#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P12979 uniprotkb:Q60929 intact:EBI-7132875|ensembl:ENSMUSP00000027730|intact:MINT-1958829 intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566 psi-mi:myog_mouse(display_long)|uniprotkb:Myog(gene name)|psi-mi:Myog(display_short)|uniprotkb:MYOD1-related protein(gene name synonym) psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kaushal et al. (1994) pubmed:7973707|imex:IM-28028 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-25419400|imex:IM-28028-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026459(gene)|ensembl:ENSMUST00000027730(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1901739"(regulation of myoblast fusion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR039704|mint:P12979|reactome:R-MMU-525793|refseq:NP_112466.1|dip:DIP-29976N refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929 - comment:mint|function:"Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein" - figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2020/01/28 2021/04/28 rogid:l3clEJXowEpguOGcxOJfG13NXvU10090 rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090 rigid:Ko6sgrUjjZBtVSQOguELJ65I6Ic false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P12979 uniprotkb:Q60929 intact:EBI-7132875|ensembl:ENSMUSP00000027730|intact:MINT-1958829 intact:EBI-2639094|uniprotkb:Q3V155|uniprotkb:Q4VA09|uniprotkb:Q6P8Q3|ensembl:ENSMUSP00000117496|ensembl:ENSMUSP00000138566 psi-mi:myog_mouse(display_long)|uniprotkb:Myog(gene name)|psi-mi:Myog(display_short)|uniprotkb:MYOD1-related protein(gene name synonym) psi-mi:mef2a_mouse(display_long)|uniprotkb:Mef2a(gene name)|psi-mi:Mef2a(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kaushal et al. (1994) pubmed:7973707|imex:IM-28028 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-25419404|imex:IM-28028-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026459(gene)|ensembl:ENSMUST00000027730(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1901739"(regulation of myoblast fusion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR039704|mint:P12979|reactome:R-MMU-525793|refseq:NP_112466.1|dip:DIP-29976N refseq:NP_001278120.1|refseq:NP_001278121.1|refseq:NP_001278124.1|refseq:NP_001278125.1|refseq:XP_011249116.1|refseq:XP_017177500.1|refseq:NP_001028885.1|refseq:XP_006540749.1|ensembl:ENSMUSG00000030557(gene)|ensembl:ENSMUST00000135493(transcript)|ensembl:ENSMUST00000156690(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q60929 - comment:mint|function:"Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein" - figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2020/01/28 2021/04/28 rogid:l3clEJXowEpguOGcxOJfG13NXvU10090 rogid:Z/iMKtSs4pNMyjZ2o808rHfEuGk10090 rigid:Ko6sgrUjjZBtVSQOguELJ65I6Ic false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10085 uniprotkb:Q02078 intact:EBI-4405734|uniprotkb:Q8C6B1|ensembl:ENSMUSP00000072330 intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9 psi-mi:myod1_mouse(display_long)|uniprotkb:Myod1(gene name)|psi-mi:Myod1(display_short)|uniprotkb:Myod(gene name synonym) psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Kaushal et al. (1994) pubmed:7973707|imex:IM-28028 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-25419415|imex:IM-28028-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034996.2|dip:DIP-37N|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0007518"(myoblast fate determination)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0014904"(myotube cell development)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|ensembl:ENSMUSG00000009471(gene)|ensembl:ENSMUST00000072514(transcript)|interpro:IPR036638|interpro:IPR039704|mint:P10085|rcsb pdb:1MDY|reactome:R-MMU-525793|interpro:IPR022032 refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078 - - - figure legend:Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/28 2021/04/28 rogid:9GpR7O8xYPiQXHqrlxB/HioqgJM10090 rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606 rigid:DFE6rvEfjfLwjn1WKUmetTXAd+I false sufficient binding region:100-318,1-62|sufficient binding region:1-126|necessary binding region:102-135 glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10085 uniprotkb:Q02078 intact:EBI-4405734|uniprotkb:Q8C6B1|ensembl:ENSMUSP00000072330 intact:EBI-2656305|uniprotkb:Q59GX4|uniprotkb:O43814|uniprotkb:Q14223|uniprotkb:Q14224|uniprotkb:Q96D14|intact:EBI-11323186|uniprotkb:B4DFQ7|uniprotkb:F6XG23|uniprotkb:Q7Z6C9 psi-mi:myod1_mouse(display_long)|uniprotkb:Myod1(gene name)|psi-mi:Myod1(display_short)|uniprotkb:Myod(gene name synonym) psi-mi:mef2a_human(display_long)|uniprotkb:MEF2A(gene name)|psi-mi:MEF2A(display_short)|uniprotkb:MEF2(gene name synonym)|uniprotkb:Serum response factor-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Kaushal et al. (1994) pubmed:7973707|imex:IM-28028 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-26965081|imex:IM-28028-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034996.2|dip:DIP-37N|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0007518"(myoblast fate determination)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0014904"(myotube cell development)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030016"(myofibril)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|ensembl:ENSMUSG00000009471(gene)|ensembl:ENSMUST00000072514(transcript)|interpro:IPR036638|interpro:IPR039704|mint:P10085|rcsb pdb:1MDY|reactome:R-MMU-525793|interpro:IPR022032 refseq:XP_011519883.1|refseq:XP_011519884.1|refseq:XP_011519888.1|refseq:NP_001124399.1|refseq:NP_005578.2|refseq:XP_016877679.1|refseq:XP_016877680.1|refseq:XP_016877682.1|refseq:XP_016877683.1|refseq:NP_001124400.1|refseq:NP_001165365.1|refseq:NP_001306135.1|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:1C7U|rcsb pdb:1EGW|rcsb pdb:1LEW|rcsb pdb:3KOV|rcsb pdb:3MU6|rcsb pdb:3P57|rcsb pdb:6BYY|rcsb pdb:6BZ1|reactome:R-HSA-198753|reactome:R-HSA-525793|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071277"(cellular response to calcium ion)|dip:DIP-40711N|mint:Q02078 - - - figure legend:Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/28 2021/04/28 rogid:9GpR7O8xYPiQXHqrlxB/HioqgJM10090 rogid:x3duUV06wVmW/uTazIAOWm0cQ8k9606 rigid:DFE6rvEfjfLwjn1WKUmetTXAd+I false necessary binding region:1-56|sufficient binding region:1-87 glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)