxB8	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9Z2D6	uniprotkb:Q99PV0	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2551815|ensembl:ENSMUSP00000018449|ensembl:ENSMUSP00000099568|uniprotkb:A5D6Q4|uniprotkb:Q7TQK2|uniprotkb:Q8BRZ5|uniprotkb:Q8K001|uniprotkb:Q5ND30|uniprotkb:Q5ND31	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:prp8_mouse(display_long)|uniprotkb:Prp8(gene name synonym)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:Prpf8(gene name)|psi-mi:Prpf8(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619186|imex:IM-28803-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	ensembl:ENSMUSG00000020850(gene)|ensembl:ENSMUST00000018449(transcript)|ensembl:ENSMUST00000102510(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q99PV0|reactome:R-MMU-72163|reactome:R-MMU-72165|interpro:IPR037518|refseq:NP_619600.2	-	-	-	figure legend:Fig. 5B|comment:TOP2b was also stated to have been detected|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:vHccw48piO1PjsNcxDszzscPO8010090	rigid:umtSquL1F14etWOfwLh4ZBWoQ1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2D6	uniprotkb:Q3TKT4	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-1210244|uniprotkb:Q6AXG8|uniprotkb:Q3TUD7|ensembl:ENSMUSP00000133922	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:smca4_mouse(display_long)|uniprotkb:Smarca4(gene name)|psi-mi:Smarca4(display_short)|uniprotkb:Baf190a(gene name synonym)|uniprotkb:Brg1(gene name synonym)|uniprotkb:Snf2b(gene name synonym)|uniprotkb:Snf2l4(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA4(gene name synonym)|uniprotkb:BRG1-associated factor 190A(gene name synonym)|uniprotkb:Protein brahma homolog 1(gene name synonym)|uniprotkb:SNF2-beta(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619186|imex:IM-28803-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_001167549.1|refseq:NP_001167550.1|refseq:NP_035547.2|refseq:XP_006510180.2|refseq:XP_006510182.2|refseq:XP_006510183.2|dip:DIP-40650N|dip:DIP-59249N|ensembl:ENSMUSG00000032187(gene)|ensembl:ENSMUST00000174008(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0001889"(liver development)|go:"GO:0002039"(p53 binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007399"(nervous system development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0007507"(heart development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010467"(gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030957"(Tat protein binding)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035887"(aortic smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030100|interpro:IPR036427|interpro:IPR038718|mint:Q3TKT4|reactome:R-MMU-1266695|reactome:R-MMU-201722|reactome:R-MMU-3214858|reactome:R-MMU-3247509|reactome:R-MMU-8939243|interpro:IPR037259	-	-	-	figure legend:Fig. 5B|comment:TOP2b was also stated to have been detected|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:uLQrygmWWugY//OpA2aX4t2VgmM10090	rigid:umtSquL1F14etWOfwLh4ZBWoQ1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2D6	uniprotkb:Q6DIC0	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-10765904	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:smca2_mouse(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:Smarca2(gene name)|psi-mi:Smarca2(display_short)|uniprotkb:Baf190b(gene name synonym)|uniprotkb:Brm(gene name synonym)|uniprotkb:Snf2a(gene name synonym)|uniprotkb:Snf2l2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619186|imex:IM-28803-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	mint:Q6DIC0|refseq:NP_001334368.1|refseq:NP_035546.2|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035887"(aortic smooth muscle cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|reactome:R-MMU-3214858|reactome:R-MMU-8939243|dip:DIP-48888N	-	-	-	figure legend:Fig. 5B|comment:TOP2b was also stated to have been detected|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:ZrEeTYo/qhRuM5fl1Ay0EyTOXJc10090	rigid:umtSquL1F14etWOfwLh4ZBWoQ1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2D6	uniprotkb:O70133	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-2657677|uniprotkb:O35931|uniprotkb:O54703|uniprotkb:Q5FWY1|uniprotkb:Q6R5F7|uniprotkb:Q9CSA2	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	psi-mi:dhx9_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Ddx9(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Maxwell et al. (2013)	pubmed:24270455|imex:IM-28803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26619186|imex:IM-28803-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_031868.2|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005844"(polysome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007623"(circadian rhythm)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|rcsb pdb:1UIL|rcsb pdb:1WHQ|rcsb pdb:2RS6|rcsb pdb:2RS7|reactome:R-MMU-1810476|reactome:R-MMU-3134963|reactome:R-MMU-72163|interpro:IPR027417|mint:O70133|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447	-	-	-	figure legend:Fig. 5B|comment:TOP2b was also stated to have been detected|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2021/02/10	2021/02/10	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	rogid:8NHxvbw0StglewhGm3e7Pi/8oOg10090	rigid:umtSquL1F14etWOfwLh4ZBWoQ1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)