#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:15414"	wwpdb:6wjt	intact:EBI-980183	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:s-adenosyl-l-methionine(display_short)|psi-mi:"CHEBI:15414"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442277|imex:IM-28473-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Fig. 1a|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.4x10^-6 ~1.5(molar)	2020/11/04	2020/11/04	-	-	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16680"	wwpdb:6wjt	intact:EBI-1180228	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:s-adenosyl-l-homocysteine(display_short)|psi-mi:"CHEBI:16680"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442331|imex:IM-28473-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Fig. 1b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.7x10^-6 ~1.9(molar)	2020/11/04	2020/11/04	-	-	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:45453"	wwpdb:6wjt	intact:EBI-9696660	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:sinefungin(display_short)|psi-mi:"CHEBI:45453"(display_long)|intact:"(2S,5S)-2,5-diamino-6-[(2R,3S,R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid"(synonym)|intact:"6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid"(synonym)|intact:"6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid"(synonym)|intact:A 9145(synonym)|intact:ADENOSYL-ORNITHINE(synonym)|intact:Antibiotic A 9145(synonym)|intact:sinefungin(synonym)|intact:sinefungina(synonym)|intact:sinefungine(synonym)|intact:sinefunginum(synonym)|intact:"(5S)-5-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-L-norleucine"(iupac name)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442338|imex:IM-28473-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	inchi key:LMXOHSDXUQEUSF-YECHIGJVSA-N	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Fig. 1c|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.8x10^-6 ~2.0(molar)	2020/11/04	2020/11/04	-	-	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	wwpdb:6wjt	intact:EBI-25591522	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442378|imex:IM-28473-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Figs. 2, 3, S5|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.3x10^-7 ~0.002(molar)	2020/11/04	2020/11/05	-	-	-	false	fluorescein label:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	chebi:"CHEBI:157761"	intact:EBI-25591522	intact:EBI-26442588	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:n7-megpppg(display_short)|psi-mi:"CHEBI:157761"(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442590|imex:IM-28473-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Figs. 2, 3|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	fluorescein label:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	wwpdb:6wjt	intact:EBI-25591522	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442590|imex:IM-28473-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Figs. 2, 3|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	fluorescein label:c-c	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	chebi:"CHEBI:157762"	intact:EBI-25591522	intact:EBI-26442629	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:n7-methyl-gpppa(display_short)|psi-mi:"CHEBI:157762"(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442631|imex:IM-28473-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Figs. 2, 3|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	fluorescein label:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	wwpdb:6wjt	intact:EBI-25591522	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442631|imex:IM-28473-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Figs. 2, 3|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	fluorescein label:c-c	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	chebi:"CHEBI:149612"	intact:EBI-25591522	intact:EBI-25591522	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442716|imex:IM-28473-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. S6|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	biotin tag:c-c	fluorescein label:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:149612"	wwpdb:6wjt	intact:EBI-25591522	intact:EBI-25491957|intenz:2.1.1.|wwpdb:7jib|wwpdb:6w4h|wwpdb:6w61|wwpdb:6w75|wwpdb:6wkq|wwpdb:6xkm|wwpdb:7bq7|wwpdb:6wks|wwpdb:6wq3|wwpdb:7c2i|wwpdb:7c2j|wwpdb:7jpe|wwpdb:7jhe|wwpdb:6wrz|wwpdb:6wvn|wwpdb:6yz1|reactome:R-COV-9694416|wwpdb:7jyy|wwpdb:7jz0|wwpdb:7koa|wwpdb:7l6t|wwpdb:7l6r|wwpdb:7lw4|wwpdb:7lw3	psi-mi:7meg5'-ppp5'accccc(display_short)|psi-mi:"CHEBI:149612"(display_long)	psi-mi:nsp10-nsp16_sars2(display_short)|psi-mi:6wjt(display_long)|intact:SARS-CoV-2 NSP10-NSP16 2'-O-methyltransferase complex(complex recommended name)|intact:"NSP10:NSP16"(complex systematic name)|intact:SARS-CoV-2 NSP16/NSP10 complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442716|imex:IM-28473-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0003723"(RNA binding)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|efo:"EFO:0000694"(see-also)|pubmed:32015508(see-also)|pubmed:31987001(see-also)|complex portal:CPX-5688(complex-primary)|intact:EBI-25766846(exp-evidence)|pubmed:32994211(see-also)	-	-	curated-complex:"2'-O-methyltransferase complex of the SARS-CoV-2 coronavirus which mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. using S-adenosyl-L-methionine (SAM, CHEBI:15414) as the methyl donor. The cap structure is essential for efficient splicing, nuclear export, translation and mRNA stability."|complex-assembly:Heterodimer|disease:"Severe acute respiratory syndrome (SARS) [EFO:0000694]: A viral respiratory infection caused by the SARS coronavirus. It is transmitted through close person-to-person contact. It is manifested with high fever, headache, dry cough and myalgias. It may progress to pneumonia and cause death."|complex-properties:NSP10 forms a homododecamer in isolation.	figure legend:Fig. S6|agonist:"Tris(hydroxymethyl)aminomethane [CHEBI:9754],  4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) [CHEBI:42334]"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/11/05	-	-	-	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449633	intact:EBI-25475880	intact:EBI-25492395	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449633(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442690|imex:IM-28473-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:6799|chain-seq-end:7096	figure legend:S2, S3b|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/12/14	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:TnbLJN5Q4tX5IUV/hhNkiSyxMsE2697049	rigid:582Rw1bwfnjhQ9Cimb1tneXw8JA	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449633	intact:EBI-25475880	intact:EBI-25492395	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449633(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26442705|imex:IM-28473-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:6799|chain-seq-end:7096	figure legend:S3a|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/12/14	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:TnbLJN5Q4tX5IUV/hhNkiSyxMsE2697049	rigid:582Rw1bwfnjhQ9Cimb1tneXw8JA	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449628	uniprotkb:P0DTD1-PRO_0000449633	intact:EBI-25475880	intact:EBI-25492395	psi-mi:p0dtd1-pro_0000449628(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449633(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0071"(molecular sieving)	Sumera Perveen, Aliakbar, et al. (2021)	doi:10.1101/2020.10.14.340034|imex:IM-28473|pubmed:33423577	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26564397|imex:IM-28473-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	chain-seq-start:4254|chain-seq-end:4392	chain-seq-start:6799|chain-seq-end:7096	figure legend:S4|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/04	2020/12/14	rogid:L4eD+20oc1IdNFJ9By3H2uun6L02697049	rogid:TnbLJN5Q4tX5IUV/hhNkiSyxMsE2697049	rigid:582Rw1bwfnjhQ9Cimb1tneXw8JA	false	his tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)